Genetic and functional analysis in zebrafish shows that Vgll4 limits tissue growth by inhibiting Yap1–Tead– mediated activation and promoting Tead-dependent repression, providing a framework for how H...

We study Cell Competition during Embryonic Development using 3D Gastruloids at the University of Freiburg. We view cells as interactive societies in development and cancer. Research, stem cells, Gastr...

Zheng et al. demonstrate that mitochondria remodel the structure and composition of mitochondrial ribosomes in response to metabolic state. This structural “gear-switching” mechanism fine-tunes mitoch...

A sea urchin is a head with a brain-like organization and a vertebrate-type retinal signature.

A method to label cultured human embryos finds chromosome segregation errors in placenta-fated cells.

PhD Project - MRC DiMeN Doctoral Training Partnership: How does Wnt and Notch (Wntch) signalling coordinate cell fate assignment during gastrulation? at University of Liverpool, listed on FindAPhD.com

Enhanced STAT3 activation combined with TGF-β inhibition reprograms human PSCs into cells specifying all early embryonic lineages. Upon 3D suspension culture, these cells self-organize within 6 days i...

Precise control of organ size is crucial during development and homeostasis. Dysregulation of the underlying mechanisms can result in organ malformation and tumorigenesis. Although the Hippo signaling...

A study reports the development of a method to trace intercellular transfer of mitochondria, and demonstrates that cancer cells that receive mitochondria from neurons have enhanced metastatic capabili...

Chordin-mediated BMP shuttling is the candidate mechanism for generating bilateral symmetry in the cnidarian-bilaterian ancestor.

Nature Metabolism - Jackson et al. provide insight into how metabolic adaptations that accompany cell state transitions drive reliance on exogenous nutrient availability, focusing on pyruvate as a...