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Leo Castanedo

@leocastanedo.bsky.social
228 followers 182 following 57 posts

Plant biologist | Proud and happy dad | Passionate about stress-resilient plants🌱, microbes🦠, and symbiotic nutrient interactions | From 🇲🇽 living in 🇪🇺 X: @leo_castanedo

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Reposted by Leo Castanedo
Ben Parker @ben-parker.bsky.social · 21/09/2026
Excited that our new paper with @henrylabsymbio.bsky.social and Kerry Oliver is out @pnas.org! We show that mobile genetic elements can spread adaptive host-benefiting traits across heritable insect symbionts on eco-evolutionary timescales.🧵 www.pnas.org/doi/10.1073/...
pnas.org
Phenotypic divergence is driven by mobile genetic elements in a heritable insect symbiont | PNAS
Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont s...
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André Marques @amarques.bsky.social · 16/09/2026
Out today in Nature: sex without crossovers. Rhynchospora tenuis makes pollen, fertilises and sets seed, yet 0 crossovers in 10,997 pollen nuclei. Chromosome drive and ~87% seed abortion rebuild the mother's genotype, so the offspring are clones. doi.org/10.1038/s415...
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Ciaran Kelly @ciarankelly.bsky.social · 08/09/2026
Our new preprint is out! 🍄 Decoupled evolution of antimicrobial repertoires in lichen-forming fungi We compared many lichen-forming fungal genomes to ask how different photobiont associations relate to their antimicrobial repertoires.
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 07/09/2026
Please submit comments to the EU Commission’s Call for Evidence on how to implement the new rules for "Plants obtained by new genomic techniques (#NGT)". Submission deadline 28 Sept. Below what I submitted. #plantscience ec.europa.eu/info/law/bet... ec.europa.eu/info/law/bet...
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Reese Richardson @reeserichardson.bsky.social · 25/08/2026
A massive update: At least ~15 companies~ are selling scientists antibodies using faked validation data. We've documented 18,000+ manipulated images on 17,000+ products sold by leading laboratory suppliers including Thermo Fisher, Abcam, Santa Cruz Biotechnology, Millipore Sigma and Bio-Techne. 1/🧵
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PlantEvolution 🌱🌾 @plantevolution.bsky.social · 13/08/2026
Remember the spectacular claims from three years ago, that science is supposedly becoming less disruptive? Seems this was at least in part due to data artifacts. To be fair, the authors of the original study push back, that the new study is flawed as well. www.nature.com/articles/s41...
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Gulnara Tagirdzhanova @metalichen.bsky.social · 11/08/2026
Our study on giant transposons Starship 🚀🧬 in the genome of the lichen fungus Xanthoria is now out in @pnas.org! What did we find out about Starships in #lichen fungi? 👇Updated thread below 🖥️ 🧪 🦠 🧫 #SymbioSky 1/6 www.pnas.org/doi/10.1073/...
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Carl Zimmer @carlzimmer.com · 06/08/2026
Here's a new kind of virus that scientists have generated with AI. And here's my story about what it means for us to have gotten to this remarkable moment: nyti.ms/4bBhoWB (Gift link) 🧪
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Christian Landry @christianlandry.bsky.social · 04/08/2026
Our latest contribution on #regulatoryevolution in which we show that the shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations. Led by @simonaube.bsky.social www.nature.com/articles/s41...
nature.com
The shape of fitness functions and the distribution of mutational effect sizes jointly limit adaptation by regulatory mutations - Nature Ecology & Evolution
Saturation mutagenesis of the FCY1 promoter in budding yeast shows that adaptation to 5-fluorocytosine is not accessible through single cis-regulatory mutations, despite large mutational effects on pr...
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Z. Jack Tseng @tsengzj.bsky.social · 30/07/2026
Exhilarated to share a 2nd @science.org cover article this month from our lab @ucberkeleyofficial.bsky.social! A collaboration with US & Mexico colleagues on the role of a Mexican biogeographic holding pen in shaping the Great American Biotic Interchange (GABI)(1/11) www.science.org/doi/10.1126/...
Cover of Science magazine for July 30, 2026. Caption from Science reads: A three-dimensional rendering shows the land bridge connection between North and South America. Research on the fossil record of mammals in Mexico suggests that the geographic region acted as a biodiversity “holding pen” for 10 million years, buffering the pace of both northward and southward movements of mammal species leading up to the Great American Biotic Interchange.
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JCarlos Villarreal @jcarlosvillarreal.bsky.social · 27/07/2026
5 (+?) independent plant lineages evolved to text the same bacteria for nitrogen. we just need to learn the language they're using. www.cell.com/trends/plant...
cell.com
Plant–cyanobacterial symbioses: mutualism with emerging translational possibilities
Engineering rhizobial–plant nitrogen fixation in crops is a major goal in plant synthetic biology. We propose expanding efforts to plant–cyanobacterial symbioses as an alternative path. Targeting the ...
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NL Institute of Ecology NIOO-KNAW @niooknaw.bsky.social · 31/07/2026
New publication: The legacy of #soil chemistry: a hidden manipulator driving plant–soil feedbacks. #belowgroundinteractions #plantperformance #volatilecompounds doi.org/10.1016/j.ti...
Figure 2 in Chen et al. (2026): "Conceptual pathways indicating the involvement of soil chemical legacies in plant–soil feedbacks.
Plant metabolites released by a growing plant, as well as those released during the decomposition of plant litter can: (i) directly affect the roots and performance of a responding plant; (ii) recruit root-associated microbiota that subsequently colonize responding plant roots and alter their performance; (iii) recruit root-associated microbiota that produce secondary metabolites directly influencing responding plant roots; and (iv) support root-associated microbiota that release secondary metabolites attracting or repelling other soil microbes, which indirectly modify the growth and defense of the responding plant."
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Jeff Groh @jeffgroh.bsky.social · 28/07/2026
Avocados come in 2 varieties - A-types start each day female and switch to male midday. B-types do the reverse. In work just published from the last chapter of my PhD, we show this system evolved 40+million yrs ago and is regulated by alleles of 1 transcription factor www.pnas.org/doi/10.1073/...
pnas.org
Balanced polymorphism in a floral transcription factor underlies the ancient rhythm of daily sex alternation in avocado | PNAS
In avocado and certain wild relatives in Lauraceae, a highly synchronized daily rhythm of floral sex timing promotes cross-pollination between two ...
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Team Thomma @teamthomma.bsky.social · 28/07/2026
📣 New preprint! 🧵 Fantastic work led by @antonkraege.bsky.social Fact: Cerato-platanins are everywhere in fungi. Found across the fungal kingdom, implicated in everything from development to virulence to immune activation. But what do they *actually* do? We finally found the answer 👇
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New Phytologist @newphyt.bsky.social · 20/07/2026
Cretaceous moss–cyanobacteria association reveals trophic interactions in polar forests of Antarctica Walker et al. habitualb.bsky.social nph.onlinelibrary.wiley.com/doi/10.1111/...
Kimmerera cyanifera gen. et sp. nov. with associated cyanobacteria, holotype UWBM 116051.
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Björn Usadel @usadellab.bsky.social · 17/07/2026
Within the @trr341.bsky.social JJ Szymanski has an interesting postdoc position for leading plant Ecological genetics AI recruiting.fz-juelich.de/jobposting/5...
recruiting.fz-juelich.de
Postdoctoral Researcher - Machine Learning for Plant Regulatory Genomics
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Sebastian Schornack @dromius.bsky.social · 13/07/2026
Preprint! How do "friendly" rhizobia build a legume nodule? @albinteulet.bsky.social found that some may carry hidden transcription factors - proteins that mimic DNA-binding folds to enter the plant nucleus and rewrite its developmental program. www.biorxiv.org/content/10.6... (1/6)
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Team_Zuccaro @algazuccaro.bsky.social · 12/07/2026
Microbial chitinases perform functions beyond antagonism, including facilitating host colonization by interfering with chitin-triggered immunity. We review evidence that their diversification reflects adaptation to distinct host-associated ecological niches. academic.oup.com/femsre/artic...
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Sebastian Schornack @dromius.bsky.social · 09/07/2026
The 'heart' of the #Mycorrhiza #fungi #symbiosis is the arbuscule where plant and fungus exchange nutrients and carbon. Try the arbuscule growth simulator. Let me know how you adjust parameters to get the most beautiful arbuscules. schornacklabslcu.github.io/Arbuscule-Sim/
image of the graphics interface of a simulation software that renders branching fungal hyphae within cells
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Nick Talbot @talbotlabtsl.bsky.social · 06/07/2026
The mycobiont of the lichen Xanthoria parietina produces the siderophore ferrichrome which enables iron acquisition and nutrient exchange with its algal photobiont. Great collaboration with my group & @metalichen.bsky.social led by Hubertus Haas 👇 www.nature.com/articles/s41...
nature.com
Siderophore production by the lichen fungus Xanthoria parietina supports its algal symbiont - Nature Communications
The mechanisms underlying the adaptation of lichens to nutrient-poor environments are poorly understood. Here, Happacher et al. show that a globally distributed lichen fungus produces an iron-scavengi...
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Richard Sever @richardsever.bsky.social · 06/07/2026
“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...
biorxiv.org
Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models
Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...
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Nature @nature.com · 01/07/2026
A biology journal trialled paying their reviewers and found it led to faster first editorial decisions – and increased review quality. go.nature.com/446SaLu
go.nature.com
Why paying peer reviewers works, according to a journal’s editor-in-chief
A biology journal which paid peer reviewers found that the approach cut the time to a first editorial decision by 85% and maintained high-quality reviews.
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Charlie Underwood @charlieunderwood.bsky.social · 02/07/2026
In meiosis homologous chromosomes pair and exchange DNA non-randomly. How does reproductive gender and chromosome sequence shape recombination landscapes? To answer this we generated new wild tomato genomes and many reciprocal crosses with @usadellab.bsky.social www.nature.com/articles/s41...
nature.com
Wild tomato genome assemblies reveal structural variants and repeat content act as recombination barriers - Nature Communications
Introgression of genes from wild tomato species can enhance the robustness of modern tomatoes. Here van Rengs et al. describe the genomes of wild tomato species and show how reproductive gender and st...
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Min-Yao Jhu @minyaojhu.bsky.social · 24/06/2026
1/ Excited to share our new bioRxiv preprint! "4D spatial transcriptomics reveals nodule identity emerges through stacked parallel developmental programs" 📄 doi.org/10.64898/202... Using Xenium, we generated a 4D (3D space + time) atlas of nodule development in Medicago truncatula.
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Harmit Singh Malik @harmitmalik.bsky.social · 24/06/2026
I know it seems like a heretical idea, but one way to figure out if a preprint is really interesting (to you) is... to read the preprint. Then, in the spirit of sharing, send a note to authors: a simple kudos or a more detailed question. I do this a dozen times a year. It's awesome. Try it.
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Björn Usadel @usadellab.bsky.social · 25/06/2026
1/8 What if the genomic features we associate with fungal pathogens were also used by mutualists? We assembled 41 scale lichen genomes across 11 Peltigera species with 30 chromosome scale and 5 T2T revealing an unexpected genomic toolkit behind lichen symbiosis. doi.org/10.64898/202... #lichen
doi.org
A chromosome-scale super-pangenome of the lichen genus Peltigera reveals genome architecture and expanded interaction repertoires shared across pathogenic and mutualistic fungi
Fungi engage in associations with other organisms across a continuum from pathogenic to mutualistic lifestyles. Hence, they require a compendium of molecular capacities, including partner recognition,...
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bioRxiv Genomics @biorxiv-genomic.bsky.social · 21/06/2026
A chromosome-scale super-pangenome of the lichen genus Peltigera reveals genome architecture and expanded interaction repertoires shared across pathogenic and mutualistic fungi www.biorxiv.org/content/10.64898/20…
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Team Thomma @teamthomma.bsky.social · 19/06/2026
📣 We are hiring! In the collaborative research center 'Plant Ecological Genetics' @teamthomma.bsky.social searches a PhD candidate to study the role of plant-associated microbiota in plant density responses and inter-plant competition. See project A07: sl1nk.com/b7z0doc Deadline July 10!
sl1nk.com
Encurtador de Link
Encurtador de Link | O melhor encurtador de links e urls gratuito da internet.
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Thomas Ott @ottlab.bsky.social · 19/06/2026
A new documentary on scientific approaches to replace industrial nitrogen fertilizers is now online @artefr.bsky.social (only in DE/FR). Among them is our and @pierremarcdelaux.bsky.social's work @ensa-research.bsky.social further supported by @cibss.bsky.social. www.arte.tv/de/videos/11...
arte.tv
Dünger der Zukunft: Die Stickstoff-Revolution - Die ganze Doku | ARTE
Ohne künstlichen Stickstoffdünger wären die hohen Erträge der industriellen Landwirtschaft undenkbar. Doch der intensive Einsatz schädigt das Klima. Weltweit wird nach klimafreundlichen Alternativen g...
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Stefan A. Rensing @rensingstefan.bsky.social · 18/06/2026
Updated @theplantjournal.bsky.social guidelines: avoid the use of terms such as “basal”, “early diverging lineage”, “primitive”, “ancestral plant”, “lower and higher plants” [..] recommends the use of specific terms such as “bryophytes”, “vascular plants” [..] onlinelibrary.wiley.com/page/journal...
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Jens Boch @mikrobenjaeger.bsky.social · 17/06/2026
Awesome! 👏 Finally, science has convinced sufficient politicians to approve the new NGT-rules to enable CRISPR-based plant breeding! Time to celebrate!🎉🎊🥂🧬✂️🌱 www.europarl.europa.eu/news/en/pres...
europarl.europa.eu
New genomic techniques for plants to boost innovation in sustainable agriculture | News | European Parliament
Parliament has adopted new rules facilitating access to new plants that are climate and pest resistant, give higher yields and require fewer pesticides.
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Megha Satyanarayana @megha.bsky.social · 16/06/2026
just before he died, craig venter spoke to @sciam.bsky.social about the state of science in the US. it's a really eye-opening interview and part of our july/aug double issue celebrating #SciAmYoungScientists. check it out. www.scientificamerican.com/article/crai...
scientificamerican.com
Craig Venter
In his final interview, the “swashbuckling” geneticist pointed the way for science
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Juliette de Meaux @meauxjuliette.bsky.social · 15/06/2026
We have openings at the University of Cologne, come and join our consortium in Plant Ecological Genetics TRR341!Applications open soon for 10 PhD position. Description here: trr341.uni-koeln.de/join-us #TRR341 #PlantEcologicalGenetics
trr341.uni-koeln.de
Join us!
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Current Biology @currentbiology.bsky.social · 12/06/2026
When a protist engulfed a cynaobacterium, Earth changed forever! @jandevries.bsky.social, @caeciliafkunz.bsky.social, @heche.bsky.social & colleagues review the origins and evolution of archaeoplastids, the lineage that arose from this event, including plants & co www.cell.com/current-biol...
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The Rokas Lab at Vanderbilt University @rokaslab.bsky.social · 11/06/2026
Interested in how #fungi came about on this planet? If so, take a look at my new article that just came out in @annualreviews.bsky.social. doi.org/10.1146/annu...
doi.org
The Origin and Early Evolution of Fungi: Challenges, Inferences, and Principles
Fungi are widespread on our planet and essential for life as we know it, but how did they come about? Their last common ancestor lived hundreds of millions of years ago, but its characteristics, and t...
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Will Shaw @willshaw.bsky.social · 11/06/2026
New preprint out 🌱 We present a new T-DNA vector system for Arabidopsis that supports clean, genomically mapped, single-copy T-DNA insertion with predictable cell-type/conditional gene expression. @mokhalil.bsky.social + Gehring labs biorxiv.org/content/10.6... 🧵1/16
biorxiv.org
Rational design of T-DNA vectors enables predictable, single-copy integration in Arabidopsis thaliana
Agrobacterium-mediated transformation is the dominant method for plant transgenesis, yet it frequently produces multi-copy, structurally complex T-DNA insertions associated with transgene silencing, u...
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Leo Castanedo @leocastanedo.bsky.social · 11/06/2026
Yesterday, Plantletics 🌿, the running group representing the Institute for Plant Sciences @unicologne.bsky.social, took part in the #UniLauf, and we had a fantastic time‼️
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Toni Gabaldón @tonigabaldon.bsky.social · 10/06/2026
Our paper "Gene ancestries reveal diverse microbial associations during eukaryogenesis.” is finally out in Nature. Eukaryogenesis was likely a gradual process shaped by multiple microbial partners and virus-mediated gene transfer, rather than a single binary symbiosis. doi.org/10.1038/s415...
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Christine Mayr @christinemayr.bsky.social · 08/06/2026
Finally out in @Cellcellpress! Proteins with long IDRs are prone to misfolding during protein synthesis. This is prevented by mRNA 3′UTRs that act as mRNA-based IDR chaperones. www.cell.com/cell/fulltex...
cell.com
mRNA 3′ UTRs chaperone intrinsically disordered regions to control protein activity
Highly conserved mRNA 3′ UTRs act as co-translational chaperones for intrinsically disordered regions (IDRs), preventing inter-domain misfolding and enabling biogenesis of fully active proteins.
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Remco Stam @rstam.bsky.social · 09/06/2026
Host killing by necrotrophs is really complex. Using a 29-gene knockout series in Botrytis cinerea, we show that removing nearly all known cell death-inducing proteins and major phytotoxins is not sufficient to prevent host necrosis. Check out the paper: www.biorxiv.org/content/10.6...
biorxiv.org
Deletion of 29 cell death-inducing proteins and phytotoxin biosynthetic genes does not completely abolish virulence of Botrytis cinerea
Botrytis cinerea is a necrotrophic plant pathogen with an extremely wide host range. During invasion, the fungus induces rapid host cell death and proliferates in the necrotic tissue. The mechanisms o...
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Clémence Marchal @clemmar.bsky.social · 08/06/2026
Hiring: Junior Group Leader (f) in Protein Science — CRC 1664 SNP2Prot, MLU Halle. Lead your own group + budget, funded PhD, world-class protein-structure facilities. 5 yrs, E14. Apply by 7 July 2026. snp2prot.uni-halle.de #ProteinScience #SNP2Prot #AcademicJobs
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Julia Frunzke @frunzkelab.bsky.social · 03/06/2026
Please RT: Registration is ongoing for our International Symposium "Microbial Networking - from organelles to cross-kingdom communities" organized as highlight of the first funding period of CRC 1535 @mibinet.bsky.social www.sfb1535.hhu.de/internationa... @dfg.de, @hhu.de, @fz-juelich.de
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Muriel Viaud @muriel-viaud.bsky.social · 03/06/2026
Happy to share our work! 🍄🍇 Botrytis cinerea grapevine-specialized strains harbor a specific repertoire of transposons. While retrotransposon-derived small RNAs do not appear to play a significant role in virulence on grapevine, a new giant transposon—a #Starship— confers arsenic resistance.
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Team_Zuccaro @algazuccaro.bsky.social · 24/05/2026
Here we show that low intra-microbiota antagonism underlies stable, protective barley root microbiota. Microbiota function cannot be predicted from beneficial traits of individual strains alone, but depends on compatibility among community members. #Microbiome #Plant www.biorxiv.org/content/10.6...
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Johana Misas Villamil @jomivi.bsky.social · 03/06/2026
📢 new preprint! How do commensal bacteria establish themselves on plant roots despite plant immunity? We identify Cpi1, a conserved membrane-anchored protease inhibitor in Pseudomonas that promotes early root colonization and modulates microbial community assembly. www.biorxiv.org/cgi/content/...
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Team Thomma @teamthomma.bsky.social · 30/05/2026
📣Last week another @biorxivpreprint.bsky.social dropped: "A fungal pathogen effector that shapes host plant microbiota kills bacteria through lipoteichoic acid binding and membrane disruption" a joint effort by @nicksnelders.bsky.social & @gabriellapetti.bsky.social www.biorxiv.org/content/10.6...
biorxiv.org
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Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Sholto David @sholtodavid.bsky.social · 28/05/2026
Reluctant to post too much about this but I did want to share my favourite finding from the dozens of manipulated or duplicated ThermoFisher verification blots. This one has a giant square. Enjoy!
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MPI for Evolutionary Biology @mpi-evolbio.bsky.social · 27/05/2026
Congratulations to Prof. Eva Stukenbrock on her appointment to the Leopoldina. Her research on fungal pathogens helps us better understand evolution and protect crops. www.evolbio.mpg.de/3882989/eva-... #EvolutionaryBiology #Leopoldina
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