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Julia Frunzke

@frunzkelab.bsky.social
528 followers 305 following 79 posts

Professor at Forschungszentrum Jülich and HHU Düsseldorf. Phage-host interaction, regulatory networks, metabolic engineering, SPP 2330

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Reposted by Julia Frunzke
Lawrence Rudy Cadena @rudycadenabioevo.bsky.social · 27/09/2026
Our paper on the subcellular proteome of Paulinella is finally out! A possible oxygen-scavenging mechanism to enhance RuBisCO carboxylation highlights how protists can reveal unexpected solutions to challenges in photosynthesis. Big kudos to everyone involved! @evanowack.bsky.social
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Dorentina Humolli @humollidorentina.bsky.social · 25/09/2026
Very happy to share that HIDEN-SEQ is now out in @natmicrobiol.nature.com! Using this technique, we recapitulated decades of established phage genetics and uncovered new gene functions, including previously unknown anti-defense factors against several defense systems. www.nature.com/articles/s41...
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Alexander Harms @aharms485.bsky.social · 25/09/2026
The final version of our manuscript on TnSeq in bacteriophages (“HIDEN-SEQ”) is out today – if you have an interesting phage phenotype and want to know the underlying genetic basis, this one is for you! 1/4
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Julia Frunzke @frunzkelab.bsky.social · 22/09/2026
Finally!! 🥳 "A consensus-based guideline for personalized bacteriophage therapy" www.nature.com/articles/s41... www.spektrum.de/news/leitlin... @spp2330.bsky.social
spektrum.de
Infektionen: Leitlinie zur Phagentherapie
Für wen eignet sich eine Phagentherapie?
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Simona Huwiler @simonahuwiler.bsky.social · 18/09/2026
#AMR superbugs are getting tougher, but predatory bacteria like B. bacteriovorus can hunt them down! We show that model bacterium E.coli 🦠 can escape these ‘living antibiotic’ by evolution, mainly through OmpF porin loss. This comes at a cost. Details at: tiny.cc/2qpa101 #MicroSky, #Evolution
Evolutionary escape from predation.
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Anthony Vecchiarelli @cellforganized.bsky.social · 19/09/2026
Applications are now being accepted for the 2027 Bacterial Cell Biology & Development GRC, June 6–11! GRS will be on June 5-6, 2027 We’ll likely be oversubscribed, so please apply early!
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Khaled_Selim Lab @selimlab.bsky.social · 19/09/2026
Our Collaborative Research Center MibiNet @mibinet.bsky.social @hhu.de was strongly present in #EMBOBacNet Best poster prize for Benita Lückel, a PhD student in Bott group @fz-juelich.de, sponsored by @natmicrobiol.nature.com Congrats🎉🎉everyone & organizers @lalouxlab.bsky.social @s-lab.bsky.social
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Reposted by Julia Frunzke
MibiNet @mibinet.bsky.social · 18/09/2026
MibiNet PI Eva Nowack (@hhu.de) has been awarded the 2026 Miescher-Ishida Award by the International Society of Endocytobiology! Honored for her work on how endosymbionts integrate into eukaryotic host cells. Huge congratulations! 👏 @evanowack.bsky.social #MibiNet www.hhu.de/news-einzela...
hhu.de
Renommierte Auszeichnung für HHU-Biologin
Die Fachgesellschaft „International Society of Endobiology“ zeichnete am 15. September 2026 Prof. Dr. Eva Nowack, Leiterin des Instituts für Mikrobielle Zellbiologie der Heinrich-Heine-Universität Düs...
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Julia Frunzke @frunzkelab.bsky.social · 19/09/2026
Proudly present our fantastic collaborative effort within SFB 1535 "Microbial networking" @mibinet.bsky.social now out in The ISME Journal. "Context-dependent siderophore exploitability shapes microbial community structure" academic.oup.com/ismej/advanc... @hhu.de @fz-juelich.de @dfg.de
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Khaled_Selim Lab @selimlab.bsky.social · 13/08/2026
🧵 #Bacterial #Multicellularity: We discovered that Ca2+ signaling controls cellular junctions in #cyanobacteria, similar to Euks @embojournal.org A great collab. w/ @weiss-lab.bsky.social #TeamTomo @hhu.de @spp2389.bsky.social @cmfi.bsky.social @mibinet.bsky.social link.springer.com/article/10.1...
link.springer.com
The calcium-binding protein CSE links Ca2+ signaling with cell-cell communication in cyanobacteria - The EMBO Journal
Multicellular cyanobacteria have evolved sophisticated cell–cell communication machinery to exchange, synchronize, and coordinate the efforts of individual cells. Analogous to gap junctions that have ...
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Julia Frunzke @frunzkelab.bsky.social · 06/08/2026
Happy to share our recent review on "Control of foreign DNA: emerging roles of xenogeneic silencers" @spp2330.bsky.social, @fz-juelich.de @hhu.de, @mibinet.bsky.social www.sciencedirect.com/science/arti...
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Borjana Arsova @borjana-a.bsky.social · 22/07/2026
📰 Nice, @vbio.bsky.social (the German Life Sciences association) posts about our work with #bacteriophages in #Plant #Protection. 🧪 #PlantScience #SciCom www.vbio.de/aktuelles/de... @fz-juelich.de @frunzkelab.bsky.social @guidogrossmann.bsky.social
vbio.de
Viren als Pflanzenschützer: Das Potenzial von Bakteriophagen
Bakterien können nicht nur Menschen und Tiere krank machen, sondern auch Pflanzen. Weltweit verursachen bakterielle Pflanzenkrankheiten erhebliche Ernteverluste. Für die Landwirtschaft ist das ein wac...
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Julia Frunzke @frunzkelab.bsky.social · 22/07/2026
Congratulations Aude and team! @spp2330.bsky.social
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Aude Bernheim @audeber.bsky.social · 21/07/2026
2/10 The biological roles of most bacterial natural products remain unknown. A few were shown to provide antiphage phenotypes, as early as 1945 by Doris Jones and more recently by the @themaxwelllab.bsky.social and @frunzkelab.bsky.social labs. Ex: www.nature.com/articles/s41...
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Borjana Arsova @borjana-a.bsky.social · 10/07/2026
Latest science in press 🗞️: Biosustainable plant protection using #viruses (bacteriophages) 🧪 🦠 #PlantScience #botany #PlantMicrobeInteractions @fz-juelich.de @ceplas.bsky.social @mibinet.bsky.social www.fz-juelich.de/en/news/arch...
fz-juelich.de
Viruses as Plant Protectors: Jülich Research Highlights the Potential of Bacteriophages
Researchers at Forschungszentrum Jülich are investigating how natural viruses that specifically infect bacteria can help plants fight off bacterial pathogens. These bacteriophages open up new prospect...
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Borjana Arsova @borjana-a.bsky.social · 10/07/2026
www.hhu.de/news-einzela...
hhu.de
Mikrobiologie: Veröffentlichung in Cell Reports
Forschende der Heinrich-Heine-Universität Düsseldorf (HHU) und des Forschungszentrums Jülich (FZJ) untersuchten, wie natürliche Viren, die gezielt Bakterien befallen („Bakteriophagen“), Pflanzen vor b...
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Sorek Lab @soreklab.bsky.social · 09/07/2026
Our paper out in Science today: The Metis defense system senses molecular byproducts released when a phage degrades the bacterial genome, and then prevents replication of the phage in the infected cell Congratulations @ostermanilya.bsky.social and co-authors!
science.org
Bacteria sense virus-induced genome degradation via methylated mononucleotides
Phages often degrade the genome of their bacterial host to individual nucleotides. Here we describe Metis, a bacterial defense system that directly senses phage-mediated host genome degradation. Metis...
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Björn Usadel @usadellab.bsky.social · 08/07/2026
@sebastianbeier.bsky.social has fixed some minor issues in our read trimmer Trimmomatic for R0.41 since the latest release just a few months ago academic.oup.com/bioinformati.... github.com/usadellab/Tr.... Please note, that the website trimmomatic.com is not ours and send you to commercials.
academic.oup.com
Trimmomatic: a decade of feature-rich, high-performance NGS read preprocessing
AbstractMotivation. Trimmomatic is a widely adopted tool for preprocessing high-throughput sequencing data, particularly from Illumina platforms. Since its
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Khaled_Selim Lab @selimlab.bsky.social · 07/07/2026
Happy to share our latest finding on ComFB, a new #cdiGMP receptor in bacteria Team effort w/ @freecyano.bsky.social at @sfb1381.bsky.social ComFB regulates type IV pilus-dependent functions via sequestering TFs (CRP1/2) @hhu.de @biologyunifreiburg.bsky.social www.sciencedirect.com/science/arti...
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Simon Roux @simrouxvirus.bsky.social · 12/06/2026
🚨 Registration for VEGA26 is 👏 officially open 👏 🚨 The 5th edition of our Viral EcoGenomics and Applications symposium will be held November 18-19, 2026, on the UC Berkeley campus 🧬 🦠 🔬 🧫 Event website ➡️ jgi.doe.gov/work-with-us... Registration link ➡️ cvent.me/e0RnA0
This image shows the VEGA logo (an Earth-shaped capsid colored with green continents and blue oceans), and the taglines: "VEGA Viral EcoGenomics & Applications", "Symposium hosted by the DOE Joint Genome Institute", "Novermber 18-19, 2026"
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Julia Frunzke @frunzkelab.bsky.social · 05/07/2026
Looking forward to Viruses of Microbes 2026 in Prague!
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Typas Lab @typaslab.bsky.social · 29/06/2026
How can we harness the vast functional diversity of microbes on our planet? Join us at EMBL Heidelberg from 8–10 December 2026 to hear about ongoing efforts to decode gene function and organisation in human gut microbes, and to present your own research. www.embl.org/about/info/c...
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Julia Frunzke @frunzkelab.bsky.social · 30/06/2026
What is the impact of phage biocontrol on plant immune responses and bacterial virulence? Very happy that this is out @cp-cellreports.bsky.social! @mibinet.bsky.social, @dfg.de, @fz-juelich.de, @hhu.de, @spp2330.bsky.social
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Melanie Blokesch @mblokesch.bsky.social · 29/03/2026
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
tiny.cc
Open Positions
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Julia Frunzke @frunzkelab.bsky.social · 27/06/2026
Congratulations @athanasios-ppdpls.bsky.social and @mibinet.bsky.social!
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Vivek Mutalik @vivekmutalik.bsky.social · 21/06/2026
Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools #phage #phagesky Trends in Microbiology www.cell.com/trends/micro...
cell.com
Beyond AMGs: Phage-encoded transcription and sigma factors as understudied virocell reprogramming tools
Phages, the most abundant biological entities on Earth, infect bacteria and reprogram them into ‘virocells’ with altered physiology and ecology. While metagenomic studies have largely inferred reprogr...
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Team Thomma @teamthomma.bsky.social · 19/06/2026
📣 We are hiring! In the collaborative research center 'Plant Ecological Genetics' @teamthomma.bsky.social searches a PhD candidate to study the role of plant-associated microbiota in plant density responses and inter-plant competition. See project A07: sl1nk.com/b7z0doc Deadline July 10!
sl1nk.com
Encurtador de Link
Encurtador de Link | O melhor encurtador de links e urls gratuito da internet.
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FEMS @femsmicro.org · 18/06/2026
Dr. Michael Sauer, FEMS Board Member and ÖGMBT President, invites you to join him this year in Vienna as collaboration takes centre stage at the FEMS Regional COLLAB. Discover how collaboration can transform ideas into impact. ⏰ 23 June EB Deadline: buff.ly/pg2yXvN
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Altegoerlab @faltegoer.bsky.social · 09/06/2026
As promised: We have an open 2-year postdoc position in my lab at HHU Düsseldorf, starting September 2026. Come join us and help pioneering structural biology of fungal GPCRs! More about the lab: altegoerlab.de Apply here: karriere.hhu.de/index.php?ac... Please share with interested candidates!
karriere.hhu.de
Postdoc (m/f/d) structural biology of fungal G-Protein coupled receptors
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Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 12/06/2026
NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back Preview of work IDing aRES, bacterial proteins that deplete cellular NAD+, generating products that cannot be utilized by phage NAD+ regeneration pathways www.cell.com/cell-host-mi...
cell.com
NAD to the bone: How bacteria put phages under aRES-t … and how phages fight back
In this issue of Cell Host & Microbe, Osterman et al. discover aRES, a new family of bacterial immune proteins that deplete cellular NAD+, generating cleavage products that cannot be utilized by canon...
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Khaled_Selim Lab @selimlab.bsky.social · 12/06/2026
Our review on structural mechanisms of #CO2 fixation machinery by #cyanobacteria @theplantjournal.bsky.social is out🎉🎉 When #CO2 is limiting, #cyano concentrate it. Discover how they thrive? @hhu.de @ceplas.bsky.social @mibinet.bsky.social @sfb1381.bsky.social onlinelibrary.wiley.com/doi/10.1111/...
onlinelibrary.wiley.com
Functional and structural insights into cyanobacterial CO2 concentrating mechanisms: from compartmentalization to regulation
Life on Earth depends on photosynthetic CO2 fixation via the Calvin–Benson–Bassham cycle to form organic carbon. This process evolved first in cyanobacteria and was later conveyed to eukaryotes, givi...
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PLOS Biology @plosbiology.org · 08/06/2026
#Biofilm matrices containing filamentous phages help #Pseudomonas aeruginosa tolerate antibiotics. @abultarafder.bsky.social @tbharat-lab.bsky.social &co show that #nanobody disruption of #phage Pf4 #LiquidCrystalline droplets restores #antibiotic susceptibility @plosbiology.org 🧪 plos.io/4xkd6Mw
Top: Nanobody binders are potent inhibitors of Pf4 liquid crystalline droplet formation and disrupt preformed droplets. Cryo-ET of Pf4 liquid crystalline droplets incubated with Nb43. Tomographic slice of a Pf4 liquid crystalline droplet specimen incubated with (left) 0.1 μM and (right) 1 μM Nb43. Bottom: Schematic representation of nanobody action in abolishing antibiotic tolerance of P. aeruginosa biofilms. In untreated biofilms (left), cells show increased antibiotic tolerance due to Pf4 liquid crystalline droplets formed by depletion attraction in the biofilm EPS matrix, where encapsulated cells are protected by an antibiotic diffusion block. In nanobody treated biofilms, patchy binding of nanobody to Pf4 filaments reduces depletion attraction between the filaments preventing liquid crystalline droplet formation and encapsulation of cells, leading to increased antibiotic susceptibility of bacteria within the biofilm.
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Julia Frunzke @frunzkelab.bsky.social · 04/06/2026
Now out in @pnas.org 🥳 "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" --> bad timing can kill you, even as a virus. www.pnas.org/doi/10.1073/... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Julia Frunzke @frunzkelab.bsky.social · 03/06/2026
Please RT: Registration is ongoing for our International Symposium "Microbial Networking - from organelles to cross-kingdom communities" organized as highlight of the first funding period of CRC 1535 @mibinet.bsky.social www.sfb1535.hhu.de/internationa... @dfg.de, @hhu.de, @fz-juelich.de
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Julia Frunzke @frunzkelab.bsky.social · 18/05/2026
Registration opened for our International Symposium of SPP 2330! This is going to be phage-tastic meeting in Berlin! Highlight of the second funding period! @spp2330.bsky.social, @dfg.de
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Luuk Loeff @lloeff.bsky.social · 14/05/2026
Happy to share our latest pre-print on the Druantia defense system. We find that Type III Druantia uses a cooperative helicase-nuclease mechanism to sense and degrade replication-associated forked DNA structures. www.biorxiv.org/content/10.6... A🧵
biorxiv.org
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Oleg Dmytrenko @olehdmy.bsky.social · 07/01/2026
Our paper is out! Hiding in plain sight among Cas12a nucleases, Cas12a3 cleaves not its RNA target but the 3′ ends of tRNA. Huge thanks to all who made this possible, especially the Beisel lab, Biao & Dirk for the structure, & @sebastianglatt.bsky.social for all things tRNA. doi.org/10.1038/s415...
nature.com
RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Cas12a3 nucleases constitute a distinct clade of type V CRISPR–Cas bacterial immune systems that preferentially cleave the 3′ tails of tRNAs after recognition of target RNA to induce growth arres...
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Julia Frunzke @frunzkelab.bsky.social · 13/05/2026
Must read: @spp2330.bsky.social
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Nature @nature.com · 10/05/2026
David Attenborough has raised awareness of the natural world and its myriad interconnections on which humans depend go.nature.com/48RTqVz
go.nature.com
Happy 100th birthday David Attenborough! Nature salutes you
Nature - The science communicator has raised awareness of the natural world andits myriad interconnections on which humans depend.
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Nature @nature.com · 10/05/2026
Experienced researchers are less likely to produce ‘disruptive’ science than are those just starting their careers, finds an analysis of scientific papers published by 12.5 million researchers over 60 years go.nature.com/3Pb1lqg
go.nature.com
Early-career researchers do more ‘disruptive’ science than veterans
Nature - Analysis of papers from millions of scientists shows that older researchers tend to stick with ideas from their past.
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Ariane Briegel @arianebriegel.bsky.social · 08/05/2026
Exciting times for our lab- recent developments in cryoET tools and workflows now allow us apply these to study microbes in the host context. #teamtomo www.sciencedirect.com/science/arti...
sciencedirect.com
Beyond resolution: Cryo-electron tomography of microbial nanomachines in native host context
Cryo-electron tomography (cryo-ET) has revolutionized visualization of bacterial nanomachines by revealing molecular structures in situ under near-nat…
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Molecular Microbiology @molmicrounihoh.bsky.social · 07/05/2026
Fresh off the press: The new Glutamate Bible! #glutamate #subtiwiki
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David Bikard @dbikard.bsky.social · 06/05/2026
Master Internships open at Eligo: www.linkedin.com/posts/duport...
linkedin.com
#internship #syntheticbiology #genetherapy #microbiometherapeutics #biotechcareers | Xavier Duportet
If "engineer bacteria to fight diseases" is your kind of fun, come build it with us. 4 Master's internships open at Eligo for Fall 2026 to work on real drug projects: engineered phage-particles to del...
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Julia Frunzke @frunzkelab.bsky.social · 06/05/2026
Very happy to share our recent preprint: “An Lsr2-like xenogeneic silencer confers immunity against AT-rich bacteriophage infection” www.researchsquare.com/article/rs-9... @fz-juelich.de; @hhu.de; @spp2330.bsky.social
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Khaled_Selim Lab @selimlab.bsky.social · 04/05/2026
Happy to share our finding on Lys-toxicity in #cyanobacteria @plantphys.bsky.social by talented PhD #AndreasEnkerlin A collaboration w/ @linkmetabolism.bsky.social @mfeldbruegge.bsky.social @dfg.de @sfb1381.bsky.social @cmfi.bsky.social @hhu.de @mibinet.bsky.social academic.oup.com/plphys/artic...
academic.oup.com
Deciphering the metabolic details of L-lysine toxicity in cyanobacteria
Metabolomic analyses revealed that lysine rapidly disrupts the cell wall, energy homeostasis, amino acid balance, and photosynthesis in cyanobacteria, expl
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Team Thomma @teamthomma.bsky.social · 30/04/2026
Delighted to see this work out in #ScienceAdvancesResearch @science.org where we uncover a surprising evolutionary origin of fungal effector proteins as ancient antimicrobials. Led by the super-star @mesny.bsky.social in the frame of @ceplas.bsky.social @mibinet.bsky.social & @madfungi.bsky.social
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Joe Bondy-Denomy @jbdsf.bsky.social · 24/04/2026
Phage community: our plasmids for executing phage transposon mutagenesis are now on AddGene and I would love for you to try it out! It is powerful for ID'ing all essential genes and knocking out all non-essentials in a single experiment :) New exp here: www.addgene.org/browse/artic...
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Khaled_Selim Lab @selimlab.bsky.social · 20/04/2026
It was a good pleasure to host Annegret Wilde @freecyano.bsky.social from @biologyunifreiburg.bsky.social and @sfb1381.bsky.social To our INSPIRE seminar series @hhu.de with a close interaction between @mibinet.bsky.social and @ceplas.bsky.social
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Julia Frunzke @frunzkelab.bsky.social · 21/04/2026
Congratulations Florian!! @mibinet.bsky.social
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David Bikard @dbikard.bsky.social · 17/04/2026
Very proud of this work and all the efforts from my team and collaborators on this! You can now use DGRs for in vivo targeted hypermutagenesis in E. coli. We also included some early proof of concept in Yeast thanks to @seth-shipman.bsky.social !
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