A collection of Protocols covering a wide range of optogenetic and non-genetic procedures that allow the stimulation of neuronal cell populations using ...

Two-photon calcium imaging is a standard tool for measuring neuronal population activity in vivo , yet how axial resolution, sensor expression strategy, and analysis pipeline jointly affect data accur...

Karl Deisseroth, Peter Hegemann and Georg Nagel are joint winners of the 2026 prize

Dear all Below is an announcement for a permanent position as a Research Engineer in the Institut Pasteur, Paris. There is a flyer attached at the bottom. We are looking ideally for a Bioimage An...

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Studying the brain mechanisms of natural behaviors is experimentally challenging. We developed a miniaturized, wireless platform to record and manipulate neural and physiological activity in small ani...

A compact protein pair that heterodimerizes upon red light activation, FenixS and Ash1, is developed for optogenetic applications.

They used lasers for the god rays of Zeus in Clash of the Titans (1981) and I don't care what you say about the rest of the movie, the lasers are doing great.

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An imaging system developed to record cellular activity throughout the whole body of zebrafish captures cellular organ dynamics and identifies multiple distributed circuits.

It took time and rejections to understand what granting agencies look for. This is how I picked up application-writing skills.

The death of the academic shows the casual conversion of humiliation into entertainment by a media running on monetised hate and cruelty

In this Analysis, Rupprecht et al. investigate the behavior of GCaMP8 variants in spike inference using several different algorithms. They highlight the role of the indicators’ linearity in the infere...

In this Virtual Pub recording, Gil Bub, McGill University, gave a talk on "Parallel microscopy - implementations and applications." Learn more about the Virtual Pub:…

Plasmid pGA-01-47 from Dr. Harrison Steel's lab contains the insert MagLOV 2 and is published in Nature. 2026 Jan 21. doi: 10.1038/s41586-025-09971-3. This plasmid is available through Addgene.

A recently developed class of magneto-sensitive fluorescent proteins are engineered to alter the properties of their response to magnetic fields and radio frequencies, enabling multimodal sensing of b...

FlatMux is an optimized microscope system for multiplexed two-photon imaging of neuronal activity with genetically encoded voltage sensors. The flexible system is demonstrated in a variety of scenario...

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Oatman et al. introduce PyCLM, a Python suite for closed-loop optogenetic experiments combining real-time biosensor measurement and segmentation of thousands of cells. The method is applied to epithel...

Bissen et al. show that prey capture learning profoundly reshapes visual cortical circuitry and function during developmental critical periods, but not in adulthood. These learning-induced structural ...

Event-based first-photon fluorescence lifetime imaging enables fluorescence lifetime imaging below one photon per pixel.

Deep imaging in complex scattering media is hindered by multiple light scattering. Here, the authors proposed a method to trace multiple scattering trajectories in situ using a recorded reflection mat...

Nature Methods - Towards a standardized file format and open-source analysis framework for Brillouin microscopy data

Kurzgesagt is a Youtube channel that breaks down science topics for a broad audience. They have great videos, both in terms of narrative, animation, and scientific accuracy. A few days ago, the cha…

Simultaneous voltage imaging of soma and dendrites in layer 2/3 cortical neurons in live mice reveals rich dynamics of spike back-propagation, with amplitude shaped by spiking history, dendrite locati...

In the past years, x-ray emission from adhesive tape peeled in vacuum has been reported and investigated. The generation of x rays is driven by fast electrons g

PinkyCaMP is a red genetically encoded calcium indicator with improved brightness and photostability. Derived from mScarlet, it does not exhibit photoswitching upon blue light illumination and is ther...

In response to changes in illumination, a swimming microorganism reverses the direction of its circular trajectory by tilting its flagella’s planes of motion.