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Julien Guglielmini

@julmini.bsky.social
39 followers 40 following 3 posts

Bioinformatician at Institut Pasteur. Evolution, Microbial genomics, Computational biology, Phylogenetics.

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Reposted by Julien Guglielmini
George Bouras @gbouras13.bsky.social · 07/04/2026
Whenever I presented Phold, I was frequently asked "can you do the same beyond phages?" We ( @oschwengers.bsky.social @linsalrob.bsky.social @binomicalabs.org et al) finally did it with Baktfold github.com/gbouras13/ba... www.biorxiv.org/content/10.6...
github.com
GitHub - gbouras13/baktfold: Rapid & standardized genome annotation using protein structural information
Rapid & standardized genome annotation using protein structural information - gbouras13/baktfold
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Gang Fang @gangfang.bsky.social · 19/05/2026
Glad that our paper is out today in @cp-cellhostmicrobe.bsky.social A baby received a routine course of amoxicillin. In that infant's #gut 💩, we could see something remarkable, already present **before** the antibiotic arriveda single strain 🦠 of #Akkermansia muciniphila was already running 1/n
cell.com
Epigenetic phase variation in the gut microbiome enhances bacterial adaptation
Ni et al. show that epigenetic phase variation (ePV)—gene expression changes mediated by bacterial DNA methylation—is prevalent in the human gut microbiome and associated with fluctuating environments...
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Molecular Biology and Evolution @molbioevol.bsky.social · 24/04/2026
@xavierdidelot.bsky.social et al. present the R package DiagnoDating for diagnosing issues in a reconstructed dated phylogeny, including outlier detection, posterior predictive checking, and residual analysis. 🔗 doi.org/10.1093/molbev/msag093 #evobio #molbio #compbio #phylogeny
doi.org
DiagnoDating: diagnostics for dated phylogenies in microbial population genetics
Abstract. Microbial population genetic studies often involve the use of a dated phylogeny to show how the genomes are related over a relevant timescale. Ma
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Raphael Laurenceau @raphael-microb.bsky.social · 16/04/2026
🔈Paper out! We turned the most fascinating phage host-switch mechanism, diversity-generating retroelements, into a programmable mutagenesis tool, DGRec. You can perform targeted hypermutation of any 50-200bp sequence directly in vivo in E. coli www.nature.com/articles/s41...
nature.com
Diversity-generating retroelements for programmable targeted hypermutagenesis - Nature Biotechnology
Diversity-generating retroelements are engineered for directed evolution in E.coli.
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Martin Steinegger 🇺🇦 @martinsteinegger.bsky.social · 30/01/2026
FoldMason is out now in @science.org. It generates accurate multiple structure alignments for thousands of protein structures in seconds. Great work by Cameron L. M. Gilchrist and @milot.bsky.social. 📄 www.science.org/doi/10.1126/... 🌐 search.foldseek.com/foldmason 💾 github.com/steineggerla...
science.org
Multiple protein structure alignment at scale with FoldMason
Protein structure is conserved beyond sequence, making multiple structural alignment (MSTA) essential for analyzing distantly related proteins. Computational prediction methods have vastly extended ou...
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George Bouras @gbouras13.bsky.social · 14/01/2026
Phold's manuscript is now available @narjournal.bsky.social thanks to @susiegriggo.bsky.social @npbhavya.bsky.social @vijinim.bsky.social @linsalrob.bsky.social @martinsteinegger.bsky.social @milot.bsky.social @eunbelivable.bsky.social & others not on bsky #phagesky academic.oup.com/nar/article/...
academic.oup.com
Protein structure-informed bacteriophage genome annotation with Phold
Abstract. Bacteriophage (phage) genome annotation is essential for understanding their functional potential and suitability for use as therapeutic agents.
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Julien Guglielmini @julmini.bsky.social · 03/11/2025
Je me suis abonné à ce compte récemment. J'étais pas prêt.
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Mediapart @mediapart.fr · 28/07/2025
L’Union européenne capitule pour éviter une guerre commerciale avec Trump Par @romaricgodin.bsky.social
l.mediapart.fr
L’Union européenne capitule pour éviter une guerre commerciale avec Trump
La présidente de la Commission européenne, Ursula von der Leyen, a conclu dimanche soir un accord avec Donald Trump qui fait la part belle aux exigences de Washington. Un droit de douane global de 15 % sera appliqué, mais Bruxelles promet aussi de financer massivement l’économie états-unienne.
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Eduardo Rocha @epcrocha.bsky.social · 23/07/2025
Here's our new broad review on the extended mobility of plasmids, about all mechanisms driving and limiting their transfer. From conjugation to conduction, phage-plasmids to hitchers, molecular to evolutionary dynamics, ecology to biotech. The state of affairs. 1/9 academic.oup.com/nar/article/...
graphical abstract of the article the extended mobility of plasmids
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Pierre Lê-Bury @pierrelebury.bsky.social · 01/07/2025
1/8 - New in @natcomms.nature.com ! ☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis. We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇 www.nature.com/articles/s41...
nature.com
In-host evolution of Yersinia enterocolitica during a chronic human infection - Nature Communications
This study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt...
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Jose F. Delgado-Blas @josefdelgadoblas.bsky.social · 23/06/2025
Excited to share this preprint focused on the genomic taxonomy of C. diphtheriae #diphtheria ➡️ www.biorxiv.org/content/10.1... Hope it helps advance research and surveillance of this relevant bacterial pathogen. Thanks to @sylvainbrisse.bsky.social and BEBP and BIGSdb teams for making it possible!
biorxiv.org
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Emile Marzolf @emilemarzolf.bsky.social · 12/06/2025
Avis aux amateurs : France Travail propose environ 12 millions d'euros pour lui développer un "agent conversationnel" pour échanger avec les demandeurs d'emplois par SMS. www.boamp.fr/pages/avis/?...
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Alexis Stamatakis @stamatak.bsky.social · 15/05/2025
RAxML-NG v2.0 beta is here github.com/amkozlov/rax... Features 1. Difficulty prediction academic.oup.com/mbe/article/... 2. Adaptive search academic.oup.com/mbe/article/... 3. Early Stop www.biorxiv.org/content/10.1... 4. Model selection 5. Rapid bootstrapping academic.oup.com/mbe/article/...
github.com
Release RAxML-NG v2.0-beta2 · amkozlov/raxml-ng
Main new features Adaptive tree search heuristic (Togkousidis 2023) , (Togkousidis 2024) Multiple fast branch support measures Integrated model testing Full Changelog: 1.2.2...2.0-beta2
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Julien Guglielmini @julmini.bsky.social · 03/02/2025
insidemedicine.substack.com/p/breaking-n...
insidemedicine.substack.com
BREAKING NEWS: CDC orders mass retraction and revision of submitted research across all science and medicine journals. Banned terms must be scrubbed.
Any unpublished manuscript mentioning certain topics, including gender and "LGBT," must be pulled or revised.
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Reposted by Julien Guglielmini
Chloé Woitier @chloew.bsky.social · 02/02/2025
Au même moment, les agences fédérales de la Défense ont reçu ordre d'annuler toutes activités autour de 11 évènements annuels sur la diversité américaine, dont le Black History Month, le Women History Month, la LGBT Pride Month, le Holocaust Remembrance Day... www.nbcnews.com/politics/don...
nbcnews.com
Federal agencies bar Black History Month and other 'special observances'
A number of federal agencies have banned celebrations related to MLK Jr. Day, Women's History Month and other such observances to comply with Trump's executive orders.
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Mediapart @mediapart.fr · 01/02/2025
Donald Trump lance sa guerre commerciale mondiale Par Martine Orange
mediapart.fr
Donald Trump lance sa guerre commerciale mondiale
Après avoir confirmé les sanctions douanières contre le Mexique et le Canada, Donald Trump vise désormais l’Union européenne. Des droits douaniers pourraient être imposés très rapidement. Tous...
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Mediapart @mediapart.fr · 31/01/2025
Le groupe TotalEnergies fait des dons à l’université de Strasbourg, notamment pour l’école de chimie. Une convention de mécénat dévoile l’emprise que la multinationale souhaite établir dans l’enseignement supérieur et la recherche. www.mediapart.fr/journal/france/310……
mediapart.fr
À Strasbourg, contre son mécénat, Total demande à « s’impliquer fortement » à l’université de Strasbourg
Le groupe TotalEnergies fait des dons à l’université de Strasbourg, notamment pour l’école de chimie. Une convention de mécénat dévoile l’emprise que la multinationale souhaite établir dans...
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Eduardo Rocha @epcrocha.bsky.social · 27/01/2025
The contribution of natural transformation for the acquisition of novel genes has been notoriously difficult to quantify because it relies on recombination (which is affected by other processes). Here's a first estimate : doi.org/10.1101/2025... (for the very busy: 1-6% of gene gains) #MicroSky
Transformation, Recombination and horizontal transfer
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Mediapart @mediapart.fr · 19/01/2025
La conversion de tout le secteur de la technologie au trumpisme est le fruit de son modèle économique. Pour poursuivre sa logique prédatrice, il a trouvé dans l’extrême droite un débouché politique utile. www.mediapart.fr/journal/economie-e……
mediapart.fr
Les Big Tech basculent à l’extrême droite : c’est l’économie, idiot !
La conversion de tout le secteur de la technologie au trumpisme est le fruit de son modèle économique. Pour poursuivre sa logique prédatrice, il a trouvé dans l’extrême droite un débouché politique...
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Eduardo Rocha @epcrocha.bsky.social · 18/01/2025
This preprint makes a point that is valid for a lot of machine learning approaches. Organisms or genes are linked by evolutionary history; they are not independent. This results in correlation between learning and test sets, and often in over-optimistic evaluations of the methods' outcome.
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Mediapart @mediapart.fr · 19/11/2024
L'équipe de Mediapart arrive progressivement sur Bluesky Les comptes à suivre sont dans notre starter pack 👇 go.bsky.app/5ueP6wM
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Oded Rechavi @odedrechavi.bsky.social · 12/11/2024
University websites are like distant stars, when you look at them you see the scientists as they used to be many years ago
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Zamin Iqbal @zaminiqbal.bsky.social · 13/06/2024
First paper from my student Daria Frolova's PhD now on biorxiv: www.biorxiv.org/content/10.1... The key question: plasmids change structurally ~as fast as they mutate, so how can we decide whether 2 plasmids are "the same plasmid" for epi purposes? 1/n
biorxiv.org
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Jorge Moura de Sousa @jmouradesousa.bsky.social · 29/04/2024
New paper from the lab, the mysteries involving the genetic elements that move by being mobilized by other MGEs. Hitcher Genetic Elements are distinctive, ancient and diverse. ecoevorxiv.org/repository/v...
ecoevorxiv.org
Hijackers, hitchhikers, or co-drivers? The mysteries of microbial mobilizable genetic elements
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Eduardo Rocha @epcrocha.bsky.social · 04/04/2024
New job offer: we search a postdoc (bioinformatics) to work on mobile genetic elements and gene flow in bacteria, with a focus on antibiotic resistance within a consortium including bioinformatics, synthetic biology, epidemiology & biochemistry. See research.pasteur.fr/en/job/postd... #MicroSky
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Keith Jolley @kjolley.bsky.social · 13/03/2024
New preprint out now - stable bacterial strain nomenclature with Life Identification Numbers using a gene-by-gene approach. From our wonderful collaborators at the Institut Pasteur. www.biorxiv.org/content/10.1...
biorxiv.org
Bacterial strain nomenclature in the genomic era: Life Identification Numbers using a gene-by-gene approach
bioRxiv - the preprint server for biology, operated by Cold Spring Harbor Laboratory, a research and educational institution
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Zamin Iqbal @zaminiqbal.bsky.social · 11/03/2024
First step in a community project to provide a uniformly assembled, annotated and searchable set of bacterial genomes, our preprint on our initial release of 1.9 million genome assemblies+taxonomic estimates. (figure compares with previous 661k dataset) www.biorxiv.org/content/10.1... #microsky
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Olaya Rendueles @olayarendueles.bsky.social · 07/03/2024
Our latest work is finally out! How #capsule serotypes of #Klebsiella pneumoniae influences #phage adsorption and infection, and #plasmid conjugation efficiency. Plasmids care about size-phages dont! Great work led by Matthieu Haudiquet in the lab @epcrocha.bsky.social doi.org/10.1038/s414...
doi.org
Capsules and their traits shape phage susceptibility and plasmid conjugation efficiency - Nature Communications
Bacterial capsules provide protection against the environment, including host immune systems. Authors swap capsule loci in Klebsiella pneumoniae to reveal the role of these sugar coats against plasmid...
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Randall Munroe @xkcd.com · 22/02/2024
I recently made a comic complaining that NASA refuses to listen to my good ideas for improving the Solar System (xkcd.com/2750). To my delight, NASA’s Science Mission Directorate has sent me an actual expert panel evaluation of my “flatten the planets” proposal! Sadly, they decided not to fund it.
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Eduardo Rocha @epcrocha.bsky.social · 31/01/2024
New from the lab. We were stuck studying plasmid mobility because we ignored most origins of transfer by conjugation. Using the occurrences of known oriT, we developed a method to find novel unrelated families. Works well. We now cover most conjugative plasmids of E coli, K pneumo & A baumannii.
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Julien Guglielmini @julmini.bsky.social · 16/01/2024
J'ai rarement vu un trailer aussi angoissant
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Gauthier 'Gautoz' Andres // Origami-ami @gautoz.cool · 09/01/2024
Oh non ! James Herbert Brennan, l'auteur de l'incroyable cycle Quête du Graal des Livres Dont Vous Êtes Le Héros, s'en est allé rejoindre le funestre paragraphe 14 à l'âge de 83 ans. Il laisse derrière lui une génération de jeunes Pip endeuillés. RIP :'( rip.ie/death-notice...
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Gavin Douglas @gmdouglas.bsky.social · 04/01/2024
The paper is "Pseudogenes act as a neutral reference for detecting selection in prokaryotic pangenomes"! (I was excepting a thumbnail of the link address to appear, but apparently I have much to learn about BlueSky!)
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Jordan Mechner @jmechner.bsky.social · 02/01/2024
"REPLAY" will make the jump from French to English on March 19, 2024! www.jordanmechner.com/en/books/rep... Un grand merci to everyone who shared the adventure in 2023. Happy New Year! #bandedessinee #graphicnovel #retrogaming #videogames #gamedev #memoir
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Zamin Iqbal @zaminiqbal.bsky.social · 02/01/2024
"BATH matches the accuracy of HMMER3 for annotation of sequences containing no errors, and produces superior accuracy to all tested tools for annotation of sequences containing nucleotide indels."
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Eduardo Rocha @epcrocha.bsky.social · 21/12/2023
Fully automated assessment of correlated evolution on phylogenetic trees: now out in OA: doi.org/10.1111/2041... Thanks to all authors (not yet here). This explains the methodological basis of our recent work on epistatic interactions in the evolution of quinolone resistance: doi.org/10.1093/molb...
doi.org
Evo‐Scope: Fully automated assessment of correlated evolution on phylogenetic trees
Correlated evolution describes how multiple biological traits evolve together. Recently developed methods provide increasingly detailed results of correlated evolution, sometimes at elevated compu...
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Ludovic Chabant @ludovic.chabant.com · 14/12/2023
This website is brilliant: an interactive look at what video games boxes looked like “back in the day”, and all the good stuff you got inside! (by the way, I’m still looking to complete my collection of Ultima boxes, if you have some)
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George Bouras @gbouras13.bsky.social · 15/12/2023
Here is Hybracter, our tool for generating automated hybrid & long-read-only bacterial genome assemblies. Github: github.com/gbouras13/hy... Docs: hybracter.readthedocs.io/en/latest/ Preprint: www.biorxiv.org/content/10.1... @npbhavya.bsky.social @linsalrob.bsky.social #Microsky
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Eduardo Rocha @epcrocha.bsky.social · 15/12/2023
New postdoc position in our lab for a project led by Marie Touchon (bioinformatics) and with O Tenaillon (experiments) on the evolution and dynamics of microbial genomes to understand their diversification by gene flow. Check research.pasteur.fr/en/job/postd...
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