Reposted by Pierre Lê-BuryYersinia Research Unit @yersiniaunit.bsky.social · 12/06/2026Check out our new preprint deciphering SlyB structural role for membrane homeostasis during Yersinia pestis infection ! 👇🏻 275
Reposted by Pierre Lê-BuryInstitut Pasteur | 130 years of biomedical research @pasteur.fr · 08/10/2025Pour chaque vie, la science agit. Le Pasteurdon, c’est maintenant ! Soutenez la recherche et celles et ceux qui la font avancer ↘️ pasteurdon.fr #Pasteurdon 02122
Reposted by Pierre Lê-BuryRyan Wick @rrwick.bsky.social · 29/09/2025Happy to share that the paper describing Autocycler is now 100% up: doi.org/10.1093/bioi... (1/3)doi.orgAutocycler: long-read consensus assembly for bacterial genomesAbstractMotivation. Long-read sequencing enables complete bacterial genome assemblies, but individual assemblers are imperfect and often produce sequence-l 16736
Reposted by Pierre Lê-BuryYersinia Research Unit @yersiniaunit.bsky.social · 23/09/2025💊 🧬 Insightful dive into in-host bacterial evolution under antimicrobial pressure, a work from @csavin.bsky.social and @pierrelebury.bsky.social in our lab at @pasteur.fr 063
Pierre Lê-Bury @pierrelebury.bsky.social · 23/09/2025Great collaboration with @csavin.bsky.social at @yersiniaunit.bsky.social in @pasteur.fr, as well as @julmini.bsky.social @chrudetours.bsky.social @univparissaclay.bsky.social @cea.fr @ap-hp.bsky.social 📖 Out in @natcomms.nature.com @natureportfolio.nature.com 👇 www.nature.com/articles/s41...nature.com 0124
Pierre Lê-Bury @pierrelebury.bsky.social · 01/07/20251/8 - New in @natcomms.nature.com ! ☣️ Meet Yersinia enterocolitica (Ye) — a lesser-known but still dangerous cousin of Yersinia pestis. We uncover how this invasive pathogen can survive and adapt for 14 years inside a human host under constant antibiotic pressure 👇 www.nature.com/articles/s41...nature.comIn-host evolution of Yersinia enterocolitica during a chronic human infection - Nature CommunicationsThis study documents the evolution of antibiotic resistance and major growth defects in Yersinia enterocolitica in a patient over 14 years, revealing genetic changes that shed light on bacterial adapt... 13917
Pierre Lê-Bury @pierrelebury.bsky.social · 18/06/2025Very clear explanation by @alicelebreton.bsky.social of our article about plague virulence reduction, in Le Monde (in French)! 010
Reposted by Pierre Lê-BuryNature Microbiology @natmicrobiol.nature.com · 04/06/2025#NatMicroPicks The plague virulence! 💀🦠 During plague epidemics, virulence gene pla in Yersinia pestis often becomes depleted, which reduces the pathogen's lethality and may help it survive in less susceptible hosts when transmission conditions worsen. #MicroSky www.science.org/doi/10.1126/...science.orgAttenuation of virulence in Yersinia pestis across three plague pandemicsYersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulen... 042
Reposted by Pierre Lê-BuryInstitut Pasteur | 130 years of biomedical research @pasteur.fr · 02/06/2025🦠 The plague bacillus became less virulent, extending the duration of two major pandemics. @yersiniaunit.bsky.social @pierrelebury.bsky.social @mcmasteruniversity.bsky.social @ravneetksidhu.bsky.socialpasteur.frThe plague bacillus became less virulent, prolonging the duration of two major pandemicsScientists at the Institut Pasteur and McMaster University have discovered that the evolution of a gene in the bacterium that causes bubonic plague, Yersinia pestis, may have prolonged the duration of... 13615
Pierre Lê-Bury @pierrelebury.bsky.social · 31/05/2025Picking up our publication on Black Death and plague pandemics: here are interesting historical thoughs about the well known but deceptive (not so) medieval plague doctor costume 131
Reposted by Pierre Lê-BuryTami Lieberman @contaminatedsci.bsky.social · 30/05/2025Our work on the facial skin microbiome of non-human primates is out in mSystems! We show there is no close relative of Cutibacterium on the faces of gorillas and chimps at the Lincoln Park Zoo, furthering the mysterious origin of the dominant human skin colonizer. journals.asm.org/doi/10.1128/...journals.asm.orgThe microbiome of the human facial skin is unique compared to that of other hominids | mSystemsUnderstanding how and why human skin bacteria differ from our closest animal relatives provides crucial insights into human evolution and health. While we have known that human facial skin hosts disti... 26426
Reposted by Pierre Lê-BuryMichael G. DeGroote Institute for Infectious Disease Research @mcmasteriidr.bsky.social · 29/05/2025IIDR researchers have discovered that a single gene in Yersinia pestis — the bacteria that causes bubonic #plague — was responsible for keeping pandemics like the Black Death burning for hundreds of years. Learn more about this evolutionary phenomenon in our all-new explainer video. #IDSky 051
Reposted by Pierre Lê-BurySébastien Bontemps-Gallo, Ph.D. @sebbontempsgallo.bsky.social · 30/05/2025Two great papers in @science.org this month on the #evolution of #vector-borne #pathogens 1 #Yersinia pestis attenuates virulence over 3 pandemics 2 Ancient #Borrelia genomes trace the rise of louse-borne relapsing fever Fascinating reads (links below) 1104
Reposted by Pierre Lê-BuryᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 29/05/2025New in 𝘚𝘊𝘐𝘌𝘕𝘊𝘌: Plague Plays the Long Game As plague pandemics decimated rodent populations, 𝘠𝘦𝘳𝘴𝘪𝘯𝘪𝘢 𝘱𝘦𝘴𝘵𝘪𝘴 adapted Virulence gene 𝘱𝘭𝘢 lost late in outbreaks ➡️ strains with reduced lethality ➡️ pathogen can persist, spread across highly fragmented host networks www.science.org/doi/10.1126/... 293
Pierre Lê-Bury @pierrelebury.bsky.social · 29/05/20251/12 - New in @science.org ! ☠️ Curious of what happened to Yersinia pestis, the bacterium responsible for the Black Death, throughout plague pandemics? Check out our new study 👇 www.science.org/doi/10.1126/...science.orgAttenuation of virulence in Yersinia pestis across three plague pandemicsYersinia pestis has spilled over from wild rodent reservoirs to commensal rodents and humans, causing three historically recorded pandemics. Depletion in the copy number of the plasmid-encoded virulen... 13618
Reposted by Pierre Lê-BuryBaptiste Darracq @baptistedarracq.bsky.social · 09/05/2025White smoke, we have a new pope and also 16 new anti-phages systems in sedentary integrons (SCIs) ! In collaboration with the Rocha lab, we show in our new paper that cassettes of these large platforms encode many known anti-phage defenses, and uncovered 16 new ones. www.science.org/doi/10.1126/...science.orgSedentary chromosomal integrons as biobanks of bacterial antiphage defense systemsIntegrons are genetic systems that drive bacterial adaptation by acquiring, expressing, and shuffling gene cassettes. While mobile integrons are well known for spreading antibiotic resistance genes, t... 13217
Reposted by Pierre Lê-BuryEloi Littner @eloilittner.bsky.social · 09/05/2025Habemus paper! Our story on integron-encoded anti-phage defenses is now out in @science.org! 16 new systems, small versions of known ones, and a lot more in this highly-collaborative study. Many thanks to everyone involved, especially my supervisor @epcrocha.bsky.social bsky.app/profile/bapt... 23318
Reposted by Pierre Lê-BuryStand Up for Science Paris et région parisienne @sufs-paris-rp.bsky.social · 04/03/2025La tribune du mouvement Stand Up for Science France parue ce matin dans Le Monde (texte complet et signataires en ALT). Mobilisons-nous le 7 mars pour défendre la recherche scientifique et l'université ! #StandUpforScience #StandUpforScienceFrance 310078
Reposted by Pierre Lê-BuryYersinia Research Unit @yersiniaunit.bsky.social · 25/02/2025New updates on our plague vaccine: we now report that the type 3 secretion system is important for innate and adaptative immunity mechanisms and useful for protection in our live Yersinia pseudotuberculosis producing the F1 pseudocapsule 👇 www.sciencedirect.com/science/arti... 042
Reposted by Pierre Lê-BuryYersinia Research Unit @yersiniaunit.bsky.social · 24/02/2025Following criticisms raised concerning our article www.nature.com/articles/s41..., we just confirmed our original conclusions, demonstrating that the rs2549794 variant near the ERAP2 locus displays a strong positive selection signal associated with the Black Death ☠️ www.nature.com/articles/s41...nature.comReply to: Insufficient evidence for natural selection associated with the Black Death - NatureNature - Reply to: Insufficient evidence for natural selection associated with the Black Death 043