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sylvain Brisse

@sylvainbrisse.bsky.social
490 followers 135 following 96 posts

professor at Institut Pasteur. Bacterial genomics, vaccine-preventable diseases, antimicrobial resistance, bioinformatics and public heath applications. International capacity building and teaching. Klebsiella diphtheria whooping cough genomic librairies

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Reposted by sylvain Brisse
Institut Pasteur | 130 years of biomedical research @pasteur.fr · 23/07/2026
Institut Pasteur researchers describe LIN codes in PLOS Biology: a standardized numerical system for identifying bacterial strains from genome data, now used in BIGSdb-Pasteur and Pathogenwatch for outbreak surveillance. @sylvainbrisse.bsky.social ↘️ doi.org/10.1371/journal.pbio.3003781
doi.org
Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens
Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...
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TheTrendsWire | US & UK @thetrendswire.com · 24/06/2026
France confirmed its first Ebola case today. 1,094 cases in DRC. 277 dead. The second largest outbreak ever. www.thetrendswire.com/blog/france-... #Ebola #France #DRC #PublicHealth #Bundibugyo #WHOAlert #OutbreakNews #GlobalHealth
thetrendswire.com
France Confirms First Ebola Case Linked to DRC Outbreak
France confirmed its first Ebola case after a doctor returning from DRC tested positive. The outbreak has now passed 1,094 cases.
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Reposted by sylvain Brisse
Nicolas Berrod @nicolasberrod.bsky.social · 24/06/2026
🥵 72 départements en vigilance rouge #canicule à partir de demain midi, c'est totalement dingue
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Dr. Serge Zaka @sergezaka.bsky.social · 19/06/2026
Quel enfer ! L’anomalie thermique moyenne sur une semaine continue de pulvériser tous les plafonds, atteignant désormais +10.00°C à l’échelle nationale. C’est très largement au-dessus de la canicule d’ordre millénaire de mai 2026. 1/2
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Nicolas Berrod @nicolasberrod.bsky.social · 12/06/2026
7 000 patients en France ont déjà reçu des CAR-T cells, sorte de cellules "tueuses de cancers" : "Même au stade d’une maladie réfractaire, on est désormais capable de guérir. Une révolution thérapeutique." ⤵️ Le Parisien (Et vive la science !) 1/10 www.leparisien.fr/so...
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PLOS Biology @plosbiology.org · 10/06/2026
#Microbiology research requires a stable, unified #taxonomy of bacterial strains. In this Essay, Federica Palma, @sylvainbrisse.bsky.social and co-authors discuss the LIN system, resolving communication issues for precise strain definitions and epidemiological tracking. 🧪 #AcademicSky bit.ly/4xrMs4r
The hierarchical structure of Life Identification Number codes for data from the Klebsiella pneumoniae Species Complex is shown via a circular packing plot.
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🦋MOM🦋 @momcjl.bsky.social · 09/06/2026
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sylvain Brisse @sylvainbrisse.bsky.social · 07/06/2026
👉 Only 2 weeks to go for registrations to the famous ICARe course on #antimicrobials and #resistance in #Annecy, France: www.icarecourse.org Great course, great venue, great networking opportunity with @gdwantibiotics.bsky.social and other huge legends in the field
icarecourse.org
Interdisciplinary Course on Antibiotics and Resistance
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Olaya Rendueles @olayarendueles.bsky.social · 01/06/2026
🌟 Very proud of the newest Dr. in the team , Dr. @julielebris.bsky.social 👩‍🎓! She brilliantly defended her PhD last Friday @pasteur.fr Excellent thesis in terms of output & quality! Thanks to the jury @lucyweinert.bsky.social @sylvainbrisse.bsky.social @edfeil.bsky.social Maria Halima Laaberki
The big moment
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sylvain Brisse @sylvainbrisse.bsky.social · 04/06/2026
It's out! The LIN code approach for genomic taxonomy of microbial strains and its applications in genomic epidemiology journals.plos.org/plosbiology/...
journals.plos.org
Life Identification Numbers: A strain nomenclature approach to aid epidemiological surveillance of bacterial pathogens
Unified bacterial strain taxonomies are needed for coherent communication of findings in microbiological research. This Essay provides an overview of a novel bacterial strain taxonomy and describes ho...
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Reposted by sylvain Brisse
Klebsiella Club @klebclub.bsky.social · 12/05/2026
Here a summary of the #Klebs2024 meeting hosted by @sylvainbrisse.bsky.social @ @institutpasteur.bsky.social www.nature.com/articles/s44...
nature.com
Global perspectives on Klebsiella epidemiology and biology: conference report on the KLEBS 2024 symposium - npj Antimicrobials and Resistance
The inaugural Klebsiella Epidemiology and Biology Symposium (KLEBS) took place in November 20-22, 2024, at the Institut Pasteur in Paris. It covered a broad multidisciplinary range of topics from fund...
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Professor Lesley Hoyles @bugsinyourguts.bsky.social · 08/05/2026
The 1st Klebsiella Epidemiology and Biology Symposium in 2024 was much needed and a great event, so I'm really looking forward to the 2nd in 2027.
2nd KLEBS meeting will be convened in Cape Town, South Africa in 2027!
When? November 17-19, 2027
Where? Century City Conference Centre, Cape Town, South Africa
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sylvain Brisse @sylvainbrisse.bsky.social · 13/03/2026
Great to see the progress made by @dndi.org against #Chagas disease! dndi.org/news/2026/20...
dndi.org
2025 R&D programmes in review: Chagas disease | DNDi
DNDi and our partners are searching for shorter, safer, more effective treatments to stop a silent killer.
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Pascaline Lécorché @pascalinelecorche.bsky.social · 07/03/2026
Aujourd’hui, @standupforscience.bsky.social fête son anniversaire. Signataire de la tribune "un an après". Une mobilisation mondiale autour d'une évidence qui ne devrait jamais être discutée : la science n’est pas une opinion. C’est un pilier de la démocratie. 🧵👇🏻 www.liberation.fr/idees-et-deb...
liberation.fr
Un an après Stand Up for Science, défendons l’université et les sciences, piliers de la démocratie
Le mouvement Stand Up for Science, issu de la mobilisation inédite des universitaires français en solidarité avec leurs homologues américains, rappelle que les campus français aussi sont malmenés par ...
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 05/03/2026
Meet Molly Ingersoll, microbiologist & immunologist. Her work shows how women and men can respond very differently to infections, and why sex-specific treatments are urgently needed. She also speaks up about the invisible hurdles women face in science. Follow her here @immunobladder.bsky.social
pasteur.fr
Molly Ingersoll: advocating for women's health and women's rights
Molly Ingersoll has been head of a research team at the Institut Pasteur in Paris since 2012. This unfailingly optimistic microbiologist and immunologist is committed to revolutionizing our approach t...
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Reposted by sylvain Brisse
Jorge Moura de Sousa @jmouradesousa.bsky.social · 02/03/2026
➡️ preprint from the lab! Bacteria have loads of antiviral defences in their mobile genetic elements (MGEs). So when MGEs move between bacteria, the defences move with them, generating a fast turnover of defences in bacteria. But what about the antiviral defence turnover in the MGEs themselves? 🤔 🧵👇
biorxiv.org
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sylvain Brisse @sylvainbrisse.bsky.social · 03/03/2026
Institut Pasteur of Guinea is looking for a head of virology www.linkedin.com/jobs/view/43...
linkedin.com
Institut Pasteur hiring Chef d'Unité de recherche en virologie - IP Guinée H/F/X in Conakry Region, Guinea | LinkedIn
Posted 4:38:22 PM. 🔬 L'Institut Pasteur de Guinée, membre du Pasteur Network, joue un rôle central en matière de…See this and similar jobs on LinkedIn.
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sylvain Brisse @sylvainbrisse.bsky.social · 02/03/2026
Improving the detection of #diphtheria toxin production by Corynebacterium diphtheriae and C. ulcerans, our latest work @pasteur.fr is out: www.biorxiv.org/content/10.6...
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sylvain Brisse @sylvainbrisse.bsky.social · 17/02/2026
A novel version of diphtOscan is available at gitlab.pasteur.fr/BEBP/diphtos.... v2.2.0 makes it easy to install on local computers. diphtOscan scans genomes and extracts information including #diphtheria toxin and antimicrobial resistance genes, biovar, species and subtyping information.
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Reposted by sylvain Brisse
France Intox 🇫🇷 @jslnrbd.bsky.social · 03/02/2026
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Raphael Laurenceau @raphael-microb.bsky.social · 30/01/2026
I couldn’t agree more! Help support Wikipedia. It has been a pillar of high-quality knowledge sharing since the early web, and it’s more relevant than ever in the fuzzy age of AI www.nature.com/articles/d41...
nature.com
Wikipedia is needed now more than ever, 25 years on
The online encyclopedia is an antidote to an increasingly poisoned information ecosystem. Researchers should help to nourish it.
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sylvain Brisse @sylvainbrisse.bsky.social · 31/01/2026
Outbreak of anti-#Klebsiella grants from @gatesfoundation.bsky.social @wellcometrust.bsky.social and novonordisk! gcgh.grandchallenges.org/grants/JTdCJ...
gcgh.grandchallenges.org
All Awards
We challenge innovators around the world to work on urgent priorities in global health and development. We issue new challenges regularly and award the most promising proposals with grant funding.&nbs...
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David Bikard @dbikard.bsky.social · 28/01/2026
🚨 Hiring Alert! 🚨My lab at Institut Pasteur is recruiting several Postdocs! We have exciting open projects in: 🦠 Synthetic Biology and🛡️ Bacterial Immunity. Come do great science with us in the middle of Paris! 🇫🇷🥐 research.pasteur.fr/en/job/postd...
research.pasteur.fr
Postdoctoral position - Synthetic Biology / Bacterial Immunity - Research
The Bikard lab at Institut Pasteur in Paris is seeking to hire postdoctoral researchers. We are investigating bacteria / bacteriophages interactions, and the genetic innovation that happens at this in...
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sylvain Brisse @sylvainbrisse.bsky.social · 28/01/2026
great update on #Klebsiella research!
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Klebsiella Club @klebclub.bsky.social · 26/01/2026
3 weeks left to submit an abstract for the Klebsiella Seminar Series! It is FREE, but registration is required. #AMR #Microsky #UTIsky sites.google.com/view/klebclu...
sites.google.com
KlebClub - Seminar Series Registration
Klebsiella Virtual Seminar Series
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Sandra Reuter @sandrareuter.bsky.social · 20/01/2026
First paper of this year is out now! 📢 Very happy to present work with my collaborators Andrew Whitelaw and Mae Newton-Foot and especially great work from PhD student Kedisaletse Moloto at Stellenbosch University: journals.plos.org/plospathogen...
journals.plos.org
Carbapenem resistant Klebsiella pneumoniae isolates at a tertiary hospital in Cape Town, South Africa, are dominated by specific local clones rather than previously described international lineages
Author summary Carbapenem resistant K. pneumoniae (CRKP) have emerged as a cause of hospital and community acquired infections, posing a significant threat to public health, and have hence been listed...
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sylvain Brisse @sylvainbrisse.bsky.social · 20/01/2026
Dermatose nodulaire contagieuse en France: épidémiologie, microbiologie et contrôle: www.sfm-microbiologie.org/2026/01/16/e... @sfmicrobiologie.bsky.social @baptistedemey.bsky.social #LumpySkinDisease
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David Bikard @dbikard.bsky.social · 19/01/2026
Deadline is approaching (Feb 9) to apply for a PI position at Institut Pasteur. Come join us and contribute to an amazing scientific environment!!!
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sylvain Brisse @sylvainbrisse.bsky.social · 14/01/2026
Dear #AMR #genomics and big data community: please be informed that the programme of the Wellcome AMR conference in Hinxton on March 23-26th is now online: coursesandconferences.wellcomeconnectingscience.org/event/antimi... - please register before Feb 24th for onsite participation
coursesandconferences.wellcomeconnectingscience.org
Antimicrobial Resistance – Genomes, Big Data and Emerging Technologies — 20260323
Highlighting the importance of genomic data in the fight against AMR
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Princess Vimentin PhD | Cancer Biologist @princess-vimentin.bsky.social · 16/12/2025
Wasting money and resources to investigate a conspiracy theory about Lyme Disease, despite the known mechanism of how it infects humans. 🧪 www.scientificamerican.com/article/rfk-...
scientificamerican.com
RFK, Jr.–Backed Lyme Disease Conspiracy Theory May Be Probed under New Bill
President Donald Trump is expected to sign a defense bill this week that orders an investigation into whether the U.S. military bioengineered Lyme disease
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Jose F. Delgado-Blas @josefdelgadoblas.bsky.social · 16/12/2025
By analysing 336 KpSC genomes from human, animal, and environmental sources, we reveal strong population compartmentalisation. Environmental sublineages (farms) are highly diverse and persistent, while human-associated strains (clinical and WWTP) show fast turnover and multidrug resistance profiles.
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Jose F. Delgado-Blas @josefdelgadoblas.bsky.social · 16/12/2025
I’m really happy to share this work, which wouldn’t have been possible without the contributions of many, especially @sylvainbrisse.bsky.social and @crodrigues87.bsky.social from @pasteur.fr, and Elodie Barbier and Pascal Piveteau from @inrae-france.bsky.social.
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sylvain Brisse @sylvainbrisse.bsky.social · 15/12/2025
Seasons greetings from @pasteur.fr
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Ben Vezina @bananabenana.bsky.social · 13/12/2025
Absolutely stoked to have this published in @plosbiology.org We looked at the metabolism of #Klebsiella pneumoniae 🦠🧫. We not only demonstrated lineage-specific #metabolism, but that lineages can cross-feed and support each other. journals.plos.org/plosbiology/... #MicroSky #microbiology 🧬 🧪 💊
journals.plos.org
A metabolic atlas of the Klebsiella pneumoniae species complex reveals lineage-specific metabolism and capacity for intra-species co-operation
Why are there so many co-circulating Klebsiella pneumoniae clones? Using genomics and large-scale metabolic modelling of >7000 isolates, this study identifies structured, clone-specific metabolic spec...
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sylvain Brisse @sylvainbrisse.bsky.social · 06/12/2025
Opening of a Group Leader position in AI in genomics at Institut Pasteur @pasteur.fr , Paris research.pasteur.fr/en/call/mid-...
research.pasteur.fr
Mid-career Group Leader position in AI in genomics at Institut Pasteur, Paris - Research
Institut Pasteur and the CNRS are launching a call for a mid-career group leader position in AI in genomics. We are looking for an experienced researcher (typically with > 8 years of research experien...
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Microbiology Society @microbiologysociety.org · 02/12/2025
📣🦠Check out our new Editor’s Spotlight! Senior MGEN editor Jesse Shapiro tells us about a recently published paper on the bystander effect on the evolution of Bordetella parapertussis, a non-target species of the pertussis vaccine #MGEN Read the full blog here: microb.io/48zfOlJ
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sylvain Brisse @sylvainbrisse.bsky.social · 02/12/2025
Global Incidence of #Pertussis after the COVID-19 Pandemic - A large collaborative effort under the auspices of the International #Bordetella Society, led by Andrew Gorringe, from the UK Health Security Agency. jamanetwork.com/journals/jam...
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sylvain Brisse @sylvainbrisse.bsky.social · 30/11/2025
Huge preprint if you are interested in bacterial strain taxonomy! The why and how of cgMLST LIN codes: An extensively revised and expanded version doi.org/10.1101/2024... I will summarize it for you in this thread 👇
doi.org
Life Identification Numbers: A bacterial strain nomenclature approach
Unified strain taxonomies are needed for the epidemiological surveillance of bacterial pathogens and international communication in microbiological research. Core genome multilocus sequence typing (cg...
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ESCMID @escmid.bsky.social · 26/11/2025
The next five videos from our #IMMEM XIV poster presentations are available on our YouTube channel and cover topics like #plasmids, #genomics, #sequencing and more. Stay tuned for more videos every Wednesday! youtube.com/playlist?list=PLBG53xT7…
youtube.com
IMMEM XIV Poster presentations
Explore the different post presentations that were recorded as part of the 14th edition of the International Meeting on Microbial Epidemiological Markers (IM...
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sylvain Brisse @sylvainbrisse.bsky.social · 26/11/2025
Cumulative cgMLST : Our novel preprint is out @biorxiv doi.org/10.1101/2025...
doi.org
Cumulative cgMLST provides increased discrimination of nested phylogenetic groups
Background Core genome multilocus sequence typing (cgMLST) is a powerful method for bacterial strain genotyping. However, the size of the core genome decreases as the phylogenetic breadth of the targe...
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sylvain Brisse @sylvainbrisse.bsky.social · 26/11/2025
Great video on the impact of the magic bullet developed by @dndi.org against human african trypanosomiasis youtu.be/GcIx32MDdkU?...
youtu.be
Beni: Surviving Sleeping Sickness
YouTube video by Drugs for Neglected Diseases initiative (DNDi)
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Reposted by sylvain Brisse
Kat Holt @katholt.bsky.social · 18/11/2025
The @klebnet.bsky.social team are pleased to share slides from our “Klebsiella pneumoniae Genomic Epidemiology & Antimicrobial Resistance” lecture series! Topics include Kleb diversity, lineages, AMR, hypervirulence, how to use Kaptive & Kleborate for typing, and more! klebnet.org/2025/11/18/k...
klebnet.org
Klebsiella pneumoniae genomics tutorials – KlebNET-GSP
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sylvain Brisse @sylvainbrisse.bsky.social · 16/11/2025
It’s out ! Evolution of Bordetella parapertussis, the second agent of whooping cough: many parallelisms with Bordetella pertussis, including rapid adaptation by loss of the pertactin vaccine antigen. Just published in @microbiosoc MGen journal www.microbiologyresearch.org/content/jour...
microbiologyresearch.org
No innocent bystanders: pertussis vaccination and evolutionary parallelisms between Bordetella parapertussis and Bordetella pertussis
Pathogens adapting to the human host and to vaccination-induced immunity may follow parallel evolutionary paths. Bordetella parapertussis (Bpp) contributes significantly to the burden of whooping coug...
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Chiara Crestani @chcrestani.bsky.social · 07/11/2025
📢 Save the Date! The 2nd Nanopore Users Day will take place 🗓️10 March 2026 at the Duclaux Amphitheater, Institut Pasteur (Paris). This edition will be open to external participants! 👉 More details and registration info coming soon! @chloebaum.bsky.social @pasteur.fr @nanoporetech.com
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sylvain Brisse @sylvainbrisse.bsky.social · 08/11/2025
www.lemonde.fr/disparitions...
lemonde.fr
James Watson, codécouvreur de la structure en double hélice de l’ADN, est mort à l’âge de 97 ans
Colauréat du Nobel 1962 pour une découverte qui a donné le coup d’envoi de la révolution génétique, l’Américain avait terni son image en minimisant le travail de la cristallographe Rosalind Franklin e...
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Institut Pasteur | 130 years of biomedical research @pasteur.fr · 28/10/2025
🇪🇺 Major recognition for Institut Pasteur Our National Reference Center for Respiratory Viruses (led by Pr Marie-Anne Rameix-Welti) selected as EU Reference Laboratory by @ecdc.europa.eu 🔬 Part of an 8-country consortium to strengthen EU's capacity against respiratory viral pathogens. #PublicHealth
Professor Marie-Anne Rameix-Welti. Head of the National Research Center for Respiratory Infections and the Molecular Mechanisms of Pneumovirus Multiplication Unit, Institut Pasteur, Paris.
©Institut Pasteur / François Gardy
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Tanja Stadler @tanjastadler.bsky.social · 25/10/2025
Open position at the Swiss Institute of Bioinformatics: We are looking for a Director of the Center of Pathogen Bioinformatics apply.refline.ch/499599/0346/... I am in the Center's steering board together with fantastic colleagues (Emma Hodcroft @firefoxx66.bsky.social, Richard Neher @neher.io, and
apply.refline.ch
Director, Center for Pathogen Bioinformatics
The Centre for Pathogen Bioinformatics (CPB) is a unit of SIB which offers expertise and services in pathogen bioinformatics, computational molecular epidemiology and related multi-site project manage...
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sylvain Brisse @sylvainbrisse.bsky.social · 21/10/2025
Almost there! Starting tomorrow morning (Paris time), the webinar on Bacterial strain Taxonomy for Genomic Surveillance organized within the ECDC sponsored GenEpi-BioTrain programme; registration is free; see more here: research.pasteur.fr/en/event/bac...
research.pasteur.fr
Bacterial strain Taxonomy for Genomic Surveillance - GenEpi-BioTrain Webinar - Research
This workshop aims to provide participants with a comprehensive understanding of bacterial classification and nomenclature approaches used in genomic surveillance. Participants will gain insight into ...
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Pascaline Lécorché @pascalinelecorche.bsky.social · 18/10/2025
Recours de Marine Le Pen rejeté. Sa tentative pour revenir sur l'exécution immédiate de sa peine d'inéligibilité de 5 ans a échoué. L'état de droit, c'est ça.
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Guillaume Limousin @sonicurticant.bsky.social · 15/10/2025
🔥📣 BREAKING NEWS Didier Raoult perd en @conseil-etat.fr (poursuites dont je suis à l'origine via rédaction de la plainte, ce qui m'a immédiatement valu une avalanche de menaces de mort et appels au meurtre, qu'il a partagés, et qui durent encore). Didier Raoult est définitivement condamné. RT SVP🔽
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