In early results from our new life sciences research lab, Claude agents found an enzyme system whose function is still unknown.

Heritable microbes profoundly influence insect biology, yet the traits they confer often evolve rapidly and differ among closely related symbiont s...

Prime assembly enables RNA-guided integration of medium-to-large DNA sequences in human cells without requiring double-strand breaks or cell cycle progression, and supports exon recoding, transgene in...

In a process known as phenotypic heterogeneity or phenotypic variation, bacteria can produce distinct phenotypes within an isogenic population in response to shifting environmental conditions. Noise i...

Symbiotic relationships of microorganisms are predicted and cataloged with a machine learning tool.

The T7 bacteriophage deactivates bacterial defence systems through T7K phosphorylation of nearly all host and phage proteins during infection.

Abstract. To successfully transfer, conjugative plasmids must overcome a recipient cell’s defence mechanisms. The leading region of many plasmids—the first

This first-in-human study of SNIPR001 supported its safety, tolerability, and restriction to the gastrointestinal tract, while not systemically disrupting the gut microbiome. These results justify fur...

The emergence of a simple version of the modern ribosome represents an indispensable step in the evolution of life as we know it. Standalone dimeri...

Enzymatic metabolism emerged from metal-catalyzed, aqueous reactions of H2, CO2, NH3 and phosphite at a hydrothermal vent.

The phage-encoded protein PptA enables its DNA to masquerade as the host and evade cleavage, providing a potential foundation for engineering therapeutic phages that could bypass this widespread defen...

Dietary fibers are a primary energy source for gut bacteria and shape the composition and function of the microbiome. Now, an active learning approach integrating explainable machine learning, Bayesia...

The gut microbiome converts dietary fiber into metabolites that shape human health, but identifying the right combinations of microorganisms and nutrients has been a challenge. A machine learning fram...

CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establis...

Plasmids are extrachromosomal mobile genetic elements that can facilitate rapid bacterial adaptation by transferring genes between individuals. Whilst plasmids are known to exist in diverse habitats a...

The outermost surface layers of Gram-negative bacteria determine phage access to terminal receptors, yet their genetic basis has been mapped almost exclusively in laboratory strains that lack them. He...

Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some nat…

Ge et al. develop a receptor-centered strategy to identify phage proteins that target host receptors during infection and discover the λ outer-membrane protein Lom. Lom binds and occludes LamB, blocki...

The design of RNA-guided nucleases with properties not limited by evolution can expand programmable genome-editing capabilities. However, generating diverse multidomain proteins with robust enzymatic ...

Comprehensive assessment of the host range of phages is a prerequisite for their safe and effective use in multiple applications but is rarely undertaken. This Review outlines the molecular and ecolog...

Horizontal gene transfer (HGT) is a driving force in microbial evolution that allows community members to rapidly evolve to cope with environmental stressors and competition. Despite the importance of...

Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...

Economics - Innovation - Inclusive Growth - Public Purpose | Mariana Mazzucato

An 8-year soil meta-omic time series shows how mobile genetic elements shape permafrost microbial diversity and impact a range of functions, including carbon and nutrient cycling.

The exchange of biological matter between bacterial cells drives adaptation and evolution. However, whether bacteria can exchange functional proteins remains unclear. In this work, we found that antib...

The crucial role of the gut microbiome in human health has driven a need to understand bacterial function within their complex native ecosystem. Howev…

Scientific Reports - Same-day tagmentation PCR-based whole genome sequencing of bacteriophage genomes from a single plaque without DNA extraction

Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

/PRNewswire/ -- Biohub today announced the release of a world model of protein biology: a scientific engine for prediction, design, and discovery that can map...

Migration of microbial communities is poorly understood. Here, the authors use a meso-tube assay to show that hundreds of microbial species co-migrate over metre scales via chemotaxis, which restructu...

The life cycle of temperate bacteriophages involves lytic or lysogenic cycles and has historically served as a model for studying genetic regulation. This Review provides an updated overview of these ...

Bacteriophages are the most abundant life form on earth and can be applied to eliminate or engineer bacteria. Here, authors demonstrate RNA barcoding as a high throughput tool to measure bacteriophage...

Here the authors review current understanding of the mechanistic marine microbial interactions that underpin large-scale ecosystem processes and biogeochemical cycling.

Because all known living organisms are made from at least 20 canonical amino acids, the feasibility of life using a more simplified alphabet remains unclear. In this work, we leveraged computational d...

Prime assembly can initiate Gibson-like assembly in cells to generate gene insertions without double-stranded DNA breaks, recombinases or homology-directed repair.