Sign in

Julie Miesch

@juliemiesch.bsky.social
94 followers 116 following 7 posts

Postdoc in the Derivery Lab at the MRC-LMB/#Postdoc.Mobility

PostsRepliesMedia
Reposted by Julie Miesch
Simon Bullock @simonbullock11.bsky.social · 28/09/2026
How are mRNAs linked to molecular motors in mammalian cells? In our new preprint, we show that FXR1/2 are RNA adaptors for the microtubule motor dynein. Our findings have also prompted us to rethink how activating adaptors contribute to motor-based transport (1/n)
16330
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 22/09/2026
We are looking for a research assistant! Come join the team: www.jobs.ac.uk/job/DSZ826/r...
jobs.ac.uk
Research Support Officer | Cell Biology | Dr Buzz Baum | LMB 2904 at MRC Laboratory of Molecular Biology
Start your UK & international job search for academic jobs, research jobs, science jobs and managerial jobs in leading universities and top...
02846
Reposted by Julie Miesch
Kashish Singh @kashishsingh.bsky.social · 13/08/2026
Very happy to see the final version of our work on the structure and composition of cytoplasmic lattices in mouse embryos, previously shared on bioRxiv, now published in The EMBO Journal! Many thanks to our editor, Ieva Gailite, and the reviewers for their constructive input.
15019
Reposted by Julie Miesch
Marko Kaksonen @kaksonen.bsky.social · 11/08/2026
Endocytic clathrin coats are surprisingly dynamic: triskelia turn over in seconds. How is the turnover regulated and what is it for? Read Anne-Laure Boinet's preprint with @rouxlab.bsky.social www.biorxiv.org/content/10.6...
17023
Reposted by Julie Miesch
Joshua Tran @joshuatran.bsky.social · 27/07/2026
💡New Preprint! How does a cell control which way a membrane bends? ESCRT-III has the remarkable ability to reshape membranes and drive reverse-topology fission, yet a fundamental question has remained: what determines the direction of membrane remodeling? www.biorxiv.org/content/10.6...
biorxiv.org
Direction of ESCRT-III-dependent membrane bending emerges from bilayer asymmetry
In cells, ESCRT-III is unique in mediating fission of membrane necks from inside, a process called reverse-topology fission. Yet, in vitro, the complex primarily assembles outside membrane necks and m...
13115
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 17/07/2026
More than 600 students from across Cambridge, Peterborough & Bedfordshire took part in this year's Microscopes 4 Schools Competition submitting images of bugs, flowers & more! 🔬 📸 2026 Winners Read more about this year’s competition here: mrclmb.ac.uk/news-events/... #LMBNews #PublicEngagement
Tarantula skin microscopyGreen flower microscopyDead fly microscopy
0125
Reposted by Julie Miesch
Gabriel Neurohr @gabrielneurohr.bsky.social · 15/07/2026
We just preprinted Marianna’s PhD work in which we asked: How does non-coding DNA affect cell physiology? And why do some organisms have so little of it while other genomes are 99% non-coding?
1146
Reposted by Julie Miesch
Derivery Lab - MRC LMB @deriverylab.bsky.social · 30/06/2026
Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years 🔬🪰🧪
2335
Reposted by Julie Miesch
Alison Kickuth @alisonkickuth.bsky.social · 18/06/2026
I am honoured to have received the Otto Hahn Medal! Thank you Jan @brugueslab.bsky.social, @ursa-ursic.bsky.social, Michael Staddon, @mpi-cbg.de, and @poldresden.bsky.social for your support during this scientific journey!
3447
Reposted by Julie Miesch
James Manton @jamesdmanton.bsky.social · 02/06/2026
We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...
Image of first two pages of manuscript.
14217
Reposted by Julie Miesch
Roux Lab, Geneva @rouxlab.bsky.social · 12/05/2026
@mhakala.bsky.social shows that HRS forms bidimensional condensates onto endosomal membranes to flatten clathrin/ESCRT-0, an observation unexplained since the 2000s. Thx to Kukulski lab, @stefvass.bsky.social @colomlab.bsky.social @kaksonen.bsky.social @mishakudryashev.bsky.social rdcu.be/fihKk
13016
Reposted by Julie Miesch
Simon Bullock @simonbullock11.bsky.social · 05/05/2026
Thrilled to see this work published. Thanks to helpful reviewer suggestions, there are some exciting new insights that were not in the preprint (particularly in Figure 4). www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
35834
Reposted by Julie Miesch
Carter Lab @carter-lab.bsky.social · 05/05/2026
Our story on RNA recognition by Egl-BicD is now published! Also delighted to share the accompanying News & Views article by Florence Besse and Andres Ramos, which beautifully highlights the work. Paper: www.nature.com/articles/s41... News & Views: www.nature.com/articles/s41...
nature.com
Structural basis for recognition of diverse localizing mRNAs by Egl–BicD - Nature Structural & Molecular Biology
Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...
04519
Reposted by Julie Miesch
Ennio @amicoennio.bsky.social · 29/04/2026
New preprint! We asked a simple question: How do very different activating adaptors all activate dynein? Turns out: same architecture, wildly different implementations 🧵👇 doi.org/10.64898/202...
doi.org
13018
Reposted by Julie Miesch
Carter Lab @carter-lab.bsky.social · 29/04/2026
New preprint from the lab, looking at how multiple different adaptors interact with dynein! Work led by @amicoennio.bsky.social. Available now on BioRxiv: doi.org/10.64898/202...
doi.org
04318
Reposted by Julie Miesch
Meg Clapperton @meganclapperton.bsky.social · 24/04/2026
It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one! Make sure to come to our other talk today on using this tech to study endosomal dynamics?
0358
Reposted by Julie Miesch
Cell Biology J-Club @cellclub.bsky.social · 21/04/2026
Bridging the lipid divide: archaeal ESCRT-III binds phosphoinositol and polarises the cytokinetic membrane www.biorxiv.org/content/10.6...
biorxiv.org
0156
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 09/04/2026
🧬 Last call to join us in Cambridge for #EMBOMBoA26 (July 6th-10th)! We are just one week away from the registration and abstract submission deadline for the EMBO Workshop on the Molecular Biology of Archaea!
42116
Reposted by Julie Miesch
Soldati Lab @soldatilab.bsky.social · 09/04/2026
📣 Happy to share our new chapter in Live Biological Imaging Across Scales! We discuss how to explore membrane damage responses using Dicty and high-throughput single-cell analyses 👀. Shout-out to @angieprrt.bsky.social and the team onlinelibrary.wiley.com/doi/10.1002/...
onlinelibrary.wiley.com
Tiny Organisms, Big Advantages: Exploring Membrane Damage Responses Using Dictyostelium discoideum in High‐Throughput Single‐Cell Analyses
The amoeba Dictyostelium discoideum (Dd) is a commonly used model for studying bacterial infection due to the high conservat...
043
Reposted by Julie Miesch
Carter Lab @carter-lab.bsky.social · 24/03/2026
Excited to share our work on the structure and function of cytoplasmic lattices within mouse embryos. A collaborative effort with @niakanlab.bsky.social and work led by @kashishsingh.bsky.social and @inaharasimov.bsky.social . It is now out on BioRxiv: www.biorxiv.org/content/10.6...
620684
Reposted by Julie Miesch
Mathilda Lennartz @mathilda95.bsky.social · 23/03/2026
I am extremely excited that my first first-author paper from my PhD is finally out 😆!! We developed a new CLEM workflow to measure lipid densities at the nanoscale. So if you are into lipids and super-resolution imaging approaches, this one is for you: www.nature.com/articles/s41...
nature.com
Visualizing suborganellar lipid distribution using correlative light and electron microscopy - Nature Cell Biology
Lennartz et al. introduce a correlative light and electron microscopy workflow, Lipid-CLEM, combining near-native lipid probes and on-section labelling via click chemistry. Lipid-CLEM quantitatively a...
814142
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 18/03/2026
How do primordial germ cells (PGCs) migrate across a developing embryo? #LMBResearch from Katharine Goodwin and Kate McDole (@cellbiol-mrclmb.bsky.social) uncovers the mechanisms PGCs use in mouse embryos to navigate this long and surprisingly risky journey. Read more: mrclmb.ac.uk/news-events/...
Microscopic view of a glowing, irregularly shaped primordial germ cell with long protrusions with purple and green fluorescence against a dark blue background.
0179
Reposted by Julie Miesch
Simon Bullock @simonbullock11.bsky.social · 18/03/2026
Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...
14219
Reposted by Julie Miesch
Derivery Lab - MRC LMB @deriverylab.bsky.social · 19/03/2026
Check out this preprint from the @simonbullock11.bsky.social lab, amazing work led by @lucas-albacete-x2.bsky.social ! 🔬
0123
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 13/03/2026
Interested in instrument development & optical microscopy? Join @immunoah.bsky.social & @jamesdmanton.bsky.social developing high-throughput light sheet microscopy to image entire tissues & progressing tissue clearing methods www.nature.com/naturecareer... Closes 07 APR #PostdocJobs #neuroimmunology
Microscopy image taken by a light sheet microscope showing an optically cleared lung in blue.
082
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 12/03/2026
On today’s episode of BBC Radio 4’s In Our Time, @buzzbaum.bsky.social, Group Leader in @cellbiol-mrclmb.bsky.social, joined for a discussion on all things archaea. Check it out here (requires BBC login): www.bbc.co.uk/programmes/m... #LMBintheNews
bbc.co.uk
BBC Radio 4 - In Our Time, Archaea
How a discovery in the 1970s changed the theory of the origin of complex life on earth.
0206
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 11/03/2026
www.biorxiv.org/content/10.6... Amazing work by Kris and gang! For the first time we have been able to image division ring components live in Sulfolobus. And guess what - CdvA is asymmetrically inherited.
biorxiv.org
14820
Reposted by Julie Miesch
Derivery Lab - MRC LMB @deriverylab.bsky.social · 19/02/2026
🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨
0203
Reposted by Julie Miesch
Vicente Planelles Herrero @vicenteph.bsky.social · 17/02/2026
Check this out! Very proud to see this out, always happy to play with "microtubules" in vitro 😍
021
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 23/01/2026
A reminder to sign up for the 2026 EMBO archaeal meeting im Cambridge: meetings.embo.org/event/26-arc.... Registration is open. We are looking forward to hosting you!
meetings.embo.org
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
04035
Reposted by Julie Miesch
Roux Lab, Geneva @rouxlab.bsky.social · 20/01/2026
Guillaume Pernollet shows that epithelial cells adjust their shape to locally flatten, forming scutoids for any geometry, changing our view of cell packing. Thanks to all! @clairedessalles.bsky.social @juanmagararc.bsky.social @sciencesunige.bsky.social www.biorxiv.org/content/10.6...
03211
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 19/01/2026
🌐Our new LMB website is live!🌐 Fresh design, better navigation, same first-class science. Take a look around ➡️ mrclmb.ac.uk
12011
Reposted by Julie Miesch
Alison Kickuth @alisonkickuth.bsky.social · 07/01/2026
Really happy to see my PhD first-author paper published in @nature.com! I’m very grateful to have worked with such a great team. Huge thanks to Urša Uršič, Michael Staddon, and Jan Brugués, as well as the @brugueslab.bsky.social, and the @poldresden.bsky.social and @mpi-cbg.de community!
58212
Reposted by Julie Miesch
Angélique Perret @angieprrt.bsky.social · 04/01/2026
🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection? Check out our latest paper published in Science Advances 👇 www.science.org/doi/10.1126/... ✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨
science.org
Membrane microdomains are crucial for Mycobacterium marinum EsxA-dependent membrane damage, escape to the cytosol, and infection
Sterol-rich microdomain accumulation at the MCV is crucial for Mm-induced damage and infection in D. discoideum and BV-2 cells.
4227
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 16/12/2025
Are you a long-time fan of Archaea, an extremophile-phile, or are you simply curious? Either way, we have good news. We’re delighted to announce the 2026 EMBO Workshop on Archaea, 6–10 July. Sign up: meetings.embo.org/event/26-arc... We look forward to seeing you in Cambridge, UK. Please repost!
meetings.embo.org
Molecular Biology of Archaea: Life Through the Prism of Archaea
In 1977, Woese and colleagues revealed Archaea as a distinct domain of life. Building on this insight, the discovery of Asgard archaea has strengthened the view that many hallmarks of eukaryotic cell…
27850
Reposted by Julie Miesch
Soldati Lab @soldatilab.bsky.social · 08/12/2025
🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩
1113
Reposted by Julie Miesch
Javier Espadas @javierespadas.bsky.social · 01/12/2025
New preprint from the lab!!🎉 We show that Asgard archaea ESCRT-III proteins can trigger membrane fission and reveal its molecular mechanism, offering clues to how these cells may have built internal compartments. But do these organisms even have these compartments? www.biorxiv.org/content/10.1...
biorxiv.org
Molecular basis for cellular compartmentalization by an ancient membrane fission mechanism
The emergence of cell compartmentalization depends on membrane fission to create the endomembrane compartments. In eukaryotes, membrane fission is commonly executed by ESCRT-III, a protein complex con...
18332
Reposted by Julie Miesch
Juanma García-Arcos @juanmagararc.bsky.social · 27/11/2025
New paper from the @rouxlab.bsky.social on Nature Communications! We study how membrane tension is spatially organized in cells. Using the mechanosensitive probe Flipper-TR to visualize tension across the plasma membrane of adherent cells and to dissect the conditions needed for a gradient to happen
68332
Reposted by Julie Miesch
Roux Lab, Geneva @rouxlab.bsky.social · 14/11/2025
Maria Tettamanti shows that inhibition of TORC2 by the small amphipath PalmC induces the TORC2-dependent internalization of sterols. Congrats to Maria and all coworkers involved, and to EMBOj for the efficient review process: use review commons! @biology-unige.bsky.social @sciencesunige.bsky.social
02417
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 10/11/2025
Considering the LMB for your PhD? We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int... Apply by 2nd DEC for Autumn 2026 admission.
Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025
079
Reposted by Julie Miesch
Simon Bullock @simonbullock11.bsky.social · 10/11/2025
Lots of exciting PhD projects on offer at the LMB, including in our group 😊
087
Reposted by Julie Miesch
Tanmay Bharat @tbharat-lab.bsky.social · 07/11/2025
An Asgard archaeon with internal membrane compartments Brilliant study led by @fmacleod.bsky.social and Andriko von Kügelgen. Tight collaboration with @buzzbaum.bsky.social and lab. Congrats to all authors! www.biorxiv.org/content/10.1...
10387168
Reposted by Julie Miesch
ImmuNoah's Ark (Noe Rodriguez) @immunoah.bsky.social · 14/10/2025
📣 Two week left to apply! 👇 Apply in the link below or, if you have specific questions, reach out!
034
Reposted by Julie Miesch
MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 13/10/2025
Join us at @pborostemfest.bsky.social on Oct 18 to test your detective skills in an interactive game, matching what you see under a microscope with different areas of LMB’s science #PSF2025 📍 ARU Peterborough 🕚 11:00 – 16:00 (Quiet time 9.30-11) www.peterboroughstemfestival.co.uk/exhibitors/m...
peterboroughstemfestival.co.uk
MRC Laboratory of Molecular Biology - Beauty is in the detail - Peterborough STEM Festival
Have a go at coding with Peterborough CoderDojo!
052
Reposted by Julie Miesch
Juanma García-Arcos @juanmagararc.bsky.social · 05/10/2025
🚨 New preprint out! “Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM” with Tithi Mandal and @rouxlab.bsky.social We benchmark and describe step-by-step Flipper-TR FLIM measurements across different set-ups and and strategies. www.biorxiv.org/content/10.1...
biorxiv.org
Fluorescence lifetime estimation: a practical approach using Flipper-TR FLIM
Flipper-TR is a membrane dye sensitive to lipid packing widely used to probe membrane tension in live cells via fluorescence lifetime imaging microscopy (FLIM). However, no consensus currently exists ...
14112
Reposted by Julie Miesch
Buzz Baum @buzzbaum.bsky.social · 02/10/2025
LMB PhD studentship available in the Baum lab to use informatics to infer cell structure from genomic data in collaboration with the brilliant Tom Williams. If you write to me and I don’t reply - try again - the spam filter is hungry…
11619
Reposted by Julie Miesch
Emmanuel Levy's lab @elevylab.bsky.social · 16/09/2025
Years ago we discovered that missense mutations in homomeric proteins often induces their supramolecular assembly, as in the 📽️👇 - Are such aberrant assemblies of *folded* proteins toxic? Surprisingly, NO. Cells are amazingly robust systems! Paper now online @molsystbiol.org doi.org/10.1038/s443...
1278
Reposted by Julie Miesch
James Manton @jamesdmanton.bsky.social · 16/09/2025
The final version of our multispectral microscopy manuscript is now online at Nature Photonics: www.nature.com/articles/s41... The main additions are some further comparisons to yet more unmixing algorithms, in which we find that our algorithm is still the most accurate.
nature.com
Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
13616
Reposted by Julie Miesch
Akaash Kumar @akaashkumar.bsky.social · 16/09/2025
🚨Publication alert🚨 My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...
nature.com
Multispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature Photonics
A tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with...
33913