Reposted by Akaash KumarJames Manton @jamesdmanton.bsky.social · 02/06/2026We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6... 14217
Reposted by Akaash KumarJames Manton @jamesdmanton.bsky.social · 25/06/2026We've updated our cleared-tissue direct-view oblique plane microscopy preprint to include our latest resolution-enhancing results. Now the Nyquist sampling of our camera is no longer a limitation and so we obtain a diffraction-limited 2 μm lateral resolution! www.biorxiv.org/content/10.6... 1153
Akaash Kumar @akaashkumar.bsky.social · 19/03/2026Great work from Lucas, the @simonbullock11.bsky.social lab and collaborators uncovering the relocalisation of organelles by dynein when cells experience stress! Check out the pre-print 👇🏽 020
Reposted by Akaash KumarJames Manton @jamesdmanton.bsky.social · 13/03/2026Myself and @immunoah.bsky.social are looking to hire a postdoctoral scientist to build a next-generation high-throughput high-resolution light sheet microscope for imaging entire cleared organs/tissues and to further develop live & fixed tissue clearing methods. www.nature.com/naturecareer... 01916
Akaash Kumar @akaashkumar.bsky.social · 16/09/2025🚨Publication alert🚨 My first, first-author paper is now out in @natphoton.nature.com! Our paper describes an iterative spectral unmixing algorithm and eight-channel camera-based hardware we developed enabling unmixing of low SNR live-cell data at video rates. www.nature.com/articles/s41...nature.comMultispectral live-cell imaging with uncompromised spatiotemporal resolution - Nature PhotonicsA tree-like arrangement of dichroic mirrors and multiple cameras coupled with an iterative spectral unmixing algorithm enables multispectral imaging of live cells in up to eight spectral channels with... 33913
Reposted by Akaash KumarJames Manton @jamesdmanton.bsky.social · 15/09/2025We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens: 37632
Akaash Kumar @akaashkumar.bsky.social · 20/05/2025Today's light sheet video of actin dynamics in cytotoxic t cells... so much fun to come! 0173
Akaash Kumar @akaashkumar.bsky.social · 14/02/2025Thank you very much for the feature and the article!! A nice surprise before the weekend... 061
Akaash Kumar @akaashkumar.bsky.social · 07/02/2025Congratulations @lara-kruger.bsky.social ! We wish you all the best! 020
Reposted by Akaash KumarDerivery Lab - MRC LMB @deriverylab.bsky.social · 17/01/2025🚨 Paper Alert 🚨 Our preprint describing Elongator as a selective microtubule polymerase that rewrites PTMs on microtubules is now published! Check it out: www.embopress.org/doi/full/10....embopress.orgElongator is a microtubule polymerase selective for polyglutamylated tubulin | The EMBO JournalimageimageElongator, an established tRNA-modifying complex, can also stabilize microtubules during asymmetric cell division. This study shows that Elongator subcomplexes achieve this by binding to mic... 1265
Reposted by Akaash KumarDerivery Lab - MRC LMB @deriverylab.bsky.social · 20/01/2025Congrats to @juliemiesch.bsky.social who was awarded a Postdoc Mobility grant by @snf-ch.bsky.social to support her research for two years. Her postdoc research will focus on the biophysical regulation of water buffering in the cell. 0175
Reposted by Akaash KumarWallace Marshall @wallaceucsf.bsky.social · 23/12/2024Mitochondria consist of networks of cylindrical tubes, right? Not necessarily! - in our new preprint, @gavsturm.bsky.social investigates how mitochondria transiently adopt a beads-on-a-string morphology www.biorxiv.org/content/10.1... 626892
Reposted by Akaash KumarMRC Laboratory of Molecular Biology @mrclmb.ac.uk · 16/12/2024Congrats to @akaashkumar.bsky.social who has won the PhD Award from the Cambridge Centre for Physical Biology for his work developing a novel microscopy system with @deriverylab.bsky.social & @jamesdmanton.bsky.social in @cellbiol-mrclmb.bsky.social. www.physbiol.cam.ac.uk/akaash-kumar #LMBintheNews 0135
Akaash Kumar @akaashkumar.bsky.social · 13/12/2024Simultaneous multispectral imaging of seven organelles in live cells using our multispectral spinning disk confocal microscope! #FluorescenceFriday You can read more about this technology in our updated pre-print: www.biorxiv.org/content/10.1... 0130
Akaash Kumar @akaashkumar.bsky.social · 11/12/2024Very happy that my work on developing multispectral live cell imaging technology has been recognised by the Cambridge Centre for Physical Biology! Thanks for the award! 1111
Reposted by Akaash KumarDerivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024In June, @akaashkumar.bsky.social and @jamesdmanton.bsky.social had their Multispectral live-cell imaging paper released on to the BioRxiv www.biorxiv.org/content/10.1...biorxiv.orgMultispectral live-cell imaging with uncompromised spatiotemporal resolutionMultispectral imaging is an established method to extend the number of colours usable in fluorescence imaging beyond the typical limit of three or four, but standard approaches are poorly suited to li... 121
Reposted by Akaash KumarDerivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024Then, in September @akaashkumar.bsky.social passed his PhD viva, becoming the latest doctor to emerge from the lab! He then won the RMS Early Career Award 2024 in October. 121
Reposted by Akaash KumarDerivery Lab - MRC LMB @deriverylab.bsky.social · 22/11/2024Later in October, the LMB had their yearly annual symposium with Post-doc Lara Kruger winning the Steitz Prize for her talk and @akaashkumar.bsky.social winning the Perutz Prize for his PhD work! 141
Akaash Kumar @akaashkumar.bsky.social · 22/11/2024Some personal news: my wife and I are finally homeowners! We got the keys to our home in Cambridge today, very exciting times! 010
Akaash Kumar @akaashkumar.bsky.social · 20/11/2024Hello Bluesky! I am an engineer/scientist currently working at the MRC LMB in Cambridge UK. During my PhD I developed new imaging technologies to shed light on the dynamics of living cells e.g. here is a movie of 6 organelles in live human cancer cells. Follow for more updates! #science #biology 15812