iiinova — where your digital self keeps evolving

Reposted by Meg Clapperton

James Manton @jamesdmanton.bsky.social · 29/09/2026

I've been working on a fast, high-ratio image compressor to try and alleviate the data storage issues myself and some of my colleagues have recently been facing. Before I 'release' version 1, it'd be great to gain some feedback regarding performance and missing features. github.com/jdmanton/rad...

github.com

GitHub - jdmanton/radelta

Contribute to jdmanton/radelta development by creating an account on GitHub.

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Reposted by Meg Clapperton

FocalPlane @focalplane.bsky.social · 24/09/2026

🌱🔬Register now for our plant imaging series! In this webinar, @madic.bsky.social will take us exploring through plant cells using cryo-ET, while @lauracopeland.bsky.social focuses on root-microbial dynamics using FPM and fluorescence microscopy. 🗓️15 October focalplane.biologists.com/2026/09/23/r...

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Fran Bottanelli @franbottanelli.bsky.social · 14/09/2026

#membranetrafficking seminars are back for the fall session! This Thursday two exciting talks from Roger Pons Lanau from @felixmendu.bsky.social lab and @veijosalo.bsky.social #ER #lipiddroplets and lots of wonderful imaging! From single molecules to cryo EM! Please repost

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Reposted by Meg Clapperton

Alex Johnson @ajcellbio.bsky.social · 04/09/2026

Super happy to announce that in October I will be joining the University of Warwick as an assistant professor! We will be continuing to examine the molecular mechanisms of intracellular trafficking using a range of samples, including plants and diatoms ⚽️🌱🔬

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Sami Chaaban @sami-c.bsky.social · 10/09/2026

Excited to share that the Chaaban Lab will be opening in January at the Crick!

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Reposted by Meg Clapperton

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 30/06/2026

Congratulations to LMB Group Leaders Emmanuel Derivery, Kelly Nguyen and Julian Sale, who have all been elected members of @EMBO.org! Read more about their research at the LMB here: mrclmb.ac.uk/news-events/... #LMBNews @deriverylab.bsky.social @kellythd-nguyen.bsky.social @juliansalelab.bsky.social

Portrait photographs of Julian Sale, Emmanuel Derivery and Kelly Nguyen

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Reposted by Meg Clapperton

Derivery Lab - MRC LMB @deriverylab.bsky.social · 30/06/2026

Deeply honored to be elected as an EMBO member. This would not have been possible without the incredible past and present members of my lab - thank you for your dedication, creativity and total lack of fear over the years 🔬🪰🧪

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 26/06/2026

2026 marks the tenth edition of the Next Generation Biophysics Symposium! Registration for this year’s event, happening at the LMB on Wednesday 16th September, is open now ➡️ www3.mrc-lmb.cam.ac.uk/sites/nextge…

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Reposted by Meg Clapperton

FocalPlane @focalplane.bsky.social · 26/06/2026

📢Check out our latest preprint list on FocalPlane In this list, we focus on the latest tools and techniques in imaging, including sample prep, probes, hardware and software. focalplane.biologists.com/2026/06/26/m... Let us know if you've been reading a preprint that we should add to our list.

focalplane.biologists.com

Microscopy preprints – new tools and techniques in imaging - FocalPlane

Microscopy preprints – new tools and techniques in imaging - News

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Reposted by Meg Clapperton

James Manton @jamesdmanton.bsky.social · 02/06/2026

We present: Index-agnostic oblique plane light sheet microscopy of centimetre-scale cleared tissues at subcellular resolution www.biorxiv.org/content/10.6...

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Reposted by Meg Clapperton

Alex Johnson @ajcellbio.bsky.social · 15/05/2026

If you ever wondered about the history and current state of plant Clathrin-mediated endocytosis....here is a review just for you! onlinelibrary.wiley.com/doi/10.1111/... Was really fun to write this with awesome co-authors! ⚽️🌱🔬

onlinelibrary.wiley.com

Clathrin‐Mediated Endocytosis in Plants: Historical to Modern Advances

Ultrastructural studies by Bonnett and Newcomb in 1966 revealed the existence of coated vesicles budding from the plant cell plasma membrane. This review introduces this discovery and early questions...

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Meg Clapperton @meganclapperton.bsky.social · 11/05/2026

In todays epidode of 'whats in the comically large thermo box?' - a comically small 250 uL secondary. 🤦‍♀️

Approximately 30 x 30 x 30 cm cardboard ThermoFisher scientific box on a lab bench, with a small 250 uL tube positioned in front.

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Reposted by Meg Clapperton

The Company of Biologists @biologists.bsky.social · 29/04/2026

There is still time to register for @focalplane.bsky.social's inaugural plant imaging webinar tomorrow. #plantimaging focalplane.biologists.com/2026/03/30/n...

focalplane.biologists.com

New webinar series on plant imaging - FocalPlane

New webinar series on plant imaging - News

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Meg Clapperton @meganclapperton.bsky.social · 24/04/2026

It was an absolute honour to win the #BSCB poster prize at #DynamicCellVI ! Its my first ever dynamic cell and I already can't wait for the next one! Make sure to come to our other talk today on using this tech to study endosomal dynamics?

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Meg Clapperton @meganclapperton.bsky.social · 20/04/2026

Going to #DynamicCellVI ? Be sure to pop by the poster flash talks and poster session on Wednesday to learn how to make any dual-camera microscope multispectral ! If you pop by the poster you can see a cool 3D printed model of the system!

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Meg Clapperton @meganclapperton.bsky.social · 31/03/2026

Presented our work on developing novel image splitters to enable dual camera simultaneous multispectral imaging with no compromise in spatiotemporal resolution, and the development of modular fluorescent microspheres at #FOM2026 ! Here for longer if anyone wants a chat!

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Meg Clapperton @meganclapperton.bsky.social · 27/03/2026

The last time I attended #FOM, I was presenting my PhD work on human tonsils - this time round, I'll be presenting fun quest in the postdoc journey where we (w/ @jamesdmanton.bsky.social and the LMBs mechanical workshop) designed and validated a novel 4-way image splitter! #FOM2026 Mon 30th @ 4:30

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Reposted by Meg Clapperton

Leighton Pritchard @widdowquinn.bsky.social · 26/03/2026

GitHub will be allowing Copilot to use your code for training its models, unless you opt out. Seems like the sort of thing some people might want to opt out of…

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Reposted by Meg Clapperton

Journal of Cell Biology @jcb.org · 19/03/2026

Deb Roy, Inoue et al. @jhu.edu introduce an #optogenetics tool to rapidly induce #microtubule acetylation in living cells and show that this triggers release of the RhoGEF GEF-H1 from #microtubules, thereby driving persistent directional cell migration. rupress.org/jcb/article/... #Cytoskeleton

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Reposted by Meg Clapperton

Simon Bullock @simonbullock11.bsky.social · 18/03/2026

Delighted to announce the posting of our latest preprint, which links stress-induced relocalisation of multiple organelles by dynein to adaptive changes in gene expression in the nucleus (1/n) 🧵 www.biorxiv.org/content/10.6...

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Reposted by Meg Clapperton

Fran Bottanelli @franbottanelli.bsky.social · 23/02/2026

#membrane seminars are back this week wirh Manu @deriverylab.bsky.social and Andela Šarić! Join us on Thursday at 5 pm CET spread the word!

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Reposted by Meg Clapperton

Johan Duchêne @johanduchene.bsky.social · 30/04/2025

Antibodies don't work. NLRP3 is by far the most studied inflammasome — yet <30% of commercial antibodies were specific. Only 4 of 14 tested antibodies detected NLRP3 specifically. Antibodies must be validated before use. Full report by @ycharos.bsky.social : zenodo.org/records/1162...

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Reposted by Meg Clapperton

Derivery Lab - MRC LMB @deriverylab.bsky.social · 19/02/2026

🚨🚨🚨Check out this new preprint from the Löwe lab proposing that microtubule architecture and dynamics evolved in Asgard archaea prior to eukaryogenesis! Happy to have had a little contribution by showing that Asgard tubulin displays a key hallmark of eukaryotic tubulins: dynamic instability! 🚨🚨🚨

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 23/01/2026

To complement the launch of our new LMB website, we’ve shared a new introductory video on our YouTube channel. Meet some of our scientists and support staff, take a look around our wonderful building and see how we come together to unravel how life works. youtu.be/JmC17_4bEMA?...

youtu.be

Through the doors of discovery - an introduction to the MRC Laboratory of Molecular Biology

YouTube video by MRC Laboratory of Molecular Biology

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Reposted by Meg Clapperton

Prof Rachel Oliver @profrachelgan.bsky.social · 12/01/2026

Following coverage over the weekend of Sir Paul Nurse's comments that suggested that the only reason that a Fellow should be expelled from @royalsociety.org is scientific misconduct, I have written to him to explain the risks such an attitude poses of increasing sexual harassment in STEM.

Dear Sir Paul,

Re: Royal Society Code of Conduct

I am sure that many scientists have written to you about the specific question of Elon Musk’s Fellowship and whether, under the Royal Society’s Code of Conduct, his retaining that Fellowship is appropriate. I will not rehash these issues. Instead, as a female scientist with extensive experience of activities aiming to increase equality, diversity and inclusion in the engineering and physical sciences sector, I am writing to you (in a personal capacity) to ask you to reconsider the statements you have recently made in this context to the UK press about the Royal Society’s Code of Conduct and how it is applied.

A 2018 report from the joint National Academies of the United States of America, concluded that “sexual harassment is common in academic science, engineering, and medicine” and that “greater than 50 percent of women faculty and staff and 20–50 percent of women students encounter or experience sexually harassing conduct in academia”. This report described codes of conduct that make clear that sexual harassment is unethical and will not be tolerated as a “powerful incentive for change”. The authors also noted that sexual harassment can have significant and damaging effects on the integrity of research. In my own praxis, I have found that clear and consistently-implemented codes of conduct that address these issues make female scientists and engineers safer, and allow them to focus more effectively on their research. For codes of conduct to have such a positive effect, it is vital that sanctions for actions which transgress the code are meaningful and substantial.

I was hence aghast to realise that in an interview with the Financial Times published on 9/1/26, you appear to have suggested that the Royal Society “should only expel fellows if their science proved “faulty or fraudulent or highly defective””. Moreover, in a further interview with the Guardian on 11/1/26 you suggested that the code “may need to be looked at again”, with the implication that your aim would be to remove the option of sanctions on Fellows for reasons not strictly related to faults or defects in their research.

I suggest that changing the Royal Society’s code of conduct so that the likelihood of serious sanctions for sexual harassment is reduced, would directly endanger women who interact with the Royal Society at events or otherwise, and would provide a licence to harass to the already powerful people on whom the Society bestows fellowship. The implications of your words - that under your leadership the only infringements of the code which are likely to receive the sanction of the Fellowship being removed are those related to research misconduct - already risk empowering harassers. You stated, in the Financial Times interview, that “there’s many bad people around, but they have made scientific advances”. Given this awareness of the possibility of bad actors in our scientific community, it is wholly irresponsible to suggest that the Royal Society would not act to sanction these people if they harass more vulnerable scientists.

I am hence writing to request that you retract any suggestion that the Society’s Code of Conduct should be changed so that the only reason a Fellow might be sanctioned by the removal of their Fellowship is “faulty or fraudulent or highly defective” research. This action is necessary to safeguard female scientists, a requirement placed on the Society by safeguarding legislation and UK statutory guidance.

Yours sincerely,

Professor Rachel A. Oliver.

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Reposted by Meg Clapperton

James Manton @jamesdmanton.bsky.social · 15/12/2025

Now published with peer-review-induced improvements in Biomedical Optics Express: doi.org/10.1364/BOE.579043 We continue to recommend the use of Sarstedt lumox dishes for ease of use and high-quality imaging performance: bsky.app/profile/jame...

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Reposted by Meg Clapperton

James Manton @jamesdmanton.bsky.social · 01/12/2025

For an internal talk, I wanted an easy way to disprove the prevailing myth that expansion microscopy gels expand due to repulsion between charged polymer strands. I did a quick calculation of the supposed energy released during a standard experiment and it's equivalent to a small nuclear bomb...

A calculation of the energy released by four-fold swelling of a 5 mm expansion microscopy hydrogel, containing 1 mmol of sodium acrylate. The calculation assumes a sphere of uniform charge density, in water, and gives an energy of 9.4E13 Joules, or approximately 22.5 kilotons of TNT.

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Reposted by Meg Clapperton

Zen Faulkes @doctorzen.net · 01/12/2025

If you run across a gen A.I. slop 🤖💩 diagram in an academic journal, I’d love to know about it! Please fill out this form: docs.google.com/forms/d/e/1F... Slop in journals is illuminating about journals’ quality control. And journals would like you to forget their mistakes. #AcademicChatter

docs.google.com

Slop graphics in academic journals

Use this form to share graphics (e.g., figures, covers, graphical abstracts) made using generative A.I. that have appeared in academic journals. The plan is to compile these slop graphics in an ope...

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 25/11/2025

There’s just ONE WEEK left to apply to join our amazing PhD programme next year! Visit our website for more information: www2.mrc-lmb.cam.ac.uk/students/int... Applications close on 2nd DEC 2025

Join the LMB's PhD programme!
Applications now open for October 2026
Deadline 2nd December 2025

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 10/11/2025

Considering the LMB for your PhD? We’ve got over 25 projects available, covering a wide array of topics. Check them out here: www2.mrc-lmb.cam.ac.uk/students/int... Apply by 2nd DEC for Autumn 2026 admission.

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Reposted by Meg Clapperton

Gail McConnell @gailmcconnell.bsky.social · 05/11/2025

We are delighted to announce the Strathclyde Optical Microscopy Course 2026 (SOMC26), taking place in Glasgow from 21st July – 30th July 2026! Please find more details at shorturl.at/xmUiZ and apply at shorturl.at/MxTlI. Deadline 16 January 2026.

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 05/11/2025

Missed the 2025 Next Generation Biophysics Symposium? Great news – you can now watch the fantastic talks on our YouTube channel! www.youtube.com/playlist?lis... Don't miss these great discussions on how new and emerging technologies may be able to address challenging biological questions.

youtube.com

Next Generation Biophysics Symposium 2025 - YouTube

The Next Generation Biophysics Symposium is an annual event, organised by MRC LMB, AstraZeneca, Imperial College London and MRC LMS examining the application...

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Reposted by Meg Clapperton

Izzy Jayasinghe @ijayas.bsky.social · 22/10/2025

📣 We are hiring! An education-focused Lecturer or Senior Lecturer in Quantitative Biomedical or Biophysical sciences. It’s a chance to be a part of a team of single molecule /cellular biophysicists building a brand new undergraduate curriculum, here at UNSW in sunny Sydney. Happy to answer queries.

external-careers.jobs.unsw.edu.au

Lecturer / Senior Lecturer in Quantitative Biomedical Sciences (Education focused)

The incumbent will contribute to undergraduate teaching in biophysics or quantitative biomedical sciences within the School of Biomedical Sciences.

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Reposted by Meg Clapperton

Sjors Scheres @sjorsscheres.bsky.social · 16/10/2025

I just made an account and voted for this biology laboratory made of LEGO to "promote biological research and inspire more people into the world of biology". They need 10K votes. Reposting and/or voting below would be helpful. 🤗 beta.ideas.lego.com/product-idea...

beta.ideas.lego.com

Biological Laboratory | LEGO® Ideas

This is a two-floor realistic Biological Laboratory building. In this design, I try to tell stories about biologists, introduce biology concepts to general publ…

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Reposted by Meg Clapperton

Matthew Freeman @mjafreeman.bsky.social · 08/10/2025

Oh how sad Really a towering figure, whose work laid the ground for stem cells, regenerative biology etc I go to know him well over many years and he was definitely one-of a-kind...

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MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 03/10/2025

Considering a PhD in molecular biology? Make sure to check out the projects on offer at the LMB! www2.mrc-lmb.cam.ac.uk/students/int... General applications by 2nd DEC. US Gates Scholarship applications by 15th OCT. #PhD

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Reposted by Meg Clapperton

James Manton @jamesdmanton.bsky.social · 15/09/2025

We present a simple method to easily increase the imageable depth of an expansion microscopy gel on a typical inverted microscope ten-fold, using some carefully placed FEP film and a water dipping objective lens:

A comparison of imaging an expansion microscopy hydrogel with a water dipping objective lens, using either eye gel as an immersion medium or a combination of Immersol W, water and a thin FEP film. In both cases, the sample is supported by a thin FEP film rather than a coverglass.

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Meg Clapperton @meganclapperton.bsky.social · 13/08/2025

Bluesky, meet Goose! Pudge is a big sister and she is not happy about it!

Black, long haired kitten sitting on top of a light wood dining table. Her tail is curled around her legs and her big green eyes are staring directly into the camera. The background has a window facing out to green leafy trees.

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Reposted by Meg Clapperton

The Company of Biologists @biologists.bsky.social · 30/07/2025

Early-career researchers, apply for a funded place at our Macro to Micro: Quantitative Plant Imaging Across Scales Workshop. Find out more: www.biologists.com/workshops/fe... #Workshop #Plants #Cells #Imaging #Microscopy #Microscope #Research #PlantPhysiology #PlantCells

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Reposted by Meg Clapperton

MRC Laboratory of Molecular Biology @mrclmb.ac.uk · 15/07/2025

Want to hear from experts about how new and emerging technologies can be harnessed to answer complex biological questions? Don’t mis the 2025 Next Generation Biophysics Symposium on Wednesday 3rd September! Find out more details and register here: www3.mrc-lmb.cam.ac.uk/sites/nextgen/

AstraZeneca, MRC Laboratory of Molecular Biology, Imperial College London, MRC Laboratory of Medical Sciences
Next Generation Biophysics Symposium 2025
Wednesday 3rd September 2025
Hybrid Symposium (Zoom & MRC LMB, Cambridge)
Keynote Speaker: Professor Cees Dekker
Registration open

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Meg Clapperton @meganclapperton.bsky.social · 04/07/2025

Pudge is thrilled about her new pal, Hamma-cat-su, picked up at #MMC2025 ! @hamamatsucorp.bsky.social

Blue/tortoiseshell British shorthair cat called Pudge, laying inside a cat carry case looking fairly grumpy (her resting grump face), next to a vibrant red stuffed toy shaped like a cartoon cat.

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