Bioinformatics can seem intimidating, especially when you're just starting out. But you don't need to be an expert to begin exploring single-cell RNA-seq data. In this short tutorial, I walk through a...

The complete cell lineage of C. elegans, mapped over four decades ago, was tractable because the animal is small, transparent, and lineage invariant. Most animals are none of these, having orders of m...

While a growing number of studies have linked environmental exposures and Parkinson's disease (PD), the impact of many pesticides remains understudied; for example, neonicotinoids are the most used in...

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Singh et al. combine cryo-electron microscopy and functional studies to reveal how a single protein complex selects diverse mRNAs for subcellular localization using a combination of shape, positional ...

I am glad not to be a Greenland shark; I don’t have enough thoughts to fill five hundred years. But I find the very...

Nature - PIEZO2 is intrinsically more rigid than PIEZO1, and disparate mechanical stimuli paradoxically evoke opposite conformational and gating responses in each channel.

Here, we present a protocol for quantifying zebrafish vertebral column morphology using micro-computed tomography (microCT) datasets for scoliosis researchers. We describe steps for orientation of ske...

Transcriptional adaptation (TA) is a genetic robustness mechanism through which mutant messenger RNA (mRNA) decay induces sequence-dependent up-regulation of so-called adapting genes. How cytoplasmica...

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This article reviews the ideological, political, economic, social, cultural, personal, moral, and ethical factors that determined the conduct of the Lenin All-Union Academy of Agricultural Sciences session in August 1948, as well as the immediate... ...

best4+ /CFTR-high expressing cells are a recently described intestinal epithelial cell type potentially altered in inflammatory bowel disease and colorectal cancer. However, their developmental origin...

Oxygen tension dynamically regulates stem cell fate and tissue regeneration, yet how local oxygen availability is controlled within the bone marrow...

Our November webinar featured two early-career researchers working on regeneration. Here, we share the talks from Stephanie Tsai (Massachusetts General Hospital) and Ben Cox (University of California,...

Author summary Tendons provide essential connections within our musculoskeletal system, transmitting the force from muscle to bone to enable movement. Concomitant with skeletal growth, tendon developm...

November: hear from two early-career researchers working on regeneration. Chaired by Development's Executive Editor, Alex Eve.

A deep-dive into the many cool (and free) resources available to zebrafish researchers! Disclaimer: This is not a comprehensive list but a list of useful

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Joint injury and disease are leading causes of disability, with mammalian joints exhibiting poor regenerative capacity. Here the authors showed that after loss of a whole joint, adult zebrafish regenerate de novo articular cartilage, ligament, and synovium into a complex joint organ.

In this Viewpoint, 2025 Lasker~Koshland Special Achievement Award in Medical Science winner Dr Lucy Shapiro discusses her discovery of how bacteria coordinate their genetic logic to generate distinct…

Biological age is a major risk factor in the development of common degenerative retinal diseases such as age-related macular degeneration and glaucoma. To systematically characterize molecular mechani...

The 2025 Albert Lasker Basic Medical Research Award honors Dirk Görlich and Steven McKnight for discoveries that exposed the structures and functions of low-complexity domains within protein…

During vertebrate development, fibroblast precursors migrate from the sclerotome to specific tissues, but the mechanisms that guide these precursors remain unclear. This study shows that Pdgfab/Pdgfra...

ALT: a bunch of clocks are hanging on a wall including one that says ' 3:00 ' on it