iiinova — where your digital self keeps evolving

💬 Perspective by Sten H. Vermund, MD, PhD: In clinical and public health research, political discretion over individual federal awards may interrupt trials, weaken community partnerships, and reduce confidence that funding decisions are based on scientific merit. ja.ma/4hjtV2K

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📝 #JAMAReview: #Cancer #vaccines are being evaluated for treatment and prevention across multiple malignant neoplasms as advances in tumor immunology, antigen discovery, and vaccine delivery reshape the field. 🔗 ja.ma/4hBPEEu

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After the 21st Century Cures Act, Medicare Advantage enrollment among patients with #KidneyFailure was associated with lower #KidneyTransplant and new wait-listing rates vs traditional Medicare. ja.ma/4xCyMCw

JAMA article: "Medicare Advantage Enrollment and Access to Kidney Transplant After the 21st Century Cures Act." Two line graphs compare transplant rates. Graph A shows cumulative incidence, and Graph B shows monthly rates, both consistently higher for Traditional Medicare than Medicare Advantage. A table of beneficiaries at risk is also present.

JAMA and the JAMA Network announce the selection of 16 early-career clinical and health services researchers for the 2026–2027 JAMA Network Peer Review Academy, a virtual program designed to cultivate excellence in peer reviewing. Read more about the program and incoming cohort: ja.ma/4yP9v9e

JAMA @jama.com · 19/09/2026

Eric Topol, MD, is a leading voice in the field of #AI in medicine. He shares his thoughts on #aging , disease prevention, and the transformative potential of AI, including how he balances healthy skepticism with hope. @erictopol.bsky.social 📌 Read more: ja.ma/4A7wuh9

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JAMA @jama.com · 18/09/2026

#ADHD diagnoses are rising among adults, and clinical assessment remains central because there is no blood test, brain scan, or other objective measure that establishes the diagnosis. 🎧 Learn more in the JAMA Medical News podcast: ja.ma/4gZy3Gr

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JAMA @jama.com · 18/09/2026

#MedNews: As more adults seek #ADHD evaluations, primary care clinicians face growing pressure to accurately diagnose and manage the condition. Find out more about the challenges of distinguishing ADHD from other conditions and how new clinical guidelines may help improve care.

jamanetwork.com

Why More Adults Are Being Diagnosed With ADHD

This Medical News article discusses the rise in adults seeking attention-deficit/hyperactivity disorder (ADHD) evaluations and the need for more consistent approaches to diagnosis and treatment as pri...

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"My progression through medical training mirrored my mom’s disease progression in a crushing reversal." In #APieceofMyMind, an infectious diseases #physician reflects on her mother’s illness and death and on how #grief reshaped her experience of #medicine, memory, and #patient care. ja.ma/46vKYty

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When intravenous moderate sedation was universally offered for #intrauterine device placement at a multisite outpatient family planning clinic, 1 in 5 patients used it. ja.ma/4hw5EI1

In nulliparous individuals receiving an #intrauterine device with a smaller-diameter placement tube, intrauterine mepivacaine was associated with lower pain scores, fewer reports of severe pain, and fewer vasovagal reactions vs placebo. ja.ma/46vGDqg

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💬 Viewpoint by Marcela Almeida, MD: #MaternalMentalHealth disorders affect approximately 1 in 5 women and are the leading overall and preventable cause of maternal mortality in the US. ja.ma/4ixMEds

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💡 JAMA Insights: #PrimaryAldosteronism is a frequently undiagnosed cause of excess aldosterone, fluid retention, and #hypertension, with hypokalemia in less than half of cases. ja.ma/4cOQivP

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Among patients with asymptomatic high-grade internal #carotid artery stenosis and reduced cognition at baseline, carotid revascularization plus intensive medical management did not improve cognitive outcomes vs intensive medical management alone over 1 year. ja.ma/4rhzaok

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In patients with severe asymptomatic #carotid artery stenosis, carotid revascularization with carotid artery stenting or carotid endarterectomy plus intensive medical management did not improve cognition vs intensive medical management alone over up to 4 years. ja.ma/4xwkzH9

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💬 Editorial by Eric E. Smith, MD, MPH, and Aravind Ganesh, MD, DPhil: In patients with asymptomatic #carotid artery stenosis, carotid revascularization did not improve cognition or prevent cognitive decline compared with medical therapy alone in the CREST-2 cognitive analyses. ja.ma/4gXxxIT

📌 Editor’s Choice from this week's issue of JAMA: ➡️ #Plasma #pTau217 Levels and Future #Cognitive Decline, ➡️ Autonomous #AI vs AI-Aided #Physicians, ➡️ High-Dose IV #VitaminC and #SevereBurn Outcomes, and more. ja.ma/4re8BQY

In the latest episode of #HealthyDialogue, health policy researcher Julie Donohue, PhD, explains the vital role Medicaid plays in the US, and what the cuts could mean for health and health care. #Medicaid #HealthCare 📌 Read more: ja.ma/4xpuzlf

JAMA @jama.com · 15/09/2026

A new JAMA study reports increased use of azithromycin in women undergoing unscheduled #cesarean deliveries, resulting in fewer #postpartum infections, following publication of the 2016 C/SOAP trial. #childbirth #csection #maternalhealth 📌 Read more: ja.ma/4hqu0C7

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💬 Perspective: Slower growth in US #HealthCareSpending does not necessarily improve affordability, because spending restraint can occur through higher patient cost sharing, reduced coverage, and delayed or forgone care. ja.ma/4A7alzn

JAMA Perspective article: 'The Next Decade of Health Spending—Affordability and Value' by Irene Papanicolas, PhD, and Anna D. Sinaiko, PhD. Published online September 14, 2026. DOI: 10.1001/jama.2026.15967.

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#IdiopathicNormalPressureHydrocephalus affects approximately 1% to 4% of adults aged ≥65 years and is associated with gait impairment, cognitive decline, and urinary dysfunction. 🎧 Learn more in this podcast: ja.ma/4dclS6I

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📝 #JAMAReview: #Idiopathic normal pressure hydrocephalus is a progressive neurologic disorder in older adults associated with gait impairment and often urinary dysfunction and cognitive decline. 🔗 Learn more: ja.ma/3Tuhut6

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💬 Editorial: For unscheduled #CesareanDelivery, real-world data on adjunctive #azithromycin support reductions in postpartum infections and may help inform future guideline recommendations. ja.ma/4xU1WOe

JAMA Network article: 'Editorial | Women's Health Azithromycin for Cesarean Delivery—From Trial to Practice.' Authored by Alan T. N. Tita, Jeff M. Szychowski, Kim Boggess. Published online September 14, 2026. DOI: 10.1001/jama.2026.16532.

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JAMA @jama.com · 11/09/2026

Among pregnant persons with unscheduled #CesareanDelivery, adjunctive #azithromycin use increased after 2016 trial publication and was associated with lower postpartum infection rates in US clinical practice. ja.ma/4h1Y489

JAMA graph on azithromycin adoption for deliveries (2013-2024). Cesarean delivery rates (orange line) rise sharply from ~2% to ~60% by 2024, showing rapid growth after 2017. Vaginal delivery rates (dark line) remain consistently near 0%.

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"Twenty-five years later, the enduring health effects of 9/11 exposures remain chronic, evolving, and clinically significant." Learn more in this #JAMAPerspective: ja.ma/4xSlUJp 🧵 This thread highlights research and commentary from across JAMA Network examining the enduring health effects of 9/11.

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JAMA @jama.com · 11/09/2026

Med News: Explore the top cardiology highlights from #ESCCongress 2026. In this Q&A, conference chair Tomasz Guzik, MD, PhD, discusses blood pressure control for dementia prevention, a new global definition of myocardial infarction, and more updates.

jamanetwork.com

A New Definition of MI and More News From ESC Congress 2026

This Medical News article is an interview with Tomasz Guzik, MD, PhD, chair of this year’s European Society of Cardiology Congress, held recently in Munich, Germany.

JAMA @jama.com · 10/09/2026

In the latest episode of #HealthyDialogue, health policy researcher Julie Donohue, PhD, explains the vital role Medicaid plays in the US, and the challenges ahead with massive cuts looming. #Medicaid #HealthCare 📌 Listen to learn more: ja.ma/4hawDZB

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JAMA @jama.com · 04/09/2026

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JAMA @jama.com · 02/09/2026

Vaccination remains the best way to reduce severe illness from COVID-19, #influenza, and #RSV. New JAMA articles provide timely evidence on #vaccine effectiveness and safety. 📖Learn more: ja.ma/3SGGi0w

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JAMA @jama.com · 01/09/2026

A new JAMA study explores birth after #uterus transplant, reporting outcomes from one specialty center between 2016 and early 2026. 📖 Read the full article to learn more: ja.ma/3T5aId7 #pregnancy #IVF #reproductivecare

JAMA @jama.com · 29/08/2026

🩺 In Japan, elective #AtrialFibrillation ablation was associated with low in-hospital mortality during a decade of rapid expansion, with no evidence that broader adoption reduced procedural safety. #ESCCongress ja.ma/4qEw6SO

Line graph: In-hospital mortality after elective atrial fibrillation ablation, 2012-2022. Y-axis: Mortality %. Annual mortality (orange line) peaked in 2013 (~0.07%), then generally declined. The 3-year moving average (blue line) shows an overall decreasing trend from 2014 to 2022 (P=.04).

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Hypertension Widely Undertreated, New Study Suggests

#MedNews: Under the updated AHA/ACC blood pressure guideline, nearly 1 in 3 adults with hypertension may be newly eligible for antihypertensive medication. Find out more about how expanding treatment could reduce mortality.

jamanetwork.com

This Medical News article discusses the estimated population-level effects of the 2025 blood pressure guideline, which expanded antihypertensive treatment eligibility.

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💬 Editorial: In #TransthyretinCardiacAmyloidosis, machine learning-based risk prediction may improve baseline prognostic assessment compared with static National Amyloidosis Centre and Mayo staging systems in treated populations. #ESCCongress ja.ma/3T2Jxj7

Diagram comparing Static Staging, ML Global Prediction, and Dynamic Prediction for Transthyretin Amyloid Cardiomyopathy (ATTR-CM). It outlines Eras, Inputs, Outputs, Limitations, and Clinical Questions for each approach, showing a progression towards more dynamic, personalized risk assessment.

In patients with #TransthyretinCardiacAmyloidosis, a machine learning-based model predicted all-cause mortality and #HeartFailure hospitalization more accurately than the National Amyloidosis Centre and Mayo Clinic staging systems. #ESCCongress ja.ma/3UmT0Ce

Table comparing discrimination performance of the RSF model against Mayo Clinic and NAC staging scores. It shows concordance index (Harrell, Uno, Antolini) and AUC (1y, 2y, 3y) for 'Score' and 'RSF' across Bern-Swiss, Other-Swiss, and Vienna cohorts.

💬 Editorial: #AI-guided #Echocardiography for #AorticStenosis could help nonexpert operators identify patients who need comprehensive imaging, with potential to expand screening where expert access is limited. #ESCCongress ja.ma/4wO0trp

Editorial in JAMA Cardiology: 'Artificial Intelligence for Acquisition and Interpretation of Echocardiography—Closing the Loop' by Thomas H. Marwick, MBBS, PhD, MPH. It discusses the use of AI in cardiology. Published online August 28, 2026.

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An #AI model applied to #FocusedCardiacUltrasound accurately detected moderate or greater #AorticStenosis, including in examinations acquired by novice operators. #ESCCongress ja.ma/4xqK2Td

Flowchart: AI-guided 2-step workflow for detecting moderate aortic stenosis with novice FoCUS. 1302 participants scanned. First pass AI review, then cardiologist overread. 4.8% referred for formal echo. Performance: sensitivity 85.4%, specificity 99.7%, PPV 91.1%, NPV 99.4%.

Figure: From Static Staging to Dynamic Risk Prediction in Transthyretin Amyloid Cardiomyopathy (ATTR-CM). This diagram compares Static Staging (pretherapy era, fixed prognosis), ML Global Prediction (contemporary, improved baseline risk), and Dynamic Prediction (expanding era, updated risk).

Table 3 shows the discrimination performance of the RSF model compared to Mayo Clinic and NAC staging scores across different cohorts. The table includes concordance index (Harrell, Uno, Antolini) and AUC (1y, 2y, 3y) values for both Score and RSF models, indicating that RSF generally shows higher values across most metrics and cohorts.

Figure: "From Static Staging to Dynamic Risk Prediction in Transthyretin Amyloid Cardiomyopathy (ATTR-CM)." This chart compares three methods: Static Staging, ML Global Prediction, and Dynamic Prediction. It details their era, inputs, outputs, limitations, and key clinical questions.

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Table comparing the discrimination performance of the RSF model versus Mayo Clinic and NAC staging scores. It shows RSF generally has higher Concordance Index and AUC values across Bern-Swiss, Other-Swiss, and Vienna cohorts for 1, 2, and 3-year predictions.