Pearling and directed trafficking as determinants of mitochondrial genome organization and network architecture - News

Winter et al. use substrate micropatterning and photoactivation to define mitochondrial subpopulations in proliferative cells. They find that biased antero

Lycas et al. develop a cryo-CLEM workflow to characterize the ultrastructure of dopaminergic varicosities. They resolve in situ structures of TRiC/CCT and

In eukaryotic cells, mitochondria form networks that range from highly fused interconnected structures to fragmented populations of individual orga...

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EPFL scientists have discovered that a simple shape change in mitochondria helps cells evenly distribute their mitochondrial DNA, solving a long-standing puzzle.

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Transient membrane constrictions, or “pearling,” underlie the regular spacing of mitochondrial genomes

The distribution of mitochondrial DNA–containing nucleoids is essential for mitochondrial function and genome inheritance; however, no known mechanisms can explain nucleoid segregation or their regula...

Mitochondrial networks exhibit remarkable dynamics that are driven in part by fission and fusion events. However, there are other reorganizations of the network that do not involve fission and fusion....