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Josefa Macuada

@jmacuada.bsky.social

140 followers 191 following 5 posts

PhD student at the Mitochondriac VEisner Lab 🇨🇱. ♥️ live-cell imaging 🔬, reading, and merken (she/ella)

Posts Replies Media

Reposted by Josefa Macuada

Juan C. Landoni @jclandoni.bsky.social · 03/04/2026

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

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Reposted by Josefa Macuada

Isi Molina-Riquelme @isimolinar.bsky.social · 21/02/2025

I'm so happy to share our work discussing nucleoid trafficking inside the mitochondrion and mitochondrial network, led by the amazing @jmacuada.bsky.social Available in @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... #mito #mitochondria

cell.com

How are mitochondrial nucleoids trafficked?

Mitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (...

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Josefa Macuada @jmacuada.bsky.social · 21/02/2025

Are you curious about how motile our mitochondrial genomes are 🧬? Live-cell nucleoid data inspired us to discuss exciting ideas from the field with amazing @isimolinar.bsky.social and Verónica Eisner in our new opinion at TCB 🤩! Here is a free-access link authors.elsevier.com/c/1keJq3QxxS....

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Reposted by Josefa Macuada

Suliana Manley @sulianamanley.bsky.social · 23/12/2024

I’m ultra excited about our preprints on mitochondrial pearling. In two concurrent collaborative studies with @wallaceucsf.bsky.social, we investigated its consequences on mtDNA nucleoids (led by @jclandoni.bsky.social) & its biophysical causes (led by @gavsturm.bsky.social). Funders HFSP, ERC, SNSF

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Reposted by Josefa Macuada

Juan C. Landoni @jclandoni.bsky.social · 23/12/2024

Stoked to share TWO preprints on mitochondrial pearling! 🎉 We uncover how spontaneous #mitochondria pearling drives #mtDNA nucleoid distribution (doi.org/10.1101/2024...), and @gavsturm.bsky.social et al. dissect the biophysics behind it (doi.org/10.1101/2024...). Details below! 🔬🧵🧪

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