iiinova — where your digital self keeps evolving

Reposted by Tamas Nagy

Rikki Garner @rikkigarner.bsky.social · 16/09/2026

Excited to announce that the Rikki Garner lab has opened its doors in beautiful Austin, TX! Our interdisciplinary lab @utaustin.bsky.social MBS investigates tissue fluidity as a universal physical regulator of multicellular patterning in health and disease. www.rikkigarnerlab.org 1/n

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Tamas Nagy @tamasnagy.com · 06/09/2026

Even with all the advancements in automated cell tracking getting us to 90%+ accuracy...that's still a lot of broken tracks over long movies! Our brains are pretty good at this so I made Vizsla 🐕, a little @napari.org plugin, to help you fix your tracks manually. 👉 pypi.org/project/napa...

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Tamas Nagy @tamasnagy.com · 08/09/2026

Wowowow. This some spectacular imaging. Amazing watching the immune cells migrate on top of the epithelia!

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Tamas Nagy @tamasnagy.com · 06/09/2026

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Tamas Nagy @tamasnagy.com · 03/09/2026

Interesting how similar this is to neutrophil/immune cell migration under confinement…huh.

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Tamas Nagy @tamasnagy.com · 16/08/2026

I've struggled to get nice, pixel-perfect borderless animations out of Napari for presentations, but I recently hacked up a nice script for it. I'm pretty happy with the results! More info 👇 tamasnagy.com/blog/2026/na...

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Tamas Nagy @tamasnagy.com · 16/08/2026

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Tamas Nagy @tamasnagy.com · 10/08/2026

This is such a good point. Given that genAI reproduces large chunks of code verbatim from open source software without crediting the original author...suffice to say, it's probably doing the same exact thing when writing.

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Reposted by Tamas Nagy

Zeke Hausfather @zekehausfather.com · 02/08/2026

I'm not sure folks have realized just how crazy the second half of 2026 and 2027 will be for global temperatures – on the back of a record-smashing El Niño event. Here is my latest estimate of where both years will end up compared to global temperatures since 1850.

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Reposted by Tamas Nagy

UCLA Broad Stem Cell Research Center @uclastemcell.bsky.social · 29/07/2026

Watch a muscle fiber take shape. 🔬 This microscopic video captures a muscle cell fusing with a developing muscle fiber, with cell membranes visible in purple and yellow. The Rando Lab uses live-cell imaging to understand how cells coordinate muscle regeneration. Credit: Tamas Nagy/Rando Lab

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jared toettcher @toettch.bsky.social · 24/07/2026

New Toettchlab paper alert! Harrison Oatman just published his beautiful work combining software design for "smart" microscopy+optogenetics and some really beautiful work understanding EGFR-driven collective cell migration. www.cell.com/cell-systems...

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Tamas Nagy @tamasnagy.com · 21/07/2026

Interesting work that shows that frontier models are basically not improving in reliability despite them appearing to do better on benchmarks. Reliability is key to trust. Hard to imagine LLMs being trusted with critical operations until this is solved, *if* it can be. arxiv.org/pdf/2602.16666

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Paul Francois @pfrancois.bsky.social · 14/07/2026

New paper 🧵 What if the "landscape" that guides cell differentiation isn't fixed, but is sculpted, in real time, by the very cells moving through it? We call this a 'sandscape' : grains of sand that carve dunes as they move, while the dunes' shape simultaneously steers where the grains go next.

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Ankita Jha @ankita13jha.bsky.social · 07/07/2026

Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1

nature.com

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

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Christophe 🔬 Leterrier @christlet.bsky.social · 24/06/2026

This is clearly top 1% quality data

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Henry De Belly @henrydebelly.bsky.social · 10/06/2026

Very excited to be sharing our new paper, just out in Nature Cell Biology! The big question we investigate: How do migrating cells put their front 🔴 and back 🔵 in the right place?

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Tamas Nagy @tamasnagy.com · 30/05/2026

Got to play around with Holotomographic imaging of muscle cells yesterday via the @uclastemcell.bsky.social imaging core and the results are pretty spectacular 🤩 You can see everything from mitochrondria to lamellipodia to macropinocytosis…with no labels!

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Tamas Nagy @tamasnagy.com · 29/05/2026

It really is concerning how few people know that this is the case.

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Reposted by Tamas Nagy

Julia Lazzari-Dean @jlazzaridean.bsky.social · 12/05/2026

We invented “triplet tumbling microscopy” (TTM) to track protein-protein interactions in living cells! Tag your protein with GFP and see it interact with *untagged* binding partners www.biorxiv.org/content/10.6...

A cartoon overview of triplet tumbling microscopy, comparing data from bound and unbound samples.

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Berna Devezer @devezer.bsky.social · 30/04/2026

📣 The difference between replicable and not replicable is not itself scientifically replicable. 📣 New work with Erkan Buzbas, showing that verdicts such as "X% of results replicated" are based on an inferential machinery that doesn't work. arxiv.org/abs/2604.26268

Screenshot of a paper's title page. Title: "The Difference Between 'Replicable' and 'Not replicable' is not Itself Scientifically Replicable". Authors: Berna Devezer and Erkan O. Buzbas, both at the University of Idaho — Devezer in the Department of Business and the Institute for Modeling Collaboration and Innovation, Buzbas in the Department of Mathematics and Statistical Science. Authors contributed equally. Corresponding author: bdevezer@uidaho.edu.
Abstract: Replication studies estimate the replicability rate of scientific results by aggregating binary verdicts of experiments. Exact replications are rarely attainable, so most replication sequences are non-exact. Experiments differ in ways that matter and do not share a single common data-generating process. We formalize two statistical interpretations of this non-exactness. In a shared latent rate model (benchmark), experiments are exchangeable and depend on a common random replicability rate. In a conditionally independent rates model (operational), each experiment has its own replicability rate drawn independently from a population distribution. Under the shared latent rate model, even small variability among replicability rates induces an irreducible variance floor on the estimated mean replicability rate that cannot be eliminated by adding more replications. Under the conditionally independent rates model, the degree of non-exactness is not identifiable from standard replication data, because one binary verdict per experiment contains no information about between-experiment heterogeneity. Researchers therefore cannot tell which precision regime they are operating in or whether high- and low-replicability sequences can be distinguished in principle. As a result, the usual data structure of one binary verdict per experiment cannot support reliable demarcation between "replicable" and "not replicable" results and systematically understates uncertainty, making high- and low-replicability sequences appear discrim…

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Tamas Nagy @tamasnagy.com · 22/04/2026

Trainees jump on this! Juan is an awesome human and he’s gonna do some amazing science ✨ Can’t wait to see what he gets up to!

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Evelyn Strickland @strickland-evelyn.bsky.social · 20/04/2026

What if you got to work with some of your best friends on a science project? I can't publish how fun this was, but I can show you the data (🧵)! Last week, we posted our second neutrophil swarming paper to bioRxiv and I wanted to post my favorite videos here~ www.biorxiv.org/content/10.6...

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Juan C. Landoni @jclandoni.bsky.social · 03/04/2026

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

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John Trant @trantteam.bsky.social · 30/03/2026

For me, the most maddening thing is when AI boosters, or detractors, all seem to agree that AlphaFold is an unmitigated good and useful tool showing the power of AI. I disagree. It's hit and miss. And the misses are REALLY expensive. Especially when the conversation suggests it is ALL HIT.

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David Ho @davidho.bsky.social · 26/03/2026

I don't think people fully appreciate how apocalyptic things are for US science. I haven't had any new funding since 2024, but I'm still ok since typical grants are for three years. This means next year I will be completely out of funding and will have to fire everyone in the lab. It's not great.

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Denis Wirtz @deniswirtz.bsky.social · 26/02/2026

Federal funding for US biomedical research is moribund. Since October 1 2025, NIH is -80% in new grants and -70% in values (total dollars). Labs are closing down and researchers are leaving science. To what end?

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Tamas Nagy @tamasnagy.com · 25/02/2026

Do folks have a preferred protocol for bleaching fluorescent proteins prior to doing Immunofluorescence? I tried a 3% H2O2 + 12mM HCl solution but I had severe cell detachment problems (despite everything being fixed).

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Tamas Nagy @tamasnagy.com · 16/02/2026

Absolutely wild timeline we live in TLDR: An agentic AI bot writes a takedown blog post of a matplotlib maintainer after he rejects its pull request. @arstechnica.com screws up and use AI to write a piece about the incident which hallucinates quotes. 🤦 theshamblog.com/an-ai-agent-...

theshamblog.com

An AI Agent Published a Hit Piece on Me

Summary: An AI agent of unknown ownership autonomously wrote and published a personalized hit piece about me after I rejected its code, attempting to damage my reputation and shame me into acceptin…

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Tamas Nagy @tamasnagy.com · 05/02/2026

Interesting study from *Anthropic* that found that AI use didn’t significantly speed up development on a novel task (w/ new Python async lib) but it did hurt understanding. Unsurprisingly, AI seems best at regurgitating common patterns and isn’t that helpful for novel ones. arxiv.org/pdf/2601.20245

arxiv.org

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Neelima Sharma @neelimasharma.bsky.social · 03/02/2026

Why is it that small animals like insects have a landspace body plan when viewed head-on, but larger animals like elephants are taller than wide? With @m-v.bsky.social, we find out in our new preprint titled 'Size and shape of terrestrial animals' - arxiv.org/html/2602.00...

an insect, a bird, and an elephant visualized with unit height scaling. insect is landscape shaped and the elephant is portrait shaped

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Brugues Lab @brugueslab.bsky.social · 28/01/2026

Really excited to share our new paper in @nature.com! We uncovered how a physical instability of the cytoplasm coupled with the cell cycle drives cytoplasmic partitioning in early embryos #zebrafish #drosophila. Read more in this🧵 www.nature.com/articles/s41... 🤩 @poldresden.bsky.social @mpi-cbg.de

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Tamas Nagy @tamasnagy.com · 28/01/2026

For all the talk about accelerating science, tools like this will likely slow things down because we have wade through mountains of AI garbage. The consequences need to grow for faking results.

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beccadownes @beccadownes.bsky.social · 28/01/2026

Peer review science relies, more than we care to admit, on what @zey.bsky.social calls "load bearing frictions" that make it difficult to fake good science, and on trust that most ppl also value science itself & won't cheat just for personal gain. This creates the wrong environment for that to hold.

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Arjun Raj @arjunraj.bsky.social · 04/01/2026

Blog post: Chance favors the (theoretically) prepared mind Data is big, machines are learning, so what good is theory anyway? Isn't most discovery driven by serendipity anyway, with theory mostly a "post-mortem"? I argue that this view discounts the value of theory. open.substack.com/pub/arjunraj...

open.substack.com

Chance favors the (theoretically) prepared mind

In defense of the role of theory in innovation

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Vaughn Smider, MD, PhD @vvsmider.bsky.social · 03/01/2026

Good review on what’s going on at NIH. “Polling consistently shows strong majorities favor federal investment in health research. The dismantling we’re witnessing is instead the result of a political moment in which a minority viewpoint holds disproportionate power.”

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Reposted by Tamas Nagy

Claire Deo @clairedeo.bsky.social · 13/11/2025

New preprint 🥳! We made photoclickable HaloTag ligands to precisely control protein labeling on living cells. With it, we can do some cool multicolor stuff. Huge congrats to Franzi and all co-authors! Check it out 👇 www.biorxiv.org/content/10.1...

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H. B. Beryl Rappaport @hbrappap.bsky.social · 25/11/2025

While 𝘝. 𝘷𝘦𝘳𝘮𝘪𝘧𝘰𝘳𝘮𝘪𝘴 max temp is around 45°C, we found 𝘐. 𝘤𝘢𝘴𝘤𝘢𝘥𝘦𝘯𝘴𝘪𝘴 grows up to 63°C with optimal growth at 55-57°C🥵. We showed cellular replication via Ultrastructure Expansion Microscopy at 63°C. The previous limit for euks is 60°C!

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Debraj Ghose @debrajghose.bsky.social · 18/11/2025

1/5: New preprint: Cytokines control the physical state of immune tissue. www.biorxiv.org/content/10.1... Unlike structured organs (heart, liver), immune tissue can shapeshift to form functional structures like germinal centers (GCs), tertiary lymphoid organs, granulomas, etc.

biorxiv.org

Cytokines control the physical state of immune tissue

Unlike most solid-like tissues, immune tissue is protean and reconfigurable—its component cells can patrol vast territories, find rare cellular partners, and dynamically self-organize into functional ...

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Tamas Nagy @tamasnagy.com · 22/10/2025

I had a great time presenting at the LLHF Annual Meeting. Lots of good feedback and lots to do!

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Tamas Nagy @tamasnagy.com · 22/10/2025

mStayRed is right around the corner, amazing to see that an unnatural amino acid can bring the benefits of mStayGold to the red channel. Someone needs to engineer a way around the UAA and it’s game time.

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Reposted by Tamas Nagy

Henry De Belly @henrydebelly.bsky.social · 16/10/2025

Thrilled to announce the launch of my lab @cri-utsw.bsky.social at UTSW this January! We will explore how cells sense and respond to mechanical forces, focusing on membrane mechanics to reveal how tension and signaling work together to shape cell behavior.

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Tamas Nagy @tamasnagy.com · 15/10/2025

Move over mScarlets, Crimson 🌶️ is the winner! It's the first red FP that I've found that properly trafficks to the membrane in primary myoblasts.

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Tamas Nagy @tamasnagy.com · 04/09/2025

With some new sorbothane feet from @thorlabs.bsky.social, the Rando lab’s @cephlainc.bsky.social Squid+ is rapidly approaching its final form. We wrapped a cheap 3D printer enclosure off of Amazon with some matte black vinyl and it’s working great as a darkbox.

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