T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-s...

By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog

Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...

A university has won a High Court challenge against England’s higher education regulator over a finding that it had infringed

A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.

This cohort study examines associations of the 9-valent human papillomavirus (HPV) vaccine with HPV-related cancers in males aged 9 to 26 years.

The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…

Despite making up 19% of the world's population, Africa contributes only 1–2% to global knowledge production across multiple fields of research. The terminology of Majority vs Minority World countries...

Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...

T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previo…

Using lower-paid workers to plug the gaps left by a failure to hire registered nurses damages safety, new research has shown

The Sanger Prize is an outreach competition aimed at undergraduate students who live and study in low or middle income countries

Human T cell responses are often studied using blood, yet most T cells reside in tissues. By comparing T cell receptor repertoires from millions of T cells from autologous tonsils and blood, Sureshcha...

Tumour-reactive CD8+ T cells are enriched in functional clusters with tumour cells and/or antigen-presenting cells and can be isolated and expanded from clinical samples.

Class I major histocompatibility complexes (MHCs), expressed on the surface of all nucleated cells, present peptides derived from intracellular proteins for surveillance by T cells. The precise recogn...