iiinova — where your digital self keeps evolving

Reposted by Gabriele Pollara

Prof Jenny Rohn @jennyrohn.bsky.social · 21/09/2026

Please do consider applying for this exciting lab role with @gpollara.bsky.social and me - nice blend of advanced culture models, immunology, microbiology and ‘omics, in our friendly Central London labs. Closes 2 Oct, please amplify! Happy to chat informally #UTI #UTISky

057

Gabriele Pollara @gpollara.bsky.social · 21/09/2026

🚨 NEW RESEARCH TECHNICIAN POST 🚨 👉 Interested in understanding the biology of recurrent UTI? 👉 Keen to work in my own and @jennyrohn.bsky.social research groups at UCL? Then please do take a look at new position available 👇. Informal enquiries encouraged. #UTISky www.ucl.ac.uk/work-at-ucl/...

ucl.ac.uk

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

135

Reposted by Gabriele Pollara

Ilan Schwartz @germhuntermd.bsky.social · 17/09/2026

Less is more, ortho-ID edition Another game changer in ortho ID from the group that brought you OVIVA Pts with ortho infections who underwent curative surgery (no DAIR) with local implantation of abx were randomized to <=7d vs >=4w ABx No Dif in 12 mo relapse www.nejm.org/doi/full/10.... #IDSky

Forest plot with primary analysis results which shows no difference in definite treatment failure, definite/probable treatment failure, or definite/probable/possible treatment failure according to treatment duration

Forest plot showing subgroup analysis which shows no difference between shorter and longer duration antibiotics in any of the subgroups including prosthetic infection, Staph aureus mono infection, and whether local gentamicin was used in mono therapy or combination therapy

23217

Gabriele Pollara @gpollara.bsky.social · 15/09/2026

Obligatory "en route" photo to EMBO "the complexity of mycobacterial infections" meeting in Paris. Looking forward to presenting some of our work on leprosy reaction immunopathogenesis. #embocomplexinfections @embo.org #TBSky #leprosy

2140

Reposted by Gabriele Pollara

Anh Hoang Le, PhD 🏳️‍🌈🏴󠁧󠁢󠁳󠁣󠁴󠁿🇻🇳 @anhhle2702.bsky.social · 07/09/2026

Very happy to share my postdoc paper is out now in @natcellbio.nature.com titled "Tissue flow acts as a guidance cue for immune cell polarization and directional migration". If you love imaging and immune cells, this is for you! #microscopymonday www.nature.com/articles/s41... A 🧵: 1/n

18392106

Gabriele Pollara @gpollara.bsky.social · 10/09/2026

Terrible advert on London Underground. How about booking an appointment to speak to a human doctor to discuss medical concerns?

360

Reposted by Gabriele Pollara

Chris Hopkins @chrishopkins123.bsky.social · 08/09/2026

Really happy to finally get this published! This is a qualitative study on front-line clinicians' rationale for sending urine cultures. The 4 themes we identified are summarised in the diagram. #UTIsky www.cambridge.org/core/journal...

cambridge.org

Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures | Antimicrobial Stewardship & Healthcare Epidemiology | Cambridge Core

Changing the culture: a qualitative study on clinicians’ rationale for requesting urine cultures - Volume 6 Issue 1

252

Gabriele Pollara @gpollara.bsky.social · 09/09/2026

Late to this, but great news!! Have always found manual thread numbering a tricky art to master 4/2 <END>

000

Gabriele Pollara @gpollara.bsky.social · 07/09/2026

"Infection-embedded (penicillin allergy) de-labelling is a high-yield intervention that can deliver immediate stewardship returns in patients with active infection needs" #IDSky #ClinMicro @jac-amr.bsky.social academic.oup.com/jacamr/artic...

052

Gabriele Pollara @gpollara.bsky.social · 06/09/2026

When I have a spare moment (badaboom! 😅) going to need to read this carefully. On face of it illustrates trade offs at the edge of minimal Abx treatment durations. What worse outcomes is one willing to accept in return for shorter treatment duration? #IDSky #MedSky www.nejm.org/doi/full/10....

nejm.org

Response-Tailored or Standard-Duration Antibiotic Treatment for Infective Endocarditis | NEJM

In patients with infective endocarditis on the left side of the heart, the current recommendation of up to 6 weeks of antibiotic therapy is based largely on expert consensus opinion. Whether a clin...

4142

Reposted by Gabriele Pollara

Ramon Garcia Maset @microberamon.bsky.social · 04/09/2026

Excited to share our new paper in Nature Communications! 🎉 Using advanced human bladder models, we explored how the urinary microenvironment and fluid flow shape UPEC pathogenesis and treatment responses. The big message: the environment matters (1/6) 🔗 www.nature.com/articles/s41...

nature.com

Effect of human urinary microenvironment and fluid flow on antibiotic and phage therapy efficacy against uropathogenic Escherichia coli - Nature Communications

Maset et al. show that bladder conditions strongly influence how urinary tract infections respond to antibiotics and bacteriophages, highlighting the need for more realistic lab models to improve diag...

3143

Reposted by Gabriele Pollara

Lepra UK @leprauk.bsky.social · 05/09/2026

Over 100 years ago, Lepra was founded on the premise of evidence-led treatment, community care and compassion - breaking down centuries of stigma. On #InternationalDayofCharity, help us continue to reach those who still desperately need us. ow.ly/Y7VE50ZFvOo 📷 Tom Bradley Photography

021

Gabriele Pollara @gpollara.bsky.social · 05/09/2026

UCL looking good (and busy) for its annual Open Day @ucl.ac.uk

050

Gabriele Pollara @gpollara.bsky.social · 04/09/2026

Delighted to have contributed (a little) to this - dissecting role of urine, flow and phages on E. coli-urothelial interaction. Most remarkable to me was ability of phages to kill intracellular bacteria AND alter the host inflammatory response. "How" is the next interesting question... 🤔 #UTISky

081

Gabriele Pollara @gpollara.bsky.social · 11/07/2026

Amazon really needs to up its game - kids are actually still at school!! Can we not even have a gap before thinking about planning the back to school bit?! 🙏

220

Gabriele Pollara @gpollara.bsky.social · 08/07/2026

I haven't watched a football match for >24 hours now!!!😱 Life feels so empty.... (thankfully will get my fix again from tomorrow! 😅) #FIFAWorldCup

040

Reposted by Gabriele Pollara

Ivan Zanoni @lozanzi.bsky.social · 07/07/2026

Excited to share this “Insight” @jem.org about an amazing new finding by Zhou, Zhang, Ye, Staeheli &co showing that type III interferons #IFNL also signal in #fibroblasts driving renal #fibrosis! #InterferonPower! #EveryCellIsAnImmuneCell! #FriendsOrFoes!

092

Reposted by Gabriele Pollara

Steven Tong @steventong.bsky.social · 16/06/2026

Great post @apsmunro.bsky.social! Doing more is such a natural reaction. But even 'benign' interventions may likely be harmful when tested properly. I'm yet to know of a trial for sepsis where adding antibiotics has been beneficial (outside of TB where we do it to prevent emergence of resistance).

1148

Gabriele Pollara @gpollara.bsky.social · 15/06/2026

"As longevity increases in Southern Africa, healthy-ageing interventions for tuberculosis survivors could improve function and survival into older age." #TBSky #IDSky by @kkranzer.bsky.social & team academic.oup.com/jid/advance-...

0111

Gabriele Pollara @gpollara.bsky.social · 15/06/2026

The 99% probability strapline is very well done .👏

291

Reposted by Gabriele Pollara

Anita Williams @catanita.bsky.social · 12/06/2026

A great episode to learn more about the current Ebola outbreak, if nothing else but to learn how to pronounce Bundibugyo #IDSky #IDEpi

043

Reposted by Gabriele Pollara

Gabriele Pollara @gpollara.bsky.social · 11/06/2026

Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....

nejm.org

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...

1154

Reposted by Gabriele Pollara

Lepra UK @leprauk.bsky.social · 11/06/2026

Run, cycle, or trek to support those affected by leprosy! Join our challenge events for unforgettable experiences that transform lives. Book your place today: www.lepra.org.uk/events/category/challenge-events #ChallengeEvents #RunForACause #CycleForChange #TrekForGood #MakeADifference

Close-up of cyclists pedaling on a sunlit road surrounded by greenery during a group ride.

Runner in an orange Lepra shirt taking part in the London Marathon. Buckingham Palace, union jacks and other runners are behind.

001

Gabriele Pollara @gpollara.bsky.social · 11/06/2026

nejm.org

Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM

1154

Reposted by Gabriele Pollara

Cell Host & Microbe @cp-cellhostmicrobe.bsky.social · 10/06/2026

Our June issue is now live. The cover image puts microbes at play. Have your own fun and enjoyment reading the content within: www.cell.com/cell-host-mi...

151

Reposted by Gabriele Pollara

Bill Hanage @billhanage.bsky.social · 09/06/2026

The current #Ebola outbreak in DRC has the potential to be even larger than those in 2018 and 2014. Why have we seen larger outbreaks in recent years? There are multiple reasons including conflict, population movement and urbanization. But the trend shows we must learn how to respond better

182

Reposted by Gabriele Pollara

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 06/06/2026

🆕💥🔴Review summarizes recent clinical trials for treatment of tuberculous meningitis 🔺Disappointing result:high dose Rifampin HARVEST 🔺The only adj Rx supported is dexamethasone(may not be universal: HIV+, ACT HIV, no survival benefit) 🔺Several ongoing RCTs #idsky www.tandfonline.com/doi/full/10....

tandfonline.com

An update on recent developments in the drug treatment of tuberculous meningitis

Tuberculous Meningitis (TBM) is an often lethal form of tuberculosis with damage to the brain resulting from a combination of direct effects from the causative pathogen M. tuberculosis and from the...

065

Reposted by Gabriele Pollara

ESGUTI Study Group (ESCMID) @esguti-studygroup.bsky.social · 05/06/2026

☀️ Don’t forget to sign for our next WEBINAR “Expert perspectives on Methenamine Hippurate for UTI prevention” ☀️ 🔜 24th June 13:00 CET ✍️ escmid.wufoo.com/forms/r1ijmo... 🥳 We are so excited to welcome you to another great ESGUTI webinar! Don’t miss out! #ESGUTI #IDSky #UTISky

156

Reposted by Gabriele Pollara

Paul Sax @paulsaxmd.bsky.social · 04/06/2026

So much we need to learn about tick-related infections, so this effort by HHS is welcome. But I worry deeply about the company they keep in their announcement. More here: #IDSky #Medsky voices.nejm.org/doi/full/10....

voices.nejm.org

Lyme Disease Deserves Better — But Better Starts with Better Evidence

A recent federal announcement to combat tick-borne disease has a promising premise but deserves scrutiny.

33414

Reposted by Gabriele Pollara

Sarah Uhm @sarahauhm.bsky.social · 05/06/2026

Excited to share my first-author research letter! Our findings highlight an important question: how therapies perform outside of clinical trials, particularly among patients often underrepresented in research. Thank you @jamanetworkopen.com! @unmccom.bsky.social @unmc-id.bsky.social

2104

Reposted by Gabriele Pollara

Adam Kucharski @adamjkucharski.bsky.social · 04/06/2026

New post, on why solving maths won’t solve intelligence: kucharski.substack.com/p/solving-ma...

kucharski.substack.com

Solving maths won’t solve intelligence

History shows what happens when axioms hit reality

2179

Gabriele Pollara @gpollara.bsky.social · 02/06/2026

Window open on warm-ish, rainy, summer day = most enjoyable working conditions. Maybe rainfall sound is soothing / promotes concentration...

160

Reposted by Gabriele Pollara

James Connolly @ruamicro.bsky.social · 02/06/2026

Latest research from the lab out now. We examined the role and expression of fimbriae during UPEC bloodstream infection. A real team effort and brilliant collaboration with Mark Schembri’s lab in Brisbane. Thanks to the MRC and BBSRC for supporting our research @ukri.org

journals.plos.org

Yad fimbriae are triggered by host cues and enhance extraintestinal pathogenic Escherichia coli tissue colonisation during bloodstream infection

Author summary Extraintestinal pathogenic Escherichia coli (ExPEC) colonise the human gut without causing disease but can disseminate to the urinary tract and bloodstream. Understanding the mechanisms...

12512

Reposted by Gabriele Pollara

Michael Marks @drmichaelmarks.bsky.social · 01/06/2026

Very pleased the @who.int Programme Managers guide for control of scabies in low income settings now out. In many areas population prevalence of scabies is 10-30% making it a major public health problem. This guide is designed to assist Ministries of Health & NTD teams in scaling up interventions.

iris.who.int

Control of scabies: a guide for national programme managers

This WHO publication provides operational guidance for national programme managers on the control of scabies, a neglected tropical disease affecting an estimated 200 million people globally, with a di...

051

Gabriele Pollara @gpollara.bsky.social · 31/05/2026

@tomgaymor.bsky.social what a time for American network to go on ad break. Missed it all! 😲

010

Reposted by Gabriele Pollara

IMAGE Lab @labphan.bsky.social · 30/05/2026

Intravital imaging showed these macs nibbling and engulfing live melanoma cells. This was independent of PS receptor MERTK. How are they able to recognise and phagocytose melanoma cells without opsonisation by antibodies? Can we exploit this for cancer immunotherapy? Lots to do! Please share! 2/2

0175

Reposted by Gabriele Pollara

IMAGE Lab @labphan.bsky.social · 30/05/2026

It's been a while time to give #immunology @bsky.app another go...Thrilled to share work led by Dr Yuki Keith & colleagues @garvaninstitute.bsky.social, UNSW & Melanoma Institute Australia now out @jem.org. CD169+ macs in skin surround & constrain melanoma growth independent of T and B cells! 1/2

rupress.org

CSF1R-dependent CD169-positive macrophages locally constrain melanoma growth in the skin

Tissue-resident CSF1R-dependent CD169+ macrophages localize deep in the skin. They surround growing tumors and directly suppress their growth independent o

1155

Reposted by Gabriele Pollara

Antibiotic Steward 🅱️C🆔🅿️🌟 @absteward.bsky.social · 29/05/2026

Amazing 😍 🔥SHORTEN 2 RCT A 7-day treatment course is superior to 14 days for uncomplicated Pseudomonas aeruginosa bacteremia, achieving similar clinical response rates with lower antibiotic exposure, fewer superinfections, and fewer serious adverse events #idsky @shorten2trial.bsky.social

3389

Gabriele Pollara @gpollara.bsky.social · 31/05/2026

this is cool - haematopoietic stem cell subsets that remember inflammatory cues. Link to human disease mortality a bit loose, personally, and not much functional readout of progenitor cells. Still, paper concept interesting, and yet another single cell popn to hunt in own datasets.... #ImmunoSky

151

Gabriele Pollara @gpollara.bsky.social · 31/05/2026

Without fail, lack of time drifts me away from this platform, then I return and spot lots of good work content, and then rue not being here more and wonder what I've missed! 🤦‍♂️🤷‍♂️ #IDSky #ClinMicro #UTISky #TBSky #AcademicSky

static.klipy.com

Danny McNamara Says Everytime

ALT: Danny McNamara Says Everytime

0120

Reposted by Gabriele Pollara

Clinical Microbiology and Infection @cmijournal.bsky.social · 30/05/2026

📣 New publication: First reported case of Andes hantavirus cardiopulmonary syndrome treated with a combination of favipiravir, ribavirin, icatibant and baricitinib: www.clinicalmicrobiologyandinfection.org/article/S119... #hantavirus

0118