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Jamie Heather

@jamieheather.bsky.social
2.5K followers 1.8K following 218 posts

🇬🇧 immunulogist in 🇺🇸 | instructor @ MGH/HMS | TCRs and pMHC Technically a James | ʤeɪmi hɛðə˞ | he/him @jamimmunology in the old place papers, tools, & 3d printed labware here: jamieheather.github.io

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Reposted by Jamie Heather
Clinical & Experimental Immunology @ceijournal.bsky.social · 05/10/2026
Check out this Editorial from @pallettlab.bsky.social and @schurichlab.bsky.social introducing our new section and the exciting research area that is #immunometabolism Read it here 🖱️ vist.ly/5m4ek
Fuel for thought: perspectives on immunometabolismCover of Clinical & Experimental Immunology with text about immunometabolism.
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Reposted by Jamie Heather
Kilian Schober @kischober.bsky.social · 02/10/2026
New preprint from our lab, now on bioRxiv! We are VERY excited about this one! www.biorxiv.org/content/10.6... How does Epstein–Barr virus (EBV) immunity become linked to multiple sclerosis (MS)? (1/8)
biorxiv.org
A pro-inflammatory effector-memory T cell program links peripheral EBV priming to CNS autoimmunity
T and B cell-mediated immunosurveillance of the central nervous system (CNS) can become maladaptive in multiple sclerosis (MS). Epstein-Barr virus (EBV) is a likely driver of MS, yet how exactly EBV-s...
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Reposted by Jamie Heather
Adrian Liston @labliston.bsky.social · 25/09/2026
Oh no…
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 23/06/2026
“The whole point of AI tools is that I no longer need to retain information in my biological memory. My biological memory is for other things now. Important things. Like my Netflix password” 😂 inpreparation.substack.com/p/opinion-i-...
inpreparation.substack.com
Opinion: I Was Not Allowed To Type Prompts Into ChatGPT During My Chalk Talk And This Is Discrimination
By Dr. Rachel Simmons, Postdoctoral Fellow, Stanford University
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Reposted by Jamie Heather
Carl T. Bergstrom @carlbergstrom.com · 23/06/2026
When I assign a research paper, it's not because I want an essay I can use to evaluate the student ex post. It's because I want the student to have the experience of going through the process of all of the above steps, perhaps iteratively, that is necessary to write a good research paper.
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Reposted by Jamie Heather
Michael Okun @michael-okun.bsky.social · 10/06/2026
I’ve officially resigned as Associate Editor for Frontiers in Systems Neuroscience. It used to be a reputable journal, but became a case study in how forced automation destroys academic integrity. 👇
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Reposted by Jamie Heather
Gabriele Pollara @gpollara.bsky.social · 11/06/2026
Fascinating paper. Not only association between auto antibodies against immunotegulatory IL-10 and some patients with inflammatory bowel disease. But also association between these antibodies and HLA risk allele for IBD. What's mechanistic link? #immunosky #MedSky www.nejm.org/doi/full/10....
nejm.org
Interleukin-10 Autoantibodies and HLA-DRB1*01:03 in Inflammatory Bowel Disease | NEJM
Neutralizing autoantibodies against interleukin-10 can result in a phenocopy of monogenic defects of interleukin-10 signaling in children and may be associated with inflammatory bowel disease (IBD)...
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Reposted by Jamie Heather
Admirable Women @admirablewomen.bsky.social · 04/06/2026
Immunologist Dr. Teruko Ishizaka co-discovered Immunoglobulin E (IgE) in 1966. This major scientific breakthrough identified the specific antibody responsible for allergic reactions and laid the foundation for modern asthma & allergy treatments. She died #OTD in 2019 at age 92. #WomenInSTEM #medsky
A black-and-white photograph of immunologist Dr. Teruko Ishizaka (1926–2019) focused on research in her laboratory. Standing in a profile view facing left, she carefully uses a pipette to transfer liquid between two glass test tubes held steady in her hands. She wears a crisp white laboratory coat over her clothing, a classic metallic watch on her left wrist, and a dark ring on her finger. Her dark hair is styled in a neat, voluminous 1960s bob, and her expression is one of deep, serene concentration as her eyes look downward at her work. The setting features mid-century stainless steel laboratory equipment, including a water bath labeled "30°C," with a rack of test tubes marked with letters "B, C, D, E" positioned on top. Industrial metal storage cabinetry looms above her. The low-angle composition highlights her dedication, evoking a serious, methodical mood that reflects her monumental co-discovery of Immunoglobulin E (IgE) in 1966.
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Reposted by Jamie Heather
Ed Zitron @edzitron.com · 01/06/2026
Today Microsoft moved all its GitHub copilot subscribers to token-based billing. If you want to see what happens when people have to pay the actual costs of AI, the day is finally here. It's obvious that every customer sees the deep, meaningful value and isn't angry at all.
r/GithubCopilot • 11m ago
Could not check
Confident-Hotel1700
Just one prompt and I got 50% of my whole month credits using Claude Sonnet 4.6.
General
This is hilarious. For context I used the Copilot Orchestrator that has Condutor, Planning, Implementator and Code review agents. But with the new "usage based pricing", seems like this is not an ideal setup anymore?
Anyone has the same experience here? I am on Copilot Prot. This is so expensive.r/GithubCopilot • 6h ago
Future-Lead-1432
Love the new Copilot token system
General
Last month I used ~60% of my quota in an entire month.
This month I've already used 25% on day one.
What an amazing improvement.r/GithubCopilot • 14h ago
Could not check
ImpossibleMuffin8791
Time to ditch Github Copilot
•..
General
First day of the new pricing model, I tried one prompt to just refine one of my existing change proposal, basically a conductor with few sub agents to update the existing change spec, architecture, test plan, prototype, tech spec and implementation plan.
About 20-30 mins task, ends up burning 16% of my monthly credits in one shot.
Bye.
↓
V Todos (15/15)
XE
create udla mouet oucumentalon
Draft implementation plan and technica...
Create test plan
Write deployment notes
Document operations notes
Copilot Pro
Credits
16% used
Upgrade
Resets Jul 1 at 10:00 AM
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Rr/GithubCopilot • 3h ago
Proper_Community 199
I just canceled my GitHub Copilot Max plan
General
You've cancelled your subscription to GitHub Copilot Max. This plan change will take effect on 2026-06-21.
Licensing
Current Copilot plan
GitHub Copilot
Your Al pair programmer
You've cancelled your subscription to GitHub Copilot Max. This plan change will take effect on Jun 21, 2026.
You can get a seat from one of your organizations. Go to Copilot settings to request a seat.
Active subscription
Copilot Max
Monthly payment
$100.00
Next payment
Jun 21, 2026
You can upgrade your subscription at any time. Read billing documentation for more details.
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Undo
It's too expensive for me. In just one day, I used 4,000/20,000 credits, which means I would end up paying $600 a month.
Copilot Max
ね
Credits
17% used
Resets Jul 1 at 8:00 AM
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Jamie Heather @jamieheather.bsky.social · 01/06/2026
It often gets stuck in a frustration spiral for me. I find a private browser window sometimes fixes it, if that helps!
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Reposted by Jamie Heather
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Reposted by Jamie Heather
Reese Richardson @reeserichardson.bsky.social · 28/05/2026
Thermo Fisher has now made public the company line, which is ?!??!?!??!?!?! you really gotta read it. cen.acs.org/research-int...
In a statement emailed to C&EN, Thermo Fisher Scientific chief communications offer Sandy Pound says, “We take antibody validation, specificity and accurate product documentation seriously, and we are committed to the transparent and ethical generation, analysis and presentation of scientific data. In the process of preparing antibody images for publication on our website, some images may have been adjusted to clarify for presentation purposes.”...In the company statement, Pound says that the company plans on “providing the original and adjusted versions of the relevant images, as well as ensuring that users are informed that antibody images may have been optimized for presentation on the website.” https://cen.acs.org/research-integrity/Sleuths-say-Thermo-Fisher-doctored/104/web/2026/05https://cen.acs.org/research-integrity/Sleuths-say-Thermo-Fisher-doctored/104/web/2026/05
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Carl T. Bergstrom @carlbergstrom.com · 25/05/2026
"Please provide a justification for the foreign collaboration." Science.
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Reposted by Jamie Heather
BWJones @bwjones.bsky.social · 25/05/2026
NIH funded peeps: This is insane and coming for us.
For FY 2026 RPPRs:
If there are any publications with a foreign co-author, a statement submitted through the Signing Official (SO) confirming the author will no longer publish or collaborate with the foreign partner is sufficient to show the collaboration has ended. Also indicate that no IDeA money was transferred via subcontract to an institution in a foreign country. This path will minimize delays.For FY2027 RPPRs onward:
Pls are required to submit prior approval requests for any publication co-authored with individual(s) affiliated with a foreign institution(s).
Per NOT-OD-26-026, prior approval requests must be initiated and submitted by a SO for the recipient organization.
In addition to noting the foreign site and the name of the foreign investigator, the prior approval request should provide information about the nature of the research being conducted; why the involvement of the foreign site is necessary; and whether any data will be transferred.
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Reposted by Jamie Heather
Caetano Reis e Sousa @reisesousalab.bsky.social · 20/05/2026
Delighted that our paper is out @natcancer.nature.com. Research led by Tom Castro-Dopico in partnership with Adendra Therapeutics reporting on a means to increase presentation of antigens from cancer cells. Read it for free at www.nature.com/articles/s43...
nature.com
Coupling dead cell recognition to Fcγ receptors augments anticancer immunity - Nature Cancer
Castro-Dopico et al. report the design of reagents to bridge F-actin and Fcγ receptors, endowing a range of antigen-presenting cells with the ability to cross-present antigens from dead tumor cells an...
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Jamie Heather @jamieheather.bsky.social · 04/05/2026
Tell this to half the podcasts I listen to begging me to go watch the show on youtube - it's never going to happen.
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Reposted by Jamie Heather
John Drury @profjohndrury.bsky.social · 29/04/2026
share.google/z1eVQD4FVd8W...
share.google
University’s £585,000 free speech fine overturned
A university has won a High Court challenge against England’s higher education regulator over a finding that it had infringed
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Jamie Heather @jamieheather.bsky.social · 24/04/2026
Me too, and I got 4 captchas down before I gave up. Private browser window seemed to skip it.
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Reposted by Jamie Heather
Immunology Podcast @immunologypodcast.com · 27/02/2026
Researchers led by Drs. Michael Gantier, Toshiyuki Shimizu, and Ben Corry show that modified #RNA from our own cells naturally blocks TLR7 and TLR8, preventing harmful immune activation. 📖: go.nature.com/4azVWjp 🔊: bit.ly/40muGA2
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Reposted by Jamie Heather
Arghavan Salles, MD, PhD @arghavansallesmd.medsky.social · 20/04/2026
At the end of 2024, the National Academies put out a report concluding the NIH has woefully underfunded women’s health research, and they suggested $15 B should be invested over the next 5 years. Here’s what’s happened instead. Hard to study women’s health if you can’t say “women.” wapo.st/4euUt1c
Figure showing number of competitive grants mentioning women from 2015-2025. The number was rising until recently, with a precipitous drop in the last year.
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Charlotte Houldcroft @virologyhouldcroft.bsky.social · 18/04/2026
www.bbc.co.uk/news/article...
bbc.co.uk
Pregnancy vaccine reduces baby hospital admissions for RSV by 80%
A study confirms the vaccine gives excellent protection for babies against life-threatening chest infections.
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Reposted by Jamie Heather
Prof Gavin Yamey MD MPH @gavinyamey.bsky.social · 15/04/2026
Boys should also get the HPV vaccine, not only to help eliminate cervical cancer through building herd immunity but also because in this latest study it cancer risk in men by about half (in 10 years of follow up; the reduction may be larger with longer follow up) jamanetwork.com/journals/jam...
jamanetwork.com
Nine-Valent HPV Vaccination and Related Cancers
This cohort study examines associations of the 9-valent human papillomavirus (HPV) vaccine with HPV-related cancers in males aged 9 to 26 years.
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Reposted by Jamie Heather
Kelvin Lau @klausenhauser on 🙅‍♂️🐘🪡 @klausenhauser.bsky.social · 20/02/2026
Started this project years ago, but now everything is deposited on @addgene.bsky.social and a short @protocolsio.bsky.social is online. Try it out to make your own (cheap) homemade nuclease/Benzonase! dx.doi.org/10.17504/protocols.io.261ged7xov47/v2 Thank you @jcoker10.bsky.social and Michael Lim!
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Jamie Heather @jamieheather.bsky.social · 02/04/2026
Mankind can't even escape from terrible work-mandated microsoft products in space
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Stuart Neil @tetherin.bsky.social · 01/04/2026
Great tribute to Robin from the Microbiology Society.
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Manchester Cancer Research Centre @mcrcnews.bsky.social · 23/03/2026
We are delighted to share that our NIHR-funded project in Kenya has been featured as a flagship impact case study by The University of Manchester. This partnership exemplifies how international cooperation can bridge the gap between laboratory research and life-saving clinical care.
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Reposted by Jamie Heather
Drug Monkey @drugmonkey.bsky.social · 19/03/2026
NIH Fellowship awards for FY2025 by race drugmonkey.wordpress.com/2026/03/19/n...
drugmonkey.wordpress.com
NIH Fellowship awards for FY2025 by race
The NIH Data Book page reporting Research Project Grants (RPG) and Fellowship awards by race has been updated for FY2025. Completely unsurprisingly, despite the impression that may have been convey…
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Jamie Heather @jamieheather.bsky.social · 17/03/2026
This guy? Whose website seems to still be offering medical services for $$$ makiscancerconsult.com/faq?
makiscancerconsult.com
Dr. William Makis MD - Innovative Cancer Treatment
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Jamie Heather @jamieheather.bsky.social · 17/03/2026
Imagine being a student in his lab now, knowing that he thinks your value isn't emerging fast enough for his taste, and that he'd likely prefer a chatbot instead
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Onisillos @onisillos.bsky.social · 12/03/2026
"Yes, Africa has challenges; we have multiple and complex disease burdens, and we have systemic resource and infrastructure issues. But we also have lessons and innovations to share with the rest of the world." www.thelancet.com/journals/lan...
thelancet.com
Amplifying African voices to lead science for better health
Despite making up 19% of the world's population, Africa contributes only 1–2% to global knowledge production across multiple fields of research. The terminology of Majority vs Minority World countries...
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Reposted by Jamie Heather
BWJones @bwjones.bsky.social · 07/03/2026
That column on the far right is the death of American biomedical science.
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AIRR-Community @airr-community.bsky.social · 27/02/2026
🚀 Registration is now OPEN for AIRR Community Meeting VIII: Decoding and Recoding Immunity! Join us June 8–11, 2026 at Yale University (USA) or attend virtually. 💸 Early-bird rates available until April 15! 🔗 Register: tinyurl.com/airrcmeeting8 #AIRRC8 #immunosky
tinyurl.com
AIRR Community Meeting VIII.
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Jamie Heather @jamieheather.bsky.social · 18/02/2026
You ever look at the human TCR gamma chain locus and ask why the constant region's so silly? It's doing stuff! www.science.org/doi/full/10.... (Very gratified to see this, having once spent an afternoon making my tool stitchr make sure it can handle the different TRGC isoforms, now feels justified)
science.org
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Reposted by Jamie Heather
Joe Sabatino @jsabatino37.bsky.social · 10/02/2026
This won’t come as a surprise to the TCR-antigen gurus, but I did want to share some lessons we learned re: partial TCR sequence alignments as predictions for antigen specificity from this study 1/
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Robin Bisson @robinbisson.bsky.social · 05/02/2026
As mentioned in another thread, four UKRI leaders spoke to journalists this morning about changes to research council funding They addressed stories broken by RPN that STFC has to find £162m of costs savings by 2029-30, and that major physics infrastructure projects have been shelved ...
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Willem van Schaik @wvschaik.bsky.social · 05/02/2026
Update from MRC re funding
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Jamie Heather @jamieheather.bsky.social · 05/02/2026
My brain tried to read this like a Lou Bega song
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Peter O'Toole @yorkbioimaging.bsky.social · 03/02/2026
Unleashing live-cell imaging for the masses! Adapting the OpenFlexure Microscope for Affordable Live-Cell Imaging www.biorxiv.org/content/10.6... Fits into existing incubators for time-lapse experiments & feeds into existing bioimaging analysis pipelines. Thanks @wellcometrust.bsky.social funding
image of the OpenFlexure Microscope on the left. On the right, our adapted live-cell imaging openflexure microscope with cradle to negate vibrations inside an existing incubator
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Stuart Neil @tetherin.bsky.social · 02/02/2026
This is finally out. Very short take home. All the variation in spike that produced the immune escape characteristics of Omicron can occur in one single persistently infected individual over the period of a year. This is why persistent infections matter www.cell.com/cell-reports...
cell.com
Antibody escape drives emergence of diverse spike haplotypes resembling variants of concern in persistent SARS-CoV-2 infections
Snell et al. develop sequencing methodology to identify full-length spike haplotypes and show that persistent SARS-CoV-2 infections drive divergent haplotype emergence, accelerating viral evolution an...
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Matthias Trost @mtrost.bsky.social · 02/02/2026
I have a 3-year postdoc position available at University of Manchester for a mass spec expert in proteomics. The person will be involved in exciting projects in single cell proteomics, drug discovery and innate immunity - on timsTOF Ultra AIP & HF & Astral Zoom. www.jobs.ac.uk/job/DQJ093/r...
trostlab.org
Home - Trost Lab
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BK. Titanji @boghuma.bsky.social · 27/01/2026
There is a cost to science denial.
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Jamie Heather @jamieheather.bsky.social · 26/01/2026
This should be a source of great national shame, and a spur to action. I sadly suspect it will be neither.
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Reposted by Jamie Heather
Rod Rahimi @rodrahimi.bsky.social · 09/01/2026
Delighted that our latest paper is out at @mucosalimmunol.bsky.social. Here, using bronchoscopies and scRNA- and TCR-seq, we found that T cells isolated from bronchoalveolar lavage versus the airway mucosal are surprisingly distinct. Summary of the original preprint below. #Immunology #PCCM
sciencedirect.com
Distinct phenotypes and repertoires of bronchoalveolar and airway mucosal T cells in health and allergic asthma
T cells play a central role in host protection against respiratory pathogens, but a maladaptive T cell response can lead to pulmonary diseases. Previo…
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Jamie Heather @jamieheather.bsky.social · 02/01/2026
Assuming this is the right one: www.boom-power.co.uk/content/uplo... ... ... looks like these panels have their axis ~2m off the ground, so the tops of the panels will be that height at sunset/sunrise, when they're at maximum tilt.
boom-power.co.uk
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Jamie Heather @jamieheather.bsky.social · 02/01/2026
Me before: "this is fun but silly" Me after: "I think there's something to this you know"
It's a screenshot of the Merrian Webster thing where you take a snap of a gif cycling through a bunch of words. I got 'prosperous'
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Jamie Heather @jamieheather.bsky.social · 22/12/2025
Is that one sheet stuck to the shaker, with matching cutouts stuck to the bottom of the clamps? Looks like a decent bit of force applied - can you go faster, or do they start to move around? (Wondering what stuff I can start to magnet together)
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Shaun Lintern @shaunlintern.bsky.social · 21/12/2025
🚨 EXCLUSIVE: English hospitals that cut registered nurses saw more deaths while those hiring nurses saw more patients survive. Even when hospitals tried to fill gaps with non-nurses, deaths still went up. Major new study exposes dangerous NHS variation: www.thetimes.com/article/7eed...
thetimes.com
Death rates rise when NHS cuts back on nursing
Using lower-paid workers to plug the gaps left by a failure to hire registered nurses damages safety, new research has shown
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Jamie Heather @jamieheather.bsky.social · 19/12/2025
A copilot button has appeared in all of my work Office programs, without need, want, or license, and without any way to get of it. Not only does IT not have a clue why it's there, no Microsoft resource can explain how to remove it. At least Clippy had the decency to get lost when you told him to.
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Jamie Heather @jamieheather.bsky.social · 16/12/2025
If my surname was Quot I'd definitely consider Alastair / Ally as a first name
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