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Jakob Schnabl-Baumgartner

@jakobschnabl.bsky.social
317 followers 598 following 25 posts

Postdoc at the FMI (@fmiscience.bsky.social) in Basel, interested in chromatin, biochemistry and SINE transposons

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Reposted by Jakob Schnabl-Baumgartner
Maëlle Bellec @bellecmaelle.bsky.social · 17h
DNA → RNA → protein. From single mRNAs to an entire developing vertebrate embryo, we can now watch this last step unfold in real time. Our paper is out today! 🐟🔬 www.science.org/doi/10.1126/...
science.org
Real-time single-molecule imaging in zebrafish embryos uncovers noncanonical translation
Precise spatiotemporal control of protein synthesis is essential during embryogenesis, yet directly measuring translation kinetics in vivo remains challenging in vertebrates. In particular, it remains...
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Reposted by Jakob Schnabl-Baumgartner
c0nc0rdance @c0nc0rdance.bsky.social · 27/09/2026
I'll save you the click-through: A lab at University of Copenhagen had been feeding draft manuscripts & data into "Claude Science" & then Anthropic announces a discovery that this lab made a year ago but hasn't published yet. It's plausible that Claude found the same signatures independently...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 26/09/2026
Amazing work!
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Reposted by Jakob Schnabl-Baumgartner
Maya Voichek @mayavoichek.bsky.social · 24/09/2026
Super excited to share my postdoctoral work at @imbavienna.bsky.social @viennabiocenter.bsky.social - We discovered that some retrotransposons, or "jumping genes" 🧬, are able to spread from cell to cell via a new viral infectivity route. A short thread: 🧵👇 (1/7)
AI-generated illustration of the soma-to-germline transmission of retrotransposons described in our work
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Reposted by Jakob Schnabl-Baumgartner
Cedric Feschotte @cedricfeschotte.bsky.social · 24/09/2026
Thrilled to see this published today! Truly special because we made the initial discovery >15 yrs ago! We found two copies of a human gene called BC200 embedded in a human poxvirus. BC200 blurs the line between gene & transposon—both functional & mutagenic! www.science.org/doi/10.1126/... 🧵1/n
science.org
Escape of the BC200 gene to a human poxvirus reveals its persistent transposition in primates
Transposable elements mobilize within and occasionally between genomes, including from host to virus. We identified two insertions of the human BC200 noncoding RNA gene in the poxvirus molluscum conta...
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Reposted by Jakob Schnabl-Baumgartner
Cell - a Cell Press journal @cp-cell.bsky.social · 23/09/2026
Now online! Direct cell-to-cell transmission of retrotransposons
dlvr.it
Direct cell-to-cell transmission of retrotransposons
Retrotransposons can infect neighboring cells using a mechanism that relies on a small fusogen-like protein rather than on the envelope protein that is typically required for infection.
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Reposted by Jakob Schnabl-Baumgartner
Sergey Ovchinnikov @sokrypton.org · 14/09/2026
Finally a more intuitaive way to learn pLDDT/pAE? 😎 sokrypton.github.io/protein_figh... (Character idea from @hannes-stark.bsky.social & Alex Waldherr)
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Reposted by Jakob Schnabl-Baumgartner
Marcin J. Suskiewicz @msuskiewicz.eurosky.social · 14/09/2026
Happy to share our preprint on a subset of ZBTB BTB domains as highly efficient natural SUMO 'supersubstrates'. The work was spearheaded by a great postdoc, El Hadji Cisse, with input from other team members and in collaboration with @defossezlab.bsky.social and @ucagne.bsky.social
biorxiv.org
A new class of inherently efficient SUMOylation substrates
SUMOylation is an essential eukaryotic ubiquitin-like post-translational modification that plays a central role in the regulation of various nuclear processes and stress responses. It canonically occu...
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Reposted by Jakob Schnabl-Baumgartner
Arnaud Krebs @arnaudkr.bsky.social · 10/09/2026
EMBL QBMM is back this year with an outstanding line-up! Plenty of talks will be selected from submitted abstracts, with emphasis on junior scientists and representation across diverse fields. The abstract deadline is the end of this week, so don’t miss out! www.embl.org/about/info/c...
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Reposted by Jakob Schnabl-Baumgartner
Madalena M. Reimão Pinto @madalenamrp.bsky.social · 07/09/2026
Applications for the IMPRS Bio-MAP PhD program now open! 🎉 dipp.cmcb.tu-dresden.de/ausschreibun...
dipp.cmcb.tu-dresden.de
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Reposted by Jakob Schnabl-Baumgartner
Anton Goloborodko @golobor.bsky.social · 03/09/2026
1/ out in @science.org! We found a new asymmetry in large-scale chromosome structure: sister chromatids are shifted by hundreds of kb in the 5′→3′ direction of their inherited strands! A close collaboration w/ @gerlichlab.bsky.social , led by @flaviacorsi.bsky.social www.science.org/doi/10.1126/...
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Reposted by Jakob Schnabl-Baumgartner
William Garland @willgarland.bsky.social · 14/08/2026
Postdoc in Nuclear RNA Biology at Aarhus University! Interested in mammalian nuclear RNA production and turnover? Come join Torben Heick Jensen’s team in Aarhus 🇩🇰 www.au.dk/om/stillinge...
au.dk
Postdoc position in Nuclear RNA Biology - Ledig stilling på Aarhus Universitet
Ledig stilling ved RNA-biologi og -innovation, Aarhus Universitet
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Reposted by Jakob Schnabl-Baumgartner
Crow @abbyjane.cloverdalelane.com · 14/08/2026
I think about this a lot.
Tim Henke
@TimHenke9
eat shit, René Magritte
Translate Tweet
Mauv @ThatsMauvelous • 1d the machine refused to recognize my humanity until i professed to believe that a sign painted to look like a traffic light is indeed a traffic light.
Show this thread
Select all squares with traffic lights
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Reposted by Jakob Schnabl-Baumgartner
Nature Biotechnology @natbiotech.nature.com · 13/08/2026
Proteome-wide identification of the druggable CRBN interactome - @labthoma.bsky.social @fmiscience.bsky.social www.nature.com/articles/s41...
nature.com
Proteome-wide identification of the druggable CRBN interactome - Nature Biotechnology
The latent interactions of molecular glue degraders are identified proteome-wide.
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Reposted by Jakob Schnabl-Baumgartner
Grosshans Lab @labgrosshans.bsky.social · 05/08/2026
RNA-binding proteins (RBPs) often bind numerous transcripts - but do they act through a network effect? Our new paper in @plosbiology.org shows that the highly conserved LIN28 RBP controls developmental timing in C. elegans larvae through only two targets. doi.org/10.1371/jour... 1/n
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Cornelia Schwayer @cschwayer.bsky.social · 03/08/2026
Looking for a PhD? Applications are now open for PhD positions at the Max Delbrück Center. 🧵 www.mdc-berlin.de/career/jobs/...
mdc-berlin.de
PhD Positions (m/f/d) in Biomedical Research
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 17/07/2026
Cool study! TEs in the male Drosophila germline jump in bursts
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bioRxiv Genetics @biorxiv-genetic.bsky.social · 17/07/2026
piRNA loss unleashes episodic transposition bursts www.biorxiv.org/content/10.64898/20…
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Luca Giorgetti lab @FMI @lucagiorgetti.bsky.social · 15/07/2026
Our preprint is now out in @natgenet.nature.com ! doi.org/10.1038/s415... We measured Sox2 promoter bursting dynamics with the SCR enhancer positioned at different distances within a genomic locus devoid of confounding effects in mESC: Main findings in the 🧵 below:
doi.org
Enhancer control of promoter activity and variability via frequency modulation of clustered transcriptional bursts - Nature Genetics
Tünnermann et al. use live-cell imaging to study promoter activity under the control of an enhancer inserted at different genomic distances. RNA production from the promoter occurs in clusters of tran...
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Rebecca Berrens @rberrens.bsky.social · 10/07/2026
Hi #TEsky, please remember that we have an amazing community in the TransposonsWorldWide slack channel (join.slack.com/t/transposon...), which I encourage you to join. Another great resource is tehub.org. Please share !
join.slack.com
Join TransposonsWorldwide on Slack
Slack is a new way to communicate with your team. It’s faster, better organized, and more secure than email.
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 09/07/2026
Thanks Peter!
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 08/07/2026
Thanks Changwei!
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Reposted by Jakob Schnabl-Baumgartner
FMI science @fmiscience.bsky.social · 08/07/2026
Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements. Two new studies from the @marcbuhler.bsky.social group, now published in @cp-molcell.bsky.social, show how cells keep these potentially disruptive sequences under control. www.fmi.ch/news-events/...
fmi.ch
How cells keep genomic hitchhikers under control
Much of the genome is made up of repetitive DNA sequences that trace back to ancient mobile elements, many of which have lost their ability to copy themselves into new locations but can still cause pr...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 07/07/2026
Thanks Julius! Somehow I can not get away from TEs...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 07/07/2026
If you want to know more details regarding the mechanism check out the paper led by @aheljo.bsky.social it is shown that the ATPase activity of CHD4 within ChAHP is crucial for SINE repression www.cell.com/molecular-ce...
cell.com
Remodeling activity of ChAHP restricts transcription factor access to chromatin
Ahel et al. show that the ChAHP complex drives SINE B2 repression independently of HP1 and not through steric occlusion. Instead, CHD4-dependent chromatin-remodeling activity repositions nucleosomes, ...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 07/07/2026
We show that the ChAHP complex specifically silences Pol III transcription of SINE B2 transposons by inhibiting recruitment of TFIIIB. Thanks to all the co-authors especially Fabio Mohn, Michi (@xxxmichixxx.bsky.social ) and Marc (@marcbuhler.bsky.social) for the collaborative effort!
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 07/07/2026
www.cell.com/molecular-ce... I'm happy to see our work published! If you are interested in transposons, transcriptional regulation and Pol III come and check it out 👀 🧫 🧬
cell.com
ChAHP silences SINE retrotransposons by inhibiting TFIIIB recruitment
SINEs are short transposable elements that make up large fractions of mammalian genomes. Known to be transcribed by RNA polymerase III, their regulation has remained largely unexplored. Schnabl-Baumga...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 07/07/2026
Congratulations! Awesome news 🌱🌊
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Luís M. Silva @luismsilva.bsky.social · 06/07/2026
1/🧵 With this paper finally published, I want to talk about the worst peer review experience of my career as a non-native English speaker, early-career researcher, and solo author, and why I think it matters. #AcademicSky #AcademicPublishing #EvoSky
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Chung Hyun Cho @chc-evobio.bsky.social · 04/07/2026
Excited to share our new preprint led by Fred and me in collaboration with the archaeal community! We found that the molecular foundation of histone-based chromatin has pre-eukaryotic roots in Asgard archaea. (1/4) #ArchaeaSky www.biorxiv.org/content/10.6...
biorxiv.org
Emergence of histone-based chromatin complexity in Asgard archaea
The emergence of the eukaryotes coincided with the diversification of histone proteins and their post-translational modifications by enzymes that constitute the core of eukaryotic chromatin. Yet the e...
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Reposted by Jakob Schnabl-Baumgartner
Claudia Keller Valsecchi @kellervalsecchi.bsky.social · 03/07/2026
We are looking for a colleague 👇👇👇
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Cornelia Schwayer @cschwayer.bsky.social · 01/07/2026
Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵
cell.com
Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning
During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...
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Jakob Schnabl-Baumgartner @jakobschnabl.bsky.social · 30/06/2026
Congratulations @cschwayer.bsky.social & @silviabarbiero.bsky.social to their opus magnum! Glad I could contribute a small piece by ChIPing 🧬🧬
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Clément Goubert @clementgoubert.bsky.social · 25/06/2026
Major development in the #Transposon world! Repbase is joining the Dfam project and becomes open-access! link.springer.com/article/10.1...
link.springer.com
Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA
Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...
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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026
Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!
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Julius Brennecke @juliusbrennecke.bsky.social · 13/06/2026
a small attempt to capture this enormous loss and what Greg meant and means to so many. www.cell.com/cell/fulltex...
cell.com
Gregory J. Hannon (1964–2026)
Gregory J. Hannon passed away in April 2026 at the age of 61. A towering figure in modern molecular biology, Greg influenced remarkably diverse areas of science. His work reshaped our understanding of...
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Reposted by Jakob Schnabl-Baumgartner
Teif lab @teiflab.bsky.social · 12/06/2026
Great preprint by @vram142.bsky.social & Co www.biorxiv.org/content/10.6... "fiber homotypy," where chromatin fibers with similar nucleosome spacing interact more frequently in 3D --> Related to our previous "nucleosome homology recognition" in chromatin royalsocietypublishing.org/rsif/article...
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Yinan Wan @yinanwan.bsky.social · 02/06/2026
Excited to share that I will start my lab at the Center for Integrative Genomics in Lausanne @unil.bsky.social in Jan 2027! I’m looking for PhD students fascinated by how cells build tissues and excited about developing new technologies to study development across scales. www.wanlab.bio/pages/9397
wanlab.bio
Yinan Wan Lab | UNIL CIG - Join us!
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Matthias Eberl @eberlmat.bsky.social · 29/05/2026
Data manipulation at a breathtaking scale by commercial providers of crucial research reagents. As if the few remaining lab scientists didn't face enough obstacles already.
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Reposted by Jakob Schnabl-Baumgartner
Cedric Feschotte @cedricfeschotte.bsky.social · 29/05/2026
📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com
thefeschottelabatcornell.com
The Feschotte Lab at Cornell
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Ashkaan K. Fahimipour @akfbio.bsky.social · 22/05/2026
Reptiles with longer Wikipedia pages tend to be bigger. The relationship is a power law with exponent = 0.85. I guess humans really like writing about big lizards? The longest article is the Komodo Dragon.
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The Cecere Laboratory @cecerelab.bsky.social · 22/05/2026
Our latest work is now online in NSMB: maternal yolk carries microRNAs from the intestine to embryos, shaping gene regulation and stress resilience in the next generation. rdcu.be/fj8Er #Epigenetics #microRNA #Inheritance @pasteur.fr @devstempasteur.bsky.social @erc.europa.eu
nature.com
Soma-to-germline miRNA inheritance through yolk promotes stress resilience in progeny - Nature Structural & Molecular Biology
In this study, the authors use the Caenorhabditis elegans model organism to show that maternal microRNAs are delivered from the intestine to embryos by the yolk, where they regulate gene expression an...
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Sholto David @sholtodavid.bsky.social · 22/05/2026
Earlier this week I posted an example of a fake western blot provided by ThermoFisher to demonstrate the validity of a p53 antibody. I considered it an amusing curiosity. In fact Thermo Fisher Scientific has systematically manipulated antibody validation data!
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Clausen Lab @clausenlab.bsky.social · 21/05/2026
Open Postdoc Position - Giant E3 ligases: mysterious mechanisms & non‑protein substrates. Interested? Join us to uncover how these molecular giants tag lipids, RNAs, sugars beyond proteins, on organelles and pathogens, to defend the cell. Details & Application here www.imp.ac.at/career/open-...
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Tschopp Lab @tschopplab.bsky.social · 14/05/2026
One of my dream projects, ever since joining here in Basel, out now in @nature.com : single-cells 🤝 eco-morphological proxies rdcu.be/fiyso How cells and tissues adapt to dietary niches... Thanks and congrats to Antoine, Walter, and all the other co-authors for this great collaboration!! 🙏🥳
rdcu.be
Adaptive cellular evolution in the intestine of hyperdiverse cichlid fishes
Nature - Single-cell transcriptomics combined with morphological and ecological data show that the rapid evolutionary radiation of cichlid fishes in Lake Tanganyika was accompanied by dietary...
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Alejandro Burga @arburga.bsky.social · 18/05/2026
🧬 New research from the Burga lab! We took a closer look at a rogue selfish protein and caught evolution in the act of turning something old into something radically new 💡 (a.k.a. neofunctionalization) @imbavienna.bsky.social www.biorxiv.org/content/10.6... Curious? Here’s a breakdown:
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The EMBO Journal @embojournal.org · 18/05/2026
Host-transposable element coexistence: a matter of resistance, tolerance and trade-off Read this new review by Séverine Chambeyron, Charlotte Grimaud, Mikiko Siomi et al link.springer.com/article/10.1...
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Dr. Tyler A. Elliott @transposableman.bsky.social · 17/05/2026
#TEsky Host–Parasite Interactions Revisited: Evidence of Horizontal Transfer of a Transposable Element Between a Snail and Its Parasite doi.org/10.1093/gbe/...
doi.org
Host–Parasite Interactions Revisited: Evidence of Horizontal Transfer of a Transposable Element Between a Snail and Its Parasite
Abstract. In eukaryotes, horizontal gene transfer (HGT) often involves transposable elements (TEs), host–parasite relationships, aquatic environments, or a
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Madalena M. Reimão Pinto @madalenamrp.bsky.social · 13/05/2026
Last call for this awesome opportunity: www.czbiohub.org/program-mpi-.... If you hold a US-PhD degree and want to join one of the labs at the @mpi-cbg.de or @mpipks.bsky.social for a fully-funded postdoc, apply! Deadline is May 20.
czbiohub.org
Global Science Scholars - Max Planck Society
Learn about the international postdoctoral fellowship program from Biohub and the Max Planck Society.
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Mart Krupovic @mkrupovic.bsky.social · 11/05/2026
With Eugene Koonin, we wrote a rather comprehensive review on the origin, evolution and organization of the #virosphere. We describe all 10 viral realms and the logic behind them, and so much more. Check it out! comptes-rendus.academie-sciences.fr/biologies/ar...
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