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Clément Goubert

@clementgoubert.bsky.social
429 followers 237 following 80 posts

🤘🧬 Transposable ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ ¦ Elements 🧬🤘 ---- Assistant Research Professor @wheelerlab.org University of Arizona

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Clément Goubert @clementgoubert.bsky.social · 25/06/2026
Major development in the #Transposon world! Repbase is joining the Dfam project and becomes open-access! link.springer.com/article/10.1...
link.springer.com
Unifying Repbase and Dfam: a new open foundation for transposable element research - Mobile DNA
Repbase and Dfam, the two foundational resources for transposable element annotation, are being unified into a single, fully open access framework, with Repbase released under CC-0 and its core curati...
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Cedric Feschotte @cedricfeschotte.bsky.social · 29/05/2026
📣 POSTDOC position available in the Feschotte Lab at Cornell to work on #TRANSPOSONS! More details below. Pls send informal application or inquiry ASAP by DM or email to cf458_at_cornell.edu. Pls spread the word 🙏 #TEsky www.thefeschottelabatcornell.com
thefeschottelabatcornell.com
The Feschotte Lab at Cornell
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Travis Wheeler @wheelerlab.org · 29/05/2026
dream postdoc | | | V
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Physalia-courses@ONLINE @physaliacourses.bsky.social · 27/04/2026
🧬 Interested in Transposable Elements? Join our course with @valentinapeona.bsky.social @ritarebollo.bsky.social @clementgoubert.bsky.social & learn about TE libraries, genome annotation, insertion polymorphism, transcriptomics, manual curation and much more www.physalia-courses.org/courses-work...
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Travis Wheeler @wheelerlab.org · 05/02/2026
Please spread the word: We invite applications to a two-week Computational Biology workshop in Singapore, June 14-27. This NSF-funded workshop brings together 16-20 US grad students with international peers. Apply by March 21: compbioasia.net 🧵 Details below:
compbioasia.net
Compbio Asia
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Clément Goubert @clementgoubert.bsky.social · 12/12/2025
WOW! Very promising new tool to facilitate collaborative manual curation of TEs link.springer.com/article/10.1...
link.springer.com
ColabCuraTE: an easy-to-use, web-based pipeline for the manual curation of transposable elements - Mobile DNA
Background Transposable elements (TEs) are widespread mobile DNA sequences that shape genome structure, function, and evolution. Although automated tools exist for the de novo identification and class...
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Clément Goubert @clementgoubert.bsky.social · 22/10/2025
www.biorxiv.org/content/10.1...
biorxiv.org
Transposable elements drive much of naturally occurring genetic lethality in Drosophila melanogaster
Recessive lethal mutations are widespread across studied species, with estimates suggesting that each individual carries at least one. Numerous lethal alleles persist in wild populations at higher fre...
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Clément Goubert @clementgoubert.bsky.social · 15/09/2025
Yummy! www.cell.com/current-biol...
cell.com
Long-term monitoring of a North American cheese cave reveals mechanisms and consequences of fungal adaptation
Using a unique longitudinal sampling approach, Louw et al. demonstrate how a cheese-associated Penicillium population has adapted in an artisan cheese production facility in Vermont, USA. Adaptation i...
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Clément Goubert @clementgoubert.bsky.social · 28/08/2025
Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence journals.plos.org/plosgenetics...
journals.plos.org
Rapid emergence of non-autonomous elements may stop P-element invasions in the absence of a piRNA-based host defence
Author summary Transposable elements (TEs) are short, self-replicating DNA sequences found in nearly all genomes. While they can be harmful to their hosts, many organisms have evolved defence systems,...
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Clément Goubert @clementgoubert.bsky.social · 26/08/2025
A Concise Guide for the Characterization and Curation of Transposable Elements in Insect Genomes -- by the excellent @valentinapeona.bsky.social link.springer.com/protocol/10....
link.springer.com
A Concise Guide for the Characterization and Curation of Transposable Elements in Insect Genomes
Transposable elements (TEs) can play a huge role in shaping the structure and evolution of genes and genomes, but it can be difficult, especially in non-model organisms, to confidently characterize th...
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Clément Goubert @clementgoubert.bsky.social · 25/07/2025
Adaptive P-element insertions in a long non-coding RNA are associated with unique silencing properties www.biorxiv.org/content/10.1...
biorxiv.org
Adaptive P-element insertions in a long non-coding RNA are associated with unique silencing properties
Transposable elements are genetic parasites whose mobilization throughout the genome is a major source of deleterious mutations. However, some TE insertions are beneficial because they improve host fi...
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Clément Goubert @clementgoubert.bsky.social · 23/07/2025
How the complex issue of delineating #Transposons families plays out in the interpretation of epigenetic experiments. Congrats Xun Chen and @guilbourque.bsky.social for leading this work, and thank you for having me on this! www.science.org/doi/10.1126/... #TEsky
science.org
A phylogenetic approach uncovers cryptic endogenous retrovirus subfamilies in the primate lineage
A phylogenetic approach reveals cryptic LTR subfamilies and functional insights at nucleotide resolution in primates.
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Clément Goubert @clementgoubert.bsky.social · 02/06/2025
Challenging the TE burst hypothesis in the adaptive radiation of Galápagos Asteraceae trees (Scalesia) with @naturalselection.bsky.social and team! mobilednajournal.biomedcentral.com/articles/10....
mobilednajournal.biomedcentral.com
No evidence of transposable element bursts in the Galápagos Scalesia adaptive radiation despite hybridization, diversification and ecological niche shifts - Mobile DNA
Transposable elements (TEs) have been hypothesized to play a pivotal role in driving diversification by facilitating the emergence of novel phenotypes and the accumulation of divergence between specie...
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Clément Goubert @clementgoubert.bsky.social · 27/05/2025
Waho this is impressive: github.com/zeqianli/tgv
github.com
GitHub - zeqianli/tgv: Explore 5,000+ genomes in the terminal. Light, blazing fast 🚀, vim-motion.
Explore 5,000+ genomes in the terminal. Light, blazing fast 🚀, vim-motion. - zeqianli/tgv
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Magdalena Skipper @magdalenaskipper.bsky.social · 24/04/2025
New genomic & genetic insights into Mendel’s pea genes, including previously uncharacterised alleles 159 years after Mendel published his work, this is a real delight (especially for a geneticist) 🧪 @nature.com www.nature.com/articles/s41...
nature.com
Genomic and genetic insights into Mendel’s pea genes - Nature
Characterization of the genetic architecture underlying the 7 pairs of contrasting traits studied by Mendel and the over 70 additional agronomic traits in pea (Pisum sativum) reveals their m...
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Clément Goubert @clementgoubert.bsky.social · 29/04/2025
Manual validation finds only ultra-long long-read sequencing enables faithful, population-level structural variant calling in Drosophila melanogaster euchromatin www.biorxiv.org/content/10.1...
biorxiv.org
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Travis Wheeler @wheelerlab.org · 22/04/2025
🧬🖥️ Thanks to Evangelos Karatzas at @ebi.embl.org, our _nail_ software for fast and sensitive protein sequence search is now available as an @nf-co.re module (nf-co.re/modules/nail...) (crates.io/crates/nail, github.com/TravisWheele...) Thanks Evangelos!
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Clément Goubert @clementgoubert.bsky.social · 25/04/2025
go.nature.com/3S27sLp
go.nature.com
Celebrating DNA Day with transposable elements
Each year on DNA Day, we celebrate the DNA double helix structure and the Human Genome Project's completion. Here we dive into a fascinating genomic component: transposable elements. Once seen as mere...
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Dr. Stephanie @punkrockscience.bsky.social · 24/03/2025
The writing’s been on the wall for a while, and in case anyone was unaware: YOUR GENOMIC DATA IS THE MOST VALUABLE ASSET THEY HAVE LEFT. Delete your data. Make sure you opt-out of any opt-outable options. Tell your friends and family - you know that technophobe cousin missed the memo. 🧪
washingtonpost.com
Column | Delete your DNA from 23andMe right now
The genetic information company declared bankruptcy on Sunday, and California’s attorney general has issued a privacy “consumer alert.”
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Clément Goubert @clementgoubert.bsky.social · 24/03/2025
Polymorphic transposable elements contribute to variation in recombination landscapes (drosohila 🪰) www.pnas.org/doi/full/10.... #TEsky
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Clément Goubert @clementgoubert.bsky.social · 19/03/2025
Rapid emergence of hyperparasitic elements may stop P-element invasions in the absence of a piRNA-based host defence www.biorxiv.org/content/10.1...
biorxiv.org
Rapid emergence of hyperparasitic elements may stop P-element invasions in the absence of a piRNA-based host defence
Transposable element (TE) invasions pose risks to both the TE and the host. All copies of a TE may be lost via genetic drift, or host populations may suffer fitness declines, potentially leading to ex...
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Clément Goubert @clementgoubert.bsky.social · 12/03/2025
#Transposons are just the best!
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Adrià Auladell @adriaula.bsky.social · 12/03/2025
Here, we demonstrate that Starships, a newly discovered group of cargo-mobilizing transposable elements, are active vectors of horizontally transferred DNA among eukaryotic species.
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Clément Goubert @clementgoubert.bsky.social · 10/03/2025
DFAM (database of transposable elements) 3.9 is out! A lot of cool new stuff and a special update for Drosophila melanogaster... 1/2 #Transposon #DFAM
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Clément Goubert @clementgoubert.bsky.social · 07/03/2025
Cool stuff from the Trono lab, as usual! Zinc-finger proteins with a co-opted capsid domain anchor nucleosomes over transposon sequences www.biorxiv.org/content/10.1...
biorxiv.org
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plantgenomics.bsky.social @plantgenomics.bsky.social · 03/03/2025
LOCATE: using Long-read to Characterize All Transposable Elements doi.org/10.1101/2025... Mapping-based Genome Size Estimation doi.org/10.1101/607390 #Genomics #Bioinformatics #OpenScience
doi.org
LOCATE: using Long-read to Characterize All Transposable Elements
Transposons constitute ~45% of the human genome, driving gene evolution and contributing to disease, but their repetitive nature complicates the identification of new insertions. We present LOCATE (Lo...
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Francois Sabot @francoissabot.bsky.social · 03/03/2025
Do you want to annotate your #pangenome graph and its embedded genome ? Then GrAnnoT is for you ! 🖥️🧬 🧪 In the present paper, our PhD student Nina Marthe developed a Python tool, a user friendly one, that allows to 1/5 www.biorxiv.org/content/10.1...
biorxiv.org
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Clément Goubert @clementgoubert.bsky.social · 24/02/2025
RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate www.nature.com/articles/s41...
nature.com
Crosstalk between RNA m6A and DNA methylation regulates transposable element chromatin activation and cell fate in human pluripotent stem cells - Nature Genetics
The N6-methyladenosine reader YTHDC2 recruits TET1 to remove 5-methylcytosine from LTR7/HERV-H loci in human embryonic stem cells. The YTHDC2/LTR7 pathway inhibits neural fate commitment.
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Clément Goubert @clementgoubert.bsky.social · 18/02/2025
Very promising approach to characterize the mobilome in pangenomes from ! I wonder how this compares/complements to Pantera (@piosierra.bsky.social) and GraffiTE www.biorxiv.org/content/10.1... #TESky #SV #Pangenomes
biorxiv.org
Pannagram: unbiased pangenome alignment and the Mobilome calling
Pannagram is a toolkit for unbiased pangenome alignment and Mobilome detection based on full-genome assemblies. It consists of two components: a command-line interface for performing the multiple geno...
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Clément Goubert @clementgoubert.bsky.social · 27/01/2025
www.biorxiv.org/content/10.1... #TEsky
biorxiv.org
Exploring the role of transposable elements to sex gap in longevity in Drosophila species
In Drosophila, like in many other animal species, females tend to live longer than males, a phenomenon known as sex gap in longevity (SGL). One of the possible causes underlying this phenomenon could ...
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Clément Goubert @clementgoubert.bsky.social · 27/01/2025
Highly recommend!
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Marlies Oomen @marliesoomen.bsky.social · 20/01/2025
Very excited to share our paper on Gene and Transposable Element expression in mammalian preimplantation development, online today! www.cell.com/cell/fulltex... A short thread to highlight some of our findings 🧵
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Clément Goubert @clementgoubert.bsky.social · 22/01/2025
www.cell.com/cell/fulltex... #transposons #mammals #development #transcripts
cell.com
An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development
Mapping transcription start sites across five mammalian species before, during, and after embryonic genome activation unveils widespread transposable element-driven transcription and co-option of evol...
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Clément Goubert @clementgoubert.bsky.social · 14/01/2025
The great @johannconfais.bsky.social on a reference-free approach (panREPET) to annotate #Transposons in #pangenomes 🧬
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Nicolas Francillonne @nico971.bsky.social · 12/01/2025
After @tehub.bsky.social satellite workshop at #ICTE2024 and the creation of a working group on benchmark, what about the next step ? A manual curation workshop ? Share your thougth with the TEhub
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Nicolas Francillonne @nico971.bsky.social · 12/01/2025
@johannconfais.bsky.social and @clementgoubert.bsky.social are presenting @tehub.bsky.social at #PAG2025, an amazing resource and driven community for anyone interested in transposable element
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Johann Confais @johannconfais.bsky.social · 11/01/2025
Amazing talk of @nico971.bsky.social from @urgi-inrae.bsky.social on RepetDB #PAG32 urgi.versailles.inra.fr/repetdb/begi...
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Clément Goubert @clementgoubert.bsky.social · 10/01/2025
#PAG32 I'd bet that every genome studied at PAG has a least 1 #Transposon, if not thousands! Find us on Sunday for an exciting session on #mobileDNA!
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Clément Goubert @clementgoubert.bsky.social · 10/01/2025
#PAG32 About to discuss #Transposons in the grain weevil genomes using pangenomic tools! Weevilomics workshop, Pacific room F!
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Alessandro Costa @costalaboratory.bsky.social · 11/12/2024
I have received a Wellcome Discovery Award to study the initiation of eukaryotic DNA replication, with 8 years of funding at the Francis Crick Institute. Looking for a postdoc in molecular mechanisms, cryo-EM, cryo-FIB and in situ structure? Contact me now! 3 postdoc positions advertised soon.
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Fabien Burki @fburki.bsky.social · 10/12/2024
I would really appreciate a wide sharing of this post, as the candidate profile I am looking for is outside of my regular circle. Thank you so much. More info and how to apply here: uu.varbi.com/se/what:job/... (2/2)
uu.varbi.com
Postdoktor inom i proteomik och eukaryotisk evolution
Postdoktor i proteomik och eukaryotisk evolution Detta projekt är en del av ett ERC Consolidator-anslag (PlastidOrigin) som tilldelats Fabien Burki och syftar till att studera en av de mest omvälvan
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Timothy Bredy @twbredy.bsky.social · 12/12/2024
It was only a matter of time. www.cell.com/cell/fulltex...
cell.com
Transposable element exonization generates a reservoir of evolving and functional protein isoforms
Transposable element exonization by unannotated splicing events produces stable protein isoforms with acquired functions that are subject to evolutionary selection.
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Clément Goubert @clementgoubert.bsky.social · 07/12/2024
Let me know If Google does that!
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Grant Jacobs BioinfoTools/NotJustDNA 🔬🧬🖥️✍️📚🇳🇿 @notjustdna.bsky.social · 07/12/2024
Apple & AI There I was hoping Apple would make this opt-in… 😑
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Clément Goubert @clementgoubert.bsky.social · 06/12/2024
Posting this to remember the day I have more followers than @cedricfeschotte.bsky.social 🤣🤣🤣
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John Greally @greally.bsky.social · 02/12/2024
We've got to do better. This field of 'social epigenomics' looks to be very lacking in self-criticism and necessary rigour, it is no wonder that these studies are wide open to criticism.
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Graham Coop @gcbias.bsky.social · 02/12/2024
We found this ghost redwood tree this weekend while camping this weekend @jrossibarra.bsky.social . It's a rare chlorophyll mutant growing clonally off of the base of huge coastal redwood
completely white needles of ghost redwood. Looks like a black and white photo, but is in fact full colour. Jeff Ross-Ibarra next to a ghost redwood tree with white needles.
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Clément Goubert @clementgoubert.bsky.social · 16/10/2024
🎉 Our #GraffiTE paper is out!!! t.co/TmoSL3WQ1P If you are interested in #Transposon insertion polymorphism, this is for you!
t.co
https://www.nature.com/articles/s41467-024-53294-2
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Molly Gale (Gale-Hammell Lab) @mollygale.bsky.social · 18/11/2024
Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out! www.mghlab.org/software
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Rebecca Berrens @rberrens.bsky.social · 19/11/2024
Please register for the course on Transposable elements in #genomics and #datascience. We will be sharing the magic of #nanopore long reads for #transposon expression #tesky
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