iiinova — where your digital self keeps evolving

Huge congratulations to Dr. Pius Galli on successfully defending his PhD at @biozentrum.unibas.ch! 🎉👏 Halfway through his PhD, Pius moved from FMI @fmiscience.bsky.social in Basel to EPFL, where he completed the final part of his research.

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Reposted by Thomä lab

Joy Jeongyoon Choi @joyjoychoi.bsky.social · 16/09/2026

I'm giving a seminar to present this work at EPFL @epflimaging.bsky.social, hosted by @beatfierz.bsky.social and @labthoma.bsky.social. Please come by if you're around campus on Tue 22nd Sept, 4:15pm (details: memento.epfl.ch/event/chroma...).

memento.epfl.ch

Chromatin structure of the inactive X chromosome revealed by in situ cryo-electron tomography - EPFL

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Thomä lab @labthoma.bsky.social · 13/08/2026

Congrats to Pius, Shuhao, and the team! Check out our latest publication: Molecular glue degraders (MGDs) like lenalidomide have transformed multiple myeloma treatment by inducing degradation of non-native substrates via the CRL4CRBN E3 ligase—but which proteins can they actually reach?

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Reposted by Thomä lab

FMI science @fmiscience.bsky.social · 31/07/2025

Our cells pack DNA into tiny bundles that hide important parts. Researchers at the FMI and EPFL found this packing affects how the cancer-fighting protein p53 works, revealing new insights into cancer. www.fmi.ch/news-events/...

fmi.ch

How DNA packaging controls the “genome’s guardian”

Our cells tightly pack DNA into structures called nucleosomes, which protect DNA but also hide important sites. The key cancer-fighting protein p53 can still access these hidden sites, especially at n...

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Thomä lab @labthoma.bsky.social · 31/07/2025

Congrats to all the authors on our latest work! We reveal how p53 interacts with chromatin and show, via ubiquitin-related factors USP7 and E6-E6AP, that only specific cofactors can co-reside on nucleosomes together with p53. tinyurl.com/2feuezvj @csandate.bsky.social @deyasinic.bsky.social

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Thomä lab @labthoma.bsky.social · 08/05/2025

📝 🚨 Review alert from the Thomä Lab @alexanderhanzl.bsky.social, Stefan and Clara collected their thoughts on recent molecular glue degrader modalities. Packed with computational predictions, mutations mimicking glues, bivalent engagement and a discussion on mode of action. tinyurl.com/mpmbuuky

tinyurl.com

Primed for degradation: How weak protein interactions enable molecular glue degraders

Molecular glues are small drug-like molecules that induce de novo protein–protein interactions or facilitate pre-existing weak interactions between pr…

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