Although tumor protein p53 (TP53) mutations are among the most common lesions in epithelial cancers, how p53 loss drives unrestrained clonal expansion remains unclear. Working with mouse epidermis, we...

Thank you for taking the time to complete this Bioconductor developer survey. For the purposes of this survey, "developer" includes package developers as well as contributors involved in…

The genomic regions regulating gene expression are often themselves transcribed into a variety of noncoding RNAs (ncRNAs). However, the regulatory roles of this noncoding transcription remain largely ...

GPT detectors frequently misclassify non-native English writing as AI generated, raising concerns about fairness and robustness. Addressing the biases in these detectors is crucial to prevent the marginalization of non-native English speakers in evaluative and educational settings and to create a more equitable digital landscape.

Nature - Science sleuth’s findings raise questions for researchers working to improve the reliability of commercial antibodies.

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Join us for 2026 Grand Challenges in Parkinson’s Disease at Van Andel Institute Stay informed about exciting upcoming events and activities.

This study introduces iChIP2, a low-input chromatin immunoprecipitation followed by sequencing method that profiles histone post-translational modifications (hPTMs) simultaneously across diverse eukar...

A longstanding mystery in antibody diversification is how AID specifically targets immunoglobulin V genes. Ancient LINE-1 retrotransposons embedded within the immunoglobulin locus provide a recruitment platform for the HUSH complex and AID to drive somatic hypermutation.

This Review describes current understanding of the epigenetic regulation of kidney development. It describes the epigenetic drivers of cell fate decisions made by nephron progenitor cells, the chromat...

Large-scale chromatin compaction quantitatively predicts the percentage of cells with durable epigenetic memory of gene silencing.

Job Title: Associate or Senior Editor, Nature Genetics Location: Shanghai, Beijing, Madrid, Milan or Pune, Hybrid Working Model Application Deadline: Aug 3rd, 2026 About Springer Nature Springer Natur...

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information on Measuring and Rewarding Scientific Impact NOT-OD-26-087. NIH

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.

Sleep and exercise can slow clonal haematopoiesis and limit mutant cell-driven atherosclerosis.

Abstract. Embryonic genome activation (EGA) marks a critical developmental transition, yet its regulatory architecture remains incompletely defined. Here,

AbstractObesity is a complex chronic disease characterized by excessive adiposity and multiple comorbidities, including an elevated risk of several cancers. Despite long-standing epidemiologic links, ...

CIHR holds several webinars that allow us to share information, exchange ideas and discuss issues of importance with our stakeholders.

Clonal hematopoiesis of Indeterminant Potential (CHIP) is an age-related phenomenon characterized by clonal expansion of hematopoietic stem cells (HSCs)1. CHIP results from a fitness advantage conferr...

Conditional genetics and single-embryo RNA-seq show that SETDB1 extinguishes the transient, retroelement-driven transcriptional programs of the totipotent two-cell state to facilitate the exit from totipotency and ensure preimplantation development.

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