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Dan Sarni

@dansarni.bsky.social
24 followers 29 following 12 posts

Postdoc in the Jackson lab @mrc_hgu. Genome instability, DNA methylation and replication

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Reposted by Dan Sarni
Institute of Genetics and Cancer @uoe-igc.bsky.social · 30/06/2026
A new study has identified a rare genetic condition which causes individuals to age at a faster rate than normal, shining a light on the mechanisms of aging. This study was jointly supervised by Kevin Myant, Elaine Dzierzak, Martin Reijns, @sproullab.bsky.social and Andrew Jackson edin.ac/4vDOCfM
edin.ac
Rare ageing disorder links ‘biological clock’ to disease | Institute of Genetics and Cancer | Institute of Genetics and Cancer
Scientists have discovered a rare genetic condition which causes people to age at a much faster rate, offering fresh insights into the ageing process.
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Dan Sarni @dansarni.bsky.social · 18/06/2026
What if DNA methylation changes aren’t just ticking of our biological clock but rather the rust breaking the gears? Very excited to share our work - how DNA methylation contributes to stem cell dysfunction and aging, published in @natgenet.nature.com doi.org/10.1038/s415... #epigenetics #aging 1/11
doi.org
A progeria syndrome links DNA hypermethylation to age-related pathology - Nature Genetics
This study investigates the consequences of hypermethylation in a progeria syndrome caused by gain-of-function DNMT3A mutations, finding effects on adult stem cell function.
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Reposted by Dan Sarni
Duncan Sproul @sproullab.bsky.social · 12/12/2024
We've been awarded a UKRI MRC grant to examine the causes and consequences of #heterochromatin hypomethylation in cancer 🥳. #postdoc opportunity coming in the near future. #epigenetics. Please share with anyone who might be interested.
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