How does the ER decide whether a misfolded protein is refolded, degraded by ERAD or cleared by ERLAD? Using mutant Neuroserpin, we show that persistent N-glycan glucosylation helps select aggregation-prone proteins for lysosomal clearance.
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tandfonline.com
The role of N-glycans and their processing in ER-to-lysosome-associated degradation of disease-causing mutant Neuroserpin
Most proteins synthesized in the endoplasmic reticulum (ER) are covalently modified upon addition of pre-assembled oligosaccharides to side chains of asparagine (N) residues. Processing of N-linked...
