Excited to share our new preprint! Using D2B “degrader-first” screening, we uncovered two unexpected routes to protein degradation involving DCAF11/16 and CRL3–SPOP. Our work adds to growing evidence that TPD can extend far beyond canonical PROTAC mechanisms. chemrxiv.org/doi/abs/10.2...
chemrxiv.org
Direct-to-Biology Bifunctional Screening Reveals Noncanonical Mechanisms of Targeted Protein Degradation | ChemRxiv
Targeted protein degradation (TPD) has emerged as a powerful strategy for modulating
protein function through small-molecule-induced proximity between a protein of interest
and typically an E3 ubiquit...
