The AAA ATPase VCP/p97 has emerged as a critical regulator of ubiquitin and chromatin-associated processes but progress in understanding has been hampered by the complexity of p97 functions and the va...

During cell division, multiple guanine nucleotide exchange factors (GEFs), including the mitotic regulator Ect2 and Lbc-type GEFs, regulate the dynamics of RhoA activity and actomyosin contractility. ...

DUBs regulate key cellular processes, but selective tools are scarce. Here, the authors developed PROTACs for the DUB USP7, comparing degraders with inhibitors. The study provides a valuable toolbox f...

Katerina Naydenova

BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mecha...

BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mecha...

imageimageThe correction of erroneous kinetochore-microtubule attachments requires tension-dependent phosphorylation of key substrates. This study reveals a novel and essential recruitment mechanism o...