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In this phase 2, randomized trial in early Alzheimer’s disease, the TREM2 agonistic antibody AL002 showed target engagement but did not meet the primary endpoint of change from baseline in Clinical Dementia Rating-Sum of Boxes score.

TREM2 is an important AD risk factor playing essential roles in the microglial response to amyloid pathology. Here, authors show using a TREM2 reporter mouse that TREM2 levels are critical for efficac...

While the photoreceptor outer segments in the bird outer retina have access to oxygen, the inner retina operates under chronic anoxia, supported by anaerobic glycolysis in the retinal neurons.

Brain-derived tau in plasma reflects the extent of brain injury in acute ischemic stroke, predicts functional outcomes, and detects treatment effects.

Microglia adopt diverse states throughout life. Whether these represent fixed lineages or reversible plasticity remains unclear. Hamagami and Kapadia et al. show that reactive microglia switch states through reprogramming of histone modifications at state-specific enhancers and associated transcription factors, linking developmental, aging, and disease phenotypes within a unified dynamic framework.

Postdoctoral role in Leuven studying resilience to neurodegeneration using multi omics data from cognitively healthy centenarian brain samples.

Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expres...

A research team led by Martin Kerschensteiner has developed an experimental platform that helps uncover the signals that instruct immune cells in neuroinflammatory disease.

Colony-stimulating factor 1 receptor (CSF1R) is primarily expressed in microglia. Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopath...

Contribute to lmu-osc/safeguar.de-hackathon development by creating an account on GitHub.

Genetic variants in TMEM106B, coding for a transmembrane protein of unknown function, have been identified as critical genetic modulators in various n…

Jacquet et al. shows that microglia use digestive exophagy to engage large Aβ deposits that cannot be phagocytosed, forming acidic extracellular compartments on the aggregates into which lysosomal enz...

How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...

Peripheral AAV-mediated delivery of brain-penetrant PGRN rescues TDP-43 pathology, neurodegeneration, and motor phenotypes in FTLD-GRN models.