Crick PACE postdoctoral fellowship with King's College London mapping epigenetic signatures of air pollution and microplastics in Parkinson's.

An international team led by Dr Sarah Marzi (UK DRI at King’s), with Dr Alexi Nott (UK DRI at Imperial) and Professor Henne Holstege (Amsterdam UMC and VIB-KU Leuven Center for Neuroscience) has won £...

Dr Sarah Marzi will co-lead team EMERALD, who have been awarded £1.5m from the Dementia Frontiers Fund to study how some people's brains may be more resiliant to dementia, with the aim to leverage these insights to develop therapeutics.

The Dementia Frontiers Fund has selected 12 teams to compete for up to £1.5 million each and tackle major unanswered questions in dementia.

Dr Sarah Marzi receives $1.4m from a Collaborative Research Network grant awarded by Aligning Science Across Parkinson's (ASAP) to study link between toxicants and Parkinson’s disease.

YouTube video by DavidPerlmutterMD

PhD programme in human genetics, AI and multi-omics to uncover causal biology and accelerate therapeutic target discovery with academic and industry partners.

UK DRI at King’s, London. Seeks Research Assistant in Dr Sarah Marzi’s group to support stem cell culture, assays, and genomic work on neurodegenerative disease

YouTube video by Dementia Researcher

npj Parkinson's Disease - Unique nigral and cortical pathways implicated by epigenomic and transcriptional analyses in rotenone Parkinson’s model

Murphy et al. develop CHAS, a computational tool that uncovers cell type-specific patterns in bulk tissue histone acetylation data. Applying CHAS to brain disorders reveals distinct cell type targets ...

Microglia have key roles in CNS development and neurodegeneration. Here, the authors provide an overview of microglia heterogeneity, cell-state annotation and model systems.

New study compares CUT&Tag to the existing standard of CHIP-seq, serving as guidelines for studying histone modification.

Cleavage Under Targets & Tagmentation is a rapidly expanding technique, but thorough evaluation and benchmarking against established ChIP-seq datasets are required. This study shows that CUT&T...

Molecular Psychiatry - Exposure to childhood maltreatment is associated with specific epigenetic patterns in sperm

Societies should learn from this and speak up to support inclusion

Techniques for genome-wide epigenetic profiling have been undergoing accelerated development toward recovery of high-quality data from bulk and single cell samples. DNA-protein interactions have tradi...