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Dr Róisín McManus

@roisinmcmanus.bsky.social
450 followers 482 following 36 posts

Group Leader @DZNE Bonn and @Institute of Innate Immunity 🇩🇪, PhD @TCD 🇮🇪 Neuroimmunologist, we study innate immune signalling, inflammasomes and immunometabolism in aging and dementia 🧠 www.iiibonn.de/roisin-mcmanus-lab/r…

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Reposted by Dr Róisín McManus
Alzheimer Forschung Initiative @afi-ev.bsky.social · 20/04/2026
Dr. @roisinmcmanus.bsky.social vom @dzne.science untersucht, wie Entzündungen im Gehirn gezielt reduziert werden können, um die Entwicklung von #Demenz zu verlangsamen. Im Mittelpunkt stehen sogenannte Mikrogliazellen, die bei Alzheimer eine wichtige Rolle spielen. ▶️ Infos zum AFI-Projekt im Video
youtu.be
Entzündungen im Gehirn und Alzheimer stoppen
YouTube video by Alzheimer Forschung Initiative
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Dr Róisín McManus @roisinmcmanus.bsky.social · 02/06/2025
🥼 We’re looking for a #MSc student to work in our lab as part of their MSc thesis or internship on an interdisciplinary project @dzne.science, in Germany! 🧠 If you’re interested in #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad👇 jobs.dzne.de/en/jobs/1014...
jobs.dzne.de
Master student (f/m/x) in the field of Neuroimmunology 1447/2025/6
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Reposted by Dr Róisín McManus
jsb-lab.bsky.social @jsb-lab.bsky.social · 16/05/2025
Can AI-designed binders degrade, aggregate, stain and enrich endogenous proteins in human cells? Check out our new preprint! www.biorxiv.org/content/10.1...
biorxiv.org
Transposon-Display of AI-designed binders enables manipulation of the proteome in human cells
Transposon-Display is a highly scalable screening method that links proteins to their encoding DNA during expression in E. coli via a mutant transposase. Leveraging this system, we identified AI-desig...
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Dr Róisín McManus @roisinmcmanus.bsky.social · 14/05/2025
📢 We are #hiring a #PhD student to work on an interdisciplinary, collaborative project @dzne.science in Bonn, Germany! 🧠 If you’re interested in western diet-induced #neuroinflammation and innate immune signalling in #alzheimersdisease, check out our ad below 👇 jobs.dzne.de/en/jobs/1014...
jobs.dzne.de
PhD student (f/m/x) in the field of Neuroimmunology 1439/2025/5]
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Dr Róisín McManus @roisinmcmanus.bsky.social · 25/04/2025
Had a great time visiting @tcddublin.bsky.social last week where I got to share some of our new work from the lab! 🧠 Really enjoyed the discussions and meeting many amazing researchers, including some old friends 😊 Thanks to @David Loane and the TCD Biochemical society for the lovely invitation
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Dr Róisín McManus @roisinmcmanus.bsky.social · 05/04/2025
Thrilled to be at #ADPD2025 in Vienna ☀️ Thanks to everyone who came to our session on innate immunity yesterday! Really enjoyed the discussions after on our findings on #metabolism & #microglia function in #alzheimer’s disease I’ve learned a lot at this meeting - looking forward to Copenhagen 2026 🧠
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Reposted by Dr Róisín McManus
DZNE research center @dzne.science · 28/03/2025
Intermittent Fasting Increases Sex Drive in Male Mice: An Approach for Low Libido in Humans? Current findings could point the way for new therapy option / Serotonin plays key role. Hot off the press from our Bonn based group of Dan Ehninger. 👉 www.cell.com/cell-metabol...
cell.com
Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
Xie et al. show that intermittent fasting (IF) enhances sexual behavior in male mice by reducing serotonergic inhibition through lower brain tryptophan. While IF does not improve endocrine function or...
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Dr Róisín McManus @roisinmcmanus.bsky.social · 28/03/2025
This month the McManus lab turns 1! 🎉 It’s been an amazing year, from starting out with an empty lab space to having our first co-authorships, grant awards and successful student projects 📄 Delighted to work with such a wonderful team of scientists on #alzheimersdisease and #dementia research 🧠
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Reposted by Dr Róisín McManus
Cluster of Excellence ImmunoSensation @immunosens.bsky.social · 27/03/2025
Visit the #exhibition "What the Health - One World. Your Health!" at the Museum Koenig in #Bonn. Check out the #events surrounding the exhibition and discover how your health and the health of the planet are connected 🌍 Learn more about the program here: bonn.leibniz-lib.de/de/ausstellu...
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Reposted by Dr Róisín McManus
Cluster of Excellence ImmunoSensation @immunosens.bsky.social · 21/03/2025
🚨 Apply now! We invite you to apply for this year's International School of Advanced Immunology taking place September 14 - 19 at Maria Laach, Germany. Visit our website for more information: www.advanced-immunology.net #international #school #immunology
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Dr Róisín McManus @roisinmcmanus.bsky.social · 17/03/2025
Happy St Patrick’s Day! And what a lovely surprise from the lab, who all wore green this morning ☺️☘️
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Reposted by Dr Róisín McManus
Linda Sinclair @lindavsinclair.bsky.social · 01/03/2025
I am overjoyed to present our latest paper on Autophagy in CD8 Tcells! www.nature.com/articles/s41... It was, as all ‘sciencing’ is, a huge team effort. I will try to do it some justice in the following thread 😊 1/n @cantrell-lab.bsky.social @immpres.bsky.social @ajmhowden.bsky.social
nature.com
Autophagy repression by antigen and cytokines shapes mitochondrial, migration and effector machinery in CD8 T cells - Nature Immunology
Sinclair et al. combine quantitative proteomics and an autophagy flux reporter to map autophagy substrates and triggers during CD8 T cell differentiation. Proteins degraded and fueled by autophagy in ...
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Dr Róisín McManus @roisinmcmanus.bsky.social · 26/02/2025
Check out the latest episode from @immunosens.bsky.social where I chat about our research on #microglia, #NLRP3 and immunometabolism in #Alzheimer’s disease that was published this month in @cp-immunity.bsky.social
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Reposted by Dr Róisín McManus
Nature @nature.com · 24/02/2025
Five days of indulging in chocolate bars, crisps and other junk foods can lead to lingering changes in brain activity, a study shows1. The resulting brain patterns are similar to those seen in people who have obesity. go.nature.com/3F61B4o
go.nature.com
How a junk-food splurge can change your brain activity
A short bout of indulgence in fatty, sugary snacks leads to lingering brain-activity changes ― even if it does not cause weight gain.
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Dr Róisín McManus @roisinmcmanus.bsky.social · 18/02/2025
Happy to share our first review from the McManus lab! 🥳 Special thanks to my PhD student & 1st author @nehalonkar.bsky.social & our co-author & collaborator Eicke Latz 📄 We summarise the key role of #metabolism on microglial function in health & #neurodegeneration 🧠 pubmed.ncbi.nlm.nih.gov/39936491/
pubmed.ncbi.nlm.nih.gov
Neuroinflammation and immunometabolism in neurodegenerative diseases - PubMed
This review highlights the recent studies that have significantly contributed to our understanding of the metabolic dysregulation observed in activated microglia in conditions such as AD, unveiling no...
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Reposted by Dr Róisín McManus
Sparwasser Lab @timsparwasser.bsky.social · 16/02/2025
2nd Brazilian-German Immunology Workshop Vienna, Austria August 15-16, 2025 DEADLINE for application: March 1 Pls apply to Tim Sparwasser (sparwasser.office’at’uni-mainz.de) or Bernardo Franklin (franklin’at’uni-bonn.de) by March 1 2025, stating the title of the lecture and a half-page abstract.
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Reposted by Dr Róisín McManus
sfb1454.bsky.social @sfb1454.bsky.social · 12/02/2025
*Job Opportunity* Prof. Dominic Lemken is seeking a PhD candidate to research Consumer Behavior and Food Choices as part of our SFB! If you are passionate about #ConsumerBehavior and #FoodEconomics find out more here: www.uni-bonn.de/de/universit...
uni-bonn.de
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Reposted by Dr Róisín McManus
Lucas Secchim Ribeiro @secchimribeiro.bsky.social · 11/02/2025
Another fantastic shot from @roisinmcmanus.bsky.social at the mechanisms of activation and modulation of the #NLRP3 inflammasome! Congratulations to the McManus team at the @dzne.science and my dear friends at the iii @unibonn.bsky.social! Fantastic work! www.cell.com/immunity/ful...
cell.com
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
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Reposted by Dr Róisín McManus
Dementia Researcher @dementiaresearcher.bsky.social · 08/02/2025
Temple University @temple.edu in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease. Closing date: 9th March www.dementiaresearcher.nihr.ac.uk/job/assistan...
dementiaresearcher.nihr.ac.uk
Assistant or Associate Professor: Therapeutic targets for Alzheimer’s
Temple University in Philadelphia is recruiting for a Assistant or Associate Professor - Tenure Track Faculty to work on seeking Therapeutic targets for Alzheimer's Disease.
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Reposted by Dr Róisín McManus
Lily Keane @lilykeane.bsky.social · 06/02/2025
🎉 Huge congratulations to @roisinmcmanus.bsky.social and Michael Heneka on this exciting study uncovering a novel role for NLRP3 in regulating microglial metabolism and phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/abs...
cell.com
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
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Reposted by Dr Róisín McManus
Alzheimer's Association @alzassociation.bsky.social · 06/02/2025
Join us along with The Rainwater Charitable Foundation and CurePSP for #Tau2025, Apr. 24-25 in London or online! Be a part of the conversation as leading experts work to address the future of tau research. Register now: alz.org/Tau
alz.org
Tau Global Conference | Alzheimer’s Association
Leading experts from academia, industry, philanthropy and government will meet to address the future of tau research. Learn more and register.
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Reposted by Dr Róisín McManus
DZNE research center @dzne.science · 04/02/2025
Congratulations to @roisinmcmanus.bsky.social from DZNE in Bonn on her newly published paper in Immunity: "NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression" 👉 doi.org/10.1016/j.im... 👉 www.dzne.de/en/news/pres...
dzne.de
Lab Findings Support the Concept that Reducing Neuroinflammation Could Help Fight Alzheimer’s
New insights into immune cells in the context of neurodegeneration.
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Reposted by Dr Róisín McManus
Dementia Researcher @dementiaresearcher.bsky.social · 04/02/2025
The UK Dementia Research Institute @UKDRI is seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor at Cardiff University. Closing date: 20th March www.dementiaresearcher.nihr.ac.uk/job/centre-d...
dementiaresearcher.nihr.ac.uk
Centre Director: UK Dementia Research Institute at Cardiff
The UK Dementia Research Institute are seeking an outstanding established academic to take the position of Centre Director, at the level of Clinical or non-Clinical Professor.
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Reposted by Dr Róisín McManus
German Neuroscience Society e.V. - NWG @neurowissg.bsky.social · 03/02/2025
Whether you feel a sudden urge to discuss your recent research findings OR have completely missed the abstract submission OR have just discovered this fabulous congress: Submit your Late Poster and/or register here: www.nwg-goettingen.de/2025/default... between 👉 03 – 20 February 2025 👈
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Reposted by Dr Róisín McManus
John Lukens @lukensjohnr.bsky.social · 03/02/2025
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression: Immunity www.cell.com/immunity/ful...
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Reposted by Dr Róisín McManus
Waggoner Lab @labwaggoner.bsky.social · 03/02/2025
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression www.cell.com/immunity/ful... @cp-immunity.bsky.social @roisinmcmanus.bsky.social
cell.com
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
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Dr Róisín McManus @roisinmcmanus.bsky.social · 03/02/2025
I am thrilled to share our latest article that has been published in @cp-immunity.bsky.social. We describe a new role for NLRP3 outside of its #inflammasome complex, where it can regulate microglial #metabolism & key metabolites that affect the epigenetic landscape(1) www.cell.com/immunity/ful...
cell.com
NLRP3-mediated glutaminolysis controls microglial phagocytosis to promote Alzheimer’s disease progression
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibiti...
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Reposted by Dr Róisín McManus
Deutsche Forschungsgemeinschaft @dfg.de · 03/02/2025
Einladung zum Webinar zu #OpenAccess-Publikationskosten an alle, die 2025 in diesem Programm einen Antrag stellen wollen (bis 4. Mai): Antragsberechtigung, Förderbedingungen und Vorbereitung in der 2. Phase. ➡️ 21.02.25, 9:30 Uhr (Registrierung nicht nötig) Zugangslink: www.dfg.de/de/foerderun...
dfg.de
Förderprogramm: "Open-Access-Publikationskosten"
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Reposted by Dr Róisín McManus
Cluster of Excellence ImmunoSensation @immunosens.bsky.social · 03/02/2025
Then join the 7th Pint of Science in Bonn from May 19-21! Pint of Science gives you the opportunity to present your research in a simple and understandable way in front of an interested audience in a pub. It will be a fun night with quizzes, Q&As and beer. #science #pub #presentation #Bonn
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Reposted by Dr Róisín McManus
WachtenLab @wachtenlab.bsky.social · 25/01/2025
Thanks a lot to #FEBS and the Norwegian bioscience society for hosting me and special thanks to @nathaliejuya.bsky.social and @emreyaksi.bsky.social for your hospitality!
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Dr Róisín McManus @roisinmcmanus.bsky.social · 02/02/2025
Delighted to start the new funding period of our #SFB1454! Can definitely recommend the exhibition @museumkoening, a must for everyone interested in healthy living and aging @dzne.science
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