Increased blood levels of phosphorylated tau (p-tau) are a diagnostic tool in Alzheimer’s disease. In a multicenter, cross-sectional study, we show that serum p-tau could also serve as a biomarker for...

Elevated serum levels of phosphorylated tau are not specific to Alzheimer’s disease and may also serve as a diagnostic tool for the most common types of systemic amyloidosis, with potential utility in...

Blood levels of neurofilament light chain (NfL) increase with age in healthy humans and can predict all-cause human mortality, but is this true across species? This study shows that NfL age-related bl...

Gómez-Pascual et al. identified that in the aged murine hippocampus, astrocytes with impaired autophagy accumulate polyglucosan bodies. Their burden, which is modulated by the Smarcal1-Usp37 locus, va...

Panagiotakopoulou et al. developed a co-culture system combining human cerebral organoids and mouse brain slices. The model supports long-term study of human microglia, enhances cortical marker expres...

Hopes that anti-tau drugs could emerge as treatments for Alzheimer's have been dented by the failure of a phase 2b trial of J&J's posdinemab.

The amyloid cascade hypothesis places amyloid-β (Aβ) at the center of Alzheimer's disease (AD) pathogenesis. Evidence suggests that AD progresses in two phases: an early phase driven by Aβ aggregatio...

A tricyclic depletion protocol allows for microglia replacement without preconditioning and mitigates pathology in mouse models of neurodegeneration.

Amyloid plaque removal by monoclonal antibody therapies slows clinical progression in symptomatic Alzheimer's disease; however, the potential for dela…

Abstract. Human growth hormone (hGH) has been in clinical use for children with GH deficiency (GHD) since the late 1950s. The original formulations were co

The US federal government can harness science to secure the health, prosperity and safety of Americans and the world.

An in vivo base editing approach targeting the PRNP gene led to a 52% increase in the lifespan of mouse models inoculated with the most common sporadic and genetic types of human pathogenic prion isol...

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All of statistics and much of science depends on probability — an astonishing achievement, considering no one’s really sure what it is.

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This study supports neurofilament light chain protein (NfL) in both cerebrospinal fluid (CSF) and blood as an early marker of neurodegeneration in Alzheimer’s disease but suggests that NfL in CSF may ...

Similarities to molecular mechanisms underlying prion diseases may help to refine Alzheimer’s disease therapies