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Christian Gonzalez-Billault

@glezbillault.bsky.social
605 followers 439 following 66 posts

“Learning that we’re only immortals for a limited time” Neurobiologist turned into Aging researcher. EMBO Member. DORA Executive Board. Views my own. Universidad de Chile Geroscience Center for Brain Health and Metabolism (GERO) The Buck Institute

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Reposted by Christian Gonzalez-Billault
Andrew Steele @statto.bsky.social · 08/05/2026
Happy 100th birthday, Sir David Attenborough! For every 1,000 boys born in 1926, only 5 are still around today. He’s a national treasure *and* a statistical outlier.
Line chart titled ‘Happy 100th birthday, David Attenborough! Here’s his incredible story compared to other babies born in 1926.’

The chart shows percent of the babies born in 1926 still alive. Two lines, male (blue) and female (red), both starting at 100% and declining. Both fall steeply in the first year of life and level off around 90%: 11% of boys and 9% of girls born in 1926 didn't make it to age 5.

A shaded band labelled WWII covers ages 13 to 19. The male curve has a visible additional dip around age 18 — the cohort turned 18 in 1944, and a substantial number of young men in particular died in the late stages of the Second World War.

By age 65 (1991), 64% of men and 75% of women born in 1926 were still alive. The female line stays consistently above the male, and the gap widens through old age.

By 2026, Sir David is one of just 0.5% of men and 1.7% of women to celebrate their 100th birthday.

Data: Human Mortality Database, England & Wales cohort life tables.
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Christian Gonzalez-Billault @glezbillault.bsky.social · 19/02/2026
Happy to share our new publication, where we describe axonal NMDA receptors supporting axon growth.
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Christian Gonzalez-Billault @glezbillault.bsky.social · 11/07/2025
Thank you so much for highlighting our recently published paper! We are genuinely thrilled about this new line of research and motivated to see where it leads. It’s an exciting journey ahead. Appreciate your interest!!
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Reposted by Christian Gonzalez-Billault
EMBO @embo.org · 20/05/2025
“Part of the success of the Chilean #research system is (...) tied with the fact that we always establish international connections,” says @glezbillault.bsky.social, Vice-Rector of R&D at @uchile.bsky.social and EMBO Associate Member Read more: buff.ly/RUqzLzC #Chile #opportunities #funding 🧪
buff.ly
Will we ever fully understand the brain? – People – EMBO
Meet Christian González-Billault, Vice-Rector of Research and Development at the University of Chile, Santiago, and EMBO Associate Member
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Christian Gonzalez-Billault @glezbillault.bsky.social · 15/05/2025
I am truly honored on my election as Council member of the @ascbiology.bsky.social. Looking forward to work with colleagues and move forward this beautiful discipline.
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Christian Gonzalez-Billault @glezbillault.bsky.social · 05/05/2025
A great week on Easter Island. Here at the Rano Kai volcano where rapamycin was discovered. #aging #science
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Christian Gonzalez-Billault @glezbillault.bsky.social · 20/04/2025
It is one week after the 7th Emerging Concepts of the Neuronal Cytoskeleton workshop in Chile. Looking forward to #neurocyto2027 in Santa Cruz, Chile
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Reposted by Christian Gonzalez-Billault
Jose A. Esteban @jaestebancbm.bsky.social · 12/02/2025
Diversity is also having a different native language. www.nature.com/articles/d41...
nature.com
Breaking language barriers: ‘Not being fluent in English is often viewed as being an inferior scientist’
Biologist Tatsuya Amano works to make science a fairer place for non-fluent speakers.
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Reposted by Christian Gonzalez-Billault
Claire Dessalles @clairedessalles.bsky.social · 03/02/2025
Today is a very special day for me: I just started as a permanent CNRS researcher at the Institute of Light and Matter! My research will focus on the physics of biological tissues and in particular the role of activity and anisotropy.🔬 @cnrs.bsky.social
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Reposted by Christian Gonzalez-Billault
Kevin Mitchell @wiringthebrain.bsky.social · 08/01/2025
A reminder: for genotypes to produce phenotypes, they have to go through development
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Reposted by Christian Gonzalez-Billault
Christophe 🔬 Leterrier @christlet.bsky.social · 08/01/2025
A neuronal Rube Goldberg machine 🤯 Wnt from surrounding cells is internalized via clathrin-coated pits at dendritic branch points before triggering microtubule nucleation at the surface of endosomes. Great work from Melissa Rolls' lab in @plosbiology.org: journals.plos.org/plosbiology/...
Cartoon of the mechanism from the last figure of Thyagarajan et al.
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Reposted by Christian Gonzalez-Billault
Sociedad Española de Bioquímica y Biología Molecular (SEBBM) @sebbm.bsky.social · 01/01/2025
Desde la SEBBM lamentamos comunicar el fallecimiento de Joan Guinovart, acontecido esta pasada madrugada. Joan fue presidente, era socio de honor y ha sido una figura clave para nuestra sociedad, además de referente de la bioquímica tanto a nivel nacional como internacional.
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Christian Gonzalez-Billault @glezbillault.bsky.social · 01/01/2025
I am deeply saddened to learn of Joan Guinovart’s passing. He was an exceptional scientist and an extraordinary individual whose contributions and presence will be profoundly missed. @irbbarcelona.org
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Reposted by Christian Gonzalez-Billault
Eric Topol @erictopol.bsky.social · 01/01/2025
Our assessment of a person's epigenetic ("biological") age has been centered on DNA methylation. A new report shows that a set of 7 histone markers has comparable accuracy and also uncovers new pathways of aging biology www.science.org/doi/10.1126/...
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Lorena Benedetti @lorenabenedetti.bsky.social · 20/12/2024
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
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Reposted by Christian Gonzalez-Billault
Andy Moore @aaandmoore.bsky.social · 18/12/2024
Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.
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Reposted by Christian Gonzalez-Billault
Elisabeth Bik @elisabethbik.bsky.social · 17/12/2024
Infamous paper that popularized unproven COVID-19 treatment finally retracted Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds @cathleenogrady.bsky.social reports. www.science.org/content/arti...
science.org
Infamous paper that popularized unproven COVID-19 treatment finally retracted
Study on hydroxychloroquine by Didier Raoult and colleagues gets pulled on ethical and scientific grounds
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Christian Gonzalez-Billault @glezbillault.bsky.social · 15/12/2024
I attended @ascbiology.bsky.social meeting almost uninterruptedly since I was PhD student back in 1999. I am missing not be there this year. Hope to come back in Philadelphia. Cell biologist and cytoskeleton researchers, enjoy!!
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Reposted by Christian Gonzalez-Billault
Chris Ho @chrisho.bsky.social · 15/12/2024
Excited to be at #CellBio2024! Today, I'll be presenting my work exploring how the actin binding proteins and E3 ubiquitin ligases regulate neuronal morphogenesis. I'll be at poster board 40 and giving a teaser talk at 10:45 in Room 33B. Come say hi, if you love neurons, cytoskeleton or ubiquitin!
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Reposted by Christian Gonzalez-Billault
Kristen Verhey @kjverhey1.bsky.social · 15/12/2024
Ever wondered about how accessible the tubulin C-terminal tails (CTTs) are within the microtubule lattice? Takashi Hotta (Puck Ohi lab) will present our work at a poster Tuesday 1:30pm (P2401, B8) and in a talk Tuesday 6:15pm (room 30C). #cellbio24 #CellBio2024 #cytoskeleton
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Reposted by Christian Gonzalez-Billault
Michael Way @drmichaelway.bsky.social · 14/12/2024
Couldn't make @ascbiology.bsky.social annual meeting this year ☹️ - hope everyone has a blast. Check out Journal of Cell Science booth @jcellsci.bsky.social - we are the good publishers who care about the science community!
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Reposted by Christian Gonzalez-Billault
Markus Schosserer @mschosserer.bsky.social · 13/12/2024
My NUS Yong Loo Lin School of Medicine Helathy Longevity Webinar is online now. I am very grateful to Brian Kennedy for the invitation to share our latest research on #RNAmodifications and for the excellent discussion. youtu.be/fFAr5RF_2vs?...
youtu.be
Exploring Ribosomal RNA Modifications in Cellular and Organismal Ageing l Dr Markus Schosserer
YouTube video by NUS Medicine
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Reposted by Christian Gonzalez-Billault
Andreas Prokop @poppi62.bsky.social · 13/12/2024
Now official: our next @embl.org course on #Drosophila Genetics & Genomics will be held 3-8 Aug '25. Send in your applications! @bsdb.bsky.social @gensocuk.bsky.social @flybase.bsky.social @fly-eds.bsky.social @socdevbio.bsky.social @the-node.bsky.social @virtualflybrain.bsky.social
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Christian Gonzalez-Billault @glezbillault.bsky.social · 13/12/2024
A beautifully written editorial by @holdenthorp.bsky.social explain why HIV/AIDS intervention merits 2024 breakthrough for Science
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Christian Gonzalez-Billault @glezbillault.bsky.social · 13/12/2024
An interesting study that address a cost for life expectancy increase. We need to find “country-specific tailored interventions to maximize equitable and sustainable healthy aging”
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Andreas Prokop @poppi62.bsky.social · 13/12/2024
Happy #FluorescenceFriday!
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Giorgia Quadrato @giorgiaquadrato.bsky.social · 12/12/2024
So excited to share our new @natureportfolio.bsky.social review on modeling human brain development using organoids! 🧠 Loved collaborating with the brilliant @lancasterlab.bsky.social , led by the incredible @marcellabirtele.bsky.social Check it out! 🔬 #Neuroscience #BrainOrganoids rdcu.be/d3llp
rdcu.be
Modelling human brain development and disease with organoids
Nature Reviews Molecular Cell Biology - This Roadmap article discusses recent advances in the production and use of brain organoids to understand brain development and associated disorders. The...
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Reposted by Christian Gonzalez-Billault
Manuel Collado @manuel-collado.bsky.social · 11/12/2024
Gentle reminder that we are looking for postdoc candidates to apply for a Juan de la Cierva contract of the @ageinves.bsky.social Get in touch if you want to work on #Senescence And please, spread the word
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Christophe 🔬 Leterrier @christlet.bsky.social · 11/12/2024
Buenos Aires is beautiful and I keep posting about how I'm having a great time, but don't forget the tragic situation for science in Argentina at the moment. Argentinian scientists are working despite this and they deserve our full support! www.nature.com/articles/d41...
nature.com
‘There will be nothing left’: researchers fear collapse of science in Argentina
One year into President Javier Milei’s presidency, scientists are exiting the country in the face of big budget cuts.
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Women in Autophagy @womeninautophagy.bsky.social · 05/12/2024
#PaperAlert we bring wonderful news about @WAutophagy ... our Mericka McCabe and our founders just published a @NatureCellBio article explaining the wonders of our Network...don't miss a bit!! With very valuables testimonials of our volunteers... rdcu.be/d10N6
rdcu.be
Women in Autophagy: an initiative to promote gender parity in science
Nature Cell Biology - Scientific questions are universal but the scientific workforce remains skewed, with women and gender minorities still underrepresented. Initiatives such as the Women in...
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Vicerrectoría de Tecnologías de la Información U de Chile @vti-uchile.bsky.social · 07/12/2024
Transformación digital: una necesidad crítica que exige visión clara y compromiso. Adaptarse continuamente a nuevas tecnologías es clave para asegurar el éxito a largo plazo en un mundo en constante cambio. #DigitalTransformation #Innovación
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Amar Sahay @amarsahay.bsky.social · 07/12/2024
Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression www.cell.com/cell-stem-ce...
cell.com
Human adult neurogenesis loss corresponds with cognitive decline during epilepsy progression
Ammothumkandy et al. provide a functional role for adult neurogenesis in human cognition. They show that immature neuron levels benefit verbal learning in mesial temporal lobe epilepsy (MTLE) patients. The decline and eventual loss of immature neurons in MTLE hippocampus occurs during a critical period of disease progression.
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Christophe 🔬 Leterrier @christlet.bsky.social · 06/12/2024
Great seminar at @inp-marseille.bsky.social this morning by @pirtahotulainen.bsky.social from Helsinki, who warned us about only seeing what we're looking for in cell biology, before offering a panorama of her group's current projects. Great way to celebrate Finland's independence day! 🇫🇮
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Marco A. Maximo Prado @maximoprado.bsky.social · 06/12/2024
Plaques? Blood vessels? From a whole Alzheimer’s mouse model 🧠 ? Kelly Summers and Arash Salahinejad got you. Part of #MouseTRAP @tridentpct.bsky.social projects
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drug doc @pkpd-babe.bsky.social · 05/12/2024
All I see are dendrites. #Neuroskyence 🧪
The thin, bare branches of tall trees, lightly covered in snow.
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Eric Topol @erictopol.bsky.social · 04/12/2024
One of the alluring and theoretical strategies for extending healthspan and longevity is to rejuvenate the thymus gland, promote an intact immune system. Now there's a way to do that in aged mice. www.science.org/doi/10.1126/...
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Vicerrectoría de Tecnologías de la Información U de Chile @vti-uchile.bsky.social · 29/11/2024
Especialistas Uchile advierten sobre aumento de casos de neumonía por mycoplasma y entregan recomendaciones
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Especialistas Uchile advierten sobre aumento de casos de neumonía por mycoplasma y entregan recomendaciones - Universidad de Chile
La jefa del Servicio Pediatría del Hospital Clínico Universidad de Chile, Mariela Muñoz, asegura que hay más casos de lo habitual de esta enfermedad, que a diferencia de
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Reposted by Christian Gonzalez-Billault
John Lukens @lukensjohnr.bsky.social · 03/12/2024
Hyperactive neuronal networks facilitate tau spread in an Alzheimer's disease mouse model www.biorxiv.org/content/10.1...
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Christian Gonzalez-Billault @glezbillault.bsky.social · 03/12/2024
This is very relevant! Congratulations to all involved!
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Eric Topol @erictopol.bsky.social · 02/12/2024
Did we conceive the structure of neurons incorrectly all these years? nature.com/articles/s41... not smooth, cylindrical strands but a string of pearls? it's controversial science.org/content/arti... @science.org
nature.com
Membrane mechanics dictate axonal pearls-on-a-string morphology and function - Nature Neuroscience
Axons have always been assumed to be cylindrical. Using in silico modeling and cryopreservation of tissues, Griswold et al. demonstrate that unmyelinated axons of the mammalian central nervous system ...
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Ardem Patapoutian @ardemp.bskyverified.social · 02/12/2024
Book rec: Neanderthal Man by 2022 @nobelprize.bsky.social laureate Svante Pääbo. A fascinating dive into sequencing ancient 🧬. Captures the thrills, setbacks, and Pääbo’s personal vulnerabilities during groundbreaking science.
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David Kuster @rnadavid.bsky.social · 02/12/2024
Why are so many proteins hyper-phosphorylated during mitosis? Well, extensive phosphorylation renders individual proteins more soluble & disrupts protein-protein interactions. So global hyper-phosphorylation may 𝐟𝐥𝐮𝐢𝐝𝐢𝐳𝐞 the cytoplasm - to mechanically aide the process of cell division.
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Rachael Ott @rachaelott.bsky.social · 02/12/2024
Super spiny dendrites captured by the FV4000 for #MicroscopyMonday 🔬
The actin cytoskeleton (fire) is shown in a primary hippocampal neuron.
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John Newman, MD, PhD @geriscidoc.bsky.social · 02/12/2024
Our latest work: a new link between metabolism and proteostasis, relevant to Alzheimer's disease. Out today in Cell Chemical Biology as open access! Stay tuned for more discussion of what we found and what it means... @buckinstitute.bsky.social @cellpress.bsky.social www.cell.com/cell-chemica...
cell.com
β-hydroxybutyrate is a metabolic regulator of proteostasis in the aged and Alzheimer disease brain
Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...
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Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 03/12/2024
Cool new work from Jenn Prescher and coworkers @ucirvine.bsky.social, “RNA lantern” technology for bioluminescence imaging of RNA transcripts www.nature.com/articles/s41...
nature.com
A modular platform for bioluminescent RNA tracking - Nature Communications
Studying RNA dynamics in vivo often relies on fluorogenic approaches, but these can be hampered by factors such as limited sensitivity and sample autofluorescence. Here, the authors describe an ultras...
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Mirre Simons @mirresimons.bsky.social · 01/12/2024
#Phd on #Aging #Ageing available in my group. Focus is long-read sequencing and splicing after treatment with DR and mTOR suppression in flies. #drosophila www.findaphd.com/phds/project...
findaphd.com
Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield on FindAPhD.com
PhD Project - Mechanisms of alternative splicing in neurodegeneration and ageing at University of Sheffield, listed on FindAPhD.com
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The Buck Institute for Research on Aging @buckinstitute.org · 02/12/2024
Take a listen! Our very own Gordon Lithgow highlights the how’s and why’s of research on aging and talks about the progress being made in extending #healthspan, in a podcast aptly named “Not born yesterday.” podcasts.apple.com/us/podcast/e...
podcasts.apple.com
Extending the Healthy Years of Life
Podcast Episode · Not Born Yesterday · 11/22/2024 · 27m
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The Buck Institute for Research on Aging @buckinstitute.org · 02/12/2024
#Ketone bodies are not just about energy. Study in @cellpress.bsky.social shows metabolites are powerful signaling molecules that help clean up damaged proteins. New biology for aging and neurodegenerative disease @geriscidoc.bsky.social @sidmadhavan.bsky.social www.buckinstitute.org/news/ketone-...
buckinstitute.org
Ketone bodies: more than energy, they are powerful signaling metabolites that clean up damaged proteins
Ketone esters help clear misfolded proteins in mouse models of aging and Alzheimer’s disease   Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular pro...
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Miguel Godinho Ferreira @miguelgf.bsky.social · 30/11/2024
“In this Review, we discuss #telomere protection, maintenance and damage. We highlight the differences between #human and #mouse telomere biology that may contribute to discrepancies between human #diseases and mouse models.” #telomerase #aging www.nature.com/articles/s41...
nature.com
Telomere function and regulation from mouse models to human ageing and disease - Nature Reviews Molecular Cell Biology
Telomere dysfunction, usually owing to shortening, activates cellular senescence and can contribute to age-associated diseases and cancer. Mouse models are crucial for telomere research, but human and...
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