Whole-slide histopathological images from 40 tissue types reveal morphological changes associated with aging, which, when paired with transcriptomic data from blood, are used to develop aging clocks t...

On 4–6 September 2025, the Gulbenkian Institute for Molecular Medicine (GIMM) hosted its inaugural GIMM Festival in Lisbon, Portugal. The three-day meeting on ‘Aging and Longevity’ brought together re...

Advances in organ and computer models are raising the prospect that some animal experiments could be eliminated. But there are still huge hurdles to overcome.

YouTube video by Leibniz-Institut für Alternsforschung - FLI e.V.

O que são os telómeros? Como pode o peixe-zebra ajudar no estudo do envelhecimento? Miguel Godinho Ferreira, cientista português a trabalhar em França, responde. Falemos então sobre a longevidade.

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

Abstract. Telomeres protect the chromosome ends from deleterious DNA damage response and repair activities. In humans, telomerase maintains telomere length

Unlocking the Fountain of Youth: Inhibition of telomeric DNA damage response reduces premature aging in zebrafish

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature...

imageimageTelomere erosion is a hallmark of aging, yet its downstream mechanisms and impact on organismal aging remain unclear. This study shows that cGAS-STING inflammatory signaling drives premature aging in response to telomere shortening in ...

Telomerase activity is restricted in somatic cells, resulting in progressive telomere shortening. Telomere erosion eventually activates the DNA damage response (DDR), inducing cell-cycle arrest and ce...

Countries must cooperate to seize a once-in-a-generation opportunity to become the top destination for scientists.

Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!

Thank you very much for your generous donation and for sharing your testimony.We hope to more people feel inspired to join this mission of discovery and innovation!

Abstract. Telomeres are the nucleoprotein structures at chromosome ends. Telomeres are particularly sensitive to oxidative stress, which can induce telomer

Using a cohort of nearly 1,000 genetically diverse mice undergoing dietary restriction over the lifespan, the authors reveal numerous insights into the interactions between the gut microbiome, host ge...

Letter to the Editor

Koch and colleagues report that epigenetic clocks mirror age predictions based on the accumulation of somatic mutations and show that somatic mutations at CpG sites coincide with extensive remodeling ...

Eukaryotes have linear DNA and their telomeres are hotspots for transposons, which in some cases took over telomere maintenance. Here we identify several families of independently evolved telomeric tr...

Zebrafish show robust heart regeneration after injury. Here they show that zebrafish cardiomyocytes experience replication stress, which BMP signaling alleviates via a conserved mechanism of replicati...