Reposted by Lorena BenedettiLeading Edge Fellows Program @leadingedgeprogram.bsky.social · 09/06/2026We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences. This is the 7th Leading Edge cohort and we are so excited to welcome them! www.leadingedgesymposium.org/fellows/ 011855
Reposted by Lorena BenedettiHenne lab @hennelab.bsky.social · 26/05/2026Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid-... 068
Reposted by Lorena BenedettiLaura Grima @lauragrima.bsky.social · 23/05/2026@fluketc.bsky.social and @dudman.bsky.social have hit it out the park again. In my (perhaps biased) opinion this - along with their previous papers - is field-defining work. www.science.org/doi/10.1126/...science.orgReward magnitude determines reinforcement learning efficiencyStandard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how reward magnitude influences initial learning across five... 28325
Reposted by Lorena BenedettiLaura Grima @lauragrima.bsky.social · 09/05/2026Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options 1213446
Lorena Benedetti @lorenabenedetti.bsky.social · 03/10/2025Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells. 041
Lorena Benedetti @lorenabenedetti.bsky.social · 03/10/2025Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post! The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER. gcamp6f.com/2025/08/11/i...gcamp6f.comInteresting papers on the role of cell organelles in neuronal dendrites for calcium signalingResearchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par… 161
Lorena Benedetti @lorenabenedetti.bsky.social · 30/05/2025Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟 #LeadingEdge2025 #WomenInScience #hhmi #janelia 1161
Lorena Benedetti @lorenabenedetti.bsky.social · 24/04/2025Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩 151
Reposted by Lorena BenedettiAndy Moore @aaandmoore.bsky.social · 10/03/2025What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens. 12912
Reposted by Lorena BenedettiAustin E. Y. T. Lefebvre @austin-lefebvre.bsky.social · 27/02/2025Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N 418774
Reposted by Lorena BenedettiJanelia Research Campus @hhmijanelia.bsky.social · 24/02/2025🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells. 🔗 www.janelia.org/news/new-ima... 0197
Lorena Benedetti @lorenabenedetti.bsky.social · 10/02/2025New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social 140
Reposted by Lorena BenedettiJanelia Research Campus @hhmijanelia.bsky.social · 07/02/2025💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠 🔗 hhmi.news/4jMHbNY 0213
Reposted by Lorena BenedettiPhilip Hubbard @philiphubbard.bsky.social · 03/01/2025This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer. 1307
Lorena Benedetti @lorenabenedetti.bsky.social · 27/12/2024Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social 0241
Reposted by Lorena BenedettiPhilip Hubbard @philiphubbard.bsky.social · 21/12/2024This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender. 0181
Reposted by Lorena BenedettiPrasanna Satpute-Krishnan @pskcellbio.bsky.social · 21/12/2024Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites. 131
Reposted by Lorena BenedettiThibaut Brunet @thibautbrunet.bsky.social · 21/12/2024I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯 0165
Reposted by Lorena BenedettiKing Cada @kingcada.bsky.social · 21/12/2024First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved! 021
Reposted by Lorena BenedettiNesia Zurek, PhD @docnessmonster.bsky.social · 21/12/2024Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence 084
Lorena Benedetti @lorenabenedetti.bsky.social · 20/12/2024I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social. 822258
Reposted by Lorena BenedettiStephan Saalfeld @herrsaalfeld.bsky.social · 20/12/2024Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration www.sciencedirect.com/science/arti... by the fabulous @lorenabenedetti.bsky.social and friends.sciencedirect.comPeriodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendritesNeuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma… 0177
Reposted by Lorena BenedettiBeata Science Art @beatascienceart.bsky.social · 19/12/2024It was such a pleasure to host you both at our #CellBio2024 #SciArt Show & Reception! Thank you for making this event so special, and for bringing your creativity and enthusiasm to our community 😍 0102
Reposted by Lorena BenedettiAndy Moore @aaandmoore.bsky.social · 18/12/2024Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation. 110814
Reposted by Lorena BenedettiAmerican Society for Cell Biology @ascbiology.bsky.social · 14/12/2024ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024 08813
Reposted by Lorena BenedettiJonny Nixon-Abell @abelljonny.bsky.social · 19/11/2024Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳 18524
Reposted by Lorena BenedettiAvezov lab @avezovlab.bsky.social · 26/11/2024 🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field. See you there! **Please RT** 🥳 t.co/6eq3cyGlVZ 09127
Reposted by Lorena BenedettiAmerican Society for Cell Biology @ascbiology.bsky.social · 27/11/2024#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology. www.ascb.org/cellbio2024/ 05718
Reposted by Lorena BenedettiAlice Ting @aliceyting.bsky.social · 04/12/2024Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation.. 33434138
Reposted by Lorena BenedettiJon Grimm @dyerfulchymist.bsky.social · 03/12/2024In honor of our annual ChemisTree event @hhmi.bsky.social @hhmijanelia.bsky.social today, here's a repost of a little video I made a few years back to demonstrate how the ornament silver plating works! #chemsky 716940
Reposted by Lorena BenedettiChristophe 🔬 Leterrier @christlet.bsky.social · 02/12/2024Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!science.orgControversial study redraws classical picture of the neuronLet’s go with: Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling 510533
Reposted by Lorena BenedettiWatanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024and a nice cover article from @science.org on our work. www.science.org/content/arti...science.orgControversial study redraws classical picture of the neuronLet’s go with: Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling 174
Reposted by Lorena BenedettiWatanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow! 2023785
Reposted by Lorena BenedettiIshier Raote @ishier.bsky.social · 02/12/2024Two exciting #MembraneSeminars this week! Thu, 5 Dec 5.00 PM CET / 11.00 AM EST Jonathon Nixon-Abell (CIMR, Univ. Cambridge, UK) Protein-lipid phase coupling in lysosomal transport Itay Budin (UCSD, CA, USA) New tools for visualizing lipid trafficking between and across organelle membranes 12514
Lorena Benedetti @lorenabenedetti.bsky.social · 30/11/2024Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨ 0549