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Lorena Benedetti

@lorenabenedetti.bsky.social
660 followers 665 following 27 posts

Neuroscientist and cell biologist dedicated to unraveling how organelles adapt their structure and function to sustain neuronal signaling and metabolism. Postdoc in the JLS lab @ HHMI Janelia

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Reposted by Lorena Benedetti
Leading Edge Fellows Program @leadingedgeprogram.bsky.social · 09/06/2026
We are thrilled to announce the 2026 Zara Weinberg Leading Edge Fellows! 40 remarkable postdocs pursuing transformative research in biological/biomedical sciences. This is the 7th Leading Edge cohort and we are so excited to welcome them! www.leadingedgesymposium.org/fellows/
Congratulations to the 2026 Zara Weinberg Leading Edge Fellows! 
Airi Yoshimoto, Yijun Yang, Alexandra Wells, Simran Virdi, Archana Venkataraman, Emery Usher, Marianna Tannus Ruckert, Wenzhi Song, Kathryn Shelley, Selin Schamiloglu, Julia Peloggia de Castro, Ines Patop, Ruhi Patel, Suranjana Pal, Bernie Simone Owusu Yaw, LaShae Nicholson, Sivapratha Nagappan Chettiar, Dallas Mould, Jessica Moore, Deka Mohamed, Sierra Marable, Annie Ly, Xi (Lucy) Lu, Deirdre Logsdon, Anna Lipkin, Ellen Lesser, Mia Konjikusic, Veronika Kondev, Cayla Jewett, Lucia Ichino, Erin Huiting, Maggie Horst, Isabella Gaeta, Martha Echevarria-Andino, Natasha Claxton, Sarah Cherkaoui, Nikita Bhalerao, Merci Best, Meenakshi Asokan, Alicer Andrew
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Henne lab @hennelab.bsky.social · 26/05/2026
Please re-post! Time is almost up to register for the 2026 FASEB Lipid Droplet Meeting. Abstracts are due May 31, 2026. See link below, and join us for an amazing SRC lipid meeting July 26-30! #LipidSRC events.faseb.org/event/Lipid-...
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Reposted by Lorena Benedetti
Laura Grima @lauragrima.bsky.social · 23/05/2026
@fluketc.bsky.social and @dudman.bsky.social have hit it out the park again. In my (perhaps biased) opinion this - along with their previous papers - is field-defining work. www.science.org/doi/10.1126/...
science.org
Reward magnitude determines reinforcement learning efficiency
Standard animal learning studies minimize individual reward magnitudes to maximize the repetitions of reinforced behaviors. We investigated how reward magnitude influences initial learning across five...
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Laura Grima @lauragrima.bsky.social · 09/05/2026
Really pleased that this work with @dudman.bsky.social is now out in Neuron: A global dopaminergic learning rate enables adaptive foraging across many options
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Lorena Benedetti @lorenabenedetti.bsky.social · 03/10/2025
Excited that our paper was featured! It was exciting to bring together advanced imaging and physiology to uncover this hidden layer of communication in brain cells.
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Lorena Benedetti @lorenabenedetti.bsky.social · 03/10/2025
Thrilled to see our paper highlighted in @ptrrupprecht.bsky.social blog post! The ER helps carry Ca2+ signals not just within dendrites but also across tiny spines, the main sites of synaptic input. This means that spines can be connected through the ER. gcamp6f.com/2025/08/11/i...
gcamp6f.com
Interesting papers on the role of cell organelles in neuronal dendrites for calcium signaling
Researchers utilize calcium imaging to track neuronal activity in the brain, highlighting the role of calcium as a signaling molecule. Recent studies investigate intracellular calcium dynamics, par…
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Lorena Benedetti @lorenabenedetti.bsky.social · 30/05/2025
Extremely honored and humbled to be part of the 2025 Leading Edge Court. Grateful for the opportunity to join this inspiring community of scientists pushing the boundaries of discovery. Looking forward to learning, connecting, and growing together! 🌟 #LeadingEdge2025 #WomenInScience #hhmi #janelia
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Lorena Benedetti @lorenabenedetti.bsky.social · 24/04/2025
Cool new #optogenetic tool developed to disassemble intermediate filaments 🤩
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Andy Moore @aaandmoore.bsky.social · 10/03/2025
What started as a brief chat with @buvansr.bsky.social and @vgelfand.bsky.social at the 2023 CellBio meeting @ascbiology.bsky.social has grown into our published collaborative work on single vimentin IF dynamics and organization in cells. Love when stuff like that happens.
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Austin E. Y. T. Lefebvre @austin-lefebvre.bsky.social · 27/02/2025
Do you LOVE organelles?? Well I am THRILLED to announce that Nellie has been published in @naturemethods.bsky.social! Nellie a fully automated pipeline for organelle segmentation, tracking, and hierarchical feature extraction in 2D, 3D, timelapse, multichannel live-cell microscopy 🧵1/N
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Janelia Research Campus @hhmijanelia.bsky.social · 24/02/2025
🔬 Researchers from the Shroff Lab & collaborators have developed a new method to simultaneously image the 3D orientation & position of biomolecules, giving scientists a new view into how structures are arranged inside cells. 🔗 www.janelia.org/news/new-ima...
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Lorena Benedetti @lorenabenedetti.bsky.social · 10/02/2025
New insights into the mysterious spine apparatus from the super talented @haniehfalahati.bsky.social
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Janelia Research Campus @hhmijanelia.bsky.social · 07/02/2025
💪New research led by @lorenabenedetti.bsky.social in the Lippincott-Schwartz Lab shows that subcellular structures similar to those that propagate signals that make muscles contract also transmit signals in the brain that may facilitate learning & memory 🧠 🔗 hhmi.news/4jMHbNY
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Philip Hubbard @philiphubbard.bsky.social · 03/01/2025
This #FluorescenceFriday video shows 89 volumes from the #HHMIJanelia FlyLight Split-GAL4 collection: premotor and related neurons from the #Drosophila fruit fly's equivalent of a spinal cord. I gave a high-level description of the video to neuVid, which drove rendering by VVD Viewer.
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Lorena Benedetti @lorenabenedetti.bsky.social · 27/12/2024
Check out the stunning movie by @xianglejerry.bsky.social from @wumin-lab.bsky.social, the winner of the 2024 ASCB Video Contest! Traveling waves of FBP17-EGFP at the cortex of immune mast cells #ASCB2024 @ascbiology.bsky.social
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Philip Hubbard @philiphubbard.bsky.social · 21/12/2024
This video was fun. I matched the #Neuroscience segmentations shown first (from the #HHMIJanelia FlyEM team) to the #CellBiology segmentations shown later (from Alyson Petruncio, @herrsaalfeld.bsky.social and the CellMap team). I described the animation with neuVid and rendered it with #Blender.
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Prasanna Satpute-Krishnan @pskcellbio.bsky.social · 21/12/2024
Congratulations to @lorenabenedetti.bsky.social and colleagues @jls_lab.bsky.social for this beautiful work revealing the role for periodic ER-PM junctions in propagating long range Ca²⁺ signaling along dendrites.
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Thibaut Brunet @thibautbrunet.bsky.social · 21/12/2024
I was amazed to see this beautiful work at @hhmijanelia.bsky.social a few months ago - happy to see it out! The ER as an integral actor of neurotransmission 🤯
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King Cada @kingcada.bsky.social · 21/12/2024
First heard of this at the cell biology of the neuron #GRC. It was such a great study with beautifully executed experiments. Congrats to everyone involved!
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Nesia Zurek, PhD @docnessmonster.bsky.social · 21/12/2024
Very cool work on ER/PM junctions in neurons and how they regulate VGCCs. #neuroskyence
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Lorena Benedetti @lorenabenedetti.bsky.social · 20/12/2024
I am super excited to share our article addressing a longstanding question in neurobiology: how Ca²⁺ signaling cascades initiated at dendritic spines operate at a distance. Check it out here: authors.elsevier.com/sd/article/S... @cp-cell.bsky.social.
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Stephan Saalfeld @herrsaalfeld.bsky.social · 20/12/2024
Learn about the periodic ER organization along neurites in insects and vertebrates and its potential role in long-range Ca2+ signal integration www.sciencedirect.com/science/arti... by the fabulous @lorenabenedetti.bsky.social and friends.
sciencedirect.com
Periodic ER-plasma membrane junctions support long-range Ca2+ signal integration in dendrites
Neuronal dendrites must relay synaptic inputs over long distances, but the mechanisms by which activity-evoked intracellular signals propagate over ma…
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Beata Science Art @beatascienceart.bsky.social · 19/12/2024
It was such a pleasure to host you both at our #CellBio2024 #SciArt Show & Reception! Thank you for making this event so special, and for bringing your creativity and enthusiasm to our community 😍
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Andy Moore @aaandmoore.bsky.social · 18/12/2024
Really bummed to have missed ASCB this year due to some last-minute circumstances, but excited that our manuscript describing an IF disassembly tool will (hopefully) be posted soon. Here's a movie of vimentin color-coded by orientation.
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American Society for Cell Biology @ascbiology.bsky.social · 14/12/2024
ASCB President Sandra Murray with our 2024 Mentoring Keynote, Sonya Neal, Associate Professor, HHMI Freeman Hrabowski Scholar, UC San Diego, HHMI #CellBio2024
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Jonny Nixon-Abell @abelljonny.bsky.social · 19/11/2024
Hullooooo Cell Biology friends. If you're heading to #CellBio2024 in (hopefully!) sunny San Diego this year, then come and check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! See you there! **Please RT** 🥳
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Avezov lab @avezovlab.bsky.social · 26/11/2024
🚨For the lucky colleagues attending #CellBio2024 in San Diego, check out our session on 'ER structure and function across cell types' Room28C- Dec18th 09:00am! A fantastic lineup covering the latest across the field. See you there! **Please RT** 🥳 t.co/6eq3cyGlVZ
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American Society for Cell Biology @ascbiology.bsky.social · 27/11/2024
#CellBio2024, the joint meeting of ASCB and EMBO, will take place December 14-18, 2024, in San Diego, California. Join us to connect with scientists, present your research, and explore the latest advancements in cell biology science and technology. www.ascb.org/cellbio2024/
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Alice Ting @aliceyting.bsky.social · 04/12/2024
Could one envision a synthetic receptor technology that is fully programmable, able to detect diverse extracellular antigens – both soluble and cell-attached – and convert that recognition into a wide range of intracellular responses, from gene expression and real-time fluorescence to modulation..
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Jon Grimm @dyerfulchymist.bsky.social · 03/12/2024
In honor of our annual ChemisTree event @hhmi.bsky.social @hhmijanelia.bsky.social today, here's a repost of a little video I made a few years back to demonstrate how the ornament silver plating works! #chemsky
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Christophe 🔬 Leterrier @christlet.bsky.social · 02/12/2024
Important article that challenges the classic view of axons as simple tubes. To what extent they fluctuate in diameter is up for debate - see some thoughts in this commentary piece in @science.org. Exciting time for axon scientists!
science.org
Controversial study redraws classical picture of the neuron
Let’s go with: Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling
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Watanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024
and a nice cover article from @science.org on our work. www.science.org/content/arti...
science.org
Controversial study redraws classical picture of the neuron
Let’s go with: Fine-grained imaging of mouse brain cells suggests “pearling” of axons that researchers think may help with signaling
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Watanabe Lab @JHU @watanabelab.bsky.social · 02/12/2024
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!
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Ishier Raote @ishier.bsky.social · 02/12/2024
Two exciting #MembraneSeminars this week! Thu, 5 Dec 5.00 PM CET / 11.00 AM EST Jonathon Nixon-Abell (CIMR, Univ. Cambridge, UK) Protein-lipid phase coupling in lysosomal transport Itay Budin (UCSD, CA, USA) New tools for visualizing lipid trafficking between and across organelle membranes
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Lorena Benedetti @lorenabenedetti.bsky.social · 30/11/2024
Kicking off here with some old but gold movies showing ER-lysosome interactions triggered by blue-light excitation of the light-sensitive protein eMags. A shining example of how light can control cellular dynamics! 💡🧫✨
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