Tsusaka et al. discover that histone deacetylases, which are well known to remove protein modifications, such as lysine acetylation and β-hydroxybutyrylation, can also reverse their chemical activity ...

Intersection of Multiple Chronic Conditions (MCCs) and Alzheimer's Disease and Alzheimer's Disease Related Dementias (AD/ADRD) (2025)

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The MSTAR program at UCSF is a summer research practicum in San Francisco, CA, designed to immerse first year medical students in aging research.

The MSTAR program at UCSF is a summer research practicum in San Francisco, CA, designed to immerse first year medical students in aging research.

Award Aims to Transform Healthcare with Personalized Analytics

Dietary restriction promotes healthy brain aging, but the mechanism is unknown. Here, the authors show that OXR1 is upregulated by dietary restriction and confers age-related neuroprotection by m...

Madhavan et al. identify and characterize the selective regulation of protein solubility by the ketone body β-hydroxybutyrate (βHB) across a range of models. βHB exposure rescues cell-based and C. ele...

Ketone esters help clear misfolded proteins in mouse models of aging and Alzheimer’s disease   Ketone bodies, produced by the body to provide fuel during fasting, have roles in regulating cellular pro...

This is "Thank you Buck Donors!" by The Buck Institute on Vimeo, the home for high quality videos and the people who love them.

KD improves memory in aged mice; however, the molecular effects governing such changes at synaptic level remain unknown. Acuna-Catalan et al. reveal that a KD improves short- and long-term memory and ...