DNA-sequencing data from primary tumours and paired metastases from participants in the TRACERx lung study and PEACE autopsy programme are used to analyse the metastatic diversity of advanced non-smal...

Nature - Polyclonal selection of immune checkpoint mutations in thyroid autoimmunity

Nature - This Review revisits tumour initiation and promotion in light of clonal diversity and the presence of cancer driver mutations in normal tissues, aiming to understand mechanisms that enable...

In a real-world cohort of 888 patients with solid cancers receiving whole-genome sequencing profiling, actionable biomarkers were identified in 73% of patients, and targeted therapies were associated ...

Under the leadership of Josep Tabernero, VHIO is an internationally recognized cancer center. Its multidisciplinary, collaborative model drives scientific progress and innovative cancer treatments.

LINE-1 (L1) retrotransposition generates somatic genomic variation in human cancer, but short-read sequencing has limited our understanding of its structural consequences and dynamics. Using long-read...

Nature - Polyclonal origins of human premalignant colorectal lesions

This study nominates immune escape as an early event in colorectal cancer and shows how this can be driven through both genetic and epigenetic changes.

Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

The obsession with economic output as a measure of human development puts sustainability on the back burner. Researchers can now help to devise better indicators.

A revised ‘Doughnut’ providing a visual assessment of trends in social deprivation and planetary degradation over the past two decades shows more than doubling of global GDP accompanied by accelerating ecological overshoot but only a modest reduction in human deprivation.

Mutations reflect the net effects of myriad types of damage, replication errors, and repair mechanisms, and thus are expected to differ across cell types with distinct exposures to mutagens, division ...

Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

A new point in history has been reached, entomologists say, as climate-led species’ collapse moves up the food chain even in supposedly protected regions free of pesticides

Una investigación periodística ha revelado que la empresa suiza Climeworks, que desde el 2021 apuesta por la captura de CO2 del aire como “solución tecnológica” a la crisis climática, emite más gases ...

The discovery that DNA methylation of different CpG sites can serve as digital barcodes of clonal identity led to the development of EPI-Clone, an algorithm that enables single-cell lineage tracing th...

Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...

Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...

Under current nationally determined contributions (NDCs) to mitigate greenhouse gas emissions, global warming is projected to reach 2.7°C above preindustrial levels. In this review, we show that at su...

Eventbrite - Precision Immunology Institute at the Icahn School of Medicine presents International Course of Immunotherapy March 10-12, 2025 - Monday, March 10, 2025 | Wednesday, March 12, 2025 - Find...