iiinova — where your digital self keeps evolving

Reposted by @meritxellnov.bsky.social

Marc A. Marti-Renom @mamartirenom.bsky.social · 23/10/2025

Fantastic #Blutorial by our friends and colleagues at the @batllelab.bsky.social . We are so happy to collaborate with them. @meritxellnov.bsky.social and Mireia Novell in the lab have participated in this very important piece on metastatic colorectal cancer. 👏🏼👇🏼👇🏼👇🏼 aacrjournals.org/cancerdiscov...

aacrjournals.org

A plastic EMP1⁺ to LGR5⁺ cell state conversion as a bypass to KRAS-G12D pharmacological inhibition in metastatic colorectal cancer

Abstract. Inhibitors of the oncogene KRAS hold promise for treating metastatic CRC (mCRC). Here we show that a selective, covalent small molecule inhibitor of the active (ON) conformation of RAS-G12D,...

062