We’re happy 😄 to share our latest work in Cancer Discov @theaacr.bsky.social – we discover that PTEN UPD 🧬 in endothelial cells causes vascular malformations in PTEN Hamartoma Tumor Syndrome (PHTS), create a new mouse model 🐀 & test PI3K signaling inhibitors 💊.
aacrjournals.org/cancerdiscov...
aacrjournals.org
Somatic uniparental disomy of PTEN in endothelial cells causes vascular malformations in patients with PTEN Hamartoma Tumor Syndrome
Abstract. PTEN Hamartoma Tumor Syndrome (PHTS) is a rare tumor risk disorder caused by germline loss-of-function mutations in PTEN. Half of these patients develop vascular malformations, a hamartoma c...
