Caspase inhibitors have repeatedly entered clinical trials but have not reached clinical practice due to toxicity and limited efficacy. Groborz and colleagues now show that gasdermin D pores admit otherwise membrane-impermeable inhibitors into pyroptotic cells, turning poor permeability into a mechanism of cell-state selectivity.

In a career defined by constant questioning, self-doubt can become an occupational hazard. Now, for the first time, a group of Cambridge scientists reveal the personal struggles they’ve faced – and co...

Science has become obsessed with publishing numbers. With this new satirical proposal, have we reached peak metric?

The kinase ZAK is activated at collided ribosomes to mediate the ribotoxic stress response.

Signaling networks may provide greater return for the investment in cancer research.

From funding squeezes to political attacks, higher education is in trouble in many parts of the world. Fresh ideas will allow the sector to thrive and deliver value for society.

Distant metastasis is the leading cause of mortality in Ewing sarcoma (EwS) -a malignant bone or soft-tissue cancer mainly affecting children, adolescents, and young adults. Despite continuous efforts...

Preinvasive squamous lung lesions are precursors of lung squamous cell carcinoma (LUSC). The cellular events underlying lesion formation are unknown. Using a carcinogen-induced model of LUSC with no a...

Excess words track LLM usage in biomedical publications.

Neurons often receive organelles called mitochondria from other cells. It emerges that neurons donate mitochondria that support cancer-cell spread.

The TP53 p.R337H variant, prevalent in Southern Brazil, is linked to variable cancer risk for pediatric and adult cancers. Unlike high-penetrance TP53 pathogenic variants, many carriers remain cancer ...

In this Tools of the Trade article, Bercin Cenik describes the development and use of TurboCas, an enzyme that pairs catalytically dead Cas9 with the proximity-labelling enzyme miniTurbo to map the re...

This link will take you to a page that’s not on LinkedIn

5’-Azacitidine (Aza) and 5-Aza-2’-deoxycytidine (Dac) are widely used demethylating drugs that directly integrate into nucleic acids. They are frequently used interchangeably, surprisingly as their se...

A multigenerational single-cell tracking approach provides a framework to dissect phenotypic plasticity at the single-cell level, offering insights into cellular processes that may resemble early even...

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Assessing a full range of environmental exposures will improve human health

F-box proteins are the substrate recognition modules of the SCF (SKP1–Cullin– F-box) E3 ubiquitin ligase complex. FBXO42, an understudied member of this family, has recently emerged as a modulator of ...

Bringing together proponents of rival theories to test their ideas against each other can advance science — but only if all sides can accept that they might be wrong.

Nature Medicine - The stochasticity of biological aging

Cell Death & Differentiation - An atlas of ferroptosis-induced secretomes

P53 plays a critical role in preventing DNA damage accumulation by activating repair processes, inducing cell cycle arrest, or triggering apoptosis. Loss of p53 leads to replication stress and genomic...

The aging process is characterized by a general decrease in physical functionality and poses the biggest risk factor for a variety of diseases such as cancer, cardiovascular diseases, and neurodegener...

Song et al. demonstrated that the cytosolic CYCS-INPP4A complex inhibits ferroptosis by promoting phosphatidylinositol-3-phosphate synthesis and preventing phospholipid peroxidation. The small molecul...