iiinova — where your digital self keeps evolving

Geoff Macintyre @gmaci.bsky.social · 12/09/2026

Checkout our latest in @nature.com Integrated Mutational Footprints (SBS+Indels+SV+CIN signatures) define the mutational processes shaping 85% of prostate cancer genomes and outcomes. Explainer 👇

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Geoff Macintyre @gmaci.bsky.social · 16/04/2026

I’m looking forward to connecting with colleagues at #AACR26 next week. The Computational Oncology group from @cniostopcancer.bsky.social will be presenting three posters that bridge the gap between chromosomal instability and clinical implementation 👇

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Geoff Macintyre @gmaci.bsky.social · 28/11/2025

Checkout the latest preprint from the lab - single-cell CIN signatures unlocked! Ongoing HRD improves PARPi sensitivity detection and ongoing NHEJ associates with subclonal diversification in TNBC

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Reposted by Geoff Macintyre

Calum Gabbutt @calumgabbutt.bsky.social · 10/09/2025

Cancer is an evolutionary disease, but does knowing a cancer’s evolutionary past help predict its future? Out today in @nature, we learnt the evolution of 2000 lymphoid cancers and found it was highly correlated with clinical outcomes! (1/7) rdcu.be/eFrrc

rdcu.be

Fluctuating DNA methylation tracks cancer evolution at clinical scale

Nature - Cancer evolutionary dynamics are quantitatively inferred using a method, EVOFLUx, applied to fluctuating DNA methylation.

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Geoff Macintyre @gmaci.bsky.social · 23/06/2025

🚨Chemo treatment upgrade!🚨 Check out our approach to modernise chemotherapy treatment published today in @natgenet.nature.com. From @cniostopcancer.bsky.social #TailorBio @cruk-ci.bsky.social www.nature.com/articles/s41... More details 👇

nature.com

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Geoff Macintyre @gmaci.bsky.social · 10/06/2025

If tumour genome evolution is deterministic, can we forecast genomic changes? Yes we can! At least for oncogene amps and tumour suppressor dels. @bhernando.bsky.social Angel Fernandez-Sanroman present our method for forecasting driver gene copy number change. Preprint: bit.ly/4kxF14y ⬇️1/

bit.ly

Forecasting oncogene amplification and tumour suppressor deletion

Oncogene amplification and tumour suppressor deletion can drive tumour initiation, progression and treatment resistance. Detection at diagnosis often signals poor prognosis, but it can also enable opp...

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Geoff Macintyre @gmaci.bsky.social · 27/04/2025

If you are at AACR and want to find out how we are turning chemotherapies into precision medicines, come to my talk on Tuesday! www.abstractsonline.com/pp8/#!/20273...

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Geoff Macintyre @gmaci.bsky.social · 24/01/2025

One more day left to apply! Come join us in our efforts to turn chemotherapy into a precision medicine.

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Geoff Macintyre @gmaci.bsky.social · 16/01/2025

We are hiring! Opportunity for a project manager to oversee all aspects of a multi-centre clinical research project to implement an AI-based genomic test that predicts resistance to chemotherapy - Madrid, Spain. PM for more details. Deadline 25 January! www.cnio.es/en/empleo/re...

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Geoff Macintyre @gmaci.bsky.social · 03/01/2025

Want to know how inherited genome instability contributes to childhood cancers? Checkout this perspective from Jayne Hehir-Kwa and me www.science.org/doi/10.1126/... on the latest brilliant work from @vanallenlab.bsky.social www.science.org/doi/10.1126/... on rare germline SVs in paediatric cancers

science.org

Inherited genome instability

Germline structural variants are a risk factor for pediatric extracranial solid tumors

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Reposted by Geoff Macintyre

Mcclelland lab @mcclellandlab.bsky.social · 14/11/2024

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...

meetings.embo.org

Chromosome Segregation and Aneuploidy

Aneuploidy is a hallmark of cancer and developmental disorders such as Down syndrome. Understanding how cells accomplish faithful chromosome segregation and how chromosomal instability (CIN) impacts …

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