Regular physical activity is fundamental in promoting health; however, uncovering the molecular adaptations remains challenging in humans. Rodent models have been indispensable for unveiling biological responses to exercise, but performing preclinical interventions can be challenging. Here, we outline key experimental considerations to guide best practices in future preclinical exercise studies.

Chivite et al. show that the genetic inactivation of the mitochondrial fusion protein MFN2 in the endothelium triggers a protective stress response that boosts fat burning, increases secretion of the ...

Overuse of our tendons can cause painful medical conditions for which only limited treatment options exist. Researchers have now deciphered an important molecular mechanism that triggers these problem...

HIF1α activation promotes tendinopathy, and its inhibition prevents overload-induced maladaptation, suggesting therapeutic potential.

Nature Cardiovascular Research - Using single-cell and spatial transcriptomics on muscle samples from non-ischemic patients and patients with peripheral artery disease (PAD), Turiel et al. identify...

Aims In a six-month randomized clinical trial, improved peripheral perfusion has been shown with liraglutide, associated with favourable vascular effects in people with type 2 diabetes and periphera...

Cancer mutations in the PIK3CA gene cause congenital disorders. The endothelium is among the most frequently affected tissues in these disorders, displaying aberrant vascular overgrowth in the form of...

Tendons are mostly avascular dense connective tissues that link muscles to bones, withstanding some of the highest mechanical stresses in the body. Mechanical overload and tissue hypervascularity are ...