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Andrew Plested

@andrewplested.bsky.social
1.4K followers 819 following 1.1K posts

Glutamate ORCID: 0000-0001-6062-0832

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Philippe Auclair @philippeauclair.bsky.social · 15h
Reading the independent report into Man City's financial "arrangements" now, stopping after every paragraph, saying "Jesus"..."JESUS!"..."Holy fuck!" and again. This is beyond anything anyone imagined. Also started to wonder whether criminal proceedings are in the picture now.
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Arnold Krille @kampfschlaefer.de · 18h
Gleich geht's los! Erstmal der Sonne entgegen, dann in die Nacht und nach Berlin. ICE1502 #trainspotting
Blick gegen die Sonne, bayrisch blauer Himmel über dem Bahnhof münchen.
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Nigella Lawson @nigella.bsky.social · 28/09/2026
I know it sounds a bit bonkers, but it doesn’t taste it: #RecipeOfTheDay is Naan Pizza! www.nigella.com/recipes/naan...
nigella.com
Naan Pizza
I beg you to keep the wherewithal for this fantastic instant snack-cum-supper in your storecupboard. It's a lifesaver! I've given my topping of preference; feel free to play about and make your own. A...
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Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 29/09/2026
@gruber.foo points to this Zuckerberg profile. At the core is a fawning overview of Meta's AI efforts and the idea that the tech is likely to be a commodity, with benefits going not to technology leaders but to those who find uses. Timing: the article is designed to harm Anthropic and Open AI IPOs.
daringfireball.net
Jeremy Stern’s Profile of Mark Zuckerberg for Colossus
Link to: https://colossus.com/article/mark-zuckerberg-profile/
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Andrew Plested @andrewplested.bsky.social · 28/09/2026
Full disclosure, so to speak.
Outgassing.
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Jason Moore @moorejh.bsky.social · 27/09/2026
And uninstalling drivers to make room in 640K of conventional memory to run Doom #retrocomputing
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Bernhard Huss @bernhardhuss.bsky.social · 27/09/2026
Maurizio Cattelan, Neue Nationalgalerie Berlin
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Andrew Plested @andrewplested.bsky.social · 27/09/2026
Imagine how long faking all those western blot, dendrites and cilia images would have taken in the old days!!!
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Fran Bottanelli @franbottanelli.bsky.social · 27/09/2026
200 papers = should have reviewed 400 papers. I bet this person reviews 0. OR papers written via generative AI should be solely reviewed with QED! Your bad if you do not make the 1% if you have 200 chances! ALSO how the hell do you find the money to publish 200 papers. So wrong in so many ways
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Carl T. Bergstrom @carlbergstrom.com · 26/09/2026
Does my Speak-n-Spell feel pain when I type O-U-C-H? The jury is out. Philosophers and neuroscientists say that's fucking stupid, but I called a guy from the Center for Pretending that Household Electronics Are Sentient and he said there's no way to know for sure.
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Lennart Hilbert @lennarthilbert.bsky.social · 24/09/2026
I hate when this happens. And, let me tell you, it happens. It’s a really bad look … omitting prior, highly relevant work is academically inappropriate, especially if it was brought to one’s attention directly. It violates commonly applicable standards and proper process.
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Martin Vögele @martinvoegele.bsky.social · 25/09/2026
New preprint: We demonstrate how to apply FEP-based ligand efficacy modeling to ion channels. #CompChem 💻:⚗️ #Science 🧪 #DrugDiscovery #IonChannel #FEP doi.org/10.64898/202...
Graphical abstract: a ligand (green) binding to an ion channel resolved in antagonist- (blue) and agonist-preferred (orange) states, with state-specific binding free energies ΔG_I and ΔG_A. The right panel shows that the free-energy difference ΔG_A − ΔG_I predicts maximal ligand response, separating agonists (orange dots) from antagonists (blue squares) via a sigmoidal fit.
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Heilemann Lab @heilemannlab.bsky.social · 25/09/2026
#FluorescenceFriday #STED pure and real 8-color STED microscopy & happy TxIF to everyone 🌴
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Claire E. Aubin @ceaubin.com · 25/09/2026
I’m telling you right now, I would rather stick a fork in my eye than watch this new movie about a PhD student falling in love with her professor
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Philippe Auclair @philippeauclair.bsky.social · 25/09/2026
Quite a few posts about Pachelbel's Canon in D on Bluesky tonight, for a reason I do not wish to know. I hate very few pieces of music; but this is one of them. That banal, ugly, offensively dull chord progression can go to hell, and every song which borrowed it too. AI music before AI.
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Matt Baume 🏳️‍🌈 @mattbaume.bsky.social · 25/09/2026
The movie ROPE came out on this day in 1948, and newspapers really struggled with how to explain that the main characters were, you know,
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Jake Watson @jakefwatson.bsky.social · 25/09/2026
Interesting to chat with Lluís Amiguet for today’s ‘La Contra‘ in @lavanguardia.com! Gracias!
lavanguardia.com
Jake Watson, neurocientífico: “Estudiar cerebros de ratón no te descubre todo sobre los humanos”
Tengo 34 años: me quedan muchos para lograr algo en ciencia, pero nunca se sabe. Soy de las islas Orcadas: piérdase allí en mayo. Tengo pareja barcelonesa. Espero hallar en cerebros vivos humanos lo q...
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Guardian Sport @sport.theguardian.com · 26/09/2026
We Manchester City fans fear relegation and losing trophies … but club are bang to rights
dlvr.it
We Manchester City fans fear relegation and losing trophies … but club are bang to rights
Despite attempts to legally filibuster the charges out of existence for the past three years, we’ve rightfully failed It couldn’t have been more prophetic. In 2008, 15 years before Manchester City were charged with financial fraud, fans started singing “City’s going down with a billion in the bank” to the tune of Yellow Submarine. This was because the former Thailand president Thaksin Shinawatra’s 15-month ownership of City had come to an abrupt end when more than £1bn of his assets were frozen. And although Sheikh Mansour of the UAE had stepped in to save City, we were sinking fast. Despite the UAE’s untold riches, by December we were in the relegation zone. It’s called Cityitis – shorthand for our tendency to self-destruct when things appear to be going well. In fact we won trophy after trophy. But we continued to sing the song about going down with a billion in the bank. When the financial fair play investigation was launched in 2018, the chant got louder. Then in 2023 we learned there were more than 100 charges. The chant became even louder and more cavalier. And now that our grubby, griftin’, cheatin’ chicken has come home to roost, you can bank on one thing (if banks still deal with us) – the chanting will be louder and more cavalier than ever. Continue reading...
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Andrew Plested @andrewplested.bsky.social · 26/09/2026
Nostalgia’s not what it used to be.
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🌈Dr. Frizzle @swilua.bsky.social · 24/09/2026
OK this description made me LAUGH go.bsky.app/JKv3BWU
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Andrew Plested @andrewplested.bsky.social · 24/09/2026
#neuroskyence
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Alexis Rohou @alexisrohou.bsky.social · 23/09/2026
This is a nice new preprint, where the authors demonstrate fairly rigid (2-point) attachment of gold nanoparticles to Fabs thanks to pairs of engineered cysteines. These are then stabilized for use in labeling experiments by PEGylating them (to prevent reduction by e.g. glutathione).
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Andrew Plested @andrewplested.bsky.social · 24/09/2026
Very nice @cathyspangler.bsky.social It was always a hope that we would be able to see receptor conformations in the native synapse. This looks like a big step towards that. And thanks for the citation for Hector's paper.
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Moby Dick @mobydickatsea.bsky.social · 24/09/2026
But no more of this.
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Andrew Plested @andrewplested.bsky.social · 24/09/2026
Paper, preprint, comment, blogpost or talk. Doesn't matter. Ignoring other people's relevant hard work is dispiriting for those involved and hurts the scientific record. We always strive to cite other work fairly and with kindness.
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Andrew Plested @andrewplested.bsky.social · 24/09/2026
Image manipulation in the Nikon Small World competition? @sholtodavid.bsky.social Hold my beer. Astonishing work and a great video explanation. www.youtube.com/watch?app=de...
youtube.com
Faked Images of Neurons in Major Journals
YouTube video by Sholto David
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www.slowtravelberlin.com @slowberlin.bsky.social · 23/09/2026
😂
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James Briscoe @jamesbriscoe.bsky.social · 01/09/2026
Our latest: Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data From Marine Fontaine and @joadelas.bsky.social with David Rand in @plosbiology.org A thread 🧵 doi.org/10.1371/jour...
doi.org
Dynamic Landscape Analysis of cell fate decisions provides predictive models of neural development from single-cell data
Applying dynamical systems theory to single-cell data can provide a detailed picture of the cellular states observed during cell fate decisions. This study presents a dynamic landscape analysis (DLA) ...
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The Man in Seat 61 @seatsixtyone.bsky.social · 23/09/2026
BREAKING: Nox Mobility will lauch a new Hamburg-Munich night train March 2027. Initially 3 per week, later daily, initially with these flatbeds, from 2029 with enclosed private rooms for 1 or 2 people. Book at noxmobility.com/en, I'm seeing a typical price of €65 one-way.
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Andrew Plested @andrewplested.bsky.social · 22/09/2026
Bingo!
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Andrew Plested @andrewplested.bsky.social · 22/09/2026
Can relate. I have broadly two settings, English or “foreign”, where Italian, German and French are. Live switching, or trying to speak French after a while in Italy, for example, is close to impossible. I often mumble “entschuldingung” whilst jogging in rural France…not that effective!
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Jason Moore @moorejh.bsky.social · 21/09/2026
This is an executive problem #leadership
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Moby Dick @mobydickatsea.bsky.social · 21/09/2026
churning and churning
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👻madeline bOoOoOoOodent👻 @oldenoughtosay.com · 20/09/2026
y’all don’t go looking for this but. one thing I really wish everyone would internalise is that we’re not gonna win against the puritans, or the fascists, or anyone else, by accepting any part of their premise as valid. they do not have legit concerns
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www.slowtravelberlin.com @slowberlin.bsky.social · 21/09/2026
Guten morgen to Herr Twain ☕️ 🇩🇪 #berlin
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Dr Seán Ketchem @cskwriter.bsky.social · 21/09/2026
The bad results in the East were bad, but a continuation of bad results in the East that has been a trend for most of this century. And it is top of mind to Merz & Co that the East for all its grumblings is only 15% of the total German electorate (minus Berlin of course).
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Mark Chadbourn @chadbourn.bsky.social · 20/09/2026
Die Linke topped Berlin’s state election today on 25%, up 13%. If the leader Elif Eralp becomes governing mayor she’ll be the first female state leader with a migration background.
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Ewerslab @ewerslab.bsky.social · 20/09/2026
Glückwunsch @voigtvision.bsky.social ! Glückwunsch MPI Science of Light!
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Kevin Mitchell @wiringthebrain.bsky.social · 18/09/2026
Like many people (though not enough), I regard compatibilism as a hopeless fudge, but it's also moot, because the universe sure doesn't seem to be deterministic 😊 link.springer.com/article/10.1...
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Richard Sever @richardsever.bsky.social · 20/09/2026
"All corners of academia will soon be flooded with AI-generated research....Maths and CS go first because their entire output is symbol manipulation...Biology comes later not because biologists are cleverer but because the rate-limiting step is physical" giorgio.gilest.ro/the-weimar-o...
giorgio.gilest.ro
The Weimar of knowledge – la bottega
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Jason Moore @moorejh.bsky.social · 20/09/2026
Love the assembly language code in The Terminator #scifi
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Elisa Fadda @elisafadda.bsky.social · 19/09/2026
21,627 applications 🤯 tells you that loads of young people still believe in scientific research, while not many older people at the government do anymore... 😞 ec.europa.eu/info/funding...
Screenshot of the EU portal stating that 21,627 applications were submitted to the MSCA posdoctoral fellowship call this year
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Andrew Plested @andrewplested.bsky.social · 19/09/2026
My gateway to modern architecture.
Edition of El Croquis about Steven Holl.
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Andrew Plested @andrewplested.bsky.social · 18/09/2026
For those who don’t know, it was Marco @beatolab.bsky.social who brought these channels to life…. Check it out. So beautiful. www.jneurosci.org/content/24/4...
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Andrew Plested @andrewplested.bsky.social · 18/09/2026
Ana was pretty happy with this one. Glycine receptor alpha1 homomer, lovely long clusters of openings at 1 mM. We do theory all morning but in the afternoons it’s full-on wet lab practicals. #singlechannels #neuroscience #BSMBC
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Andrew Plested @andrewplested.bsky.social · 18/09/2026
And that’s that. The 3rd edition of #BSMBC is done. We ended with some analysis examples and software demonstrations. Many thanks to course faculty @ewerslab.bsky.social Max Ulbrich, Jelena Baranovic and Claudio Grosman, our students, and our super coordinator Dr Sandra Keiper, without whom🙏❤️
3 mugs for the 3 Berlin Single Molecule Biophysics Courses
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Andrew Plested @andrewplested.bsky.social · 18/09/2026
One of the most beautiful experiments ever! Single proton pKa measurements from the nicotinic receptor, Claudio Grosman’s masterpiece. #BSMBC www.nature.com/articles/nat...
Claudio Grosman shows single proton binding and unbinding to a single channel.
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Ewerslab @ewerslab.bsky.social · 18/09/2026
At Single Molecule Biophysics course, @andrewplested.bsky.social showing how it’s done. Great to feel the excitement and passion for science at the course! There may be one next year…!
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Andrew Plested @andrewplested.bsky.social · 18/09/2026
Now part two. No colour but incredible details from a giant of the field. Claudio Grosman outlines his pioneering work on reaction mechanisms via single channel recording. #BSMBC
Claudio Grosman lecturing.
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Ewerslab @ewerslab.bsky.social · 18/09/2026
having so much fun on the microscope! Thanks for organizing this phantastic event!
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