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Shu-Sin Chng

@figlegend.bsky.social
451 followers 329 following 100 posts

Assoc Professor @ National University of Singapore. 🇸🇬 NUS Assoc Dir for SCELSE. Membrane/lipid biochemist. Educator who teaches chemistry in biology. Advocate (Vice Dean) for students. Horn player. 📯📯 chemistry.nus.edu.sg/people/chng-sh…

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Reposted by Shu-Sin Chng
Simonetta Gribaldo @sgribaldo.bsky.social · 23/09/2026
Interested in #archaea, #methane, #cell-envelopes? New paper out @nature.com ! We discovered an enzyme that specifically cleaves the cell wall of methanogens, revealing a new chemical structure of archaeal peptidoglycan, 50 yrs after its first description www.nature.com/articles/s41... #MicroSky 🧵👇
nature.com
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 15/09/2026
How do proteins localize in bacteria? Usually by binding to a prelocalized protein-but how does that protein localize? @vanipande.bsky.social found a #Bacillus subtilis protein that localizes via a lipid cue,undecaprenyl phosphate,that guides it to sites of PG synthesis www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Shu-Sin Chng @figlegend.bsky.social · 13/09/2026
Great to visit both the de Duve Inst and Pasteur Inst after 10 yrs! Many thanks to Jean-François Collet and Nienke Buddelmeijer, respectively, for hosting the visits/seminars! It was a lot of fun catching up with new/old friends and discussing science! Excited for the EMBO mycobacteria mtg next wk!
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Jamie Blaza @jnb-lab.bsky.social · 17/08/2026
Our preprint is now published!
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Shu-Sin Chng @figlegend.bsky.social · 06/08/2026
Congrats Cristina!!
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Michael Glickman @michaelglickman.bsky.social · 23/07/2026
Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com
scholar.google.com
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Shu-Sin Chng @figlegend.bsky.social · 10/07/2026
Had absolutely fabulous times this wk visiting @yaleschoolofmed.bsky.social and @weillcornell.bsky.social and sharing our work! Great thanks to my wonderful hosts Wei MI and @saehrt.bsky.social! Enjoyable conversations and discussions with colleagues too! Finally bk to SG after the fruitful 3 wks!
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Shu-Sin Chng @figlegend.bsky.social · 10/07/2026
Had absolutely fabulous times this wk visiting @yaleschoolofmed.bsky.social and @weillcornell.bsky.social and sharing our work! Great thanks to my wonderful hosts Wei MI and @saehrt.bsky.social! Enjoyable conversations and discussions with colleagues too! Finally bk to SG after the fruitful 3 wks!
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Georgia Isom @georgiaisom.bsky.social · 10/07/2026
Interested in joining our group in Oxford? We are looking for a PDRA with single particle Cryo-EM experience to help us figure out how sphingolipids are transported to the cell surface of Gram-negative bacteria. The deadline is 31st July. Informal enquires are welcome. Please share!
my.corehr.com
Job Details
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Kimberly Kline 🏔 @kimingeneva.bsky.social · 09/07/2026
🚨Join us at the University of Geneva! We're seeking an outstanding junior researcher to apply for an ERC or SNSF Starting Grant with our institutional support in host–pathogen interactions, bacteriology, virology, parasitology, or mycology. www.unige.ch/medecine/mim... Please share!
unige.ch
Open call : MIMOL Junior Group Leader’s application for a Starting Grant - Microbiology and molecular medicine - UNIGE
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Xavier Charpentier @labxc.bsky.social · 07/07/2026
Adding to our results, another immune system was recently shown to also trigger cell death in E. coli upon plasmid conjugation, but it's targeting VirB4 rather than VirB2 or VirB8. www.biorxiv.org/content/10.6...
biorxiv.org
A recipient-based anti-conjugation factor triggers an abortive mechanism by targeting the Type IV secretion system
Many bacterial defense (immune) systems prevent the entry of foreign DNA by directly recognizing and targeting nucleic acids, effectively blocking all mechanisms of horizontal gene transfer[1][1]. How...
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Xavier Charpentier @labxc.bsky.social · 07/07/2026
#microsky New preprint from the lab! Widespread immune systems protect bacteria against conjugative plasmids www.biorxiv.org/content/10.6... Kudos to the extremely talented lead author Ludovic Poiré! Key contributions by @francoisrousset.bsky.social and also help from C. Lesterlin/TacC lab. 🧵⬇️
biorxiv.org
Widespread immune systems protect bacteria against conjugative plasmids
Conjugative plasmids are a class of mobile genetic elements capable of efficient transfer between bacterial cells. Although they can introduce beneficial traits such as antibiotic resistance to recipi...
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Shu-Sin Chng @figlegend.bsky.social · 05/07/2026
I will be visiting @yaleschoolofmed.bsky.social and @weillcornell.bsky.social on 6 (12 pm) and 8 July (11 pm), respectively. Do come by for the seminars if you are interested and available!
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Shu-Sin Chng @figlegend.bsky.social · 05/07/2026
Intense week of science at Bacterial Cell Surfaces GRC! Best part was catching up with old/new friends! Tagging peeps in pics @paulhoskisson.bsky.social @hendersonlab.bsky.social @namurxa.bsky.social @sujeetkumar.bsky.social @weeboont.bsky.social @yeowjiang.bsky.social @siegristpalmore.bsky.social
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Paula Navarro @navarropaula.bsky.social · 03/07/2026
🚨 New in @natmicrobiol.nature.com! We reveal how the antibiotic target PBP1b fortifies the E.coli division site against osmotic rupture. Proud this was completed in our independent labs @dmf-unil.bsky.social, with @avettiger.bsky.social. Congratulations to all authors! 🦠❄️🔬 #teamtomo bit.ly/3SCbOg1 👇
doi.org
The penicillin-binding protein PBP1b fortifies the Escherichia coli division site against osmotic rupture - Nature Microbiology
A specific isoform of PBP1b functions independently of the activator protein, LpoB, to drive generation of a wedge-like peptidoglycan structure that strengthens the division site in Escherichia coli.
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Shu-Sin Chng @figlegend.bsky.social · 02/07/2026
Big congrats Jeremy!
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Nature Microbiology @natmicrobiol.nature.com · 01/07/2026
Out Now! Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning #MicroSky
go.nature.com
Identification of chemical features for improved outer membrane permeation in mycobacteria using machine learning
Nature Microbiology, Published online: 30 June 2026; doi:10.1038/s41564-026-02412-5Screening 1,572 compounds for mycomembrane permeation plus cheminformatic and machine learning analyses reveals features associated with improved permeation in the pathogen Mycobacterium tuberculosis and model organism M. smegmatis.
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Shu-Sin Chng @figlegend.bsky.social · 26/06/2026
Awesome visit to @jhu.edu yesterday - lots of good questions during the seminar! Besides conversations with @goleylab.bsky.social, Tamara O'Connor and Gira Bhabha, it was fun chatting with trainees! Thanks again @jiexiaolab.bsky.social for great hospitality and catch-up! On to Gordon conf next wk.
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Shu-Sin Chng @figlegend.bsky.social · 26/06/2026
Unfortunately didn't get to meet him!
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Patrick Moynihan @pmoyniha.bsky.social · 24/06/2026
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
nature.com
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
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Shu-Sin Chng @figlegend.bsky.social · 24/06/2026
Started my 3-wk US trip with a visit to the NIH yesterday! Had a great time giving an ad-hoc Lambda lunch talk and discussing science with old/new friends @anukharelab.bsky.social! Many thanks @ramamurthilab.bsky.social for the hospitality! Next stop: @jhu.edu SOM on 25th - cya at 11 am for my talk!
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Tracy Palmer @proftracypalmer.bsky.social · 24/06/2026
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
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See-Yeun Ting 陳詩允 @seeyeunting.bsky.social · 17/06/2026
Excited to share our new preprint on a question that has puzzled us for a long time: How can the bacterial nano-weapon, type VI secretion system (T6SS), load and deliver so many antibacterial toxins that are completely different in structure and function? www.biorxiv.org/content/10.6...
biorxiv.org
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Andy Edwards @bugsinblood.bsky.social · 11/06/2026
New pre-print from the lab! Murepavedin is a Pseudomonas-specific antibiotic, but it disrupts the outer membranes of a wide range of different Gram-negatives. www.biorxiv.org/content/10.6...
biorxiv.org
Murepavadin is a broad-spectrum outer membrane permeabiliser
Murepavadin is a Pseudomonas-specific antibiotic that targets LPS transport protein LptD. However, whilst the mode of action of murepavadin is well defined, the mechanism by which the drug gains acces...
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Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 11/06/2026
EMBO Symposium alert: Save the date: 9–12 March 2027 Join us in scenic Heidelberg for this unique meeting, covering everything about drug resistance and tolerance. Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer www.embl.org/about/info/c...
embl.org
Mechanisms of drug resistance and tolerance in bacteria, fungi, and cancer
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Tobias Warnecke @tobiaswarnecke.bsky.social · 11/06/2026
Archaea the hornets of the microbial world. Discuss. www.biorxiv.org/content/10.6... TLDR: Archaeon kills bacterium with secreted phospholipase. Pretty nifty way to kill bacteria if you are a microbe with a very different lipid make-up, I reckon. No need to worry about accidentally killing yourself.
biorxiv.org
A Bactericidal Phospholipase from Archaea
Archaea kill bacteria, at least on occasion. The molecular underpinnings of these lethal interactions are barely understood. Here, we describe cinquedea, an α/β hydrolase secreted by the halophilic ar...
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 06/06/2026
@felixrl.bsky.social presenting his work at #ASMicrobe today. His preprint follows up on his recent work on orthogonal cell division in S. aureus and reports that PcdA, the division septum placement factor, is required for forming staphylococcal abscess colonies.
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 06/06/2026
@vanipande.bsky.social presenting her work at #ASMicrobe today.... Check out her recent preprint about a spontaneously inserting integral membrane protein that localized by recognizing a lipid cue
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The Rockefeller University @rockefeller.edu · 01/06/2026
A new study from the @rocklabtb.bsky.social in @natmicrobiol.nature.com finds that one of the most common drug resistance mutations in #tuberculosis creates subtle metabolic weaknesses that could be exploited with future combination therapies. 🔗: bit.ly/3RG6wj2
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Kumaran Ramamurthi @ramamurthilab.bsky.social · 29/05/2026
Bacterial transmembrane proteins usually localize inside the cell by "finding" a pre-localized protein, but how did the 1st protein get there? @vanipande.bsky.social found a protein in #B.subtilis that localizes by recognizing a *lipid* localization cue. #Microsky www.biorxiv.org/content/10.6...
biorxiv.org
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Tiago Costa @tcostalab.bsky.social · 28/05/2026
Our new study reveals how bacterial toxins are physically captured through a sequential, concentration-dependent assembly mechanism before secretion via the T6SS. Fantastic collaboration with @fillouxlab.bsky.social. Congrats Patricia & Ambre for leading this work. Paper here: shorturl.at/O31Vn
shorturl.at
Molecular basis of type VI secretion system effector loading - Nature Microbiology
Structural analysis reveals that the type VI secretion system effector cargo is enclosed within hexameric Hcp3 rings that form sequentially to enable effector loading and delivery by the Pseudomonas aeruginosa H3-type VI secretion system.
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SCELSE - a biofilm & microbiome research centre in NTU & NUS @scelse.bsky.social · 28/05/2026
How do dangerous bacteria arm themselves before attack? Scientists from NTU-SCELSE and Imperial College London uncovered a previously unknown mechanism showing how bacteria load toxins into a microscopic weapon system before firing. Nature Microbiology-> rdcu.be/fk0Bq @fillouxlab.bsky.social
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Microbiology Society @microbiologysociety.org · 26/05/2026
'The thing that you probably learn most, are from the mistakes that you make' We caught up with the Prize Medal 2026 winner, Paul Williams and asked him how it feels to win the prize and have the chance to present and reflect on his career. Congratulations Paul!
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Gabriel Oka @okagu.bsky.social · 11/05/2026
Happy to share our new bioRxiv preprint: “To Kill or not to Kill: A Conserved Trans-Intoxication Protection Factor Blocks X-T4SS-Mediated Fratricide through Interaction with VirB5” www.biorxiv.org/content/10.6...
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Maelle Paillat @maellepllt.bsky.social · 08/05/2026
Very happy to see the second story from my PhD out in @currentbiology.bsky.social An exciting project where we explored the roles of secretion systems and gliding motility in predatory behavior in F. johnsoniae. www.cell.com/current-biol...
cell.com
Type VI and type IX secretion systems and gliding motility contribute to facultative predation by Flavobacterium johnsoniae
Paillat et al. show that Flavobacterium johnsoniae combines type VI and type IX secretion systems with gliding motility to efficiently kill diverse bacterial competitors. They demonstrate that nutrien...
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AnniZLab: [🦠, 🧬 , ✨] @annizlab.bsky.social · 25/04/2026
1) DNA-protein binding prediction AI (40 species' bindings coming in v1 this summer; 6k+ species' bindings coming in v2 this year! 2) Microbiome knowledge graph based on 143k literature (100% data coming in v1 this summer)! Please reach out if you are interested :) #microsky #microbiomesky
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Cristina Colomer-Winter @colomer-winter.bsky.social · 24/04/2026
Super excited to share the final version of our story on how Enterococcus faecalis remodels membrane lipids to protect itself from daptomycin! 🥳 www.pnas.org/doi/10.1073/...
pnas.org
A two-component system signaling hub controls enterococcal membrane remodeling in response to daptomycin | PNAS
Daptomycin is a last resort antibiotic used to treat vancomycin-resistant enterococcal infections, but daptomycin resistance (DAPR) arises quickly ...
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Paul Hoskisson 🧫 🦠🐸 @paulhoskisson.bsky.social · 23/04/2026
Come and study for a PhD with us on antibiotic-producing Streptomyces, trying to understand the roles of primary metabolic enzymes with additional cellular roles - Details below - please repost www.findaphd.com/phds/project...
findaphd.com
Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde on FindAPhD.com
PhD Project - Primary metabolic enzymes in antibiotic-producing Streptomyces bacteria, but not as we know them! at University of Strathclyde, listed on FindAPhD.com
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Amelia McKitterick @amelia-mckitterick.bsky.social · 23/04/2026
Happy to share the finalized version of my paper on phage lysis in bacteria with unique envelopes! 🎉 Bacteriophages target membrane-anchored glycopolymers to promote host cell lysis and progeny release www.pnas.org/doi/10.1073/...
pnas.org
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
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Sorek Lab @soreklab.bsky.social · 23/04/2026
We found that TIR domains in animal immune proteins, including the human TLR4, are enzymes that cleave NAD+ to produce the signaling molecule cADPR Read our new preprint by talented Bohdana Hurieva: “Conserved catalytic activity of immune TIR domains in animals” www.biorxiv.org/content/10.6...
biorxiv.org
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Freya Harrison @friendlymicrobe.bsky.social · 20/04/2026
My super department @warwicklifesci.bsky.social is hiring 6 assistant profs in the wake of recent retirements. We're looking for people in microbiology/infection, cellular disease / immunity; environmental biology; and plant/crop science. #MicroSky warwick-careers.tal.net/vx/lang-en-G...
warwick-careers.tal.net
Assistant Professor x6 (111522-0426) - University of Warwick
Title: Assistant Professor x6 (111522-0426). Application Deadline: . Position Type: Permanent
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Shu-Sin Chng @figlegend.bsky.social · 17/04/2026
And I finally took some time off with my wife to be a real tourist in the UK for once! Lots of walking for the rest of the week, but had a great trip 🙂 till the next time UK!
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Shu-Sin Chng @figlegend.bsky.social · 17/04/2026
Finished my work trip earlier this week with a visit and seminar at @imperialcollegeldn.bsky.social - many thanks to @bugsinblood.bsky.social for playing host! Great catch up with Gadi Frankel too! Most coincidentally, met @hendersonlab.bsky.social on ICL campus - what are the odds?!
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Shu-Sin Chng @figlegend.bsky.social · 17/04/2026
Found time to meet f2f for the first time and catch up with Yin Chen, who co-supervised a joint Warwick-A*STAR student!
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Shu-Sin Chng @figlegend.bsky.social · 17/04/2026
Had lots of fun too at the Memb Prot Conf in Birmingham a few days prior, getting to know @chrismulligan.bsky.social, @gavinhthomas.bsky.social, @allistercrow.bsky.social, @renaeryan.bsky.social and catching up Andy Lovering, Jani Bolla, @pstansfeld.bsky.social & @davidroper2.bsky.social of course!
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Shu-Sin Chng @figlegend.bsky.social · 17/04/2026
Thanks @pstansfeld.bsky.social and @davidroper2.bsky.social for hosting a wonderful visit last week at Warwick! Great discussions also with @chelseabrown.bsky.social, @allistercrow.bsky.social and @melissawebby.bsky.social! Definitely looking fwd to more Warwick-NUS interactions!
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Shu-Sin Chng @figlegend.bsky.social · 26/03/2026
Thanks Vivek!
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Shu-Sin Chng @figlegend.bsky.social · 26/03/2026
Thanks Cristina!
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Shu-Sin Chng @figlegend.bsky.social · 26/03/2026
Thanks Zam!
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Shu-Sin Chng @figlegend.bsky.social · 23/03/2026
One day, we may yet be able to design anti-conjugation strategies that can slow down spread of virulence and antibiotic resistance. Hopefully this story excites you just as it excited us! Give it a read and let us know what you think! Kudos and congrats to the team led by Liyana OW YONG! 7/7
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