Sign in

Maelle Paillat

@maellepllt.bsky.social
114 followers 195 following 5 posts

PhD student in Cascales Lab in Marseille Trying to decipher the #T9SS sécrétion pathway

PostsRepliesMedia
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 11/09/2026
New paper in Current Biology @currentbiology.bsky.social 🦠 Why do bacteria ditch their T6SS weapon? E. coli keeps it vs susceptible rivals, but loses it when facing immune ones. Great work by @bobytaillefer.bsky.social & Jonas Desjardins! www.cell.com/current-biol...
cell.com
Experimental evolution reveals genetic routes for adaptive loss of the antibacterial type VI secretion system
Taillefer et al. show that a bacterial type VI secretion system is lost or attenuated during experimental evolution when it provides no competitive advantage but is maintained in the presence of susce...
02713
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 07/08/2026
Happy to share our latest review on the "Structure and function of the #T9SS for protein secretion and cellular motility" to be published in the incoming volume 80 of Annual Review in Microbiology. Kudos to Yaelle Aouizerate and @thicoz.bsky.social ! www.annualreviews.org/content/jour...
24021
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 18/06/2026
Extension of the deadline for latecomers. Register to the Secretion Days in Marseille !
01010
Reposted by Maelle Paillat
Jeunes microbiologistes de la SFM @jm-sfm.bsky.social · 04/06/2026
Ce mois-ci, Marie nous présente 𝗹'𝗮𝗿𝘁𝗶𝗰𝗹𝗲 𝗰𝗼𝘂𝗽 𝗱𝗲 ❤️ 𝗱𝘂 𝗥𝗲𝗝𝗠𝗶𝗙 : Vous êtes vous déjà demandé comment remporter la victoire dans une compétition inter-bactérienne ? 𝗣𝗮𝗶𝗹𝗹𝗮𝘁 𝗲𝘁 𝗮𝗹., oui ! Ils ont découvert la stratégie de 𝘍𝘭𝘢𝘷𝘰𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘶𝘮 𝘫𝘰𝘩𝘯𝘴𝘰𝘯𝘪𝘢𝘦 pour éliminer ses concurrents ! urlr.me/yAHSbK
085
Reposted by Maelle Paillat
PLOS Biology @plosbiology.org · 05/06/2026
The T6SS is a widespread nanoweapon deployed by #bacteria, but why is it deployed heterogeneously? @cascaleslab.bsky.social &co show that #Ecoli adopt distinct #T6SS attacker "ON" & defender "OFF" roles to optimize survival, a key strategy in microbial warfare @plosbiology.org 🧪 plos.io/3S5dL45
Top: Representative confocal fields of the 3 types of TssC-GFP-TssK microcolonies (homogeneous ON, heterogeneous, homogeneous OFF). Scale bars, 10 μm. Bottom:  Model for the role of T6SS phenotypic heterogeneity in EAEC. Top: The Psci1 promoter integrates Fur- and Dam-dependent regulation, generating ON (T6SS⁺, yellow) and OFF (T6SS⁻, blue) subpopulations at a reversible equilibrium. Bottom left: OFF (blue) cells, which do not express T6SS, do not kill competitors but avoid triggering such defences (1). Due to the absence of killing activity, OFF cells are unable to colonize the niche (2). Bottom centre: While ON (yellow) cells assemble and deploy functional T6SS (1) and kill susceptible competitors (2), they provoke retaliatory attacks from defensive T6SS⁺ species (gray) and are eliminated and fail to colonize the niche (3). Bottom right: Heterogeneous ON/OFF population (1) optimizes colonization by killing neighboring cells (2). While ON (yellow) cells are eliminated by counterattacks by defensive T6SS+ species (gray), OFF (blue) cells resist (3) and can ensure a continuous supply of ON cells (4-5) while limiting population-wide exposure to retaliation.
1176
Maelle Paillat @maellepllt.bsky.social · 08/05/2026
Very happy to see the second story from my PhD out in @currentbiology.bsky.social An exciting project where we explored the roles of secretion systems and gliding motility in predatory behavior in F. johnsoniae. www.cell.com/current-biol...
cell.com
Type VI and type IX secretion systems and gliding motility contribute to facultative predation by Flavobacterium johnsoniae
Paillat et al. show that Flavobacterium johnsoniae combines type VI and type IX secretion systems with gliding motility to efficiently kill diverse bacterial competitors. They demonstrate that nutrien...
1186
Reposted by Maelle Paillat
Marie Vasse @marievasse.bsky.social · 23/02/2026
Interested in microbial predation? Join us in Ticino Switzerland on July 27-31, 2026! More info at microbialpredation.ethz.ch #predation #ecology #evolution #microbes
11212
Maelle Paillat @maellepllt.bsky.social · 16/11/2025
Proud to share my first first-author article from my PhD! A big thank to my chiefs @thicoz.bsky.social @cascaleslab.bsky.social and congratulations to all co-authors @audebertstephane.bsky.social @Caterina comas
1142
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 09/10/2025
Open position to work on Type IX secretion (#T9SS) in our lab, in collaboration withe the group of Eric Reynolds at the Dental School of the University of Melbourne. Please spread the word, and forward to anyone potentially interested ! Apply here: emploi.cnrs.fr/Offres/Docto...
emploi.cnrs.fr
Portail Emploi CNRS - Offre d'emploi - Thèse en Microbiologie-Biochimie (H/F)
02535
Reposted by Maelle Paillat
Julien GIRAUD @juliengiraud.bsky.social · 04/10/2025
Amazing science at the 2nd edition of the Secretion Days in Marseille 🌞 ! Huge thanks to all participants and to @archaellum.bsky.social for an outstanding opening talk. Looking forward to the next edition!
5207
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 08/07/2025
We have an open engineer position to work on type IX secretion (T9SS), under the supervision of @doan_thierry (collab with HP Fierobe & A. Tolonen). 1-year contract, renewable up to 3.5 years. Please apply here or forward to anyone potentially interested: emploi.cnrs.fr/Offres/CDD/U...
emploi.cnrs.fr
Portail Emploi CNRS - Offre d'emploi - Ingénieur d'Etude en Microbiologie (H/F)
02332
Reposted by Maelle Paillat
Abhishek Shrivastava @shrivastavalab.bsky.social · 13/06/2025
Our paper on how a conveyor belt-associated protein of T9SS-driven gliding bacteria acts as a molecular switch, reversing T9SS rotation to fine-tune movement - like a smart conveyor or biological snowmobile adapting to changing terrain is out now in @mbio.bsky.social journals.asm.org/doi/10.1128/...
journals.asm.org
A molecular conveyor belt-associated protein controls the rotational direction of the bacterial type 9 secretion system | mBio
The type 9 secretion system (T9SS) is fundamental to bacterial gliding motility, pathogenesis, and surface colonization. Our findings reveal that the C-terminal region of the conveyor belt-associated ...
073
Reposted by Maelle Paillat
Glen Dsouza @nonresidentdesi.bsky.social · 13/06/2025
Thrilled to share our new paper in @science.org describing our discovery that bacteria can switch from competitors to bonafide predators when resources run dry—arming nanoscale “spears” (T6SS) to stab & consume neighbours. www.science.org/doi/10.1126/... #MicroSKy #Microbiology
science.org
Antagonism as a foraging strategy in microbial communities
In natural habitats, nutrient availability limits bacterial growth. We discovered that bacteria can overcome this limitation by acquiring nutrients by lysing neighboring cells through contact-dependen...
1213271
Reposted by Maelle Paillat
Julien GIRAUD @juliengiraud.bsky.social · 13/05/2025
👉Reminder : ONE WEEK LEFT👈 📅 Secretion Days 2025 will take place on October 2–3 in Marseille 🌊 🎤Invited speaker : Sonja-Verena Albers; @archaellum.bsky.social 🆓 Free, spot are limited ! 📥 Registration is open until May 20 via the following link: docs.google.com/forms/d/e/1F...
docs.google.com
Journées Sécrétion 2025
Contact: secretion@imm.cnrs.fr
112
Maelle Paillat @maellepllt.bsky.social · 29/04/2025
A great opportunity to meet the Secretion community and to enjoy our sunny city !
030
Maelle Paillat @maellepllt.bsky.social · 17/03/2025
The Journées Sécrétion are back! 2nd and 3rd October in Marseille Keynote lecture by: @archaellum.bsky.social Registration is open until May 15: forms.gle/2qxHntTktoxw... Organized by Romé Voulhoux @lcbofficiel.bsky.social, @cascaleslab.bsky.social, Thierry Doan, @juliengiraud.bsky.social
1138
Reposted by Maelle Paillat
bioRxivpreprint @biorxivpreprint.bsky.social · 10/02/2025
Molecular bases for the loss of type VI secretion system activity during enteroaggregative E. coli experimental evolution www.biorxiv.org/content/10.1101/202…
001
Reposted by Maelle Paillat
Cascales Lab @cascaleslab.bsky.social · 18/01/2025
We have an open PhD position to work on bacterial secretion systems. Please RT, write us or apply through the CNRS job portal: t.co/HxX23Od1oa
t.co
https://emploi.cnrs.fr/Offres/Doctorant/UMR7255-ERICAS-004/Default.aspx?lang=EN
14554