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Patrick Moynihan

@pmoyniha.bsky.social
760 followers 529 following 180 posts

Interested in all things mycobacteria and cool science broadly. Ass. Prof at the Univ. of Western Ontario. Editor for Microbiology. Views are mine. @pmoyniha@mstdn.science, @pmoyniha pmoyniha.github.io/moynihan-lab

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Reposted by Patrick Moynihan
Louis Ates @mycolates.bsky.social · 28/09/2026
Hey all, If you're interested in the work we do on designing mRNA encoded TB vaccines at BioNTech, check out this webinar I gave recently for the @isv-news.bsky.social webinar series. youtube.com/playlist?lis...
youtube.com
ISV Webinar Series - YouTube
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Reposted by Patrick Moynihan
Alex Merz 🇺🇸🇨🇦🇺🇦 @merz.bsky.social · 08/09/2026
Anyone who opposes universal vaccination for HPV is in the pocket of the pro-cancer lobby.
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Jim Sun, PhD @sunlab.bsky.social · 09/09/2026
We are looking for a postdoctoral fellow to join the team @ubcmicroimmuno.bsky.social @science.ubc.ca to study TB pathogenesis and host-directed therapy! Please help disseminate amongst your network. ubc.wd10.myworkdayjobs.com/ubcfacultyjo...
ubc.wd10.myworkdayjobs.com
Postdoctoral Research Fellow - Host-Pathogen Interactions & Host-Directed Therapeutics
Academic Job Category Faculty Non Bargaining Job Title Postdoctoral Research Fellow - Host-Pathogen Interactions & Host-Directed Therapeutics Department Research I Sun I Department of Microbiology...
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Reposted by Patrick Moynihan
Alex Usher @alexusherhesa.bsky.social · 02/09/2026
Here is my letter to the MacDonald Laurier Institute on the subject of their appalling research. Use as you will. I recommend sending something of your own, though. And if you know anyone associated with MLI - and Board directors, say - send it to them, too.
docs.google.com
Alex Usher email to Brian Lee Crowley
(text of an email sent to Brian Lee Crowley of the MacDonald Laurier Institute on September 2, 2026) Dear Brian, I am writing to you and your board with respect to the publication “The equity excelle...
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Tracy Palmer @proftracypalmer.bsky.social · 25/08/2026
Happy to see this work preprinted! Only our second foray into the mycobacterial T7SS
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Ravi Menon @northernthrux.bsky.social · 25/08/2026
Stop. Blaming.Universities. The fundamental problem is there is no venture capital in Canada. It’s why Canadian tech leaders all move south.
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Lis Lowe @lislowe.bsky.social · 15/08/2026
New preprint out - Jenn’s hard work over the last few years collaborating with @jnb-lab.bsky.social, Overkleeft Lab in Leiden, Spencer Williams, Hannah Bridges at Cryosparc and @pmoyniha.bsky.social. Feat. her beautiful 1.5A cryo structure with a covalent inhibitor 😍. www.biorxiv.org/content/10.6...
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Patrick Moynihan @pmoyniha.bsky.social · 02/08/2026
Took the family to see the MC Escher exhibit in Montreal. Loved seeing lots of commentary about the influence of crystallography on his work.
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Reposted by Patrick Moynihan
Michael Glickman @michaelglickman.bsky.social · 23/07/2026
Please repost! #microsky🦠 The Glickman Lab at MSK is recruiting! Projects in Mtb pathogenesis, basic biology of mycobacteria, and mycobacterial cancer therapies. See our publications here: tinyurl.com/3f386f4x Send CV and cover letter to: glickmanmycolab@gmail.com
scholar.google.com
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Patrick Moynihan @pmoyniha.bsky.social · 22/07/2026
Very fortunate to get my lab up and running at @westernu.ca over the last year with new grants from NSERC and now CIHR. Excited about the future for our lab, but overall success rates need to improve in Canada.
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bioRxiv Biochemistry @biorxiv-biochem.bsky.social · 10/07/2026
Denuded peptidoglycan oligosaccharides enable the biochemical investigation of bacterial cell wall recognition, modification, and degradation www.biorxiv.org/content/10.64898/20…
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Reposted by Patrick Moynihan
Count Binface @countbinface.bsky.social · 09/07/2026
What’s that, Dale? You want to give me an unconditional personal gift of £5million to do whatever I want with? Sure! I just need to fill out a form. If I didn’t declare it that would be silly.
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Patrick Moynihan @pmoyniha.bsky.social · 03/07/2026
Found this photo of me writing my PhD thesis. Not shown is my daughter who was a month old at the time.
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Melanie Blokesch @mblokesch.bsky.social · 29/03/2026
Open postdoc position in my lab on HGT and interbacterial competition. We seek candidates with a PhD in microbiology (or related fields)+ strong 1st-author publications. Curious, highly motivated, and dedicated team players ready to contribute fully are encouraged to apply. Details: tiny.cc/cz01101
tiny.cc
Open Positions
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Patrick Moynihan @pmoyniha.bsky.social · 29/06/2026
To give folks a sense of how bad the heat was in the UK last week, my lab had to put some solvents in the fridge because the lab was over the boiling point for several. Single paned glass and zero air control @unibirmingham.bsky.social
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Patrick Moynihan @pmoyniha.bsky.social · 28/06/2026
Amazing to see Canada as the first club out of the round of 32. 🇨🇦🇨🇦🍁🍁🇨🇦🇨🇦🍁🍁🇨🇦🇨🇦
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Ran Blekhman @blekhman.bsky.social · 27/06/2026
I wanted to like QED's new 1% preprint ranking. I really did. But the more I looked at the data, the more uncomfortable it made me. Here is my full peer review. open.substack.com/pub/blekhman...
open.substack.com
My Peer Review of The 1%
I wanted to like QED's new 1% ranking. I don't.
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Drug Monkey @drugmonkey.bsky.social · 28/06/2026
“The biases do not disappear; they get encoded into the model and then laundered into outputs that feel objective because they are numerical. “
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christoph_STCmicrobeblog @christophstc.bsky.social · 26/06/2026
...with their signature 'knick' during cell division! chapeau to your daughter, pat 👏
source: https://www.nature.com/articles/s41564-024-01846-z
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Patrick Moynihan @pmoyniha.bsky.social · 26/06/2026
To celebrate the new paper my 12 year old daughter made me a dividing TB cell.
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Tracy Palmer @proftracypalmer.bsky.social · 25/06/2026
This has been such a fun collaboration and a great example of team science
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Tracy Palmer @proftracypalmer.bsky.social · 24/06/2026
Check out our latest T7SS toxin story. These reverse toxins aren’t as rare as we thought!
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Thomas Lemberger @tlemberger.bsky.social · 24/06/2026
We have journals with impact factor >40 We have journals with acceptance rates <5% Now we have the QED 1% superstar list... Great progress? QED is a great tool for authors to pre-check their papers. But fuelling the ranking frenzy through QED score optimization? Is this the revolution we want?
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Joe @twitskeptic.sirvin.com · 24/06/2026
Scammy. They train on your submitted papers. They sell the personal info they get via their loss leader "free" server. Check out the privacy policy and terms of use.
Customer Data. Subject to the confidentiality obligations set forth herein, you hereby grant QED a non-exclusive, worldwide, non-revocable license to: (i) use, process, display, copy, and store the Customer Data (as defined below) in order to generate reports for you; (ii) train, fine-tune, and evaluate QED’s models; and (iii) create aggregated or anonymized analytics that QED may share or commercialize. QED will never publicly release, republish, or cite an unpublished manuscript without your explicit consent; assert authorship of your works or content; or interfere with publisher copyright choices. No model provider used by QED to provide the Service may train its own foundation models on user data without QED’s control. The license granted herein shall terminate when you delete the relevant Customer Data, except that (a) back-ups may persist for up to thirty (30) days, and (b) parameters learned by models are not retroactively editable or removable. You acknowledge that the Service does not operate as an archive or file storage service. You are solely responsible for the backup of Customer Data, and you alone can implement back-up plans and safeguards appropriate for your requirements. “Customer Data” means your research paper that you upload into the Service and any data provided by you to us for the purpose of and in connection with your use of the Service. You shall own all rights, title, and interest in and to all of the Customer Data. You represent and warrant that you own or have obtained the rights to all of the rights subsisting in the Customer Data and you have the right to provide us the license granted herein to use such Customer Data in accordance with these Terms. You shall have sole responsibility for the reliability, integrity, accuracy, and quality of the Customer Data.
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Patrick Moynihan @pmoyniha.bsky.social · 24/06/2026
New paper in collaboration with @proftracypalmer.bsky.social, @lislowe.bsky.social and many more. We show that mycobacteria produce Type VII secreted anti-bacterial protein toxins. Excited to explore this new area of mycobacterial biology. www.nature.com/articles/s41...
nature.com
A Type VII-secreted toxin enables inter-mycobacterial competition - Nature Communications
Mycobacteria have not yet been reported to engage in interbacterial competition via secretion of proteinaceous toxins. Here, Benedict et al. show that some mycobacteria can use their type-VII secretio...
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Robert Insall @robinsall.bsky.social · 24/06/2026
This, emphatically, shouldn't have been done, and shouldn't be used. You'd think we'd have learned that someone else's contextless algorithmic division of science outputs into "the best" and "not the best" is a disaster. Doesn't matter whether AI or Elsevier does it. the-one-percent.qedscience.com
the-one-percent.qedscience.com
QED — The most compelling preprints of 2025
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Reese Richardson @reeserichardson.bsky.social · 05/06/2026
The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
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Reposted by Patrick Moynihan
Carl T. Bergstrom @carlbergstrom.com · 29/05/2026
Of all the harm this administration has done to US science, today's proposed changes to the way federal grants are awarded and administered is the most damaging yet. The text of the federal register document is impenetrably tedious by design, so here's an excellent summary of what it says.
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Reese Richardson @reeserichardson.bsky.social · 28/05/2026
TL;DR: We've identified more than 100 cases of apparent manipulation in Thermo Fisher Scientific's antibody verification data. @sholtodavid.bsky.social @johanduchene.bsky.social reeserichardson.blog/2026/05/28/h...
reeserichardson.blog
How much of Thermo Fisher’s antibody data has been manipulated?
We’ve documented more than 100 instances of apparent data manipulation in Thermo’s catalog
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Wilbert Bitter @wilbertbitter.bsky.social · 22/05/2026
shocking statistics, but only limited public outcry.. We should be more vocal about this tb.impactcounter.com
tb.impactcounter.com
Tuberculosis Impact Counter | Tracking TB Funding Impact
Tracking the impact of TB funding via USAID
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Reposted by Patrick Moynihan
Reese Richardson @reeserichardson.bsky.social · 21/05/2026
@johanduchene.bsky.social @sholtodavid.bsky.social Spent the last hour looking, found ten more apparently manipulated Western blots in Thermo Fisher's antibody verification data (across eight different catalogued products). Thread below. www.thermofisher.com/antibody/pro...
Apparent manipulation in the antibody verification data in Thermo Fisher's online catalog
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Sholto David @sholtodavid.bsky.social · 17/05/2026
Surprised to discover that Thermo Fisher appears to show a fake western blot for the validation of one of their p53 antibodies. I've added a diagram to show the very similar bands. This does not appear to be one of the "published figures" but their own internal data.
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Andrew Pruszynski @andpru.bsky.social · 14/05/2026
CIHR has launched a trial ballon that suggests shifting to one competition a year. This is the worst idea I have heard in a long time. The only benefit is making top-line success rates look better than they are. Keep it as is, do in-person reviews, and keep the pain in the open.
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Amit Chandra, MD @amitchandramd.bsky.social · 14/05/2026
Via @madhupai.bsky.social: "...every US$1 invested in TB yields $46 in benefits." "Greater investments by high-burden countries make them less reliant on development assistance and more likely to have a sustainable TB response"
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Daniel Padfield @padpadpadpad.bsky.social · 14/05/2026
BBSRC Early Independence Fellowships had an Outline stage this year to try help with amount of peer review. Turns out they received 586 applications, a 110% increase on 2025, and only typically fund 15 a year. They are cancelling this stage and going straight to full app with an institutional sift.
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Patrick Moynihan @pmoyniha.bsky.social · 06/05/2026
This is super cool. Perhaps finally pointing towards a purpose for vaults?
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Reposted by Patrick Moynihan
Daniel L. Barber, PhD @danbarberphd.bsky.social · 29/04/2026
So we blocked IFNγ in Mtb infected macaques and….the animals were fine. Turns out mice overestimate the importance of IFNγ in TB because IFNγ drives iNOS in mice but not macaques or humans. This means we don’t actually know how T cells suppress Mtb. rdcu.be/ff9GB #tuberculosis #immunology
rdcu.be
IFNγ blockade in Mycobacterium tuberculosis infected macaques alters the granuloma environment but not bacterial control
Nature Communications - Here, the authors show that IFNγ blockade does not impair resistance to Mycobacterium tuberculosis infection in macaques, opposed to what has been observed in mice, due...
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Lis Lowe @lislowe.bsky.social · 29/04/2026
We have a PhD studentship open! (UK only sadly) but if you are or know a student keen to work on some *really* weird mycobacterial enzymes then get in touch! #glycotime Advert below www.findaphd.com/phds/project...
findaphd.com
Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University on FindAPhD.com
PhD Project - Uncovering a new class of toxins in pathogenic mycobacteria at Newcastle University, listed on FindAPhD.com
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Wyoming Wormboy @wyomingwormboy.bsky.social · 25/04/2026
Please repost! This comes from the good people at ChimeraX, who produce powerful up-to-date software to study protein (etc) structures, which are FREE to the community. 🙏 To stay viable and serve us, they need an experienced structural biologist to assume the leadership role on a funded project.
aprecruit.ucsf.edu
Faculty Position – In-Residence
University of California, San Francisco is hiring. Apply now!
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Patrick Moynihan @pmoyniha.bsky.social · 21/04/2026
This is one of the cooler papers I have seen in a while: journals.asm.org/doi/10.1128/...
journals.asm.org
Facultative predation expands the ecological repertoire of Streptomyces | mBio
Soil is a rich environment for microbes, where they compete for space and resources. Streptomyces bacteria are well known for their ability to synthesize natural products, particularly antibiotics, th...
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Kimberly Beatty @beattylab.bsky.social · 20/04/2026
New work from my team: pubs.acs.org/doi/10.1021/... We used probes to ID targets of carbapenems in M. abscessus. 17 targets active in both carbon starved and replicating cultures. Includes validation of 9 targets. Part of a special issue ("NTM Pathogens – Biology, Infection, and Drug Discovery).
pubs.acs.org
Chemoproteomic Elucidation of β-Lactam Drug Targets in Mycobacterium abscessus
The pathogen Mycobacterium abscessus (Mab) can cause severe and difficult-to-treat chronic lung infections. Despite the rising incidence and clinical concern of Mab infections, treatment options are l...
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Dr Katherine Duncan @kateduncan.bsky.social · 16/04/2026
Wonderful to have @pmoyniha.bsky.social from Western University, Canada (hosted by @lislowe.bsky.social) giving a @mhd-newcastle.bsky.social seminar @medicalsciencesncl.bsky.social @newcastleuni.bsky.social #mycobacterium #tb #cellwalls
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Fiona J Whelan @whelanfj.bsky.social · 13/04/2026
Each publication in a #Microbio26 journal helps fund 4 student travel grants. Please publish with us if you can!
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Patrick Moynihan @pmoyniha.bsky.social · 13/04/2026
Always nice to have the chance to visit a UNESCO site. Giant’s Causeway, NI.
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Patrick Moynihan @pmoyniha.bsky.social · 10/04/2026
Looking forward to attending the @microbiologysociety.org annual general meeting in Belfast. I'll be speaking in the Mycobacteria session on Tuesday. Also plenty of posters from the group!
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Willem van Schaik @wvschaik.bsky.social · 09/04/2026
If you are working on staphylococci you might want to travel to Banff this September banff.isssi2026.com/event/ISSSI/...
banff.isssi2026.com
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Dutchscientist (the real one) @dutchscientist.bsky.social · 29/03/2026
www.pnas.org/doi/10.1073/... If you ever need lto be convinced by how bad the "Contributed by" track is at @pnas.org ... Only author: David Lipman, handling editor: David Lipman. Only integrity-free person not embarrassed by such a paper: David Lipman. Even uses "I did" in the abstract. Shameful.
pnas.org
Genomic epidemiology of Salmonella and Campylobacter in poultry production: Quantifying the contribution of primary breeders | PNAS
The US broiler production system processes over 9.3 billion chickens annually through a highly integrated pyramid structure where two primary breed...
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ᐯIᑕTOᖇ ᑎIᘔET, ᗰᗪ @nizet.bsky.social · 25/03/2026
Please Repost 🔄 Global Staphylococcus research community is heading to the Canadian Rockies! Join the 20th International Symposium on Staphylococci and Staphylococcal Infections 📅 September 20–24, 2026 📍 Banff Centre for Arts and Creativity, Banff, Canada #ISSSI2026 #Staphylococcus
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Patrick Moynihan @pmoyniha.bsky.social · 27/03/2026
PSA: If you are thinking about putting a 3D data plot into an output that will primarily be viewed in 2D, don't.
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Patrick Moynihan @pmoyniha.bsky.social · 27/03/2026
I should add this is just the tip of the iceberg. Plenty more to come on this story from our group, @proftracypalmer.bsky.social, @lislowe.bsky.social and others. There is such an astonishing diversity of toxins in these bacteria and so much we don't yet fully understand.
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