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Xavier De Bolle : Xa Team at UNamur

@namurxa.bsky.social
129 followers 121 following 15 posts

Research team interested in molecular and cellular biology of the Brucella abortus pathogen

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Reposted by Xavier De Bolle : Xa Team at UNamur
Cascales Lab @cascaleslab.bsky.social · 07/08/2026
Happy to share our latest review on the "Structure and function of the #T9SS for protein secretion and cellular motility" to be published in the incoming volume 80 of Annual Review in Microbiology. Kudos to Yaelle Aouizerate and @thicoz.bsky.social ! www.annualreviews.org/content/jour...
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Reposted by Xavier De Bolle : Xa Team at UNamur
bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 09/07/2026
A polarity-controlled Tad nanomachine enables prey invasion in a bacterial predator www.biorxiv.org/content/10.64898/20…
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Reposted by Xavier De Bolle : Xa Team at UNamur
Dr. Sunny Shin @sunnyshinlab.bsky.social · 28/02/2026
Please join us for the Cold Spring Harbor Asia @cshlnews.bsky.social meeting on Bacterial Infection & Host Defense this May 11-15 in Suzhou, China! We have a fantastic lineup of speakers. Abstract deadline is March 6. Hope to see you there!
Poster of the 2026 CSHA meeting on Bacterial Infection & Host Defense.
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Reposted by Xavier De Bolle : Xa Team at UNamur
Badreddine Douzi @badreddinedouzi.bsky.social · 18/02/2026
Happy to share a new review proposing a unified nomenclature for T4SSs. Great collaboration with Peter J Christie, Gabriel Waksman, Ronnie Per-Arne Berntsson and our team. academic.oup.com/femsre/artic... #T4SS#Microbiology
academic.oup.com
Type IV secretion systems: reconciling diversity through a unified nomenclature
This review presents a comprehensive overview of Type IV Secretion Systems (T4SSs), focusing on their structural, functional, and evolutionary diversity ac
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Reposted by Xavier De Bolle : Xa Team at UNamur
Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 07/02/2026
Cytosine methylation contributes to the fitness of Caulobacter cells naturally expressing a Vsr-like protein: iScience www.cell.com/iscience/ful... 🦠
cell.com
Cytosine methylation contributes to the fitness of Caulobacter cells naturally expressing a Vsr-like protein
Properties of biomolecules; Epigenetics; Microbial genomics; Transcriptomics
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Reposted by Xavier De Bolle : Xa Team at UNamur
Marie Delaby @mariedelaby.bsky.social · 02/02/2026
CauloCon 2026 is coming! 🔬✨ March 3–5 (fully virtual + free). Keynotes by Yves Brun, Becky Lamason & Martin Thanbichler. Great chance for grad students & postdocs to present their work (work-in-progress welcome!). Submit an abstract by Sun Feb 8. Register + submit: www.caulocon.com
caulocon.com
CauloCon 2026
A free, 3-day virtual meeting on all things Caulobacter and Alphaproteobacteria
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Reposted by Xavier De Bolle : Xa Team at UNamur
Carolyn Bertozzi @carolynbertozzi.bskyverified.social · 06/01/2026
Cool new chemistry for covalent ligand development targeting arginine 👏
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Reposted by Xavier De Bolle : Xa Team at UNamur
Luiz Pedro Carvalho, PhD @luizcarvalholab.bsky.social · 22/12/2025
We’re excited to share our latest study that reshapes our understanding of Mycobacterium tuberculosis (Mtb) lipid composition, with major implications for drug discovery, immunity, and vaccine development. www.nature.com/articles/s41... A thread.
nature.com
Mycobacterium tuberculosis overcomes phosphate starvation by extensively remodelling its lipidome with phosphorus-free lipids - Nature Communications
Here, the authors show that Mycobacterium tuberculosis manipulates lipid metabolism to overcome host restriction, by remodelling its lipidome and utilising host lipids as an alternative phosphate sour...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Kimberly Kline 🏔 @kimingeneva.bsky.social · 18/12/2025
🧵Enterococcus faecalis is not just an extracellular organism. 🧵 A growing body of work shows it can survive + REPLICATE inside host cells, and that intracellular life may seed persistence, dissemination, and reinfection. 1/n #MMBR @asm.org journals.asm.org/doi/10.1128/...
journals.asm.org
Enterococcus faecalis: an overlooked cell invader | Microbiology and Molecular Biology Reviews
SUMMARYEnterococcus faecalis and Enterococcus faecium are human pathobionts that exhibit a dual lifestyle as commensal and pathogenic bacteria. The pathogenic lifestyle is associated with specific conditions involving host susceptibility and intestinal ...
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Reposted by Xavier De Bolle : Xa Team at UNamur
STCmicrobeblog @stcmicrobeblog.bsky.social · 12/12/2025
did you notice, there 's a new kid on the (alpha)block... and it competes with Caulo for the cutest shape (*hides under cushion)
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Reposted by Xavier De Bolle : Xa Team at UNamur
Michael Deghelt @michaeldeghelt.bsky.social · 13/11/2025
The diderm cell envelope is not a stack of layers but a unified scaffold of Inner Membrane–Peptidoglycan–Outer Membrane. We discuss how tethering the OM to the PG in E. coli preserves integrity — and extend the concept across diderm bacteria. Curr Opin Microbiol: doi.org/10.1016/j.mi... #microsky 🔬
doi.org
Redirecting
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Xavier De Bolle : Xa Team at UNamur @namurxa.bsky.social · 22/11/2025
New preprint of the Brucella team in Namur. Our first suppressor analysis 😉 www.biorxiv.org/content/10.1...
biorxiv.org
Brucella abortus histidine auxotrophs are copper sensitive
Despite decades of investigation into bacterial pathogens, the conditions met by intracellular bacteria are still unclear. These conditions can include access to nutrients, such as amino acids, and ex...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Martin Thanbichler @thanbichlerlab.bsky.social · 02/11/2025
📢 Postdoc position: Cell Biology of Cyanobacteria in my group, as part of the Excellence Cluster "Microbes for Climate" (M4C) in Marburg, Germany. More information at shorturl.at/wNnDT (see Project 2) 🔗Apply at shorturl.at/VsEDl 📅Deadline: Nov 16, 2025 Please repost. #Postdoc
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Reposted by Xavier De Bolle : Xa Team at UNamur
Yves Brun lab @brunlabcaulo.bsky.social · 31/10/2025
Forgot to post the recently published version of this paper on the role of a minor pilin-like protein in surface sensing journals.asm.org/doi/10.1128/...
journals.asm.org
Stimulation of the Caulobacter crescentus surface sensing pathway by deletion of a specialized minor pilin-like gene | mBio
Surface sensing allows bacteria to colonize surfaces and form biofilms, with wide-ranging implications for bacterial survival, ecology, and human health. In Caulobacter crescentus, tight adherence (Ta...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Eva Nowack @evanowack.bsky.social · 01/11/2025
✨X-ray crystallography reveals surprising twist in how proteins enter the unique photosynthetic organelles of Paulinella. The chromatophore targeting peptide (crTP) folds into a 3D structure, hinting that folded proteins cross peptidoglycan and inner membrane. (1/2) academic.oup.com/plphys/artic...
crTP X-ray structure
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Reposted by Xavier De Bolle : Xa Team at UNamur
Géraldine Laloux @lalouxlab.bsky.social · 25/09/2025
📝New preprint! #MicroSky 🕰️We chart the full, synchronized lifecycle of a predatory bacterium using Hi-C, RNA-seq, ChIP-seq & microscopy. 🧬We uncover dramatic shifts in nucleoid architecture & transcription, tightly coordinated with predation. www.biorxiv.org/content/10.1...
biorxiv.org
Dynamics and interplay of gene expression and chromosome organization across a predatory lifecycle
The obligate predatory bacterium Bdellovibrio bacteriovorus alternates between a motile attack phase and a growth phase inside another bacterium, during which it undergoes multiple rounds of DNA repli...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Géraldine Laloux @lalouxlab.bsky.social · 17/09/2025
🚨New paper out! #MicroSky Studying obligate predators like Bdellovibrio bacteriovorus is tricky—essential genes for predation are also essential for survival. We expanded its genetic toolbox: 🧬promoters to fine-tune expression 🧬IPTG-inducible system 🧬CRISPRi for rapid knockdown bit.ly/46GUn2c 1/4
academic.oup.com
Expanding the genetic toolbox of the obligate predatory bacterium Bdellovibrio bacteriovorus with inducible gene expression and CRISPR interference
Inducible gene expression and CRISPR interference-mediated depletion in the predatory bacterium Bdellovibrio bacteriovorus.
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Reposted by Xavier De Bolle : Xa Team at UNamur
Yoann Santin @ysantin.bsky.social · 11/09/2025
I wrote a Preview in @cp-cellhostmicrobe.bsky.social ! A new study suggests that #curli may protect prey from bacterial predators like #Bdellovibrio. Really looking forward to seeing this model confirmed with live-cell imaging and specific reporters! www.cell.com/cell-host-mi...
cell.com
When predators meet the matrix: Natural resistance via amyloid fibers
How do bacteria protect themselves against predators? In a recent issue of Nature, Ledvina et al. reveal curli fibers as a genetically encoded defense against Bdellovibrio predation in wild E. coli st...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Justine Collier @justinecollier.bsky.social · 05/09/2025
🤩 Exciting Summer! 🤩 Two of my former postdocs in Switzerland🇨🇭 obtained Lecturer positions (Maîtres de Conférences) in French universities 🇨🇵 : congrats to Antonio Frandi and Florian Fournès !!!! 👏 La relève est assurée! All the best to both of you for this new start. 🤩
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Reposted by Xavier De Bolle : Xa Team at UNamur
Nena of Ely @nenaofely.bsky.social · 23/08/2025
If the fossil fuel industry didn’t have our president and corporate America by the throat, we could have nice things like this too.
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Reposted by Xavier De Bolle : Xa Team at UNamur
César Sánchez @twistedbacteria.bsky.social · 22/08/2025
How Israel's policies created famine in Gaza bbc.com/news/article...
bbc.com
How Israel's policies created famine in Gaza
Israel has systematically obstructed food entering Gaza, aid agencies say, as a UN-backed body confirms a famine.
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Xavier De Bolle : Xa Team at UNamur @namurxa.bsky.social · 13/08/2025
Great work by Adélie Lannoy on Brucella abortus, just published in The EMBO Journal www.embopress.org/doi/full/10..... Thanks to fantastic collaborators! An enigmatic, perhaps ancestral, protein complex predicted as a tunnel-like structure between membranes. Crucial for survival in macrophages
According to Alphafold3 predictions and homology modeling, the Mpc complex is composed of an octameric lipoprotein MpcA anchored at the outer membrane, interacting with a hexameric tunnel-like MpcD, itself associated with an inner membrane complex comprising MpcE and MpcF ATPase. Absence of the Mpc complex modifies the lipid composition of outer membrane vesicles, suggesting that Mpc could be involved in lipid transport between inner and outer membrane.
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Reposted by Xavier De Bolle : Xa Team at UNamur
The EMBO Journal @embojournal.org · 06/08/2025
Xavier DeBolle @namurxa.bsky.social and collaborators identify and characterize a novel conserved complex mediating lipid-transport between inner and outer membrane in gram-negative Brucella abortus bacteria www.embopress.org/doi/full/10....
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Reposted by Xavier De Bolle : Xa Team at UNamur
Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 03/08/2025
Queuosine is incorporated into precursor tRNA before splicing 💫 intron-containing precursors of tRNATyr are modified with Q or with galQ before being spliced #rnasky from @francescatuorto.bsky.social lab with @sebastianglatt.bsky.social and Helm labs www.nature.com/articles/s41...
nature.com
Queuosine is incorporated into precursor tRNA before splicing - Nature Communications
tRNA modifications are essential for function, yet their timing relative to processing is unclear. Here, the authors show that queuosine and derivative modifications occur before splicing of pre-tRNA^...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Yoann Santin @ysantin.bsky.social · 14/07/2025
Excited to share our newly book chapter on using #miniTurbo proximity labeling in #bacteria We wrote it as a hands-on guide for anyone looking to get started with this approach. Congrats to @coralietesseur.bsky.social and Ophélie Remy 👏 @lalouxlab.bsky.social link.springer.com/protocol/10....
link.springer.com
Identification of In Vivo Protein Networks Using miniTurbo Proximity Labeling in Bacteria
Protein–protein interactions play a crucial role in many bacterial cell processes. miniTurbo-based proximity labeling has emerged as a powerful tool for the identification of in vivo protein net...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Géraldine Laloux @lalouxlab.bsky.social · 25/07/2025
#MicroSky Summer read! Predatory bacteria kill and eat other bacteria. Their deadly actions come in many flavors, often via direct physical contact between predator & prey 🧛 How do they do it? Our review 📖 @coralietesseur.bsky.social @ysantin.bsky.social www.sciencedirect.com/science/arti...
sciencedirect.com
Strategies and mechanisms of contact-dependent predation in bacteria
Predatory bacteria kill other bacteria to acquire nutrients. Among diverse strategies to kill and feed on prey, contact-dependent predation stands out…
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Reposted by Xavier De Bolle : Xa Team at UNamur
Suzana Salcedo @suzanasalcedo.bsky.social · 21/07/2025
Charline studied how some clinical strains of Acinetobacter baumannii create a transient intracellular niche before infecting neighboring cells. Great collaboration with @kroegerlab.bsky.social If you are interested, check out her preprint! www.biorxiv.org/content/10.1...
Human endothelial cell infected with Acinetobacter baumannii strain ABC141. Bacteria are visible with Dapi in white along with the nucleus of the cell. Bacteria are mostly organized in a large cluster with a few scattered ones. Mitochondria are visible in red.
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Reposted by Xavier De Bolle : Xa Team at UNamur
Alex Crits-Christoph @acritschristoph.bsky.social · 29/06/2025
Cool result: Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii "Exposure of a transposon insertion mutant library to extended weak antibiotic selection ... revealed genes that indirectly increased fitness due to elevated general mutation rates"
journals.asm.org
Transposon insertion sequencing reveals novel hypermutator genes in Acinetobacter baumannii | mBio
All organisms have the capacity for evolution through mutation. Bacteria with high mutation rates have a survival advantage in some stressful environments because they generate beneficial mutations mo...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Séamus Holden 🔬🦠🧫 @seamusholden.bsky.social · 08/04/2025
Fellow bacterial cell biologists, message me if you use @thermofishersci.bsky.social Gene Frames for microscopy! Thermo are planning to discontinue these in September but have indicated they will look into this further. If I make list of labs using them Thermo might not kill the product Please RT🔬🦠
jove.com
Live Cell Imaging of Bacillus subtilis and Streptococcus pneumoniae using Automated Time-lapse Microscopy
42.1K Views. University of Groningen. This protocol provides a step-by-step procedure to monitor single cell behavior of different bacteria in time using automated fluorescence time-lapse microscopy....
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Reposted by Xavier De Bolle : Xa Team at UNamur
Andreas Bäumler @abaumler.bsky.social · 26/06/2025
The new open access policy of NIH will take effect next week (July 1st). All NIH funded research 🔬🧪🧬accepted after July 1st must be open access upon publication. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
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Erin Goley @goleylab.bsky.social · 06/06/2025
Just part of the Caulo crew at BCBD GRC. We would’ve gotten all the alphaphiles but it was too many people to herd into a pic!
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Zeynep Baharoglu @zeynepbaharoglu.bsky.social · 21/05/2025
Marie Curie fellowship, post-doc hosting oppotunity in my lab. MSCA Post-doctoral Fellowship at IBPC Paris on RNA modifications in bacteria (FRANCE) 🦠💫 euraxess.ec.europa.eu/jobs/hosting...
euraxess.ec.europa.eu
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Reposted by Xavier De Bolle : Xa Team at UNamur
Andreas Bäumler @abaumler.bsky.social · 04/04/2025
🚨 Big news! Infection and Immunity is now open access! 🌍🔬 That means wider visibility & impact for your research. Worried about fees? 💸 Check out how IAI stacks up against other journals—you might be surprised. #OpenAccess #SciComm #Microbiology
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RCSB Protein Data Bank @rcsbpdb.bsky.social · 27/03/2025
Thousands of 3D protein structures locked up in big-pharma vaults will be used to create a new AI tool that won’t be open to academics. www.nature.com/artic...
nature.com
AlphaFold is running out of data — so drug firms are building their own version
Nature - Thousands of 3D protein structures locked up in big-pharma vaults will be used to create a new AI tool that won’t be open to academics.
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Mandy Muller @mandymuller.bsky.social · 25/02/2025
For my first official post on here I have some news to share: the lab is moving! After ~12 wonderful years in the US, Muller lab 2.0 will reopen this summer at the Institute of Microbiology in Lausanne🇨🇭Switzerland🇨🇭! We'll be recruiting at all levels so keep us in mind for your future adventures!
Vue sur la Cité, le lac , les Alpes, Lausanne -- Fotograf: Regis Colombo 2014
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Eduardo Rocha @epcrocha.bsky.social · 27/03/2025
Phage satellites are now known to be very diverse, numerous and ancient. They pose many evolutionary, ecological and mechanistic questions. Lots of fun in perspective! Great pleasure to write this review to show it, with @jrpenades.bsky.social @dbikard.bsky.social Kim Seed & John Chen.
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Reposted by Xavier De Bolle : Xa Team at UNamur
Pauline Cherry @pauline-chry.bsky.social · 24/03/2025
We showed that iron import by a TonB-dependent receptor is important to tolerate copper excess, and this protein requires the activity of its oxygenase partner. Check to have the whole story ;)
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Reposted by Xavier De Bolle : Xa Team at UNamur
Pauline Cherry @pauline-chry.bsky.social · 24/03/2025
Hi everyone! I am thrilled to finally share with you the result of my Ph.D. thesis. In this study, we used genetics and metal quantifications to study the link between iron and copper homeostasis in Caulobacter crescentus. journals.asm.org/doi/10.1128/...
journals.asm.org
Role of a TonB-dependent receptor and an oxygenase in iron-dependent copper resistance in Caulobacter crescentus | Journal of Bacteriology
Copper is an essential metal for many living organisms, as it helps to drive crucial chemical reactions. However, when present in excess, copper turns toxic due to its high reactivity with biological ...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Nature @nature.com · 18/03/2025
We urge all leaders, for the good of their nations’ health, not to ignore or contradict advice that is supported by a consensus of evidence from research. go.nature.com/43Rfr5a
go.nature.com
Vaccines save lives. Leaders must champion them
Attacks on vaccines and the cancellation of research into what causes vaccine hesitancy puts people in harm’s way.
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bioRxiv Microbiology @biorxiv-microbiol.bsky.social · 11/03/2025
Lipopolysaccharide lateral mobility in the Gram-negative bacterial outer membrane is confined and governed by interactions within the conserved Lipid A anchor www.biorxiv.org/content/10.1101/202…
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Xavier De Bolle : Xa Team at UNamur @namurxa.bsky.social · 10/03/2025
I just wrote to ERC-PRESIDENT@ec.europa.eu to ask for a solution to welcome US scientists in Europe 🇺🇸🇪🇺 You can do the same if you wish...
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Reposted by Xavier De Bolle : Xa Team at UNamur
Cascales Lab @cascaleslab.bsky.social · 07/03/2025
Great talk on RNA modifications in bacteria by Zeynep Baharoglu @zeynepbaharoglu.bsky.social at the weekly IMM seminar today !
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Henri-François Renard @renardhf.bsky.social · 07/03/2025
First PhD student finishing since I started my lab as a PI… Emotional moment 🥲 Fingers crossed for your public defense next week and already congrats @shiqiang.bsky.social 😎🍾👏🏻
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Erik van Nimwegen @erikvannimwegen.bsky.social · 01/03/2025
Great idea. To add to this list, my institute @biozentrum.unibas.ch has a wonderful international PhD fellowship program: www.biozentrum.unibas.ch/phd/internat... Students do rotations and choose their PhD lab. Also great for students with quantitative background.
biozentrum.unibas.ch
Biozentrum PhD Fellowships Program
The Biozentrum encourages talented, ambitious and highly motivated young scientists from all over the world to apply for the prestigious and sought after fellowships offered by the Biozentrum Basel In...
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Hank Green @hankgreen.bsky.social · 02/03/2025
We are experiencing an assault on science unparalleled by anything I’ve seen in my life. It’s not one issue or another anymore, the entire institution is under attack by the most powerful individuals in the country. This Friday, where will you be? standupforscience2025.org
standupforscience2025.org
STAND UP FOR SCIENCE
March 7, 2025. Washington DC and nationwide. Because science is for everyone.
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Frédéric Silvestre @fsilvestrelab.bsky.social · 02/03/2025
US national parks are among the most wonderful and spectacular of the planet. This action at Yosemite, a park that I know well and that I love, is a brilliant symbol of resistance against the fascism that has taken place at the WH. www.nytimes.com/2025/02/24/u...
nytimes.com
Protesters Display Upside-Down American Flag at Yosemite
Organizers said the inverted flag, historically used as a sign of distress, was meant to draw attention to the Trump administration’s cuts to the National Park Service.
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Simonetta Gribaldo @sgribaldo.bsky.social · 27/02/2025
Yes Archaea too can get fat 😁 New paper from the lab (by bsky-less Guillaume Borrel)! Check it out👇👇 #archaeasky #microsky @institutpasteur.bsky.social academic.oup.com/ismej/advanc...
academic.oup.com
Halophilic archaea produce wax esters and use an alternative fatty acyl-CoA reductase for precursor synthesis
Abstract. Wax esters are fatty acid-based neutral lipids thought to be restricted to bacteria and eukaryotes that play a key role in the functioning and ma
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Charline Focant @charlinef.bsky.social · 21/02/2025
Another week, another destination, another conference ! This week I had the chance (again) to present my work through a short talk at the #T4SSconference in Nancy 👩🏽‍🔬🇫🇷. I’m grateful to have had great discussions with such amazing people, specially from our Brucella community! @namurxa.bsky.social
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Erin Goley @goleylab.bsky.social · 20/02/2025
I approve.
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Brian Stevenson Ph.D. spirochete lab @bstevensonlab.bsky.social · 19/02/2025
I had two grant proposals up for review in the NIH Bacterial Virulence (BV) study section. It was canceled without notice this morning. Without those grants, my lab must close within a year. And so the purge of scientific research in the US continues 🤬 #MicroSky 🦠🧫🧪🧬🔬
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