iiinova — where your digital self keeps evolving

Caitie McCafferty @computingcaitie.bsky.social · 16/09/2026

Experience w proteomics data analysis? Come to the FMI!! #proteomics #massspec

Reposted by Caitie McCafferty

FMI science @fmiscience.bsky.social · 16/09/2026

We’re hiring! The FMI Computational Biology Facility is seeking a Computational Biologist with experience in proteomics data analysis. Join a collaborative team working with scientists across the FMI to turn complex datasets into biological insight. Apply by Oct 25: www.fmi.ch/education-ca...

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Baukje Hoogenberg @baukjeje.bsky.social · 11/09/2026

Do you want to label the nuclear envelope? Do you work on a non-model species? Try Concanavalin A! We tested ConA on various species across the eukaryotic tree and find it is a very useful ExM-compatible marker for the NE and ER. Read all about it in our preprint: www.biorxiv.org/content/10.6...

biorxiv.org

Concanavalin A as a pan-eukaryotic nuclear envelope marker for expansion microscopy

Across eukaryotes, the nuclear envelope exhibits distinct remodelling strategies during mitosis: complete breakdown (open mitosis), partial disruption (intermediate), or full retention (closed). Howev...

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Caitie McCafferty @computingcaitie.bsky.social · 09/09/2026

I am looking for a lab manager for my group that I will be starting at the @fmiscience.bsky.social in February! We will use in situ structural biology to investigate dynamic ciliary processes. More info here —> bsky.app/profile/comp... #cilia #teamtomo #proteomics #protistsky

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Janani Durairaj (Jay) @ninjani.bsky.social · 28/08/2026

Some exciting news: I'm joining the University of Lausanne @unil.bsky.social @dbc-unil.bsky.social as an Assistant Professor next month 🎉 My group will work on context-aware deep learning for protein structure, interaction & design. Postdoc and PhD openings coming soon - keep an eye out!

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Kirsty Wan @micromotility.bsky.social · 17/08/2026

What does a single-celled organism tell us about the origins of complex behaviour? Delighted to see the final version of our paper: Embodied behavioural complexity in a ciliated microorganism out in@natcomms.nature.com (Funded by @erc.europa.eu ERC) doi.org/10.1038/s414... #cilia #protistsonsky

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Caitie McCafferty @computingcaitie.bsky.social · 07/08/2026

See you in Basel soon for cilia takeover ✨

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John Wallingford @jbwallingford.bsky.social · 04/08/2026

Cilia alert! Last year Juyeon Hong described a new domain in 9+2 cilia called the EDT, the extreme distal tip. Now, she's found a new protein required for its assembly, but only in non-mammalian vertebrates. A cool evo-cell / protein evolution story in @cellreports.bsky.social tinyurl.com/2xvdskx6

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Florent Waltz @florentwaltz.bsky.social · 27/07/2026

This story is now published in @natplants.nature.com ! 🎉🎩 Check out the final article here: nature.com/articles/s41477-026-02361-1 Very similar to the original bioRxiv preprint, with the addition of some cool polysome analysis (in the supplementals)! Thanks and congrats to everyone involved! 🙏

nature.com

Chloroplast-encoded small subunit extensions reshape the Chlamydomonas chlororibosome - Nature Plants

Using in situ cryo-electron tomography, researchers found a unique ‘arm’ domain on the small subunit of Chlamydomonas chlororibosomes. This discovery suggests that chlororibosome structure is more evo...

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sofie.rec @sofie-dot-rec.bsky.social · 27/07/2026

The artist formerly known as #thatmitoriboguy has now become #thatchlororiboguy Check out some cool tomo from @florentwaltz.bsky.social @phaips.vd.st

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Ben Engel @cellarchlab.com · 03/07/2026

Super excited to launch this search for a new endowed professor at the @biozentrum.unibas.ch! Join us to build a research cluster in Climate Biophysics! 🌍🌊🌾🔬🧪 This is a unique opportunity to create a community in Basel🇨🇭working together on this timely topic! ⏳🌡️ Questions? Please reach out! 👩‍🔬👨‍🔬

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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026

I will forgive the photosynthesis comment bc your compared me to your favorite animal :p

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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026

Incredibly grateful for the amazing mentorship I’ve had over the years @cellarchlab.com @edwardmarcotte.bsky.social David Taylor and @jbwallingford.bsky.social and can’t wait to pay it forward :D

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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026

I will be hiring at all levels so if you are interested and want to learn more, please get in touch! 📻 ❄️ 🔬 🦠 🧬 #cilia #cryoet #proteomics #exm #protistsonsky

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Caitie McCafferty @computingcaitie.bsky.social · 22/06/2026

Happy to finally share that I will be starting my independent group at the @fmiscience.bsky.social in Feb 2027 in a vibrant new environment. We will use integrative in situ structural cell biology methods to investigate ciliary structure and dynamics in several model (and non-model 👀) systems!!

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EuroCilia2027 @eurocilia.bsky.social · 04/06/2026

Big congratulations to our winners: Smilla-Maria Koy (1st), Chandrama Ghosh (2nd), and Anthony Rabaté (3rd)! Check out their breath-taking micrographs and the rest of the Top 15 entries in the stunning poster attached. The future of cilia research looks beautiful. 📸 #Cilia2027

micrographs depicting cilia in different forms

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Caitie McCafferty @computingcaitie.bsky.social · 24/05/2026

Great opportunity to work in an exciting environment and a wonderful group!!

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Reposted by Caitie McCafferty

Ben Larson @blarson.bsky.social · 19/05/2026

And now it's out! Happy that PNAS selected for the cover this SEM image snapped by @samjlord.bsky.social, one of the most evocative visualizations of Euplotes that I have ever encountered. www.pnas.org/doi/10.1073/... Stay tuned for what is shaping up to be some fascinating follow-up in the lab...

Scanning electron microscopy image of the ciliate Euplotes gigatrox on the cover of the journal PNAS. Distinct punk rock vibes

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HHMI @hhmi-science.bsky.social · 10/05/2026

This mesmerizing timelapse captures the nonstop motion inside an animal cell. Red/orange streaks are the growing ends of microtubules, tiny “highways” that can rapidly assemble and disassemble to move proteins & other molecules within the cell. 📸: Andy Moore, HHMI’s Janelia Research Campus

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Ben Engel @cellarchlab.com · 14/04/2026

Across scales from cells🦠 to atoms⚛️ – We reveal how anaerobic #bacteria break down very stable aromatic compounds found e.g. in oil spills 🛢️ #Bioremediation #TeamTomo 🧪 🧶🧬 🔬 Awesome collab with Lena, Matthias, @schullerjm.bsky.social @rnfr2d2.bsky.social @tomaspascoa.bsky.social @tamb-o.bsky.social

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I told you it was final 😉, now we celebrate 🎉

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Reposted by Caitie McCafferty

Ben Engel @cellarchlab.com · 08/04/2026

This is why I’m not allowed in the wet lab anymore 🥼 🕺. My technique is too effective! 🤪 #PILife #TeamTomo 🧪

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Ricardo D. Righetto @lifeonthewedge.bsky.social · 08/04/2026

Now THIS one was quite the journey. I'm beyond happy to see this work out in the world 🥹 Huge congrats to @computingcaitie.bsky.social and also to @hugovdhoek.bsky.social and everyone else involved ♥️ with @centriolelab.bsky.social @stearnslab.bsky.social @cellarchlab.com #Cilia #CryoET #TeamTomo

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Ben Engel @cellarchlab.com · 08/04/2026

It’s done!! Molecular architecture of the ciliary base in mammalian multiciliated cells! A study 13 years in the making 👴, thanks to collab with @stearnslab.bsky.social + @centriolelab.bsky.social & visionary work by @computingcaitie.bsky.social, who integrated native #cryoET with #XLMS & #UExM 🧪🧶🧬🔬

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sofie.rec @sofie-dot-rec.bsky.social · 08/04/2026

Crazy things have been happening in cilia world, catch up on them in Caitie's new paper! 🪱

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

And over the years several people in the @cellarchlab.com contributed to this work including @phaips.vd.st and @lifeonthewedge.bsky.social

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

This project was started over 10 yrs ago between @cellarchlab.com and @stearnslab.bsky.social, I think I was taking organic chemistry at the time 😝. @hugovdhoek.bsky.social heroically put in a huge effort to get these cells on grids and acquire some beautiful tilt series 💪

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

Using this powerful combo of tools we observe other features of the ciliary base including the ciliary necklace aligned w the transition zone, IFT trains present at mature cilia and undocked centrioles near ciliary vesicles, and a cytoskeleton network of bundled actin and intermediate filaments

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

While XL/MS provided several candidates for microtubule binding proteins, the subciliary localization was further verified by @marinebrunet.bsky.social w U-ExM. This combo identified several new microtubule binding proteins including DNAJB6, which is abundant in the transition zone and axoneme

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

To supplement our cryo-ET and generate candidates for proteins that localize to different ciliary regions, we took a trip to the local butcher to pick up some cow trachea to build a mammalian multiciliated cell interactome using XL/MS (enjoy this vid of @cellarchlab.com shaking cilia off trachea)

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

Using subtomogram averaging and classification, we map out structural changes along the microtubules of the ciliary base, highlighting densities specific to each region. The transition zone is marked by distinct features including the A-B linker, outer helical wrap, MIP helix, and absence of NME7

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Caitie McCafferty @computingcaitie.bsky.social · 08/04/2026

I am excited to share our most recent work collaborating with @centriolelab.bsky.social and @stearnslab.bsky.social to look at the ciliary base of mammalian multiciliated cells w/ cryo-ET, XL/MS, and U-ExM www.biorxiv.org/content/10.6...

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Spang Lab @spanglab.bsky.social · 30/03/2026

What if you could cut out sub cellular structures and measure the proteome? SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection www.biorxiv.org/content/10.6... awesome work by Curdin Franziscus, @imcf-lex.bsky.social, @biehli.bsky.social, Alexander Schmidt!

biorxiv.org

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Caitie McCafferty @computingcaitie.bsky.social · 19/03/2026

New protein complex stoichiometry prediction tool from talent PhD student @daniil-litvinov.bsky.social, check out the thread below!

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Caitie McCafferty @computingcaitie.bsky.social · 11/03/2026

Exciting opportunity to work in a lab that’s pushing the boundaries of environmental sampling and work with an amazing scientist!!! 👩‍🔬🔬

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Thibaut Brunet @thibautbrunet.bsky.social · 28/02/2026

Final version @nature.com of our paper describing unconventional multicellular development in a choanoflagellate inhabiting an extreme environment. A ton of new data since the first @biorxivpreprint.bsky.social preprint (which we've kept updating). A brief 🧵 (carried over from the old place)

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Caitie McCafferty @computingcaitie.bsky.social · 25/02/2026

Nice collab w my neighbor in Basel @abimoye.bsky.social on SAXO6 mol bio and genetics!!

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Abigail Moye @abimoye.bsky.social · 24/02/2026

Thrilled to share that our paper on a novel IRD gene has been published in The American Journal of Human Genetics (AJHG)! 🎉 This wouldn’t have been possible without the incredible group of colleagues and collaborators. Special thanks to @computingcaitie.bsky.social, Ditta Zobor, and ERDC members!

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IOB - Institute of Molecular and Clinical Ophthalmology Basel @iobswiss.bsky.social · 24/02/2026

📏🔬In collaboration with @computingcaitie.bsky.social and @cellarchlab.com, SAXO6 localization was mapped along ciliary microtubules with direct links to α-tubulin, linking this structural protein class to human retinal disease for the first time. 👉 @ajhgnews.bsky.social #Ophthalmology

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Florent Waltz @florentwaltz.bsky.social · 10/02/2026

Long in the making, but happy to present the Chlamydomonas chlororibosome! Cryo-ET🔬reveals a large new domain on the small subunit, built from multiple extensions in conserved ribosomal proteins. bioRxiv 📖: shorturl.at/q44tG This suggests greater chlororibosome diversity than expected! 1/n 🧵

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Helen Foster @helenfoster.bsky.social · 06/02/2026

Very happy to say that our work on how axonemes are generated is now available on bioRxiv: www.biorxiv.org/content/10.6... - if you’ve ever wondered how the incredibly beautiful, complex structures within motile #cilia are constructed then this is for you!

biorxiv.org

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German Society for Plant Sciences (DBG) @plantsciencedbg.bsky.social · 03/02/2026

For #ECR’s: DBG’s Hot Tpoic Workshop on Cryo-Electron Tomography + FIB-milling 13 – 15 April 2026 In @cellarchlab.com 's lab @biozentrum.unibas.ch Organised by @tamb-o.bsky.social, Karen Zinzius, @fannyleblanc.bsky.social Details: www.deutsche-botanische-gesellschaft.de/en/about-us/...

deutsche-botanische-gesellschaft.de

Hot Topic Conference

Support for an "Eduard Strasburger Hot Topic Conference" for DBG's members

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