A quiet policy change means the government is making fewer bets on long-term science.

Nature Neuroscience - Zamboni et al. reveal how enhancers encode cell-type-specific responses to CNS injury. By combining multiomic profiling, deep learning and in vivo screening, they uncover...

Neuropsychopharmacology - Leveraging high-resolution brain imaging and (epi)genomic approaches to improve women’s mental health

Even in scientific areas in which women are well represented, they are up to 40% more likely than men to leave research within 20 years.

Using a novel PET tracer for imaging inflammation, Appleton et al. show that people with mild cognitive impairment with onset before the age of 65 years sh

Acute oral metformin administration lowers blood glucose levels by targeting mitochondrial complex I.

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Traumatic brain injury (TBI) after high-energy, behind helmet blunt trauma (BHBT) is an important but poorly understood clinical entity often associated with apnea and death in humans. In this study, ...

In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a protein-based single-cell profiling ...

This Medical News article discusses a new report from the National Academies of Sciences, Engineering, and Medicine on persistent gaps in women’s health research and key recommendations that would req...

Blood-CNS barriers protect the CNS from circulating immune cells and damaging molecules. It is thought barrier integrity becomes disrupted with aging, contributing to impaired CNS function. Using geno...

Early-life stress can have lifelong consequences, enhancing stress susceptibility and resulting in behavioural and cognitive deficits. While the effects of early-life stress on neuronal function have ...

Blood vessel integrity is critical to maintain brain health. Here, the authors show that both the liver and the muscles secrete HFE2, a protein that promotes blood vessel integrity in healthy animals ...

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The lateral septum contains neurons that mediate stress responses, but the role of astrocytes remained unclear. Here, the authors show that lateral septum astrocytes modulate nearby neurons and enhanc...

The advent of droplet-based single-cell RNA-sequencing (scRNA-seq) has dramatically increased data throughput, enabling the release of a diverse array of tissue cell atlases to the public. However, we...

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Astroglial clones vary in distribution, within or across cortical layers. Distribution of clones depends on their origin. Layer-specific clones have fewer, less dispersed cells. Juxtavascular clones...

Manganese (Mn) is an essential trace metal that is necessary for life. Its duality as both a crucial

As Lee Cunningham and Ashford explore in their new article, “When Qualified Women Resist the Leader Label,” the "Leader-Identity/Competence Paradox" is observed in various data points.

PhD Project - (VIDA DTC) Exploring the role of the astrocyte-leptomeningeal vessel interface in dementia at University of Edinburgh, listed on FindAPhD.com

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Impaired cerebral glucose metabolism is a pathologic feature of Alzheimer’s disease (AD), with recent proteomic studies highlighting disrupted glial metabolism in AD. We report that inhibition of indo...

The blood-brain barrier (BBB) protects the brain from circulating metabolites and plays central roles in neurological diseases. Endothelial cells (ECs) of the BBB are enwrapped by mural cells includin...

We have limited knowledge of how aging affects brain vascular structure and function. Here, the authors show that aging induces selective reduction of vasculature and related cell types in key cogniti...