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María A. Moro

@mariangelesmoro.bsky.social

269 followers 116 following 386 posts

Researcher at CNIC, Madrid, Spain. Former Professor of Pharmacology at UCM. Professional interests: stroke, vascular dementia, neurovascular pathophysiology, cardiovascular risk factors and brain health, mentoring

Posts Replies Media

María A. Moro @mariangelesmoro.bsky.social · 29/09/2026

www.cell.com/neuron/fullt...

Cervical lymphadenectomy impairs brain lymphatic clearance and synaptic proteostasis

Khan, Clement et al. show that subjects undergoing removal of cervical lymph nodes presented an elevated risk for cognitive impairment. The disruption of brain lymphatic clearance triggers metabolic a...

María A. Moro @mariangelesmoro.bsky.social · 20/09/2026

www.nature.com/articles/s43...

A microprotein atlas of the human frontal cortex in Alzheimer’s disease - Nature Aging

A new atlas identifies 1,067 unannotated microproteins in the human frontal cortex with strong spectral grades. A subset is differentially expressed in Alzheimer’s disease independently of their canon...

María A. Moro @mariangelesmoro.bsky.social · 18/09/2026

www.nature.com/articles/s41...

Atypical Alzheimer disease: a multi-axis framework toward defining heterogeneity - Nature Reviews Neurology

Atypical Alzheimer disease (AD) denotes cases that meet the neuropathological criteria for AD but manifest predominantly with non-amnestic network failure. In this Review, the authors argue that atypi...

María A. Moro @mariangelesmoro.bsky.social · 18/09/2026

www.nature.com/articles/s41...

Joint impact of pathological burden and cognitive resilience on Alzheimer’s disease risk - Nature Medicine

A 15-year cohort study shows that Alzheimer’s dementia risk is jointly shaped by Alzheimer’s pathology and cognitive resilience, with high resilience linked to lower risk, even under greater pathology...

María A. Moro @mariangelesmoro.bsky.social · 16/09/2026

www.nature.com/articles/s41...

Myeloperoxidase inhibition with mitiperstat in heart failure with preserved or mildly reduced ejection fraction: a randomized phase 2b trial - Nature Medicine

In a phase 2 randomized clinical trial, treatment with the myeloperoxidase (MPO) inhibitor mitiperstat, intended to target the neutrophil–MPO inflammatory pathway, did not improve symptoms or exercise...

María A. Moro @mariangelesmoro.bsky.social · 15/09/2026

www.nature.com/articles/s42...

The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research - Nature Metabolism

This broad group of authors summarizes the impact of circadian factors on metabolic biology and offers recommendations on how to account for and report biological, environmental and experimental facto...

María A. Moro @mariangelesmoro.bsky.social · 12/09/2026

www.nature.com/articles/s41...

Intestinal infections establish antigen-specific, long-lived memory CD4+ T cells in the brain and meninges - Nature Neuroscience

Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation and cytokine production f...

María A. Moro @mariangelesmoro.bsky.social · 08/09/2026

www.nature.com/articles/s41...

Bone marrow myelopoiesis dysfunction in Alzheimer’s disease limits monocyte homing to the brain and drives disease progression - Nature Neuroscience

Alzheimer’s disease progression involves reduced bone marrow production of myeloid cells due to type I interferon signaling, which hampers the homing of protective immune cells to the affected brain. ...

María A. Moro @mariangelesmoro.bsky.social · 06/09/2026

www.science.org/doi/10.1126/...

Tumor-derived antioxidants suppress immunity by depriving T cells of reactive oxygen species

Reactive oxygen species (ROS) promote genomic instability and fuel oncogenic signaling in cancer, but antioxidant therapies have so far failed to improve, or worsen, cancer outcomes. Emerging data sug...

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María A. Moro @mariangelesmoro.bsky.social · 05/09/2026

www.science.org/doi/10.1126/...

Sequential clearance of neutrophil extracellular traps for precision therapy of sepsis

Sepsis, a life-threatening syndrome driven by dysregulated host response to infection, is critically exacerbated by the uncontrolled formation of neutrophil extracellular traps (NETs), which amplify i...

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María A. Moro @mariangelesmoro.bsky.social · 29/08/2026

elpais.com/opinion/2026...

Enfermedad cardiovascular: cuando el riesgo ya es enfermedad

Un proyecto permitirá saber si conocer la presencia y la extensión de la enfermedad permite salvar vidas

María A. Moro @mariangelesmoro.bsky.social · 28/08/2026

www.science.org/doi/10.1126/...

SGLT2 inhibitors activate pantothenate kinase in the human heart

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) reduce mortality in heart failure, but their pharmacological target remains unclear. In this study, we showed that SGLT2i directly activate pantothen...

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María A. Moro @mariangelesmoro.bsky.social · 27/08/2026

www.nature.com/articles/d41...

The brain struggles to make new neurons in people with depression

High resolution, wide-coverage map of the hippocampus reveals possible pathways for therapy.

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María A. Moro @mariangelesmoro.bsky.social · 27/08/2026

www.cell.com/cell-biomate...

Reverse the progression of Alzheimer’s disease through Nano-ERASER-based adult neuroregeneration

Neurodegeneration in Alzheimer’s disease outpaces the brain’s ability to regenerate neurons. Wang et al. develop a Nano-ERASER platform that delivers anti-PTBP1 antibodies into astrocytes, enabling pr...

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María A. Moro @mariangelesmoro.bsky.social · 26/08/2026

www.nature.com/articles/s41...

Oligodendrocyte dysfunction in human age-related cognitive decline - Nature Medicine

This study identifies oligodendrocytes as active contributors to cognitive decline in aging, by leveraging a unique human brain bank with more than 70 years of associated cognitive data combined with ...

María A. Moro @mariangelesmoro.bsky.social · 23/08/2026

www.science.org/doi/10.1126/...

Modality-specific neurovascular coupling via layer-segregated arteriole networks

The brain’s vascular system dynamically regulates energy supply through neurovascular coupling. In this study, we show that in mice, neurovascular coupling is modality-dependent: Distinct sensory inpu...

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María A. Moro @mariangelesmoro.bsky.social · 22/08/2026

www.nature.com/articles/s41...

Dysregulated adult hippocampal neurogenesis in major depressive disorders - Nature Medicine

The largest multiomic atlas of the adult human hippocampus identifies disrupted neurogenesis, gene regulation and neural circuits in major depressive disorder, revealing molecular pathways and potenti...

María A. Moro @mariangelesmoro.bsky.social · 20/08/2026

www.cell.com/cell/fulltex...

Neurodegeneration as a dysregulation of neuroimmune crosstalk

This perspective provides an overview of the growing literature on the role of the immune system in driving neurodegeneration and argues that restoring neuroimmune dialogue, rather than simply clearin...

María A. Moro @mariangelesmoro.bsky.social · 15/08/2026

www.science.org/doi/10.1126/...

aDISCO: A clearing method to enable 3D microscopy of large archival paraffin-embedded human tissue blocks

Human surgery and autopsy specimens are routinely stored as formalin-fixed paraffin-embedded (FFPE) tissue blocks for decades, creating vast archives of healthy and diseased tissues. While tissue clea...

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María A. Moro @mariangelesmoro.bsky.social · 15/08/2026

www.science.org/doi/10.1126/...

Prediction of mild cognitive impairment progression using time-sensitive multimodal biomarkers

Alzheimer’s disease (AD) develops silently for years before symptoms emerge, making early identification of at-risk individuals essential for prevention trials and early intervention. We tested whethe...

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María A. Moro @mariangelesmoro.bsky.social · 15/08/2026

www.nature.com/articles/s41...

AhR inhibition promotes axon regeneration via a stress–growth switch - Nature

AhR functions as a neuronal brake on axon regeneration, integrating environmental sensing, protein homeostasis and metabolic signalling to control the balance between stress adaptation and axonal repa...

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María A. Moro @mariangelesmoro.bsky.social · 15/08/2026

www.cell.com/cell/fulltex...?

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human

This study identifies cMAF as a key transcription factor that orchestrates the molecular crosstalk between brain perivascular macrophages and arteries, thereby sustaining cerebrovascular function in h...

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María A. Moro @mariangelesmoro.bsky.social · 14/08/2026

www.nature.com/articles/s41...

Blood-based circular RNAs for early diagnosis of Alzheimer’s disease - Nature Medicine

Tested in large cohorts, a predictive model including 34 blood circular RNAs predicts progression to symptomatic AD, outperforming pTau217 and amyloid-PET.

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María A. Moro @mariangelesmoro.bsky.social · 14/08/2026

www.nature.com/articles/s41...

Early detection of Alzheimer’s disease with circular RNA from blood - Nature Medicine

Early diagnosis of Alzheimer’s disease is important to ensure timely and accurate treatment. We show that a blood-based circular RNA signature can accurately detect Alzheimer’s disease as well as, or ...

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María A. Moro @mariangelesmoro.bsky.social · 14/08/2026

www.sciencedirect.com/science/arti...

sciencedirect.com

Engineering functional human vasculature: iPSC-derived vascular cells and organoids for disease modeling and translation

Human vascular function depends on tightly coordinated structural, mechanical, and cellular interactions, yet these features remain difficult to recap…

María A. Moro @mariangelesmoro.bsky.social · 13/08/2026

www.nature.com/articles/d41...

A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know

Jaw-dropping patient videos and miraculous testimonials ignited a frenzy in China over a technique that aims to improve drainage from the brain. Now it is entering trials worldwide.

María A. Moro @mariangelesmoro.bsky.social · 11/08/2026

jamanetwork.com/journals/jam...

jamanetwork.com

Unifying Terminology for Ischemic Core Size in Acute Stroke

This Viewpoint presents a new, unified terminology framework for ischemic core size in patients with acute stroke.

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María A. Moro @mariangelesmoro.bsky.social · 09/08/2026

www.cell.com/trends/immun...

Microglia as integrators of brain-associated molecular patterns

Microglia are brain-resident macrophages that play key roles in brain development and experience dependent plasticity. In this review we discuss recent findings regarding the molecular mechanisms thro...

María A. Moro @mariangelesmoro.bsky.social · 08/08/2026

www.science.org/doi/10.1126/...

Epigenetic and 3D genome reprogramming during the aging of the human hippocampus

Changes in gene expression have been observed in the aging human brain, but our understanding of the underlying regulatory mechanisms remains limited. To unravel these complexities, we analyzed single...

María A. Moro @mariangelesmoro.bsky.social · 08/08/2026

www.cell.com/cell-metabol...

Gut microbial metabolism via hippocampal indole-AhR signaling regulates emotional symptoms

Wang et al. reveal a gut-brain pathway linking intestinal microbes to emotional symptoms in IBS. Loss of A. shahii lowers microbial metabolite indole, weakening AhR signaling in the affective brain re...

María A. Moro @mariangelesmoro.bsky.social · 07/08/2026

www.neurology.org/doi/10.1212/...

Midlife Vascular Risk Burden and Dementia-Free Survival Years | Neurology Open Access

Background and ObjectivesMidlife vascular risk factors are associated with both dementia and premature death; however, their combined association with dementia-free survival years remains unclear. Thi...

María A. Moro @mariangelesmoro.bsky.social · 07/08/2026

www.nature.com/articles/s41...

FNIP1 variants are associated with favourable metabolism in 1 million humans - Nature

The FNIP1 pathway has a role in human energy metabolism, and its inhibition is a potential therapeutic strategy in cardiometabolic disease.

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María A. Moro @mariangelesmoro.bsky.social · 05/08/2026

www.cell.com/neuron/fullt...

Intrinsic endothelial remodeling drives brain capillary repair

Condrau et al. show that mouse brain capillaries rapidly repair after the loss of a single endothelial cell. Neighboring endothelial cells extend to reconnect the vessel and restore blood flow. Repair...

María A. Moro @mariangelesmoro.bsky.social · 05/08/2026

www.cell.com/cell/fulltex...

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

Cancer-associated somatic variants are enriched in the brain immune cells of Alzheimer’s disease (AD) patients, driving them toward inflammation and proliferation, which may contribute to neuroinflamm...

María A. Moro @mariangelesmoro.bsky.social · 05/08/2026

www.nature.com/articles/s41...

A reproducible three-dimensional model of human brain tissue to investigate physiological and disease-associated microglia phenotypes - Nature Neuroscience

Klimmt, Cardoso Gonçalves et al. developed a reproducible human three-dimensional brain tissue model with neurons, astrocytes and microglia, replicating in-vivo-like maturation and enabling the study ...

María A. Moro @mariangelesmoro.bsky.social · 03/08/2026

www.science.org/doi/10.1126/...

Glial heterogeneity shapes region-specific angiogenesis and neurovascular integrity in the CNS

Astrocyte and oligodendrocyte lineage cells differentially drive gray and white matter angiogenesis via distinct pathways.

María A. Moro @mariangelesmoro.bsky.social · 01/08/2026

jamanetwork.com/journals/jam...

jamanetwork.com

FDA Approves First Oral PCSK9 Inhibitor to Lower LDL Cholesterol

The US Food and Drug Administration (FDA) approved the first oral protein convertase subtilisin/kexin type 9 (PCSK9) inhibitor to reduce low-density lipoprotein (LDL) cholesterol. PCSK9 inhibitors hav...

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María A. Moro @mariangelesmoro.bsky.social · 31/07/2026

www.cell.com/cell/fulltex...

Spatial atlas of the human brain vasculature reveals specialized cell ensembles

An integrative cell and spatial atlas defines the organizing logic of the adult human cerebrovasculature, providing a framework for studying how vascular cell states support brain function and shape n...

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María A. Moro @mariangelesmoro.bsky.social · 30/07/2026

www.ahajournals.org/doi/10.1161/...

ahajournals.org

Opportunistic Coronary Artery Calcium Screening: Time for Clinical Implementation | Circulation

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María A. Moro @mariangelesmoro.bsky.social · 30/07/2026

journals.sagepub.com/doi/abs/10.1...

journals.sagepub.com

EXPRESS: Stage-Dependent Deep Gray Matter Alterations in Cerebral Small Vessel Disease Revealed by 7T Quantitative Susceptibility Mapping - yue yuan, Shuai Jiang, Youjie Wang, Huilou Liang, Marta Lanc...

Susceptibility alterations in deep gray matter (DGM) across clinical stages of cerebral small vessel disease (CSVD) remain unclear. In this case-control study, ...

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María A. Moro @mariangelesmoro.bsky.social · 30/07/2026

www.nejm.org/doi/full/10....

Phase 2b Trial of a NaV1.8 Inhibitor for Acute Pain | NEJM

Nav1.8, a voltage-gated sodium channel expressed in the peripheral nervous system, has a critical role in pain signaling. Previous trials of NaV1.8 inhibitors have shown effectiveness in reducing p...

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María A. Moro @mariangelesmoro.bsky.social · 30/07/2026

jamanetwork.com/journals/jam...

jamanetwork.com

Sleep Health and Obesity

This JAMA Insights discusses sleep and obesity and urges clinicians to address sleep health and, indirectly, address obesity prevention and treatment by asking patients about their sleep quality and q...

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María A. Moro @mariangelesmoro.bsky.social · 30/07/2026

jamanetwork.com/journals/jam...

jamanetwork.com

Global Burden of Elevated LDL-C

This study from the Global Burden of Disease quantifies the global, regional, and national burden of cardiovascular disease (CVD) attributable to elevated low-density lipoprotein cholesterol (LDL-C) a...

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María A. Moro @mariangelesmoro.bsky.social · 22/07/2026

www.cell.com/cell/fulltex...

CSF clearance through arachnoid fenestrations to olfactory meningeal lymphatics

Cerebrospinal fluid (CSF) crosses arachnoid fenestrations near the olfactory bulbs to reach dural lymphatics that traverse the cribriform plate, connect to nasal lymphatics, and drain to cervical lymp...

María A. Moro @mariangelesmoro.bsky.social · 21/07/2026

jamanetwork.com/journals/jam...

jamanetwork.com

New Dyslipidemia Guidelines Lower the Lipid Treatment Goals and Raise the Bar for Clinical Practice

New dyslipidemia guidelines from multiple US medical organizations1 simultaneously lowered the goals for lipid levels in many US patients and raised the bar for clinicians to help those patients reach...

María A. Moro @mariangelesmoro.bsky.social · 18/07/2026

www.science.org/doi/10.1126/...

Varicose projection astrocytes: Conserved reactive cells in brain pathology

Varicose projection astrocytes emerge as a conserved reactive phenotype linked to inflammation and brain pathology.

María A. Moro @mariangelesmoro.bsky.social · 16/07/2026

www.nature.com/articles/s41...

Microglia prune developing cortical blood vessels through PD-1 signaling - Nature Neuroscience

Visualizing microglia and blood vessels in postnatal mouse cortex reveals that microglia contact and prune vessels, which is mediated by PD-L1–PD-1 signaling.

María A. Moro @mariangelesmoro.bsky.social · 16/07/2026

www.science.org/doi/10.1126/...

Restored clearance of senescent neutrophils by tissue-resident macrophages limits organ aging

Aging disrupts tissue homeostasis across organ systems. Here, we identify tissue-resident macrophages (TRMs) as central coordinators of age-related organ decline through impaired clearance of senescen...

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María A. Moro @mariangelesmoro.bsky.social · 16/07/2026

www.nature.com/articles/s41...

Neurovascular interactions in the ageing heart - Nature Reviews Cardiology

The ageing process leads to cellular changes that disrupt the intricate axis between the nervous and vascular systems that governs cardiac function. In this Review, Wagner and Dimmeler describe the cr...

María A. Moro @mariangelesmoro.bsky.social · 16/07/2026

www.science.org/doi/10.1126/...

Glymphatic dysfunction in Alzheimer’s disease: A critical appraisal

Thirteen years after the initial publication defining the glymphatic system, we critically reappraise the role of its dysfunction in Alzheimer’s disease (AD). Our understanding of glymphatic function ...