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Eduardo Zimmer

@erzimmer.bsky.social
1.5K followers 1.1K following 98 posts

Researcher interested in neurodegeneration and astrocytes. Assistant professor at UFRGS (🇧🇷), Researcher at Hospital Moinhos de Vento (🇧🇷) and Adjunct Professor at McGill (🇨🇦) zimmer-lab.org 🌎 zimmerneurolab.bsky.social 🦋

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Reposted by Eduardo Zimmer
Zimmer Lab @zimmerneurolab.bsky.social · 07/11/2025
Just published in Nat. Neurosci. Led by J.P. Ferrari-Souza, this study used imaging & fluid biomarkers to reveal that microglia modulate Aβ-related astrocyte reactivity, which in turn contributes to AD progression. @erzimmer.bsky.social @natureportfolio.nature.com www.nature.com/articles/s41...
nature.com
Microglia modulate Aβ-dependent astrocyte reactivity in Alzheimer’s disease - Nature Neuroscience
Microglia influence amyloid-β effects on astrocyte reactivity in the living brain of individuals with Alzheimer’s disease. This phenomenon further contributes to cognitive impairment via tau phosphory...
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Sudeshna Das, PhD @sdas617.bsky.social · 09/08/2025
Another reason to study developmental biology for #Alzheimer disease @erzimmer.bsky.social
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Shannon Macauley @macauleylab.bsky.social · 31/07/2025
Tau pathology reprograms glucose metabolism to support glutamatergic activity and excitatory imbalance
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Crystal M. Glover, Ph.D. @cgster.bsky.social · 15/05/2025
@beyoung40.bsky.social speaking about the @rushalzheimers.bsky.social Latino Core in Lima for the @alzassociation.bsky.social #AAICSatellite. Plus, she shouted out the team! @drmlamar.bsky.social and Dr. David Marquez She’s so good! @alzdemjournals.bsky.social
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Zimmer Lab @zimmerneurolab.bsky.social · 14/05/2025
Dr. @erzimmer.bsky.social in action at the #AAICSatellite in Peru, presenting the landscape of 🩸biomarkers in Brazil. His talk highlighted key advances and outlined promising perspectives to boost Brazil’s response to dementia — from research to public health @alzassociation.bsky.social
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Eduardo Zimmer @erzimmer.bsky.social · 22/04/2025
What a spectacular event the first @embo.org #Astrocyte Workshop was!
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Eduardo Zimmer @erzimmer.bsky.social · 14/04/2025
An inspiring kickoff to the #EMBOastrocytes workshop honoring the legacy of #ElenaGalea
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Carolyn Fredericks @carolynfredericks.bsky.social · 28/03/2025
We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral... Please share with your circles!
The Fredericks Lab! - with deliberately poor photoshopping of lab members who couldn't be there that day.
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NeuroscienceNext Argentina @neurosciencenext.bsky.social · 01/03/2025
Day 3 of Neuroscience Next 2025 - Buenos Aires Hub 🇦🇷 #neuroscience #AAlCNeuroscienceNext #fleni #alzheimer #alzheimersassociation #dementia #neuropsychology #ENDALZ #argentina #buenosaires #aging @erzimmer.bsky.social @luciacrivelli.bsky.social @alzassociation.bsky.social @nvillain-alz.bsky.social
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Baptiste Lacoste @blacoste.bsky.social · 01/03/2025
I hope you haven’t missed this awesome new study by @caromenard666.bsky.social’s team, where the dreamy keys worlds #astrocyte and #BloodBrainBarrier coexist 🤩🥰
nature.com
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
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Caroline Menard @caromenard666.bsky.social · 27/02/2025
So excited to share the work of the fantastic Katarzyna, 1st 🧪PhD student of my lab 🧠, out in @natureneuro.bsky.social 🥂🥳 Cheers to the team, thanks to our precious collaborators and support from @braincanada.bsky.social #CIHR @fondsrechercheqc.bsky.social #newPI www.nature.com/articles/s41...
nature.com
Astrocytic cannabinoid receptor 1 promotes resilience by dampening stress-induced blood–brain barrier alterations - Nature Neuroscience
The mechanisms of neurovascular adaptations underlying stress resilience remain unclear. Here the authors show that the astrocytic endocannabinoid system modulates the blood–brain barrier changes duri...
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Crystal M. Glover, Ph.D. @cgster.bsky.social · 26/02/2025
#AAICNeuro Cameroon Hub: Day Two!
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Zimmer Lab @zimmerneurolab.bsky.social · 24/02/2025
Kickoff of #AAICNeuro in Porto Alegre! 🌎 This week, 12 hubs worldwide will showcase the next generation of Alzheimer’s & dementia researchers and clinicians. Stay tuned for updates throughout the day! @alzassociation.bsky.social @erzimmer.bsky.social #CristianoAguzzoli
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Eduardo Zimmer @erzimmer.bsky.social · 24/02/2025
#AAICneuro POA Hub just started in our beloved Porto Alegre 🇧🇷! A great pleasure to co-host the event with #CristianoAguzzoli @zimmerneurolab.bsky.social @alzassociation.bsky.social
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Eduardo Zimmer @erzimmer.bsky.social · 14/02/2025
Despite carrying a genetic mutation associated with early-onset #Alzheimer’s, a man remained free of dementia symptoms for at least 2 decades longer than expected 👉 genetic variants may explain this remarkable resilience. See more here: www.nature.com/articles/d41...
idp.nature.com
A man was destined for early Alzheimer’s — these genes might explain his escape
Scientists identify nine genetic variants that could have helped a man to avoid dementia for at least two decades longer than expected.
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Eduardo Zimmer @erzimmer.bsky.social · 14/02/2025
Important work by #JorgeLibre-Guerra and team on @naturemedicine.bsky.social about genetic resilience to early onset #alzheimers👇 www.nature.com/articles/s41...
nature.com
Longitudinal analysis of a dominantly inherited Alzheimer disease mutation carrier protected from dementia - Nature Medicine
A rare case of asymptomatic dominantly inherited Alzheimer’s reveals confined tau pathology and unique proteomic features, highlighting potential resilience mechanisms decades beyond expected onset.
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Eduardo Zimmer @erzimmer.bsky.social · 10/02/2025
@stforner.bsky.social presenting the @alzassociation.bsky.social global funding programs at #FloripaNeuro 🇧🇷
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Wyllians Borelli, MD PhD @vbwyll.bsky.social · 08/02/2025
Incredibly happy to share this co-first publication in the Lancet Global Health with #DaRos and #Aguzzoli guided by the brilliant @erzimmer.bsky.social
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Eduardo Zimmer @erzimmer.bsky.social · 07/02/2025
If you are a scientist in the Global South 👇👇👇👇
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Alzheimer's Association @alzassociation.bsky.social · 03/02/2025
Hello, #Bluesky! With so many voices making their way to this new community, we are excited to enter the conversation. #ENDALZ
The words "Hello, Bluesky!" with the Bluesky butterfly logo below. They are white against a purple background.
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ISTAART @istaart.bsky.social · 03/02/2025
The ISTAART Ambassador Program is still open for applications! Hear what the current cohort has to say about the program, what it meant to them, and why you should apply! www.youtube.com/watch?v=Y_7-...
youtube.com
The ISTAART Ambassador Program: Your Passport to a Global Dementia Research Community
YouTube video by Paige Logan
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Trends in Neurosciences @cp-trendsneuro.bsky.social · 04/02/2025
'Origins of food selectivity in human visual cortex' by Margaret Henderson, Michael Tarr & Leila Wehbe www.cell.com/trends/neuro...
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Eduardo Zimmer @erzimmer.bsky.social · 02/02/2025
In 🇧🇷, and probably in most countries with high levels of disparities and inequalities, education is one the most important risk factors for cognitive decline! Amazing work by #LucasdaRos @vbwyll.bsky.social #CristianoAguzzoli and team @thelancet.bsky.social
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Gabriela M. Baldasso @baldassogabi.bsky.social · 30/01/2025
Check out our group's new study highlighting the importance of understanding the population in the Global South! 👇 Congrats #LucasdaRos @vbwyll.bsky.social @erzimmer.bsky.social
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Zimmer Lab @zimmerneurolab.bsky.social · 30/01/2025
New Study just out in The Lancet Global Health! #LucasDaRos, @vbwyll.bsky.social, #CristianoAguzzoli & colleagues used a machine learning model to determine the most important risk factors for cognitive and functional decline in Brazil and other LATAM Countries 🧵 www.thelancet.com/journals/lan...
thelancet.com
Social and health disparities associated with healthy brain ageing in Brazil and in other Latin American countries
Our findings indicate that Brazil converges with other Latin American countries to show that heterogeneous factors impacted more than demographic factors, but also showed a unique set of health factor...
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Mychael Lourenco @mvlourenco.bsky.social · 27/01/2025
Our comment on a very interesting @elife.bsky.social paper showing how S1PR signaling may underlie pain-associated memory impairment is now out! Check it out! elifesciences.org/articles/105...
elifesciences.org
Pain-Related Memory Impairment: How does chronic pain lead to memory loss?
A dysfunctional signaling pathway in the hippocampus has been linked to chronic pain-related memory impairment in mice.
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Baptiste Lacoste @blacoste.bsky.social · 25/01/2025
Just received 🤩 (yes, I will read the other chapters😇)
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Eduardo Zimmer @erzimmer.bsky.social · 22/01/2025
The Global South united in science 💜🇧🇷🤝🇳🇬💜 #PromoteDiversity #BuildCapacity @zimmerneurolab.bsky.social
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David Jones @davidjonesbrain.bsky.social · 18/01/2025
FDG is a key clinical tool for all degenerative diseases of the mind.
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Eduardo Zimmer @erzimmer.bsky.social · 13/01/2025
A must read for people working with amyloid and tau PET👇👇👇
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Gabriela M. Baldasso @baldassogabi.bsky.social · 08/01/2025
Take a look at this awesome perspective from @limberger-chris.bsky.social and @erzimmer.bsky.social! Check it out! 👇
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sambooker.bsky.social @sambooker.bsky.social · 07/01/2025
We just published a thing! In this study, we provide compelling evidence that a lack of microglia during early brain development does not lead to wholesale alterations of synaptic and cellular function. www.nature.com/articles/s41...
nature.com
Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus - Nature Neuroscience
Microglia are proposed to have a role in brain development through synaptic engulfment and paracrine signaling. O’Keeffe et al. show that certain neurodevelopmental processes attributed to microglia c...
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Eduardo Zimmer @erzimmer.bsky.social · 07/01/2025
Our spotlight on @cp-trendsneuro.bsky.social, commenting on this great article by the Herfert Group 👇
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Eduardo Zimmer @erzimmer.bsky.social · 01/01/2025
There are some books I have read multiple times, and each time feels like a completely new experience. One of them is Gabo’s “Cien años de soledad”—what a wonderful read! 👇 This special edition is truly beautiful, with so many amazing illustrations!
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Eduardo Zimmer @erzimmer.bsky.social · 31/12/2024
The year is coming to a close, and we’ve just signed a major Alzheimer’s blood biomarkers program with the Brazilian Ministry of Health! Exciting science with a clear goal to make a real impact is on the way!🩸🇧🇷
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Ingo Greger @igreger.bsky.social · 24/12/2024
The Neurobiology Division at the MRC LMB is looking for a new group leader: www.nature.com/naturecareer...
nature.com
Research Group Leader - Neurobiology - LMB 2531 - Cambridgeshire job with MRC Laboratory of Molecular Biology (LMB) | 12832855
Research Group Leader Starting Salary £50,608 - £58,919 per annum for appointment to Senior Investigator Scientist Salary £65,940 - £74,448 per ann...
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Eduardo Zimmer @erzimmer.bsky.social · 24/12/2024
Exciting news this Christmas: our spotlight, led by @limberger-chris.bsky.social, on Haas, Bravo et al. 2024 is out now in @cp-trendsneuro.bsky.social 👉 www.sciencedirect.com/science/arti... @zimmerneurolab.bsky.social
sciencedirect.com
Assessing brain-wide outcomes of dopamine system activation in the living rodent brain
In a recent study, Haas, Bravo, and colleagues integrated optogenetic stimulation with simultaneous functional in vivo positron emission tomography (P…
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Lance Johnson @johnsonlab.bsky.social · 21/12/2024
new preprint! www.biorxiv.org/content/10.1... a characterization of APOE effects on the lipid droplet-ome (turns out you see a lot of "AD-related" proteins!) first authors Cassi Friday & Isaiah Stephens + great collaborators Scott Gordon, @cohenlaboratory.bsky.social @morganti.bsky.social
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Trends in Biochemical Sciences @cp-trendsbiochem.bsky.social · 12/12/2024
Hi! We made it, and just in time to share our last issue of 2024! You can find it here 👉 www.cell.com/trends/bioch...
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Ali Twelvetrees @dozenoaks.bsky.social · 11/11/2024
Trying for a molecular and cellular neurobiology starter pack - happy to add folks and connect :) #neuroskyance #cellbiology go.bsky.app/PgEk7aF
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Eduardo Zimmer @erzimmer.bsky.social · 11/12/2024
@zimmerneurolab.bsky.social team is slowly making the move to 🦋! So, I’ll start introducing our team members. 👉 Do you like our website (zimmer-lab.org) our cards, and media content? That’s all thanks to @rigonfr.bsky.social
zimmer-lab.org
Home Page - Zimmer Lab
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Dementia Researcher @dementiaresearcher.bsky.social · 10/12/2024
Associate or Full Prof Neuroimager Faculty Position at Northwestern University exploring mechanisms of cognition, brain aging, and the pathobiology of dementia. Closing date: 6th March www.dementiaresearcher.nihr.ac.uk/job/associat...
dementiaresearcher.nihr.ac.uk
Associate or Full Professor Neuroimager Faculty Position
Associate or Full Prof Neuroimager Faculty Position at Northwestern University exploring mechanisms of cognition, brain aging, and the pathobiology of dementia
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Shane Liddelow @liddelowsa.bsky.social · 10/12/2024
it's big, and it's a review of 601 papers on the topic - but here's an update on Neuroinflammation in Alzheimer's Disease www.nature.com/articles/s41... led by Michael Heneka, published in @natrevimmunol.bsky.social today (MANY more authors listed and linked below)
nature.com
Neuroinflammation in Alzheimer disease - Nature Reviews Immunology
This Review provides an in-depth examination of how inflammation contributes to neurodegeneration in Alzheimer disease. The authors explore the impact of extrinsic factors, such as brain trauma, diet ...
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Fernando González Ibáñez @fgi-em-neuro.bsky.social · 09/12/2024
New publication on Cell Reports! We describe a mechanism by which #microglia degrade amyloid-beta deposits that they can't phagocytose. Collaboration between the Tremblay lab and Rudy Jacquet, Santiago Solé-Domènech and Frederick Maxfield at Weill Cornell. www.sciencedirect.com/science/arti...
sciencedirect.com
Microglia degrade Alzheimer’s amyloid-beta deposits extracellularly via digestive exophagy
How microglia digest Alzheimer’s fibrillar amyloid-beta (Aβ) plaques that are too large to be phagocytosed is not well understood. Here, we show that …
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Shari Wiseman @shariwiseman.bsky.social · 09/12/2024
Nature Neuroscience is hiring a computational/systems/cognitive editor! Come join our team! Happy to answer any questions. springernature.wd3.myworkdayjobs.com/SpringerNatu...
springernature.wd3.myworkdayjobs.com
Associate or Senior Editor, Nature Neuroscience
Job Title: Associate or Senior Editor, Nature Neuroscience Location: New York, Jersey City, Philadelphia, Washington D.C., Berlin or Shanghai Application Deadline: January 6, 2025 About Springer Natur...
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Eduardo Zimmer @erzimmer.bsky.social · 07/12/2024
Today I turned 40! My tip for young scientists (and everyone else): Learn from the past, envision the future, but always live in the present. 💜
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Eduardo Zimmer @erzimmer.bsky.social · 06/12/2024
This is very useful to understand @altmetric.com score! 👇👇👇
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Andrew Octavian Sasmita @aosasmita.bsky.social · 06/12/2024
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease This further adds to the mounting evidence that microglia are perhaps much better at Aβ plaque formation than plaque clearance. What a fantastic study 🤩
nature.com
Homeostatic microglia initially seed and activated microglia later reshape amyloid plaques in Alzheimer’s Disease - Nature Communications
The role of microglia in Alzheimer’s disease is debated. This paper shows that homeostatic microglia seed amyloid plaques in early disease stages and activated microglia compact plaques at later stage...
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